Implementation of IMMPDAF Algorithm in LabVIEW for Multi Sensor Single Target Tracking

Real time IMMPDAF algorithm has been implemented and tested in LabVIEW. Single aircraft flight profiles have been simulated and the plot data from multiple radars observing the single aircraft are generated with noise as well as clutter. The performance of the algorithm is evaluated using standard procedures. Since it is implemented and tested in LabVIEW, this algorithm can be easily realized in hardware for real time tracking applications

Tracking filter and multi-sensor data fusion

In this paper factorization filtering, fusion filtering strategy and related algorithms are presented. Some results of implementation and validation using realistic data are given

Factorization filtering algorithm with colored noise for tracking

In this paper factorization filtering algorithms are described and used for processing13; data from a typical flight test range. Specifically U-D (unit upper triangular-diagonal)13; factorization based Kalman filtering algorithms are considered. The algorithms are13; validated using simulated data and implemented in MATLAB and alpha DEC machines.13; UDP protocols are used to transfer data from one DEC machine to another where the13; UD filter algorithm is activated to process the data. A very brief description of the fusion13; scheme in which the UD filtering algorithms are being used is given

Estimation methods for determination of drag characteristics of fly-by-wire aircraft

In this paper, several parameter/state estimation approaches for the determination of dragpolars from flight data are described and evaluated for a fly-by-wire (FBW) aircraft. Both model-based approaches (MBAs) and non-model-based approaches(NMBAs) are considered. Dynamic response data from roller coaster and wind-up-turn manoeuvres are generated in a FBW aircraft flight simulator at different flight conditions and the typical performance results are presented. A novel approach to estimate the drag polar has been evaluated. It has been found that the NMBAs perform better than the MBAs. Classically, the MBAs have been used for the determination of drag polars. The merits of an NMBA are that it does not require specification of the detailed model of the aerodynamic coefficients and it can be suitably used for online estimation of drag polars from the flight data of aerospace vehicles

POTENTIAL ANTI-TUMOR AND ANTI-INFLAMMATORY ACTIVITY OF SIX MISTLETOE PLANTS IN THE FAMILY VISCACEAE PRESENT IN WESTERN GHATS, INDIA

ABSTRACTObjectivesTo find out the cytotoxicity, anti-tumor and anti-inflammatory activities of six species of plants belongs to Viscaeceae family available in Western Ghats (India).MethodsIn vitro cytotoxicity of Viscum extracts was studied by trypan blue exclusion method and MTT assay using various cell lines. Anti-tumor activity was determined using Ehrlich ascites carcinoma (EAC) and Dalton's lymphoma ascites (DLA) cells in mice. Anti-inflammatory activities of Viscum extracts were studied using carrageenan and dextran induced mouse paw edema models in mice.ResultsAll six Viscaeceae plant extracts studied were cytotoxic towards transformed cell lines like DLA and EAC as well as to MCF-7, MDA-MB-231 and SKBR3 cell lines. V.orientale, V.nepalense and V.ramosissimum, V.trilobatum were cytotoxic towards normal cells while V.angulatum and V.capitellatum were found to be nontoxic. Excepting V.angulatum all the other species selected here showed toxicity to animals. Administration of nontoxic concentration of extracts of Viscaeceae plants significantly (P<0.001) increased the lifespan of ascites tumor bearing animals and reduced DLA cells induced solid tumor development. All these plants except V.capitallatum and V.trilobatum showed significant (P<0.001) anti-inflammatory activity against carrageenan and dextran models and reduced pro-inflammatory cytokine levels.ConclusionOut of six species studied four species of Viscum species studied were cytotoxic to tumour cells and inhibited tumour development. Of the six species studied V. angulatum was non-toxic to animals and showed maximum efficiency as an antitumour agent. These plants showed significant anti-inflammatory activity and reduced inflammatory markers

Self-assembly of cis- and trans-cyclic-1,2-diols. Supramolecular synthon equivalence between cis-1,2-diols and primary amides

Inspite of the fact that the self-assembly of compounds containing hydroxyl group has been enormously documented in the literature, our studies with aliphatic cyclic diols have offered the unique opportunity to examine the self-assembly of gauche and anti forms of ethylene glycol. Whereas the cis-diols are found to form dimers that infinitely assemble further to yield tapes, the anti-diols are found to form linear chains that link up further to yield molecular tapes. Notably, both the isomers lead to molecular tapes, which have attracted immense attention since the inception of self-assembly for controlling molecular organization. Quite remarkably, the self-assembly observed with cis-diols establish a formal equivalence between supramolecular synthons associated with cis-1,2-diols and primary amides. Although the assembly of diols is akin to the tape structure adopted by primary amides, we prefer to view the association of diols as a ladder. The structures of 5-cis and 8-cis are both step-ladder assemblies. That formed by 5-trans is a new variant termed as rope-ladder assembly. The ring motifs observed in the crystal packing suggest for further scope in exploiting the polyhydroxyl compounds for self-assembly in a predictive manner

Estimation Methods for Determination of Drag Characteristics of Fly-by-Wire Aircraft

