Inside Political Parties: Factions, Party Organization and Electoral Competition

How do parties organize, and do parties' organizational differences matter? Different organization patterns are empirically associated with varying electoral performance, voters' participation, policy-making, and party systems' shape and stability.Despite the empirical relevance of party organization, theoretical scholarship has overwhelmingly focused on other functions of parties — namely the electoral one, simplifying the political world for voters, and the policy-making one in the legislative arena. The papers in this dissertation advance a new theoretical agenda on the organization of political parties, generating insights that I test with novel data. The main contribution of the dissertation is to treat party organization as an endogenous rather than exogenous variable. This approach allows to generate novel insights on how the electoral environment influences the way parties organize, and outcomes such as parties' electoral performance and the process of party system stabilization. The first paper conceives the internal organization of a party as being driven by factional competition. What brings opposing factions to engage in sabotage rather than enhance the party image, and what strategies can parties adopt to contain it? The paper introduces a model of elections in which intra-party factions can devote resources to campaign for the party or to undermine each other and obtain more power. The party redistributes electoral spoils among factions to motivate their investment in campaigning activities. The model shows that sabotage increases when the stakes of the election are low — e.g., in consensus democracies that grant power to the losing party — because the incentives to focus on the fight for internal power increase. It also suggests that the optimal party strategy for winning the election in the face of intra-party competition is to reward factions with high powered incentives when campaigning effort can be easily monitored, but treat factions equally otherwise. Finally, the model shows that, when a party weakens electorally, factions’ incentives move from campaigning for the party to sabotaging each other to obtain electoral spoils. A testable implication of this result is the emergence of political scandals triggered internally as a product of factional sabotage. The second paper tests this empirical implication using original data on judicial investigations of Italian MPs involved in various misbehaviors. Judicial investigations of politicians are a fundamental component of politics, often leading to scandals. Yet, empirical evidence of the strategic determinants of judicial investigations is intrinsically hard to gather, a problem that has significantly limited the study of this important phenomenon. The paper studies the politics behind judicial investigations leveraging new data on prosecutors' informants in 1125 episodes of misbehavior of Italian MPs involved in different crimes (1983-2019). Results provide evidence in favor of a political use of denunciations for corruption crimes: when a party weakens, the likelihood that political enemies denounce past misbehavior of members of the weakened party increases, suggesting that the political use of denunciation is elastic to changes in the electoral performance. The timing of past misbehavior is crucial: members of weakened parties are more likely to be accused of misbehavior that happened a long time before the accusation, which further supports the conjecture that accusations are politically motivated. The third paper moves to the topic of party organization in the presence of multi-party competition. It conceives of the choice over party organization as parties' decision to form different types of alliances. Despite being pervasive, little is known about the conditions facilitating different forms of pre-electoral alliances. The paper presents a model of electoral competition in which parties can form alliances before elections, and decide how binding these should be. Parties face a dynamic trade-off between insuring themselves against large shifts in public opinion and allowing flexibility to respond to future changes in voters' preferences. The model shows that more binding alliances such as mergers emerge in equilibrium when electoral volatility is high; otherwise, parties form more flexible pre-electoral coalitions. It also suggests that some power concentration is needed for alliances to emerge in equilibrium, whereas parties run alone under consensual democracies that share power among all parties

Sickle cell maculopathy : identification of systemic risk factors, and microstructural analysis of individual retinal layers of the macula

PURPOSE:To identify systemic risk factors for sickle cell maculopathy, and to analyze the microstructure of the macula of Sickle Cell Disease (SCD) patients by using automated segmentation of individual retinal layers. METHODS: Thirty consecutive patients with SCD and 30 matched controls underwent spectral-domain optical coherence tomography (SD-OCT) and automated thickness measurement for each retinal layer; thicknesses for SCD patients were then compared to normal controls. Demographic data, systemic data, and lab results were collected for each SCD patient; multivariate logistic regression analysis was used to identify potential risk factors for sickle cell maculopathy. RESULTS: Ongoing chelation treatment (p = 0.0187) was the most predictive factor for the presence of sickle cell maculopathy; the odds were 94.2% lower when chelation was present. HbF level tended to influence sickle cell maculopathy (p = 0.0775); the odds decreased by 12.9% when HbF increased by 1%. Sickle cell maculopathy was detected in 43% of SCD patients as patchy areas of retinal thinning on SD-OCT thickness map, mostly located temporally to the macula, especially in eyes with more advanced forms of sickle cell retinopathy (p = 0.003). In comparison to controls, SCD patients had a subtle thinning of the overall macula and temporal retina compared to controls (most p<0.0001), involving inner and outer retinal layers. Thickening of the retinal pigment epithelium was also detected in SCD eyes (p<0.0001). CONCLUSIONS: Chronic chelation therapy and, potentially, high levels of HbF are possible protective factors for the presence of sickle cell maculopathy, especially for patients with more advanced forms of sickle cell retinopathy. A subtle thinning of the overall macula occurs in SCD patients and involves multiple retinal layers, suggesting that ischemic vasculopathy may happen in both superficial and deep capillary plexi. Thinning of the outer retinal layers suggests that an ischemic insult of the choriocapillaris may also occur in SCD patients

