Atypical presentation of Non-Hodgkin Lymphoma (NHL): a case report

Lymphomas infrequently cause peripheral nerve complications. These syndromes mostly occur by direct compression or infiltration of nerves (neurolymphomatosis), but may also be due to a remote effect as paraneoplastic syndromes, neurotoxic complications of chemotherapy, antibody-mediated or autoimmune mechanisms.We report the case of a 60-year-old woman who presented with a complex peripheral nervous system involvement as initial manifestation of Non-Hodgkin Lymphoma (NHL). This case sheds light on "protean" mechanism of peripheral nerve complications during the course of NHL and related diagnostic dilemma

La Modellazione Diacronica di Risorse Termino-Ontologiche nell'Ambito delle Digital Humanities: Esperimenti su Clavius

Abstract English. In this work, we present an experiment in the modeling of a diachronic termino-ontological resource named CLAVIUS through both the N-ary relations model and the 4D-fluents approach. Some of the salient differences of these two models are discussed. The overall objective of this research is to illustrate the main advantages and disadvantages in the adoption of a given model to build diachronic resources. Italiano. In questo lavoro, si illustra un esperimento di modellazione di una risorsa termino-ontologica diacronica (CLAVIUS) secondo due approcci, quello N-ario e quello dei 4D-fluents. Le differenze salienti dei due approcci verranno presentate e discusse. L'obiettivo generale della ricerca qui introdotta è quello di mostrare i principali vantaggi e svantaggi che l'adozione di un determinato modello può comportare nella modellazione di risorse diacroniche. Introduzione Pànta rei è la celebre espressione attribuita da Platone ad Eraclito. Tutto è sottoposto alla inesorabile legge del mutamento: la realtà, le categorie attraverso le quali la organizziamo e le parole che usiamo per parlare di essa. Quali sono gli strumenti a disposizione dell'umanista digitale di oggi, che si trovi a dover rappresentare in modo esplicito e formale tale evoluzione diacronica dei concetti e dei termini in un determinato ambito, in modo che tale formalizzazione sia computabile ad un calcolatore? In questi ultimi anni, ed in particolar modo nell'ambito delle Digital Humanities, si è sottolineata l'importanza di operare con tecnologie che siano alla base del Semantic Web e dei Linked Open Data per garantire interoperabilità e riuso delle risorse all'interno della comunità scientifica In questa ottica, le ontologie -e l'OWL, il loro linguaggio di rappresentazione standard -giocano un ruolo fondamentale. Tuttavia, il carattere fondamentalmente statico di questi ultimi e la necessità di modellare aspetti di evoluzione temporale sembrano a prima vista inconciliabili. Le riflessioni che presentiamo in questo articolo nascono dalle esperienze condotte in seno al Progetto Clavius on the Web 1 . Tra gli obiettivi del Progetto, infatti, vi è anche quello di creare una risorsa termino-ontologica (RTO) che rappresenti l'evoluzione delle teorie matematicoastronomiche dall'antichità al XVI -XVII secolo, così come viene descritta da Clavius nei suoi Euclidis Elementorum Libri XV. Accessit XVI e In sphaeram Ioannis de Sacro Bosco Commentarius. Il Contesto Come sottolineato nell'Introduzione, il linguaggio OWL (e la sua estensione OWL2) è lo standard W3C per la creazione e condivisione di ontologie nel Semantic Web. In particolare, OWL DL implementa la logica descrittiva SHOIN (D n ), che garantisce una maggiore espressività rispetto a RDF e RDFS, senza compromettere la decidibilità e il meccanismo inferenziale. Tuttavia, OWL è un linguaggio statico; in esso le proprietà e le relazioni tra entità sono fondamentalmente binarie, espresse sotto forma di triple <Subject predicate Object>. Tale restrizione sintattica rende più complessa la rappresentazione 1 http://claviusontheweb.it (ultimo accesso: 13/10/2016

Type 1 diabetes, sport practiced, and ankle joint mobility in young patients: What is the relationship?

