19 research outputs found
Synthesis, characterization and cellular location of cytotoxic constitutional organometallic isomers of rhenium delivered on a cyanocobalmin scaffold
- Publication venue
- Publication date
- 01/01/2015
- Field of study
Constitutional isomers of cyanocobalamin adducts based on a fluorescent rhenium tris-carbonyl diimine complex were prepared, characterized and tested against PC-3 cancer cells. The adducts differ only in the relative binding position of the organometallic species which is either bound at the cyano or the 5âČ-hydroxo group of vitamin Bââ. When tested for their cytotoxic potency, the species showed ICâ
â values in the low ÎŒM rage. Upon conjugation to the vitamin an energy transfer process causes an extremely low quantum yield of fluorescence emission, making the conjugates unsuitable for fluorescence imaging. However, by exploiting the vibrational signature of the fac-[Re(CO)â]âș core, their cellular distribution was evaluated via FTIR spectromicroscopy
Search for gravitational-lensing signatures in the full third observing run of the LIGO-Virgo network
- Author
- Abbott R.
- Abe H.
- Acernese F.
- Ackley Kendall
- Adhicary S.
- Adhikari Naresh
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- Zheng Yanyan
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- Zhu Xingjiang
- Zhu Zong-Hong
- Zimmerman Aaron
- Zucker M. E.
- ĂrpĂĄd Gergely LĂĄszlĂł
- ć ćæŹœ
- æčćšéź
- çè°š
- éœäžž éèĄ
- Publication venue
- Publication date
- 01/04/2023
- Field of study
Gravitational lensing by massive objects along the line of sight to the source causes distortions of gravitational wave-signals; such distortions may reveal information about fundamental physics, cosmology and astrophysics. In this work, we have extended the search for lensing signatures to all binary black hole events from the third observing run of the LIGO--Virgo network. We search for repeated signals from strong lensing by 1) performing targeted searches for subthreshold signals, 2) calculating the degree of overlap amongst the intrinsic parameters and sky location of pairs of signals, 3) comparing the similarities of the spectrograms amongst pairs of signals, and 4) performing dual-signal Bayesian analysis that takes into account selection effects and astrophysical knowledge. We also search for distortions to the gravitational waveform caused by 1) frequency-independent phase shifts in strongly lensed images, and 2) frequency-dependent modulation of the amplitude and phase due to point masses. None of these searches yields significant evidence for lensing. Finally, we use the non-detection of gravitational-wave lensing to constrain the lensing rate based on the latest merger-rate estimates and the fraction of dark matter composed of compact objects
Observation of gravitational waves from the coalescence of a 2.5â4.5 Mâ compact object and a neutron star
- Author
- Abac Adrian
- Abbott R.
- Abouelfettouh I.
- Acernese F.
- Ackley Kendall
- Adhicary S.
- Adhikari Naresh
- Adhikari Rana X.
- Adkins V. K.
- Afif Ismail M.
- Agarwal Deepali
- Agathos Michalis
- Aghaei Abchouyeh Maryam
- Aguiar Odylio D.
- Aguilar I.
- Aiello Lorenzo
- Ain Anirban
- Ajith Parameswaran
- Akcay Sarp
- Akseli Hannuksela Otto
- Akutsu Tomotada
- Al-Jodah Ammar
- Al-Shammari S.
- Albanesi Simone
- Alex iandolo Guido
- Alfaidi Reem Atallah E
- Allocca Annalisa
- Alléné C.
- Altin Paul
- Alvarez-Lopez Sofia
- Amato Alex
- Amez-Droz L.
- Amorosi A.
- Amra C.
- Ananyeva A.
- Anderson Stuart
- Anderson Warren G.
- Andia Manuel
- Ando M.
- Andrade T.
- Andrea Prodi Giovanni
- Andres Nicolas
- Andric Tomislav
- Andrés Vallejo Peña Sergio
- Andrés-Carcasona Marc
- Anglin J.
- Anne Bizouard Marie
- Ansoldi Stefano
- Antelis Javier M.
- Antier Sarah
- Antoni Ramis Vidal Felip
- Antonietta Palaia Maria
- Antonio Font Roda Jose
- Aoumi M.
- Appavuravther E. Z.
- Appert S.
- Apple S. K.
- Arai Koji
- Araya Akito
- Araya Melody
- Areeda Joseph
- Argianas L.
- Arif Shaikh Md
- Aritomi N.