"In this paper, several parameter/state estimation approaches for the determination of drag polars from flight data are described and evaluated for a fly-by-wire (FBW) aircraft. Both model-based approaches (MBAs) and non-model-based approaches (NMBAs) are considered. Dynamic response data from roller coaster and wind- up-turn manoeuvres are generated in a FBW aircraft flight simulator at different flight conditions and the typical performance results are presented. A novel approach to estimate the drag polar has been evaluated. It has been found that the NMBAs perform better than the MBAs. Classically, the MBAs have been used for the determination of drag polars. The merits of an NMBA are that it does not require specification of the detailed model of the aerodynamic coefficients and it can be suitably used for online estimation of drag polars from the flight data of aerospace vehicle

Optical Imaging of Lipopolysaccharide-induced Oxidative Stress in Acute Lung Injury from Hyperoxia and Sepsis

Reactive oxygen species (ROS) have been implicated in the pathogenesis of many acute and chronic pulmonary disorders such as acute lung injury (ALI) in adults and bronchopulmonary dysplasia (BPD) in premature infants. Bacterial infection and oxygen toxicity, which result in pulmonary vascular endothelial injury, contribute to impaired vascular growth and alveolar simplification seen in the lungs of premature infants with BPD. Hyperoxia induces ALI, reduces cell proliferation, causes DNA damage and promotes cell death by causing mitochondrial dysfunction. The objective of this study was to use an optical imaging technique to evaluate the variations in fluorescence intensities of the auto-fluorescent mitochondrial metabolic coenzymes, NADH and FAD in four different groups of rats. The ratio of these fluorescence signals (NADH/FAD), referred to as NADH redox ratio (NADH RR) has been used as an indicator of tissue metabolism in injuries. Here, we investigated whether the changes in metabolic state can be used as a marker of oxidative stress caused by hyperoxia and bacterial lipopolysaccharide (LPS) exposure in neonatal rat lungs. We examined the tissue redox states of lungs from four groups of rat pups: normoxic (21% O2) pups, hyperoxic (90% O2) pups, pups treated with LPS (normoxic + LPS), and pups treated with LPS and hyperoxia (hyperoxic + LPS). Our results show that hyperoxia oxidized the respiratory chain as reflected by a ~ 31% decrease in lung tissue NADH RR as compared to that for normoxic lungs. LPS treatment alone or with hyperoxia had no significant effect on lung tissue NADH RR as compared to that for normoxic or hyperoxic lungs, respectively. Thus, NADH RR serves as a quantitative marker of oxidative stress level in lung injury caused by two clinically important conditions: hyperoxia and LPS exposure

ACTINOMYCIN “D” FROM MARINE SEDIMENT ASSOCIATED STREPTOMYCES CAPILLISPIRALIS MTCC10471

In our screening program for new bio-active metabolites from marine actinomycetes, a cyclic depsipeptide wasfound in the fermentation medium of marine Strepromyces (SS23/4) isolated from sediments collected from Bayoff Bengal, vellampattai,Tamilnadu. It showed strong biological activity against gram-positive / gram negativebacteria by agar overlay technique. It was taxonomically characterized by the basis of morphological andphenotypic characteristics, genotypic data and phylogenetic showing Streptomyces sps. Bio active compoundwas obtained by solvent extraction and purification using column chromatography followed by reverse phaseHPLC. The pure compound had potent activity against Mycobacterium tuberculosis and Multi Drug ResistantMycobacterium tuberculosis strains (437RU) at a concentration of 10 μg/mL, and The minimum inhibitoryconcentration (MIC) against standard test organisms was found to be 1μg/mL against B.subtilis, E.coli andMethicillin resistant Staphylococcus aureus. The compound exhibited potent cytotoxic activity against breastcarcinoma (MCF-7), melanoma cells (A375), prostate carcinoma (DU145) and lung carcinoma (A549) cellswith IC values 20μg/ml. The symbiotic Streptomyces capillispiralis MTCC 10471 produces crude antibiotic30mg/Lt by using nonoptimized fermentation conditions. The structure of the antibiotic was explained by 1D,2D NMR and LC-ESI-MS/MS, MALDI-TOF/MS experiments, revealed that it belongs to cyclic ploy peptideActinomycin D

INTERACTING MULTIPLE MODEL SEEKER FILTER FOR TRACKING EVASIVE TARGETS

Seeker filter is an important subsystem in modern homing guidance system of advanced intercepting missiles. Seeker filter design for homing guidance requirements are highly demanding and challenging. Very low filter lag, high noise attenuation are some of the challenges that need to be addressed. This paper presents an interacting multiple model augmented extended Kalman filter (IMM-AEKF) design to operate as seeker filter in close loop homing guidance of an interceptor to track evasive targets. The performance of the seeker filter is verified with six degree of freedom interceptor-target engagement simulation with seeker filter in guidance loop of the interceptor. Different filter performance criteria have been used to verify the performance of the seeker filter. The seeker filter efficiently handles the various seeker noise and provides a smooth estimate of target states to generate guidance command for intercepting missile. The miss distance achieved is within the acceptable limits