Liver involvement in pediatric celiac disease

Celiac disease (CD) is an intestinal inflammatory disease that manifests in genetically susceptible individuals when exposed to dietary gluten. It is a common chronic disorder, with a prevalence of 1% in Europe and North America. Although the disease primarily affects the gut, the clinical spectrum of CD is remarkably varied, and the disease can affect many extraintestinal organs and systems, including the liver. The hepatic dysfunction presenting in CD ranges from asymptomatic liver enzyme elevations or nonspecific reactive hepatitis (cryptogenic liver disorders), to chronic liver disease. In this article, we review the clinical presentations and possible mechanisms of CD-related liver injury to identify strategies for the diagnosis and treatment of these disorders in childhood

Qualidade de vida e a competência moral entre diabéticos que não e que prestam serviço social: um estudo correlacional

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Criação de comunidade de marca no ambiente B2B

O presente trabalho tem como objetivo identificar como pode ser criada uma comunidade de marca em um ambiente B2B em empresas de tecnologia na cidade de Porto Alegre. Entendendo que a comunidade de marca é vantajosa, uma vez que chegar como precursora no segmento atuante é estabelecer sua posição no mercado. Assim, foi feita uma pesquisa de caráter qualitativo para atender ao objetivo do presente trabalho. A principal técnica de análise de dados se deu por meio de entrevistas realizadas com gestores e gerente de TI do setor de telecomunicações realizado através de entrevistas qualitativas por meio de um roteiro de perguntas semiestruturadas. Os resultados da pesquisa foram analisados a partir dos conceitos do marketing de relacionamento e do que se entende por comunidade de marca. Visto que na comunidade devam estar presentes a inovação e conhecimento gerado, a qualidade dos serviços prestados e o atendimento comercial pré e pós-venda

Prevalence and risk factors for atopic disease in a population of preschool children in Rome: Challenges to early intervention

Background: Allergic diseases are complex identities determined by an interplay of genetic and environmental factors, resulting in the clinical manifestation of the disease. So far in Italy, updated data about the prevalence and risk factors of respiratory and allergic diseases in preschool children are not available. Methods: Children aged 3-5 years, attending four different nursery schools in an urban district of the city of Rome. A standardized questionnaire developed under the SIDRIA-2 protocol was administered to the parents of the children for the assessment of the potential risk factors and the outcomes. Results: A total of 494 children were enrolled in the study; 289 of them (60.3%) performed a skin prick test (SPT). In the 12 months preceding the interviews, 15% of children experienced at least one episode of wheezing, 5.5% of allergic rhinitis, 11% of children had a doctor diagnosis of asthma, 12% of children who underwent the SPT were positive to at least one of the tested allergens, being diagnosed as atopic. The univariate analysis for the health outcomes of the study shows that asthma was positively associated with daycare attendance, mother's history of atopy, siblings' history of atopy, recurrent siblings' bronchitis, and dermatitis. Atopy was positively associated with mother's history of atopy and dermatitis, whereas there is a borderline protective association with recurrent siblings' bronchitis. Conclusions: This study represents a first comprehensive epidemiological evaluation of prevalence of respiratory and allergic diseases in children aged 3-5 years in the city of Rome and an updating of the evolution of allergic diseases

O assédio sexual contra as mulheres no ambiente de trabalho: uma análise sobre a efetividade da repressão no Brasil

O presente trabalho tem como objetivo geral analisar como a inefetividade da repressão dos assediadores sexuais contra mulheres no ambiente de trabalho acaba por obstaculizar a busca por reparação do ilícito e o encaminhamento de denúncias pelas vítimas. O trabalho está desenvolvido em três tópicos. O primeiro aborda as razões socioculturais da prática de assédio sexual no ambiente de trabalho, realizada, em geral, por homens contra as mulheres, e os motivos de sua aceitação coletiva. O segundo tópico apresenta dados relativos à prática de assédio sexual contra mulheres no mercado de trabalho. Por fim, no último tópico, reflete-se sobre as formas de repressão nos âmbitos trabalhistas, civis e penais, e a garantia de proteção das mulheres vítimas. Assim, serão apresentadas as seguintes hipóteses: a sociedade brasileira está marcada pelo machismo, que desconsidera o valor da mulher em ambientes profissionais, e, embora haja mecanismos protetivos no Direito, a sua não efetividade torna ineficazes as formas de combate ao assédio sexual. Para o desenvolvimento da pesquisa, foi utilizada a metodologia bibliográfica e a pesquisa de dados sob o critério qualitativo