- Armato Federico
- Arnaud Nicolas
- Arogeti Megan
- Aronson Scott
- Arun K. G.
- Ashton Gregory
- Aso Yoichi
- Assiduo M.
- Aston S. M.
- Astone Pia
- Attadio Francesca
- Aubin Florian
- AVALLONE Guerino
- Azrad D.
- Babak Stanislav
- Badaracco Francesca
- Badger C.
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- Chalathadka Subrahmanya Shreevathsa
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- Chassande-Mottin Eric
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- Zweizig John
- ĂrpĂĄd Gergely LĂĄszlĂł
- ć ćæŹœ
- éœäžž éèĄ
- Publication venue
- Publication date
- 23/04/2024
- Field of study
Search for eccentric black hole coalescences during the third observing run of LIGO and Virgo
- Author
- Abac A. G.
- Abbott R.
- Abe H.
- Acernese F.
- Ackley Kendall
- Adamcewicz C.
- Adhicary S.
- Adhikari Naresh
- Adhikari Rana X.
- Adkins V. K.
- Adya V. B.
- Affeldt C.
- Afif Ismail M.
- Agarwal D.
- Agathos Michalis
- Aguiar Odylio D.
- Aguilar I.
- Aiello Lorenzo
- Ain Anirban
- Ajith Parameswaran
- Akseli Hannuksela Otto
- Akutsu Tomotada
- Al-Jodah Ammar
- Albanesi S.
- Alberto Trani Alessandro
- Alfaidi Reem Atallah E
- Allocca Annalisa
- Alléné C.
- Almualla M.
- Altin Paul
- Amato Alex
- Amez-Droz L.
- Amorosi A.
- Anand S.
- Ananyeva A.
- Andersen R.
- Anderson Stuart
- Anderson Warren G.
- Andia Manuel
- Ando M.
- Andrade T.
- Andrea Prodi Giovanni
- Andres Nicolas
- Andric Tomislav
- Andrés-Carcasona Marc
- Anne Bizouard Marie
- Ansoldi S.
- Antelis Javier M.
- Antier Sarah
- Antonio Font Roda Jose
- Aoumi M.
- Apostolatos T.
- Appavuravther E. Z.
- Appert S.
- Apple S. K.
- Arai Koji
- Araya Akito
- Araya Melody
- Areeda Joseph
- Arif Shaikh Md
- Aritomi Naoki
- Armato F.
- Arnaud Nicolas
- Arogeti Megan
- Aronson Scott
- Arun K. G.
- Ashton Gregory
- Aso Yoichi
- Assiduo M.
- Aston S. M.
- Astone Pia
- Aubin Florian
- Babak Stanislav
- Badalyan A.
- Badaracco Francesca
- Badger C.
- Bae Sangwook
- Bagnasco Stefano
- Bai Y.
- Baier Jeremy
- Bajpai Rishabh
- Baka T.
- Ball M.
- Ballardin G.
- Ballmer S. W.
- Baltus Grégory
- Banagiri Sharan
- Banerjee Biswajit
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- Baral Pratyusava
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- Barone Fabrizio
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- Barton Mark Andrew
- Bartos I.
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- Caudill S.
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- Cella Giancarlo
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- Chan C.
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- Chandra K.
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- Chang R. -J.
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- Chanial Pierre
- Chao Shiuh
- Chapman-Bird Christian
- Charlton E. L.
- Charlton Philip
- CHASSANDE-MOTTIN Eric
- Chastain L.
- Chatterjee Chayan
- Chatterjee Debarati
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- Chaturvedi M.
- Chaty Sylvain
- Chatziioannou Katerina
- Chen A.
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- Christensen Nelson
- Chua Sheon S. Y.
- Chun Lung Chan Juno
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- Ciani Giacomo
- CiecielÄ g PaweĆ
- CieĆlar Marek
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- Ciolfi Riccardo
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- Concetta Tringali Maria
- Conti Livia
- Cooper Sam
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- Cordero-CarriĂłn Isabel
- Corezzi S.
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- Corsi Alessandra
- Cortese Stefano
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- Cottingham R.
- Coughlin Michael
- Couineaux A.
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- Cousins Bryce
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- Coyne Robert
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- Crockett-Gray J. C. G.
- Croquette Michaël
- Crouch R.
- Crowder S. G.
- Cudell Jean-René
- Cullen T. J.
- Cumming Alan
- Cuoco E.
- CuryĆo M.
- Cusinato Marco
- D'Angelo Beatrice
- D'Antonio S.
