Validité de construit d’un test d’évaluation de la stabilité lombo-pelvienne, le soulèvement actif de la jambe tendue (SAJT) version objective

Introduction : L’évaluation clinique du contrôle neuromusculaire des muscles du tronc est criante en réhabilitation et en entraînement. L’objectif principal de cette étude a été d’évaluer la reproductibilité intra et inter-évaluateur d’un test clinique le soulèvement actif de la jambe tendue (SAJT) chez une population active et saine. Méthode : Chaque sujet (18 joueurs de tennis) a été testé à deux reprises par 2 physiothérapeutes avec le SAJT. Résultats : La reproductibilité intra-évaluateur s’est avérée élevée à très élevée (ICC = 0.81 à 0.93) tandis la reproductibilité inter-évaluateur s’est avérée cliniquement non viable. Conclusion : À notre connaissance, le SAJT est le premier test clinique reproductible évaluant le contrôle neuromusculaire du tronc avec des compensations musculaires et cinétiques chez des sujets actifs et sains. Une formation plus importante des évaluateurs aurait certainement amélioré la reproductibilité inter-évaluateur.Introduction: The clinical assessment of the trunk muscles neuromuscular control is lacking in rehabilitation and in conditioning. The main goal of this study was to assess the intra and inter-rater reliability of a clinical test, the active straight leg raise (ASLR), on an active and healthy population. Method: Each subject (18 tennis players) was tested twice by 2 physiotherapists with the ASLR. Results: The intra-rater reliability turned out to be high to very high (ICC = 0.81 à 0.93) while the inter-rater reliability came out clinically unsustainable. Conclusion: To our knowledge, the ASLR is the first reliable clinical test to assess the core neuromuscular control based on muscular and kinetic compensation observations with active and healthy subjects. A more exhaustive training of the assessors would definitely improve the inter-rater reliability

Plateforme informatique pour l'assistance à l'autonomie à domicile de personnes âgées

RÉSUMÉ : Ambient Assisted Living (AAL) en général et Activity Recognition (AR) en particulier sont des domaines de recherche actifs qui visent à aider les personnes dans leurs activités de la vie quotidienne (AVQ). Au cours des dernières années, nous avons constaté un intérêt accru pour leur applicabilité aux personnes âgées vivant en milieu rural qui perdent lentement leur autonomie en raison du vieillissement et aux maladies chroniques. Une avenue de recherche importante consiste à agréger et à rechercher des corrélations entre les données physiologiques qui servent à surveiller la santé des personnes âgées, leurs AVQ, leurs mouvements et toute autre donnée pouvant être recueillis sur leur environnement immédiat. Dans ce travail, nous abordons la possibilité de développer une plateforme non intrusive et abordable en raison de l'absence d'une telle plateforme. Elle est basée sur des capteurs de santé, de mouvement, d'activité et de localisation. En outre, nous discutons des principaux concepts derrière la création d'une architecture en couches, flexible et hautement modulaire qui se concentre sur la façon dont l'intégration de données de capteurs combinés peut être réalisée. À l'aide d'un prototype d'application de téléphonie mobile, nos travaux ont montré que nous pouvons intégrer de nombreuses technologies non invasives qui ne sont pas nécessairement les plus récentes, mais les plus abordables, évolutives et prêtes à être déployées dans des environnements réels. Un autre domaine de recherche découlant de ces avancées est de savoir comment la technologie et l'analyse pourraient bénéficier à la prévention et au traitement des maladies chroniques chez le nombre croissant de personnes âgées ayant des problèmes de santé. De nombreuses architectures sont proposées dans la littérature, mais elles manquent de modularité et de flexibilité pour différents types de capteurs. À cette fin, nous proposons une architecture à quatre couches et hautement modulaire pour l'analyse de la santé des personnes âgées. Finalement, nous évaluons l'approche en implémentant une partie de l'architecture sur des nœuds de brouillard et le cloud. De plus, nous déployons ces capteurs abordables, de qualité, et accessibles au grand public dans un appartement afin d'avancer vers l'utilisation du système proposé. Des données recueillies sont utilisées comme un test préliminaire pour évaluer les capacités de la plate-forme. En utilisant les données collectées lors de l'étape de validation, nous effectuons des prévisions d'une semaine dans le futur pour des séries univariées en utilisant des méthodes classiques populaires et les méthodes d'apprentissage en profondeur les plus récentes. Une comparaison de précision est présentée. -- Mot(s) clé(s) en français : IoT, suivi à distance des personnes âgées, santé intelligente et connectée, analyse, assistance à la vie ambiante, capteurs, intelligence artificielle. -- ABSTRACT : Ambient Assisted Living (AAL) in general and Activity Recognition (AR) in particular are active fields of research that aim at assisting people in their Activities of Daily Living (ADL). In recent years, we have seen an increased interest in their applicability to the rural seniors who are slowly losing their autonomy due to aging and chronic diseases. One research venue is to aggregate and seek for correlations between the physiological data that serves to monitor the health of the elderly, their ADLs, their movements and any other data that may be collected about their immediate environment. In this work, we are tackling the possibility of developing a non-intrusive and affordable platform due to the lack of such a platform. It is based on embedded health, movement, activity and location sensors. Furthermore, we discuss the main concepts behind the creation of a layered, flexible and highly modular architecture that focuses on how the integration of newly combined sensor data can be achieved. Using a mobile phone application prototype, our work has shown that we can integrate many non-invasive technologies that are not necessarily the newest, but the most affordable, scalable and ready to be deployed in real life settings. Another researched venue deriving from these advances is how the technology and analytics could benefit the prevention and treatment of chronic diseases in the escalating number of elderly people experiencing health issues. Many architectures are proposed in the literature, but they lack modularity and flexibility for different types of sensors. To that end, we propose a four layered and highly modular architecture for health analytics of elderly people. In the final analysis, we evaluate the approach by implementing part of the architecture on fog nodes and the cloud. Moreover, we deploy these affordable consumer grade sensors in an apartment in order to move toward the use of the system proposed. The data collected from this experiment is used as a preliminary test of the capabilities of the platform. We perform univariate series forecasting using a popular classical methods and the more recent deep learning methods by using the data collected in the validation stage. An accuracy comparison is presented. -- Mot(s) clé(s) en anglais : IoT, remote elderly monitoring, smart and connected Health, analytics, ambient assisted living, sensors