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Sea buckthorn bud extract displays activity against cell-cultured Influenza virus

Introduction - Vaccines and antiviral drugs are the most widely used methods of preventing or treating Influenza virus infection. The role of sea buckthorn (SBT) bud dry extract as a natural antiviral drug against Influenza was investigated.Methods - Influenza virus was cultured in the MDCK cell line, with or without SBT bud extract, and virus growth was assessed by HA and TCID50 virus titration in terms of cytopathic effect on cells. Several concentrations of extract were tested, the virus titer being measured on day 4 after infection.Results - After infection, the virus titer in the control sample was calculated to be 2.5 TCID50/ml; treatment with SBT bud extract reduced the virus titer to 2.0 TCID50/ml at 50 µg/ml, while the HA titer was reduced from 1431 (control) to 178. Concentrations lower than 50 µg/ml displayed an inhibitory effect in the HA assay, but not in the TCID50 virus titration; however, observation of the viral cultures confirmed a slowdown of viral growth at all concentrations.Discussion - Natural dietary supplements and phytotherapy are a growing market and offer new opportunities for the treatment of several diseases and disorders. These preliminary experiments are the first to show that SBT bud extract is able to reduce the growth of the Influenza A H1N1 virus in vitro at a concentration of 50 µg/ml. This discovery opens up the possibility of using SBT bud extract as a valid weapon against Influenza and, in addition, as the starting-point for the discovery of new drugs

Celiac Disease Negatively Influences Lipid Profiles in Youngest Children With Type 1 Diabetes: Effect of the Gluten-Free Diet

The association between low HDL cholesterol (HDL-C) concentrations and increased cardiovascular risk is well established. Low HDL-C levels were found in subjects with type 1 diabetes (T1D) who presented complications and in untreated subjects with celiac disease (CD). The association between TID and CD might therefore enhance this lipid abnormality and accelerate the atherosclerotic process

Immune response to SARS-CoV-2 Omicron variant in patients and vaccinees following homologous and heterologous vaccinations

Antibodies elicited by a triple homologous or heterologous vaccination regimen or following natural SARS-CoV-2 infection combined with a two-dose vaccine course, result in highest neutralization capacity against the Omicron variant BA.1.The SARS-CoV-2 Omicron variant has rapidly replaced the Delta variant of concern. This new variant harbors worrisome mutations on the spike protein, which are able to escape the immunity elicited by vaccination and/or natural infection. To evaluate the impact and susceptibility of different serum samples to the Omicron variant BA.1, samples from COVID-19 patients and vaccinated individuals were tested for their ability to bind and neutralize the original SARS-CoV-2 virus and the Omicron variant BA.1. COVID-19 patients show the most drastic reduction in Omicron-specific antibody response in comparison with the response to the wild-type virus. Antibodies elicited by a triple homologous/heterologous vaccination regimen or following natural SARS-CoV-2 infection combined with a two-dose vaccine course, result in highest neutralization capacity against the Omicron variant BA.1. Overall, these findings confirm that vaccination of COVID-19 survivors and booster dose to vaccinees with mRNA vaccines is the correct strategy to enhance the antibody cross-protection against Omicron variant BA.1

Outcome of 421 adult patients with Philadelphia-negative acute lymphoblastic leukemia treated under an intensive program inspired by the GIMEMA LAL1913 clinical trial: a Campus ALL study

The introduction of pediatric-inspired regimens in adult Philadelphia-negative acute lymphoblastic leukemia (Ph-ALL) has significantly improved patients’ prognosis. Within the Campus ALL network we analyzed the outcome of adult Ph-ALL patients treated according to the GIMEMA LAL1913 protocol outside the clinical trial, to compare the real-life data with the study results. We included 421 consecutive patients, with a median age of 42 years. The complete remission (CR) rate after the first course of chemotherapy was 94% and a measurable residual disease (MRD) negativity after the third course was achieved in 72% of patients. The 3-year overall survival (OS) and disease-free survival (DFS) were 67% and 57%, respectively. In a multivariate analysis, MRD positivity negatively influenced DFS. In a time-dependent analysis including only very high risk (VHR) and MRD positive cases, transplanted (HSCT) patients had a significantly better DFS than non-HSCT ones (P=0.0017). During induction, grade ≥2 pegaspargase-related hepato-toxicity was observed in 25% of patients (vs 12% in the GIMEMA LAL1913 trial, P=0.0003). In this large real-life cohort of Ph-ALL, we confirmed the very high CR rate and a superimposable OS and DFS compared to the GIMEMA LAL1913 clinical trial: CR rate after C1 94% vs 85%, P=0.0004; 3-year OS 67% vs 67%, P=0.94; 3-year DFS 57% vs 63%, P=0.17. HSCT confirms its important role in VHR and MRD-positive patients. The rate of pegaspargase-related toxicity was significantly higher in the real-life setting, emphasizing the importance of dose adjustment in the presence of risk factors to avoid excessive toxicity