- d'Emilio V.
- D'Onofrio Luca
- D'Urso D.
- Dabadie P.
- Dal Canton Tito
- DALL'OSSO Simone
- Danilishin Stefan
- Danzmann K.
- Darroch K. E.
- Darsow-Fromm Christian
- Dartez L. P.
- Dasgupta A.
- Datta Sayantani
- Dattilo V.
- Daumas A.
- Dave I.
- Davenport A.
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- Davis Derek
- Davis Michael C.
- Daw Edward
- Dax Maximilian
- De Laurentis Martina
- De Lillo Federico
- de Lluc Planas Maria
- De Marco F.
- De Matteis F.
- De Pietri Roberto
- De Rosa Rosario
- de rossi camilla
- De Simone R.
- de Souza Melo S. Assis
- Deenadayalan M.
- Degallaix Jerome
- Del Pozzo W.
- Delfavero Vera
- Dell'Aquila Daniele
- Deléglise Samuel
- Demos N.
- Dent Thomas
- Depasse Antoine
- Dhurandhar S.
- Di Fiore L.
- Di Fronzo Chiara
- di giovanni Fabrizio
- Di Giovanni M.
- Di Girolamo Tristano
- Di Michele Alessandro
- Di Renzo Francesco
- DI. PALMA Irene
- Diab R.
- Diamond P. Z.
- Diaz J. Casanueva
- Didio N. A.
- Diego Bonavena Luis
- Dietrich Tim
- Diksha D.
- Ding Jacques
- Divyajyoti
- Dmitriev Artemiy
- Doctor Zoheyr
- Dohmen E.
- Doleva P. P.
- Donahue L.
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- Dooley Katherine L.
- Dooney T.
- Doravari Suresh
- Dorosh O.
- Drago Marco
- Driggers Jennifer C.
- Drori Y.
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- Ducoin J. -G.
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- Dupletsa U.
- Duval Hannah
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- DĂĄlya Gergely
- Eassa C.
- Ebersold Michael
- Eckhardt Tobias
- Eddolls Graeme
- Edelman Bruce
- Edo T. B.
- Edy Oliver
- Effler Anamaria
- Eichholz Johannes
- Einsle H.
- Eisenmann M.
- Eisenstein R. A.
- Ejlli Aldo
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- Elizabeth Ramirez Guevara Karla
- Engelby E.
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- Erasmo Peña Arellano Fabiån
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- error error
- error error
- error error
- error error
- Estellés Estrella Héctor
- Estevez Dimitri
- Etzel T.
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- Evans Matthew J.
- Evans T. M.
- Evstafyeva T.
- Ewing B. E.
- Fabrizi Federica
- Faedi F.
- Fafone Viviana
- Fair H.
- Fairhurst Stephen
- Fan Pinchen
- Farah Amanda M.
- Farr Ben
- Farr Will M.
- Fauchon-Jones E. J.
- Favaro Giulio
- Favata Marc
- Fays Maxime
- Feicht J.
- Fejer M. M.
- Fenyvesi Edit
- Ferguson Deborah
- Ferrante Isidoro
- Ferreira T. A.
- Fidecaro Francesco
- Fiori Alessio
- Fiori Irene
- Fishbach Maya
- Fisher R. P.
- Fittipaldi R.
- Fiumara V.
- Flaminio R.
- Fleischer Svenja
- Fleming L. S.
- Floden E.
- Fong H.
- Fornal Bartosz
- Forsyth P. W. F.
- Franceschetti K.
- Francisco Nuño Siles José
- Franke A.
- Frasca S.
- Frasconi Franco
- Frei Zsolt
- Freise Andreas
- Freitas Osvaldo
- Frey Raymond
- Frischhertz W.
- Fritschel P.
- Frolov V. V.
- Fujii S.
- Fukunaga I.
- Fulda P.
- Fung Wong Chun
- Fyffe M.
- Gabella William
- Gadre Bhooshan
- Gaetano Fronzé Gabriele
- Gair Jonathan
- Gais J.
- Galaudage S.
- Gallardo S.
- Gamba Rossella
- Ganapathy Dhruva
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- LIETO ALBERTO. DI.
- LIGO Collaboration
- Lin Chien-Yu
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- Lin En-Tzu
- Lin F.
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- MASCIOLI ADRIANO. FRATTALE.
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- MORALES ESTER. RUIZ.
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- Yokozawa T.