Un effet de composition? : le rôle de la composition culturelle et économique des écoles secondaires fréquentées à 15 ans sur la faible diplomation à 25 ans

L’objectif de ce mémoire est d’analyser le rôle de la composition culturelle et économique des écoles secondaires fréquentées à 15 ans sur l’échec scolaire à 25 ans. À partir des données de Statistique Canada (Enquête sur les jeunes en Transition), nous proposons une analyse originale portant sur l’inégalité des chances en matière de réussite scolaire ou plutôt de l’échec scolaire au secondaire à 25 ans. Théoriquement, nous mobilisons le cadre d’analyse théorique de la reproduction sociale de Pierre Bourdieu. L’originalité de notre approche est double. Nous prenons d’abord en compte à la fois des caractéristiques individuelles des élèves, mais aussi de la composition sociale des établissements qu’ils fréquentent. Nous intégrons par ailleurs à ces deux niveaux d’analyse une multiplicité d’indicateurs identifiés comme importants dans la réussite scolaire : multiplicité pouvant être culturelle, économique, sociale, ethnique et de genre. Nos résultats nous conduisent à constater l’existence d’un double primat du capital culturel en éducation dans la mesure où le niveau d’éducation des parents et le pourcentage de parents sans diplômes dans l’école sont de loin les deux facteurs explicatifs les plus déterminants de l’absence de diplomation du secondaire à 25 ans. Cela nous conduit à critiquer la production d’indices synthétiques de défavorisation par les acteurs scolaires : la proportion de familles monoparentales, divorcées ou vivant seuls, la proportion de chômeurs, le revenu moyen du quartier ou encore la proportion de gens sans diplômes dans l’agglomération d’une école. En plus de ne pas contribuer à prédire l’échec scolaire, ces indices pourraient contribuer à renforcer la stigmatisation des écoles. Enfin, nous montrons que le statut de l’école (public régulier, public enrichi et privé), le genre, l’origine ethnique et le revenu des parents conservent un impact significatif après contrôle du capital culturel au niveau individuel et de l’école.The objective of this thesis is to study the role of the cultural and economic composition of elementary schools attended at age 15, on non-graduation at age 25. Using data from Statistics Canada (Youth in Transition Survey), we proposed an original analysis of the inequality of opportunities in terms of academic success or rather non-success in high school at age 25. Theoretically, we use Pierre Bourdieu's theoretical framework for social reproduction. The originality of our approach is twofold. We first take into account both the individual characteristics of the students, but also the social composition of schools they attend. We also integrate at these two levels a multiplicity of indicators identified as important in educational success: cultural, economic, social, ethnic and gender. Our results lead us to note the existence of a double primacy of cultural capital in education insofar as the level of parents' education and the percentage of parents without a diploma in school are by far the two most important explanatory factors of non-graduation from high school at age 25. The study allowed us to criticize the production of synthetic indices of deprivation by educational actors: the proportion of single-parent families, divorced or living alone, the proportion of unemployed, the average income of the district or the proportion of people without qualifications in the agglomeration. of a school, in addition to not helping to predict academic non-success in high school, could contribute to reinforcing the stigmatization of schools. Finally, we show that the status of the school (regular public, enriched public and private), gender, ethnicity and parental income retain a significant impact after controlling cultural capital at the individual and school level

