Coherent X-radiation generated by relativistic elektron along its velocity in periodically lavered medium

Dynamic theory of coherent X-radiation generated by relativist.ic electron crossing multilayered medium is developed. It is found the radiation along the electron velocity vector in Bragg’s scattering geometry for general asymmetric case. The comparison of analogous radiation generated by relativist.ic electron in the single crystal medium is done. The developed theory predicts some conditions under which this coherent, radiation exists and also it describes its spectral and angular characteristicsyesБелгородский государственный университе

Developing competency profiles of IT specialists based on semantic analysis of vacancies

The article focuses on applying Big Data processing methods and tools for creating specialists' competency profiles. It covers the approach developed to formulate the key competencies required for the IT vacancies. The first stage of the research includes carrying out a semantic analysis of the IT vacancies database. The second stage includes clustering of the results of semantic analysis and using them for building the map of the competencies of IT specialists. The modularity score reveals a significant isolation of the specialties in this area. The performed approach can be implemented in designing the professional standards and competency based education programs. © Published under licence by IOP Publishing Ltd

Melting Point and Lattice Parameter Shifts in Supported Metal Nanoclusters

The dependencies of the melting point and the lattice parameter of supported metal nanoclusters as functions of clusters height are theoretically investigated in the framework of the uniform approach. The vacancy mechanism describing the melting point and the lattice parameter shifts in nanoclusters with decrease of their size is proposed. It is shown that under the high vacuum conditions (p<10^-7 torr) the essential role in clusters melting point and lattice parameter shifts is played by the van der Waals forces of cluster-substrate interation. The proposed model satisfactorily accounts for the experimental data.Comment: 6 pages, 3 figures, 1 tabl

Antimicrobial therapy of severe “civilian” intra-abdominal infections: a modern approach to empiric antibiotic therapy

This publication discusses the problems of treatment of severe intra-abdominal infections, namely empirical antimicrobial therapy for secondary peritonitis in view of the current state of the issue as understood by the authors, as well as modern guidelines and orders of the Ministry of Health of Ukraine. The use of well-known, but new for Ukraine drug, such as piperacillin / tazobactam, carbapenems, reserve antibiotics, is explored. We do not consider candidal, primary and tertiary peritonitis here, we hope to pay attention to this in future publications

Coherent X-radiation generated by relativistic elektron along its velocity in periodically lavered medium

yesDynamic theory of coherent X-radiation generated by relativist.ic electron crossing multilayered medium is developed. It is found the radiation along the electron velocity vector in Bragg’s scattering geometry for general asymmetric case. The comparison of analogous radiation generated by relativist.ic electron in the single crystal medium is done. The developed theory predicts some conditions under which this coherent, radiation exists and also it describes its spectral and angular characteristicsБелгородский государственный университе

Adiponectin gene single-nucleotide polymorphisms in patients with type 2 diabetes mellitus and nonalcoholic fatty liver disease

Background. It is generally believed that environmental and genetic factors interact with the formation of nonalcoholic fatty liver disease (NAFLD) phenotype and determine its progression. Both NAFLD and type 2 diabetes (T2D) are heterogeneous diseases with common pathogenic pathways. Adiponectin is an adipokine, which increases the sensitivity of hepatocytes and muscle to insulin, modulates energy homeostasis, glucose/lipid metabolism, and inflammatory response. A number of significant adiponectin gene polymorphisms are known in this area. The purpose of the study was to evaluate the possible association between two adiponectin gene (ADIPOQ) variants, +276 G/T (rs1501299) and –11391 G/A (rs17300539), and susceptibility to NAFLD in T2D patients of Ukrainian population. Materials and methods. Case-control study included a total of 155 persons with T2D (males/females: 77/78, age 54.55 ± 0.73 years, T2D duration 6.66 ± 0.49 years, body mass index 32.20 ± 0.43 kg/m2, waist/hip circumference 0.98 ± 0.01 m, HbA1c 7.26 ± 0.11 %) for biochemical characteristics (lipid profile, non-esterified fatty acids (NEFA), insulin, total adiponectin, etc.), including 90 T2D patients with NAFLD, 245 — with rs1501299 genotyping, 155 — with rs17300539 genotyping, and 51 sex and age-matched control subjects. The +276 G/T and –11391 G/A were determined by polymerase chain reaction — restriction fragment length polymorphism method with endonucleases Mva1269I (BsmI) and MspI (HpaII). Insulin resistance (IR) was assessed using homeostasis model assessment (HOMA) algorithm and as adipose IR (Adipo-IR, NEFAxinsulin). Unpaired Student’s t test, c2 test and Spearman’s rank order were used. To predict the probabilities of genetic risk in NAFLD, the odds ratio (OR) and 95% confidence interval (CI) were calculated. Results. T2D patients were characterized by overweight and obesity, which were more significant in the presence of NAFLD (p < 0.01). It was accompanied by an increase in НОМА-IR (p < 0.05) and triglycerides (p < 0.001) levels. We found that Adipo-IR was higher in patients with T2D as compared to the controls (p < 0.001), and this index was significantly increased in T2D patients with NAFLD in contrast to obesity-matched persons without NAFLD (190.18 ± 22.15 vs 133.32 ± 13.58 mmol/L·pmol/L, p < 0.02), with negative correlation between Adipo-IR and adiponectin level in T2D patients with NAFLD only (rs = –0.350, p = 0.021). Stratification of non-NAFLD patients by +276G/T genotype suggests the prevalence of GT- and TT-genotypes. Thus, the rs1501299 G-allele increased the risk of NAFLD in comparison with T-allele (OR = 4.44, 95% CI = 2.89–6.81, p < 0.05). We also found a significant difference in the frequency of –11391G/A between T2D and control groups, but not between the patients with and without NAFLD. We observed that the haplotype of GT/GG had been more common in T2D with NAFLD, and twice less often detected in patients without hepatic disease (33 and 16.49 %, respectively, p < 0.05). Conclusions. We can recommend Adipo-IR index as a predictive marker for the NAFLD development and the indicator for therapy success in T2D patients. We established new genetic markers (rs1501299 G-allele, rs17300539 and rs1501299 GG/GG and GT/GG haplotypes, respectively) for the risk of NAFLD development in T2D patients