- Yoo Jooheon
- Yu Hang
- Yuzurihara Hirotaka
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- Zucker M. E.
- Zweizig John
- Ălvarez-LĂłpez S.
- ĂrpĂĄd Gergely LĂĄszlĂł
- ć ćæŹœ
- æčćšéź
- éœäžž éèĄ
- Publication venue
- Publication date
- 01/08/2023
- Field of study
Despite the growing number of confident binary black hole coalescences observed through gravitational waves so far, the astrophysical origin of these binaries remains uncertain. Orbital eccentricity is one of the clearest tracers of binary formation channels. Identifying binary eccentricity, however, remains challenging due to the limited availability of gravitational waveforms that include effects of eccentricity. Here, we present observational results for a waveform-independent search sensitive to eccentric black hole coalescences, covering the third observing run (O3) of the LIGO and Virgo detectors. We identified no new high-significance candidates beyond those that were already identified with searches focusing on quasi-circular binaries. We determine the sensitivity of our search to high-mass (total mass M>70 Mâ) binaries covering eccentricities up to 0.3 at 15 Hz orbital frequency, and use this to compare model predictions to search results. Assuming all detections are indeed quasi-circular, for our fiducial population model, we place an upper limit for the merger rate density of high-mass binaries with eccentricities 0<eâ€0.3 at 0.33 Gpcâ3 yrâ1 at 90\% confidence level
Ultralight vector dark matter search using data from the KAGRA O3GK run
- Author
- Abac A. G.
- Abbott R.
- Abe H.
- Abouelfettouh I.
- Acernese F.
- Ackley Kendall
- Adamcewicz Christian
- Adhicary S.
- Adhikari Naresh
- Adhikari Rana X.
- Adkins V. K.
- Adya V. B.
- Affeldt C.
- Afif Ismail M.
- Agarwal Deepali
- Agathos Michalis
- Aguiar Odylio D.
- Aguilar I.
- Aiello Lorenzo
- Ain Anirban
- Ajith Parameswaran
- Akseli Hannuksela Otto
- Akutsu Tomotada
- Al-Jodah Ammar
- Al-Shammari S.
- Albanesi S.
- Alberto Trani Alessandro
- Alfaidi Reem Atallah E
- Allocca Annalisa
- Alléné C.
- Altin Paul
- Alvarez-Lopez Sofia
- Amato Alex
- Amez-Droz L.
- Amorosi A.
- Amra C.
- Anand S.
- Ananyeva A.
- Anderson Stuart
- Anderson Warren G.
- Andia Manuel
- Ando M.
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- Andrea Prodi Giovanni
- Andres Nicolas
- Andric Tomislav
- Andrés-Carcasona Marc
- Anglin J.
- Anne Bizouard Marie
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- Antier Sarah
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- Yang Kate Z.
- Yang L. -C.
- Yang Yi
- Yarbrough Zach
- Yeh S. -W.
- Yelikar A. B.
- Yeung S. M. C.
- Yin X.
- Yokoyama Jun'ichi
- Yokozawa T.
- Yoo Jooheon
- Yu Hang
- Yuzurihara Hirotaka
- ZadroĆŒny A.
- Zahoor Jan Aasim
- Zannelli A. J.
- Zanolin M.
- Zeeshan M.
- Zelenova T.
- Zendri J. -P.
- Zeoli M.
- Zerrad M.
- Zevin Michael
- Zhang A. C.
- Zhang Jue
- Zhang L.
- Zhang Rui
- Zhang T.
- Zhang Ya
- Zhao C.
- Zhao Yue
- Zhao Yuhang
- Zheng Yanyan
- Zhong Haowen
- Zhong S.
- Zhou R.
- Zhu Zong-Hong
- Zucker M. E.