Guia do fotógrafo experimental: uma introdução à fotografia alternativa

Este projeto tem como objeto de estudo a fotografia experimental de formato analógico e o uso do design como ferramenta didática. A fotografia é estudada no ambiente das universidades desde o século XX, porém nas últimas décadas há um afastamento das técnicas analógicas como uma consequência do uso de câmeras e de processos de ajustes da imagem na área digital. Com a crescente escassez de ensino de métodos alternativos para criação dentro do laboratório de fotografia, este projeto é dedicado ao resgate destes conhecimentos. Foi criado um livro cujo conteúdo tem o objetivo de reacender o interesse pelo assunto dentro do corpo discente de design gráfico e fotografia, procurando ser um produto atrativo para o leitor por meio de imagens e infográficos. A elaboração desse projeto utilizou o referêncial teórico de Christopher James, Jan Tschichold, Richard Hendel, Andrew Haslam entre outros

Cardiorespiratory fitness and sports activities in children and adolescents with solitary functioning kidney

Background: An increasing number of children with chronic disease require a complete medical examination to be able to practice physical activity. Particularly children with solitary functioning kidney (SFK) need an accurate functional evaluation to perform sports activities safely. The aim of our study was to evaluate the influence of regular physical activity on the cardiorespiratory function of children with solitary functioning kidney. Method: Twenty-nine patients with congenital SFK, mean age 13.9 ± 5.0 years, and 36 controls (C), mean age 13.8 ± 3.7 years, underwent a cardiorespiratory assessment with spirometry and maximal cardiopulmonary exercise testing. All subjects were divided in two groups: sedentary (S) and trained (T) patients, by means of a standardized questionnaire about their weekly physical activity. Results: We found that mean values of maximal oxygen consumption (VO2max) and exercise time (ET) were higher in T subjects than in S subjects. Particularly SFK-T presented mean values of VO2max similar to C-T and significantly higher than C-S (SFK-T: 44.7 ± 6.3 vs C-S: 37.8 ± 3.7 ml/min/kg; p < 0.0008). We also found significantly higher mean values of ET (minutes) in minutes in SFK-T than C-S subjects (SFK-T: 12.9 ± 1.6 vs C-S: 10.8 ± 2.5 min; p <0.02). Conclusion: Our study showed that regular moderate/high level of physical activity improve aerobic capacity (VO2max) and exercise tolerance in congenital SFK patients without increasing the risks for cardiovascular accidents and accordingly sports activities should be strongly encouraged in SFK patients to maximize health benefit

Malocclusion and rhinitis in children: an easy-going relationship or a yet to be resolved paradox? A systematic literature revision

Objective: The relation between nasal flow and malocclusion represents a practical concern to pediatricians, otorhinolaryngologists, orthodontists, allergists and speech therapists. If naso-respiratory function may influence craniofacial growth is still debated. Chronic mouth-breathing is reported to be associated also with a characteristic pattern of dental occlusion. On the other hand, also malocclusion may reduce nasal air flows promoting nasal obstruction. Hereby, the aim of this review was to describe the relationship between rhinitis and malocclusion in children. Methods: An electronic search was conducted using online database including Pubmed, Web of Science, Google Scholar and Embase. All studies published through to January 30, 2017 investigating the prevalence of malocclusion in children and adolescents (aged 0-20 years) affected by rhinitis and the prevalence of rhinitis in children with malocclusion were included. The protocol was registered at PROSPERO - International prospective register of systematic reviews under CRD42016053619. Results: Ten studies with 2733 patients were included in the analysis. The prevalence of malocclusion in children with rhinitis was specified in four of the studies ranging from as high as 78.2% to as low as 3%. Two out of the studies reported the prevalence of rhinitis in children with malocclusion with a rate ranging from 59.2 to 76.4%. Conclusion: The results of this review underline the importance of the diagnosis and treatment of the nasal obstruction at an early age to prevent an altered facial growth, but the data currently available on this topic do not allow to establish a possible causal relationship between rhinitis and malocclusion

Diffuse large B-cell lymphoma, not otherwise specified of the palate: a case report

Diffuse large B-cell lymphoma (DLBCL) is the most frequent type of non-Hodgkin´s lymphoma found in oral and maxillofacial regions. A large number of cases may be biologically heterogeneous, which are commonly defined as DLBCL, not otherwise specified (NOS) by the World Health Organization (WHO-2008). The present case reports on an ulcer of raised and irregular edges, found on the border between the hard and soft palate, as the first and only manifestation of an extranodal non-Hodgkin lymphoma in an 85-year-old patient. Incisional biopsy was carried out, and the specimen revealed a proliferation of large lymphoid cells suggestive of diffuse large cell lymphoma. An immunohistochemical analysis was performed. EBV-RNA was assessed by in situ hybridization that also proved to be negative. Immunohistochemical and EBV analyses are important to avoid delays and inappropriate treatment strategies. Although advanced age is considered an adverse prognostic factor, early diagnosis did prove to be a key contributory factor in the cure of non-Hodgkin lymphoma