Características físicas y químicas de jabones de tocador fabricados a partir de aceite de semilla de albaricoque y estearina de palma.

The objective of the present work was to use apricot kernel oil with palm stearin in toilet soap-making. Apricot kernel oil was obtained from apricot kernel seed (Prunus armeniaca) through hydraulic pressing (12000lb/in2). Kernel contained 43.3% oil. The fatty acids of apricot kernel oil had high oleic acid (81.73%) while, the major of the fatty acid in palm stearin was palmitic acid (55.17%). Eight of the toilet soap samples were prepared from apricot kernel oil, palm kernel oil and palm stearin at different ratios. The structure of soap samples nº1 and 8 were sticky and with bad physical properties. On the other hand, the physical characteristics of blends nos 2, 3, 4, 5 and 6 had firm consistency and creamy lather while, in soap nº 7, its were moderatement; i. e. medium hard makeup with fairly lather. After storage (6 months) on a shelf at room temperature, all soaps (nº1-8) were declined in their moisture content. On contrary, the total fatty acids of the same samples were augmented at different ratios during storage. Physical characteristics of soap samples nos 2, 3, 4, 5, 6 and 7 were increased after the storage time (6 months), their consistencies were very firm with creamy lather and reducement in their erosion from handwashing ratios was observed. It can be recommended that apricot kernel oil can be used in the manufacturing of toilet soap until ratio 50% of the fatty blend (the blend was bear palm stearin).El objetivo del presente trabajo fue el uso del aceite de semilla de albaricoque con estearina de palma en la fabricación de jabón de tocador. El aceite de semilla de albaricoque (Prunus armeniaca) se obtuvo por presión hidráulica (12000lb/in2), y la semilla contenía el 43.3% de aceite. Los ácidos grasos del aceite de semilla de albaricoque tenían altos contenidos de ácido oleico (81.73%) mientras, el ácido graso mayoritario en la estearina de palma fue el ácido palmítico (55.17%). Se prepararon ocho muestras de jabón de tocador a partir de aceite de semilla de albaricoque, aceite de semilla de palma y estearina de palma en diferentes proporciones. La estructura de las muestras de los jabones nº1 y 8 fueron viscosas y blandas con malas propiedades físicas. Por otro lado, las características físicas de las mezclas nos 2, 3, 4, 5 y 6 tuvieron una consistencia firme y espuma cremosa, mientras en el jabón nº 7 fueron moderadas, esto es dureza intermedia con espuma adecuada. Después del almacenamiento (6 meses) en estantería a temperatura ambiente, todos los jabones (nº 1-8) disminuyeron su contenido en humedad. Por el contrario, los ácidos grasos totales de las mismas muestras aumentaron en diferente proporción durante el almacenamiento. Las características físicas de las muestras de jabones nos 2, 3, 4, 5, 6 y 7 mejoraron después del tiempo de almacenamiento (6 meses), su consistencia fue muy firme con espuma cremosa y se observó una reducción en el desgaste en función del número de lavados. Se recomienda el uso del aceite de semilla de albaricoque en la fabricación de jabones de tocador hasta una proporción del 50% de la mezcla grasa (la mezcla fue estearina de palma corriente)

Alpha-enolase is a potential prognostic marker in clear cell renal cell carcinoma

Clear cell renal cell carcinoma (ccRCC) is an aggressive disease with unpredictable behaviour. Clinical parameters are not always accurate for prognosis prediction. The integration of molecular markers to prognostic models can significantly improve prognostic assessment and consequently patient management. We assessed the expression of alpha-enolase (ENO1) protein by immunohistochemistry in 360 patients with primary ccRCC and correlated its expression with multiple clinicopathological parameters including stage, grade, tumor size, disease-free and overall survival. Cox proportional hazard regression models adjusted for clinicopathological factors were used to test for a link between ENO1 expression and both disease-free and overall survival. We correlated ENO1 mRNA expression with overall survival in an independent set of 428 ccRCC cases from The Cancer Genome Atlas. ENO1 showed cytoplasmic, membranous and nuclear staining patterns. There is a statistically significant negative correlation between ENO1 expression, tumor stage, and grade. ENO1 expression also shows a statistically significant direct correlation with disease-free survival (p = 0.011) and overall survival (p = 0.030) in ccRCC. Patients with higher ENO1 expression had lower hazard ratio of recurrence, although this was not statistically significant (HR = 0.330, p = 0.060). These findings were validated at the mRNA level in an independent set of 428 ccRCC cases which also showed that low ENO1 expression is associated with significantly shorter overall survival. Down-regulation of ENO1 can be a predictor of poor prognosis in ccRCC, and it can be a potential prognostic marker. © 2015, Springer Science+Business Media Dordrecht