An evaluation of preoperative CA 15-3 measurement in primary breast carcinoma.

In this study of 500 patients with breast carcinoma, we have prospectively assessed the role of preoperative CA 15-3 as a marker of disease burden over a 7 year period. CA 15-3 levels at presentation correlate with stage of disease, tumour size, lymph node status, the presence of metastases and lymphocyte infiltration into the tumour. CA 15-3 alone is not an independent prognostic indicator, although a serum level of > 40 U ml-1 has a positive predictive value of 83% for the presence of advanced disease. We recommend the routine use of this marker in the preoperative assessment of primary breast carcinoma

The emergency use of endografts in the carotid circulation to control hemorrhage in potentially contaminated fields

We report our experience with the use of endoluminal grafts to control emergency bleeding in two patients with tracheoinnominate fistulas and three patients with carotid blowouts. Systemic infectious complications were not seen. However, rebleeding occurred in one patient, and extensive stent coverage to control bleeding was required in a second. Survival was usually limited by the patient’s cancer. There was one long-term survivor without cancer whose tracheostomy was placed for neurologic compromise. A review of the literature for similar cases identified 18 additional endografts placed for carotid blowout and 3 placed for tracheoinnominate fistulas. Overall, infectious complications occurred in only two patients, whereas rebleeding occurred in eight patients. On the basis of these findings, we believe that endografts are useful to control emergency hemorrhage in these two pathologies because treatment is usually palliative, given the poor survival secondary to the underlying disease. However, more extensive graft coverage may be necessary considering the erosive nature of these processes

Persistence of Tall Fescue and Cattle Grazing Preference as Affected by Endophyte Status

Endophyte-infected (E+) grasses often exhibit increased survival, growth and resistance to herbivory compared to uninfected counterparts. Latch (1997) proposed a strategy for cultivar improvement of infecting elite cultivars with strains of Neotyphodium coenophialum that are non-toxic to livestock, but still able to convey the persistence advantage shown with wild-type, toxic endophyte. The strategy of re-infecting tall fescue (Lolium arundinaceum (Schreb.) Darbysh.) cultivars with naturally occurring, non-ergot-producing endophytes appears promising for removing animal toxicity symptoms and retaining agronomic performance (Bouton et al., 2002; Hill et al., 2002). The objective of this study was to compare the effect of endophyte status on grazing preference and persistence of tall fescue stand

Theory of continuum percolation III. Low density expansion

We use a previously introduced mapping between the continuum percolation model and the Potts fluid (a system of interacting s-states spins which are free to move in the continuum) to derive the low density expansion of the pair connectedness and the mean cluster size. We prove that given an adequate identification of functions, the result is equivalent to the density expansion derived from a completely different point of view by Coniglio et al. [J. Phys A 10, 1123 (1977)] to describe physical clustering in a gas. We then apply our expansion to a system of hypercubes with a hard core interaction. The calculated critical density is within approximately 5% of the results of simulations, and is thus much more precise than previous theoretical results which were based on integral equations. We suggest that this is because integral equations smooth out overly the partition function (i.e., they describe predominantly its analytical part), while our method targets instead the part which describes the phase transition (i.e., the singular part).Comment: 42 pages, Revtex, includes 5 EncapsulatedPostscript figures, submitted to Phys Rev

Motional Squashed States

We show that by using a feedback loop it is possible to reduce the fluctuations in one quadrature of the vibrational degree of freedom of a trapped ion below the quantum limit. The stationary state is not a proper squeezed state, but rather a ``squashed'' state, since the uncertainty in the orthogonal quadrature, which is larger than the standard quantum limit, is unaffected by the feedback action.Comment: 8 pages, 2 figures, to appear in the special Issue "Quantum Correlations and Fluctuations" of J. Opt.

Central exclusive production of longlived gluinos at the LHC

We examine the possibility of producing gluino pairs at the LHC via the exclusive reaction pp -> p+gluino+gluino+p in the case where the gluinos are long lived. Such long lived gluinos are possible if the scalar super-partners have large enough masses. We show that it may be possible to observe the gluinos via their conversion to R-hadron jets and measure their mass to better than 1% accuracy for masses below 350 GeV with 300/fb of data.Comment: 13 pages, 9 figures. Minor corrections to version

Death and transfiguration in static staphylococcus epidermidis cultures

The overwhelming majority of bacteria live in slime embedded microbial communities termed biofilms, which are typically adherent to a surface. However, when several Staphylococcus epidermidis strains were cultivated in static liquid cultures, macroscopic aggregates were seen floating within the broth and also sedimented at the test tube bottom. Light- and electron microscopy revealed that early-stage aggregates consisted of bacteria and extracellular matrix, organized in sheetlike structures. Perpendicular under the sheets hung a network of periodically arranged, bacteria-associated strands. During the extended cultivation, the strands of a subpopulation of aggregates developed into cross-connected wall-like structures, in which aligned bacteria formed the walls. The resulting architecture had a compartmentalized appearance. In late-stage cultures, the wall-associated bacteria disintegrated so that, henceforth, the walls were made of the coalescing remnants of lysed bacteria, while the compartment-like organization remained intact. At the same time, the majority of strand containing aggregates with associated culturable bacteria continued to exist. These observations indicate that some strains of Staphylococcus epidermidis are able to build highly sophisticated structures, in which a subpopulation undergoes cell lysis, presumably to provide continued access to nutrients in a nutrient-limited environment, whilst maintaining structural integrity

CAD in mammography: lesion-level versus case-level analysis of the effects of prompts on human decisions

Object: To understand decision processes in CAD-supported breast screening by analysing how prompts affect readers’ judgements of individual mammographic features (lesions). To this end we analysed hitherto unexamined details of reports completed by mammogram readers in an earlier evaluation of a CAD tool. Material and methods: Assessments of lesions were extracted from 5,839 reports for 59 cancer cases. Statistical analyses of these data focused on what features readers considered when recalling a cancer case and how readers reacted to CAD prompts. Results: About 13.5% of recall decisions were found to be caused by responses to features other than those indicating actual cancer. Effects of CAD: lesions were more likely to be examined if prompted; the presence of a prompt on a cancer increased the probability of both detection and recall especially for less accurate readers in subtler cases; lack of prompts made cancer features less likely to be detected; false prompts made non-cancer features more likely to be classified as cancer. Conclusion: The apparent lack of impact reported for CAD in some studies is plausibly due to CAD systematically affecting readers’ identification of individual features, in a beneficial way for certain combinations of readers and features and a damaging way for others. Mammogram readers do not ignore prompts. Methodologically, assessing CAD by numbers of recalled cancer cases may be misleading