- Zweizig John
- ĂrpĂĄd Gergely LĂĄszlĂł
- ć ćæŹœ
- æčćšéź
- éœäžž éèĄ
- Publication venue
- Publication date
- 01/03/2024
- Field of study
Among the various candidates for dark matter (DM), ultralight vector DM can be probed by laser interferometric gravitational wave detectors through the measurement of oscillating length changes in the arm cavities. In this context, KAGRA has a unique feature due to differing compositions of its mirrors, enhancing the signal of vector DM in the length change in the auxiliary channels. Here we present the result of a search for U(1)BâL gauge boson DM using the KAGRA data from auxiliary length channels during the first joint observation run together with GEO600. By applying our search pipeline, which takes into account the stochastic nature of ultralight DM, upper bounds on the coupling strength between the U(1)BâL gauge boson and ordinary matter are obtained for a range of DM masses. While our constraints are less stringent than those derived from previous experiments, this study demonstrates the applicability of our method to the lower-mass vector DM search, which is made difficult in this measurement by the short observation time compared to the auto-correlation time scale of DM
Proton therapy: A therapeutic opportunity for aggressive pediatric meningioma
- Author
- Publication venue
- 'Wiley'
- Publication date
- 01/01/2021
- Field of study
Meningiomas are an extremely rare histology among pediatric brain tumors, and there
is a shortage of literature on their management. Proton therapy is currently used safely
and effectively for many types of both pediatric and adult cancer, and its main advantage
is the sparing of healthy tissues from radiation, which could translate in the reduction
of late side effects.We review the literature on radiotherapy and proton therapy
for pediatric meningiomas and report clinical outcomes for two aggressive pediatric
meningiomas we treated with protons. Proton therapy might be a safe and effective
therapeutic option for this rare subgroup of tumors
Toxicity and Clinical Results after Proton Therapy for Pediatric Medulloblastoma: A Multi-Centric Retrospective Study
- Author
- Publication venue
- 'MDPI AG'
- Publication date
- 01/06/2022
- Field of study
Medulloblastoma is the most common malignant brain tumor in children. Even if current treatment dramatically improves the prognosis, survivors often develop long-term treatment-related sequelae. The current radiotherapy standard for medulloblastoma is craniospinal irradiation with a boost to the primary tumor site and to any metastatic sites. Proton therapy (PT) has similar efficacy compared to traditional photon-based radiotherapy but might achieve lower toxicity rates. We report on our multi-centric experience with 43 children with medulloblastoma (median age at diagnosis 8.7 years, IQR 6.6, M/F 23/20; 26 high-risk, 14 standard-risk, 3 ex-infant), who received active scanning PT between 2015 and 2021, with a focus on PT-related acute-subacute toxicity, as well as some preliminary data on late toxicity. Most acute toxicities were mild and manageable with supportive therapy. Hematological toxicity was limited, even among HR patients who underwent hematopoietic stem-cell transplantation before PT. Preliminary data on late sequelae were also encouraging, although a longer follow-up is needed
Additional file 4: of Clinical and genomic safety of treatment with Ginkgo biloba L. leaf extract (IDN 5933/GinkgoselectÂźPlus) in elderly: a randomised placebo-controlled clinical trial [GiBiEx]
- Author
- Barbara Benassi (738042)
- Eugenia Cordelli (27373)
- Francesca Pacchierotti (825020)
- Giulia Prinzi (4787271)
- Giuseppe Rasoni (4787280)
- Irene Paximadas (4787268)
- Maria SĂĄnchez-Flores (4787286)
- Martina Panatta (4787277)
- Marzia Ruggi (4787283)
- Palma Lamonaca (4787292)
- Paola Villani (825021)
- Patrizia Russo (4787289)
- Raffaella Rossi (208574)
- Salvatore Malandrino (4787274)
- Stefano Bonassi (136975)
- Vanessa Valdiglesias (4787265)
- Publication venue
- Publication date
- 01/01/2018
- Field of study
Gene expression Raw data. Data were analyzed in each sample in terms of increase/decrease of the specific gene expression at T1 compared to T0, with a cut-off value â„2-fold change (The values reported represent the excel conversion of the original raw data (average Ct calculated out of four replicates loaded onto the 48-wells PCR plate); the raw data are produced as â.csvâ file by the EcoIllumina software and need to be converted into excel file for delta delta Ct analysis). (PDF 163 kb
Clinical and genomic safety of treatment with Ginkgo biloba L. leaf extract (IDN 5933/GinkgoselectÂźPlus) in elderly: a randomised placebo-controlled clinical trial [GiBiEx]
- Author
- A Lindstrom
- Barbara Benassi
- Eugenia Cordelli
- Francesca Pacchierotti
- Giulia Prinzi
- Giuseppe Rasoni
- H Yang
- Irene Paximadas
- KJ Livak
- M Stepien
- Maria SĂĄnchez-Flores
- Martina Panatta
- Marzia Ruggi
- Palma Lamonaca
- Paola Villani
- Patrizia Russo
- PDRHM Ginkgo
- Raffaella Rossi
- S Klein
- Salvatore Malandrino
- Stefano Bonassi
- Vanessa Valdiglesias
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study