237 research outputs found
Light Ion Accelerating Line (L3IA): Test Experiment at ILIL-PW
The construction of a novel Laser driven Light Ions Acceleration Line(L3IA)
is progressing rapidly towards the operation, following the recent upgrade of
the ILIL-PW laser facility. The Line was designed following the pilot
experimental activity carried out earlier at the same facility to define design
parameters and to identify main components including target control and
diagnostic equipment, also in combination with the numerical simulations for
the optimization of laser and target parameters. A preliminary set of data was
acquired following the successful commissioning of the laser system >100 TW
upgrade. Data include output from a range of different ion detectors and
optical diagnostics installed for qualification of the laser-target
interaction. An overview of the results is given along with a description of
the relevant upgraded laser facility and features.Comment: 6 pages, 7 figures, 18 references, presented at the EAAC 201
Allelic Variation of Wheat Flour Allergens in a Collection of Wheat Genotypes
Wheat is the most widely grown crop in the world and provides 20% of the daily protein and food calories for 4.5 billion people. Together with rice, it is the most important food crop in the developing world. In the last decades, various symptoms have been recorded across the population due to the consumption of wheat products, also summarized as "wheat allergy." Wheat allergy is usually reported as a food allergy but can also be a contact allergy as a result of exposure to wheat. Several important wheat allergens have been characterized in the last years through biochemical, immunological, and molecular biological techniques. In the present work, the identification of allelic variation of genes involved in wheat allergy was reported. A collection of wheat genotypes was screened in order to identify new alleles. A total of 14 new alleles were identified forprofilin, triosephosphate-isomerase, dehydrin, glyceraldehyde-3-phosphate-dehydrogenase,α/βgliadin, GluB3-23,andGlutathione transferaseallergen genes (located on chromosomes 1B, 3B, 6A, and homoelogous groups 5 and 7), potentially related to a minor allergenicity and useful in breeding programs
Isolation and characterisation of cytosolic glutamine synthetase (GSe) genes and association with grain protein content in durum wheat
Glutamine synthetase (GS) enzyme (EC 6.3.1.2) plays a central role in assimilating ammonia produced in the leaf from metabolic processes, spanning from assimilation to transamination reactions and catabolic processes. GS is located in both cytoplasm (GS1, GSe and GSr) and plastids (GS2) of plant cells. Glutamine and glutamate, produced by the concerted action of GS and glutamate synthase, are then transported from the leaf to the developing sinks or grain in wheat. The goal of the present study was to characterise GSe genes and to assess the linkage with grain protein content, an important quantitative trait controlled by multiple genes. Here, we report the isolation of the complete cytosolic GS gene sequences of the durum wheat cvv. 'Ciccio' and 'Svevo' (characterised by low and high protein content, respectively). GSe-A4 located on 4A chromosome comprises 12 exons separated by 11 introns, while the GSe-B4 gene on 4B chromosome comprises 11 exons separated by 10 introns. Quantitative real-time PCR indicated different expression levels of GSe-A4 and GSe-B4 genes in the two wheat cvv. 'Ciccio' and 'Svevo'. The two GSe genes were significantly associated to quantitative trait loci for grain protein content
Allelic Variation of Wheat Flour Allergens in a Collection of Wheat Genotypes
Wheat is the most widely grown crop in the world and provides 20% of the daily protein and food calories for 4.5 billion people. Together with rice, it is the most important food crop in the developing world. In the last decades, various symptoms have been recorded across the population due to the consumption of wheat products, also summarized as “wheat allergy.” Wheat allergy is usually reported as a food allergy but can also be a contact allergy as a result of exposure to wheat. Several important wheat allergens have been characterized in the last years through biochemical, immunological, and molecular biological techniques. In the present work, the identification of allelic variation of genes involved in wheat allergy was reported. A collection of wheat genotypes was screened in order to identify new alleles. A total of 14 new alleles were identified for profilin, triosephosphate-isomerase, dehydrin, glyceraldehyde-3-phosphate-dehydrogenase, α/β gliadin, GluB3-23, and Glutathione transferase allergen genes (located on chromosomes 1B, 3B, 6A, and homoelogous groups 5 and 7), potentially related to a minor allergenicity and useful in breeding programs
BNCT dosimetry: peculiarities and methods
Dosimetry in tissue exposed to the epithermal neutron beams utilized for BNCT is
complex, due to the multiplicity of the possible neutron reactions and consequently of the
secondary radiation that contains photons, charged particles and recoil nuclei. Owing to the
different radiobiological effectiveness of the various components of the absorbed dose, it is
necessary to attain the evaluation of each of them. In addition, the spatial distributions of these
dose components changes considerably with size and shape of the irradiated volume.
