Il ruolo delle tecnologie informatiche nella ricerca in matematica

ItIn questo articolo sono riportate alcune considerazioni sull'importanza delle tecnologie informatiche nella "ricerca in Matematica". Dopo una breve descrizione di "Che cos'e' la ricerca in Matematica", si analizza il ruolo e l'importanza delle Tecnologie Informatiche sia nella ricerca in "Matematica pura" che nella ricerca in "Matematica applicata". Inoltre, si presentano alcuni esempi, nel campo della ricerca, dove l'uso delle tecnologie informatiche ha una grande influenza

Association between Protective and Deleterious HLA Alleles with Multiple Sclerosis in Central East Sardinia

The human leukocyte antigen (HLA) complex on chromosome 6p21 has been unambiguously associated with multiple sclerosis (MS). The complex features of the HLA region, especially its high genic content, extreme polymorphism, and extensive linkage disequilibrium, has prevented to resolve the nature of HLA association in MS. We performed a family based association study on the isolated population of the Nuoro province (Sardinia) to clarify the role of HLA genes in MS. The main stage of our study involved an analysis of the ancestral haplotypes A2Cw7B58DR2DQ1 and A30Cw5B18DR3DQ2. On the basis of a multiplicative model, the effect of the first haplotype is protective with an odds ratio (OR) = 0.27 (95% confidence interval CI 0.13–0.57), while that of the second is deleterious, OR 1.78 (95% CI 1.26–2.50). We found both class I (A, Cw, B) and class II (DR, DQ) loci to have an effect on MS susceptibility, but we saw that they act independently from each other. We also performed an exploratory analysis on a set of 796 SNPs in the same HLA region. Our study supports the claim that Class I and Class II loci act independently on MS susceptibility and this has a biological explanation. Also, the analysis of SNPs suggests that there are other HLA genes involved in MS, but replication is needed. This opens up new perspective on the study of MS

Il ruolo delle Tecnologie Informatiche nella ricerca in Matematica

In this paper some considerations about the importance of Information technology in Mathematics researches are reported. After a brief description of ``What is research in Mathematics?\u27\u27, the role and the importance of Information Technology, both in pure and applied researches, are analyzed. Some examples of research fields where the use of Information Technology has great influence are presented.In questo articolo sono riportate alcune considerazioni sull\u27importanza delle tecnologie informatiche nella \u27ricerca in Matematica\u27. Dopo una breve descrizione di \u27Che cos\u27e\u27 la ricerca in Matematica\u27, si analizza il ruolo e l\u27importanza delle Tecnologie Informatiche sia nella ricerca in \u27Matematica pura\u27 che nella ricerca in \u27Matematica applicata\u27. Inoltre, si presentano alcuni esempi, nel campo della ricerca, dove l\u27uso delle tecnologie informatiche ha una grande influenza

Il contributo del C.N.R. alla formazione degli insegnanti

In this paper the activities for teachers education and training, carried out by some researchers of the Italian National Council of Researches, are presented. In particular, the activities based on the use of Information and Communication Technologies are taken into consideration. Some meaningful experiences are described.Il lavoro illustra le attivita\u27 svolte da ricercatori del Consiglio Nazionale delle Ricerche per la formazione degli insegnanti. In particolare, sono descritti i progetti di formazione basati sull\u27utilizzo di Tecnologie informatiche e vengono presentati alcuni esempi particolarmente significativi

d-Indobufen extended-release pellets prepared by coating with aqueous polymer dispersions

A multiple units dosage form has been prepared in order to control the release of d-Indobufen, a carboxylic acid used as an inhibitor of platelet aggregation. The system consists of cores containing the active substance coated with a diffusive film and represents a classic “reservoir” system. Extrusion-spheronization was used in order to prepare the active cores. The drug release control was obtained by modifying both the core composition and the film composition characteristics. Acid and basic compounds were incorporated in the core to influence the inside microenvironment pH. Polymers chosen for the film formulation were: ethylcellulose (Aquacoat) and copolymers of acrylic esters with differing permeability characteristics (Eudragit RL/RS 30D). Technological and physical characteristics of coated pellets proved the production feasibility of an extended release multiple unit dosage form of d-Indobufen. Preliminary data of accelerated stability indicated the important role played by the thermal treatment of polymer membrane after the coating process