Valutazione della capacità di rientro alla base di un elicottero in presenza di danno balistico ad un albero di trasmissione della linea rotore di coda

Nella progettazione di un elicottero militare, destinato ad operare a bassa quota e in ambienteostile, il danneggiamento di componenti critici, conseguente ad impatto balistico, riveste un ruolo primario nellavalutazione delle possibilità di sopravvivenza dell’intera macchina. In questo articolo è quindi proposto unostudio sperimentale, suddiviso in diverse fasi, riguardante la verifica della capacità di un elicottero di portare atermine una missione di rientro alla base a potenza ridotta e in presenza di danneggiamento balistico ad unalbero di trasmissione della linea rotore di coda.Il lavoro ha richiesto dapprima l’esecuzione, su esemplari del componente in esame, di prove sperimentali diimpatto balistico, condotte utilizzando un proiettile calibro 7.62 NATO. Successivamente su ciascun alberodanneggiato sono state eseguite prove torsionali statiche ed a fatica, il cui scopo è stato verificare la resistenzaresidua del componente all’applicazione di opportuni carichi rappresentativi delle sollecitazioni riscontratedurante la missione di rientro

Improving Bowen-ratio estimates of evaporation using a rejection criterion and multiple-point statistics

The application of the Bowen ratio method to estimate evaporation is heavily affected by uncertainties on the measured quantities. Time series collected with a hydro-meteorological monitoring station often contain measurements for which a reliable estimate of evaporation cannot be computed. Such measurements can be identified with standard error propagation methods. However, simply discarding some values might introduce a bias in the cumulative evaporation for long time intervals, also depending on the threshold of acceptance. In this paper, we propose the use of multiple-point statistics simulation to integrate the time series of reliable evaporation estimates. A test conducted on a two-year-long time series of data collected with a hydro-meteorological station in the Po plain (Italy) shows that the usage of a rejection criteria in conjunction with multiple-point statistics simulation is a promising and useful tool for the reconstruction of reliable evaporation time series. In particular, it is shown that if the rejected values are not replaced by simulation, then the cumulative evaporation curves are estimated with a bias comparable with estimates of cumulative annual evaporation. Moreover, the test gives some insights for the selection of the best rejection threshold

CDKL5 expression is modulated during neuronal development and its subcellular distribution is tightly regulated by the C-terminal tail

Mutations in the human X-linked cyclin-dependent kinase-like 5 (CDKL5) gene have been identified in patients with Rett syndrome (RTT), West syndrome, and X-linked infantile spasms, sharing the common feature of mental retardation and early seizures. CDKL5 is a rather uncharacterized kinase, but its involvement in RTT seems to be explained by the fact that it works upstream of MeCP2, the main cause of Rett syndrome. To understand the role of this kinase for nervous system functions and to address if molecular mechanisms are involved in regulating its distribution and activity, we studied the ontogeny of CDKL5 expression in developing mouse brains by immunostaining and Western blotting. The expression profile of CDKL5 was compared with that of MeCP2. The two proteins share a general expression profile in the adult mouse brain, but CDKL5 levels appear to be highly modulated at the regional level. Its expression is strongly induced in early postnatal stages, and in the adult brain CDKL5 is present in mature neurons, but not in astroglia. Interestingly, the presence of CDKL5 in the cell nucleus varies at the regional level of the adult brain and is developmentally regulated. CDKL5 shuttles between the cytoplasm and the nucleus and the C-terminal tail is involved in localizing the protein to the cytoplasm in a mechanism depending on active nuclear export. Accordingly, Rett derivatives containing disease-causing truncations of the C terminus are constitutively nuclear, suggesting that they might act as gain of function mutations in this cellular compartment

Meta-analysis on the Effect of Mild Primary Hyperparathyroidism and Parathyroidectomy upon Arterial Stiffness

Context: Current data about the cardiovascular manifestations of mild primary hyperparathyroidism (pHPT) are often conflicting. Pulse wave velocity (PWV) is the gold standard for assessing aortic stiffness, and it predicts cardiovascular morbidity and mortality. Objective: Primary outcomes were to investigate if mild pHPT was associated with higher PWV and if parathyroidectomy (PTX) reduced PWV in mild pHPT. Secondary outcome was to investigate blood pressure changes after PTX. Methods: Sources were PubMed, Google Scholar, SCOPUS, Web of Science, and the Cochrane Library. Eligible studies included reports of PWV in patients with mild pHPT and controls, or in patients with mild pHPT before and after PTX. Two investigators independently identified eligible studies and extracted data. Pooled mean difference (MD) was the summary effect measure. Data were presented in forest plots with outlier and influential case diagnostics. Nine observational studies and one randomized clinical trial were selected, including 433 patients with mild pHPT, 171 of whom underwent PTX, and 407 controls. PWV was significantly higher in mild pHPT than in controls (MD = 1.18, 0.67 to 1.68, P <. 0001). Seven studies evaluated the effect of PTX on PWV. PTX significantly reduced PWV (MD =-0.48,-0.88 to-0.07, P =. 022). Conclusion: Aortic stiffness is increased in patients with mild pHPT, supporting the notion that mild pHPT is also associated with adverse cardiovascular manifestations. PTX significantly reduced arterial stiffness in mild pHPT, indicating that the benefit of PTX over cardiovascular manifestations should not be dismissed but it deserves further studies

All-optical delay line using semiconductor cavity solitons (vol 92, 011101, 2008)

Correction of Pedaci, F. and Barland, S. and Caboche, E. and Firth, W.J. and Oppo, G.L. and Tredicce, J.R. and Ackemann, T. and Scroggie, A.J. (2008) All-optical delay line using semiconductor cavity solitons. Applied Physics Letters, 92 (1). ISSN 0003-695