Childhood-onset dystonia-causing KMT2B variants result in a distinctive genomic hypermethylation profile

Background: Dystonia is a clinically and genetically heterogeneous movement disorder characterized by sustained or intermittent muscle contractions causing abnormal, often repetitive, movements and/or postures. Heterozygous variants in lysine methyltransferase 2B (KMT2B), encoding a histone H3 methyltransferase, have been associated with a childhood-onset, progressive and complex form of dystonia (dystonia 28, DYT28). Since 2016, more than one hundred rare KMT2B variants have been reported, including frameshift, nonsense, splice site, missense and other in-frame changes, many having an uncertain clinical impact. Results: We characterize the genome-wide peripheral blood DNA methylation profiles of a cohort of 18 patients with pathogenic and unclassified KMT2B variants. We resolve the “episignature” associated with KMT2B haploinsufficiency, proving that this approach is robust in diagnosing clinically unsolved cases, properly classifying them with respect to other partially overlapping dystonic phenotypes, other rare neurodevelopmental disorders and healthy controls. Notably, defective KMT2B function in DYT28 causes a non-random DNA hypermethylation across the genome, selectively involving promoters and other regulatory regions positively controlling gene expression. Conclusions: We demonstrate a distinctive DNA hypermethylation pattern associated with DYT28, provide an epigenetic signature for this disorder enabling accurate diagnosis and reclassification of ambiguous genetic findings and suggest potential therapeutic approaches

Tra i Leoni: Revealing the Preferences Behind a Superstition

We investigate a superstition for which adherence is nearly universal. Using a combination of field interventions that involve unsuspecting participants and a lab-style value elicitation, we measure the strength of peoples' underlying preferences, and to what extent their behavior is driven by social conformity rather than the superstition itself. Our findings indicate that both mechanisms influence behavior. While a substantial number of people are willing to incur a relatively high individual cost in order to adhere to the superstition, for many, adherence is contingent on the the behavior of others. Our findings suggest that it is the conforming nature of the majority that sustains the false beliefs of the minority

DYT2 screening in early-onset isolated dystonia

Background: Mutations in HPCA, a gene implicated in calcium signaling in the striatum, have been recently described in recessive dystonia cases previously grouped under the term "DYT2 dystonia". Positive patients reported so far show focal onset during childhood with subsequent generalization and a slowly progressive course to adulthood. Methods: 73 patients with isolated dystonia of various distribution, manifesting within 21 years of age, were enrolled in this Italian study and underwent a mutational screening of HPCA gene by means of Sanger sequencing. Results/conclusions: Mean age at onset was 10.2 (+/- 5.1) years and mean age at the time of genetic testing was 33 (+/- 14.2) years. Mean disease duration at the time of enrollment was 22.7 (+/- 12.8) years. None of the patients enrolled was found to carry HPCA mutations, rising suspicion that these probably represent a very rare cause of dystonia in childhood-adolescence. Larger studies will help determining the real mutational frequency of this gene also in different ethnic groups. (C) 2016 European Paediatric Neurology Society. Published by Elsevier Ltd. All rights reserved

Comparison of total retinal thickness of the macular region and of the temporal retina between sickle cell disease eyes and control subjects.

<p>Comparison of total retinal thickness of the macular region and of the temporal retina between sickle cell disease eyes and control subjects.</p

Optical coherence tomography imaging protocol and analysis, for both foveal-centered and temporally centered scans.

<p>(Left column) Color-coded retinal thickness maps were generated by the built-in software of the device, which then automatically applied the ETDRS grid after scanning eyes using 31 high-resolution B-scans. The nasal quadrant and the central ring of the temporally-centered scan were systematically not measured because overlapping with the temporal quadrant of the foveal-centered scan. (Right column) The segmentation software of the SD-OCT device automatically detected each retinal layer, including retinal nerve fiber layer, ganglion cell layer, inner plexiform layer, inner nuclear layer, outer plexiform layer, outer nuclear layer, photoreceptor layer, and retinal pigment epithelium. Segmentation of the choroid was performed manually.</p

Comparison of individual retinal layer thickness of the macular region and of the temporal retina between sickle cell disease eyes with and without sickle cell maculopathy.

<p>Comparison of individual retinal layer thickness of the macular region and of the temporal retina between sickle cell disease eyes with and without sickle cell maculopathy.</p

Comparison of total retinal layer thickness of the macular region and of the temporal retina between sickle cell disease eyes with and without sickle cell maculopathy.

<p>Comparison of total retinal layer thickness of the macular region and of the temporal retina between sickle cell disease eyes with and without sickle cell maculopathy.</p

Results of the stepwise logistic regression model for sickle cell maculopathy.

<p>Results of the stepwise logistic regression model for sickle cell maculopathy.</p