Therefore, BNCT dosimetry requires suitably developed calculations and experimental
methods. In this work, Monte Carlo simulations in phantoms of different sizes and shapes have
been developed. Experimental methods for separating the dose components, mainly based on
gel dosimeters and thermoluminescence detectors, have been applied. Moreover, the change in
the absorbed dose resulting from the addition of 157Gd was investigated. Both measurements
and calculations have been done with the BNCT epithermal beam of the LVR-15 reactor
The PLASMONX Project for advanced beam physics experiments
The Project PLASMONX is well progressing into its
design phase and has entered as well its second phase of
procurements for main components. The project foresees
the installation at LNF of a Ti:Sa laser system (peak
power > 170 TW), synchronized to the high brightness
electron beam produced by the SPARC photo-injector.
The advancement of the procurement of such a laser
system is reported, as well as the construction plans of a
new building at LNF to host a dedicated laboratory for
high intensity photon beam experiments (High Intensity
Laser Laboratory). Several experiments are foreseen
using this complex facility, mainly in the high gradient
plasma acceleration field and in the field of mono-
chromatic ultra-fast X-ray pulse generation via Thomson
back-scattering. Detailed numerical simulations have
been carried out to study the generation of tightly focused
electron bunches to collide with laser pulses in the
Thomson source: results on the emitted spectra of X-rays
are presented
Advancing Alternative Analysis: Integration of Decision Science.
Decision analysis-a systematic approach to solving complex problems-offers tools and frameworks to support decision making that are increasingly being applied to environmental challenges. Alternatives analysis is a method used in regulation and product design to identify, compare, and evaluate the safety and viability of potential substitutes for hazardous chemicals.Assess whether decision science may assist the alternatives analysis decision maker in comparing alternatives across a range of metrics.A workshop was convened that included representatives from government, academia, business, and civil society and included experts in toxicology, decision science, alternatives assessment, engineering, and law and policy. Participants were divided into two groups and prompted with targeted questions. Throughout the workshop, the groups periodically came together in plenary sessions to reflect on other groups' findings.We conclude the further incorporation of decision science into alternatives analysis would advance the ability of companies and regulators to select alternatives to harmful ingredients, and would also advance the science of decision analysis.We advance four recommendations: (1) engaging the systematic development and evaluation of decision approaches and tools; (2) using case studies to advance the integration of decision analysis into alternatives analysis; (3) supporting transdisciplinary research; and (4) supporting education and outreach efforts
Brixsino High-Flux Dual X-Ray and THz Radiation Source Based on Energy Recovery Linacs
We present the conceptual design of a compact light source named BriXSinO. BriXSinO was born as demonstrator of the Marix project, but it is also a dual high flux radiation source Inverse Compton Source (ICS) of X-ray and Free-Electron Laser of THz spectral range radiation conceived for medical applications and general applied research. The accelerator is a push-pull CW-SC Energy Recovery
Linac (ERL) based on superconducting cavities technology and allows to sustain MW-class beam power with almost just one hundred kW active power dissipation/consumption. ICS line produces 33 keV monochromatic X-Rays via Compton scattering of the electron beam with a laser system in
Fabry-Pérot cavity at a repetition rate of 100 MHz. The THz FEL oscillator is based on an undulator imbedded in optical cavity and generates THz wavelengths from 15 to 50 micron
A Muon Collider Facility for Physics Discovery
Muon colliders provide a unique route to deliver high energy collisions thatenable discovery searches and precision measurements to extend ourunderstanding of the fundamental laws of physics. The muon collider design aimsto deliver physics reach at the highest energies with costs, power consumptionand on a time scale that may prove favorable relative to other proposedfacilities. In this context, a new international collaboration has formed tofurther extend the design concepts and performance studies of such a machine.This effort is focused on delivering the elements of a 10 TeV center ofmass (CM) energy design to explore the physics energy frontier. The path tosuch a machine may pass through lower energy options. Currently a 3 TeV CMstage is considered. Other energy stages could also be explored, e.g. ans-channel Higgs Factory operating at 125 GeV CM. We describe the status of theR&D and design effort towards such a machine and lay out a plan to bring theseconcepts to maturity as a tool for the high energy physics community.<br
- …