Material dependence of Casimir forces: gradient expansion beyond proximity

A widely used method for estimating Casimir interactions [H. B. G. Casimir, Proc. K. Ned. Akad. Wet. 51, 793 (1948)] between gently curved material surfaces at short distances is the proximity force approximation (PFA). While this approximation is asymptotically exact at vanishing separations, quantifying corrections to PFA has been notoriously difficult. Here we use a derivative expansion to compute the leading curvature correction to PFA for metals (gold) and insulators (SiO$_2$) at room temperature. We derive an explicit expression for the amplitude $\hat\theta_1$ of the PFA correction to the force gradient for axially symmetric surfaces. In the non-retarded limit, the corrections to the Casimir free energy are found to scale logarithmically with distance. For gold, $\hat\theta_1$ has an unusually large temperature dependence.Comment: 4 pages, 2 figure

Effects of economic crisis on fertility: a comparison between South Korea and Italy

Over the past decades, economic downturns have affected fertility dynamics in several countries in Asia and in Europe. The main purpose of this study is to perform a comparative analysis between South Korea and Italy on the effects of the economic crises, started respectively in 1997 and 2007, on the levels and patterns of fertility. A “tight family system” but very low fertility levels characterize both the se two countries . The data sets used come from the 2006 Korean National Fertility, Family Health and Welfare Survey and from the 2012 Italian Multipurpose Survey on Aspects of Everyday Life. Our sample focuses on women aged 20-49 urrently married at the time of the survey. We summarize the distinctive patterns in the socioeconomic characteristics of the bserved groups of women in Italy and South Korea. We also apply regression analyses to assess the changing effect of economic status on fertility. Our findings confirm that the recession affected fertility significantly both in South Korea and in Italy. Changes in eproductive behavior have been most evident among women characterized by a high level of fertility and among those who received unior high school education or lower. As the level of wife’s education rises, the number of children ever born after the crisis tends to ncrease

Epidemiological, genetic and epigenetic aspects of the research on healthy ageing and longevity

Healthy ageing and longevity in humans result from a number of factors, including genetic background, favorable environmental and social factors and chance

Fibronectin-1 expression is increased in aggressive thyroid cancer and favors the migration and invasion of cancer cells

n this study we analyzed the expression levels of markers of epithelial-to-mesenchymal transition (EMT) in several papillary thyroid carcinomas (PTCs) and the relation with tumor genotypes and clinicopathological characteristics. The role of fibronectin-1 (FN1) was investigated by analyzing the effects of FN1 silencing in two human thyroid cancer cell lines. Most of EMT markers were significantly over-expressed in a group of 36 PTCs. In particular, FN1 mRNA levels were higher in tumor vs non-tumor tissue (117.3, p < 0.001) and also in aggressive and BRAF(V600E) samples. Similar results were observed (and confirmed at the protein level) when FN1 expression was analyzed in a validation group of 50 PTCs and six lymph node (LN) metastases. Silencing of FN1 in TPC-1 and BCPAP thyroid cancer cells significantly reduced proliferation, adhesion, migration, and invasion in both cell lines. Collectively, our data indicate that FN1 overexpression is an important determinant of thyroid cancer aggressiveness

XSTest: A Test Suite for Identifying Exaggerated Safety Behaviours in Large Language Models

Without proper safeguards, large language models will readily follow malicious instructions and generate toxic content. This motivates safety efforts such as red-teaming and large-scale feedback learning, which aim to make models both helpful and harmless. However, there is a tension between these two objectives, since harmlessness requires models to refuse complying with unsafe prompts, and thus not be helpful. Recent anecdotal evidence suggests that some models may have struck a poor balance, so that even clearly safe prompts are refused if they use similar language to unsafe prompts or mention sensitive topics. In this paper, we introduce a new test suite called XSTest to identify such eXaggerated Safety behaviours in a structured and systematic way. In its current form, XSTest comprises 200 safe prompts across ten prompt types that well-calibrated models should not refuse to comply with. We describe XSTest's creation and composition, and use the test suite to highlight systematic failure modes in a recently-released state-of-the-art language model.Comment: v1 to document initial data releas

Early Enrollees and Peer Age Effect: First Evidence from INVALSI Data

This paper estimates peer age effect on educational outcomes of Italian pupils attending primary school by exploiting changes in enrollment rules over the last few years. The empirical procedure allows to understand if there is selection in classroom formation, arguing that in the absence of pupils sorting by early age at school entry, it is possible to estimate the “true” peer age effect. Results suggest that the proportion of youngest students “in advance” in the classroom has a positive impact on child’s achievements measured by Normalized and Rasch test scores both in Reading and Mathematics. Additional empirical evidence shows that the effect on individual scores of sharing the classroom with pupils “in advance” differs by students’ age group and it is higher for youngest pupils. Findings do not seem to be invalidated by “cheating” phenomena that may occur during the implementation and evaluation of tests

The mitochondrial DNA control region shows genetically correlated levels of heteroplasmy in leukocytes of centenarians and their offspring

<p>Abstract</p> <p>Background</p> <p>Studies on heteroplasmy occurring in the mitochondrial DNA (mtDNA) control region (CR) in leukocytes of centenarians and younger subjects have shown that the C150T somatic transition is over-represented in centenarians. However, whether the occurrence/accumulation of heteroplasmy is a <it>phenotypic consequence </it>of extreme ageing or a <it>genetically controlled event </it>that may favor longevity is a question that deserves further attention. To clarify this point, we set up a Denaturing High Performance Liquid Chromatography (DHPLC) protocol to quantify mtDNA CR heteroplasmy. We then analyzed heteroplasmy in leukocytes of centenarians (100 subjects), their offspring and nieces/nephews (200 subjects, age-range 65–80 years, median age 70 years), and in leukocytes of 114 control subjects sex- and age-matched with the relatives of centenarians.</p> <p>Results</p> <p>The centenarians and their descendants, despite the different ages, showed similar levels of heteroplasmy which were significantly higher than levels in controls. In addition we found that heteroplasmy levels were significantly correlated in parent-offspring pairs (r = 0.263; p = 0.009), but were independent of mtDNA inherited variability (haplogroup and sequence analyses).</p> <p>Conclusion</p> <p>Our findings suggest that the high degree of heteroplasmy observed in centenarians is genetically controlled, and that such genetic control is independent of mtDNA variability and likely due to the nuclear genome.</p