Méthodes mixtes, jeux, matériel ouvert et traduction en santé

Breathing Games est une communauté internationale qui crée des jeux et capteurs librement reproductibles pour la santé respiratoire et mentale. Nous proposons un retour d’expérience sur les succès et défis rencontrés depuis l’affiche présentée en 2017. Co-création : de la compliance à l’adhésion thérapeutique. Participation aux études cliniques : limiter l’investissement. Traductions des jeux : meilleure accessibilité des contenus. Commun en accès libre : autonomie et appartenance. Protocole : gestion de maladie ou santé publique critique ? Matériel : choix d’une éthique inclusive

Optimal human papillomavirus vaccination strategies to prevent cervical cancer in low-income and middle-income countries in the context of limited resources: a mathematical modelling analysis

Introduction of human papillomavirus (HPV) vaccination has been slow in low-income and middle-income countries (LMICs) because of resource constraints and worldwide shortage of vaccine supplies. To help inform WHO recommendations, we modelled various HPV vaccination strategies to examine the optimal use of limited vaccine supplies and best allocation of scarce resources in LMICs in the context of the WHO global call to eliminate cervical cancer as a public health problem. Methods In this mathematical modelling analysis, we developed HPV-ADVISE LMIC, a transmission-dynamic model of HPV infection and diseases calibrated to four LMICs: India, Vietnam, Uganda, and Nigeria. For different vaccination strategies that encompassed use of a nine-valent vaccine (or a two-valent or four-valent vaccine assuming high cross-protection), we estimated three outcomes: reduction in the age-standardised rate of cervical cancer, number of doses needed to prevent one case of cervical cancer (NNV; as a measure of efficiency), and the incremental cost-effectiveness ratio (ICER; in 2017 international $per disability-adjusted life-year [DALY] averted). We examined different vaccination strategies by varying the ages of routine HPV vaccination and number of age cohorts vaccinated, the population targeted, and the number of doses used. In our base case, we assumed 100 Findings We predicted that HPV vaccination could lead to cervical cancer elimination in Vietnam, India, and Nigeria, but not in Uganda. Compared with no vaccination, strategies that involved vaccinating girls aged 9-14 years with two doses were predicted to be the most efficient and cost-effective in all four LMICs. NNV ranged from 78 to 381 and ICER ranged from$28 per DALY averted to $1406 per DALY averted depending on the country. The most efficient and cost-effective strategies were routine vaccination of girls aged 14 years, with or without a later switch to routine vaccination of girls aged 9 years, and routine vaccination of girls aged 9 years with a 5-year extended interval between doses and a catch-up programme at age 14 years. Vaccinating boys (aged 9-14 years) or women aged 18 years or older resulted in substantially higher NNVs and ICERs. Interpretation We identified two strategies that could maximise efforts to prevent cervical cancer in LMICs given constraints on vaccine supplies and costs and that would allow a maximum of LMICs to introduce HPV vaccination. Funding World Health Organization, Canadian Institute of Health Research, Fonds de recherche du Québec-Santé, Compute Canada, PATH, and The Bill & Melinda Gates Foundation. Translations For the French and Spanish translations of the abstract see Supplementary Materials section

Evolution of Chromosome-Arm Aberrations in Breast Cancer Through Genetic Network Rewiring

The basal breast cancer subtype is enriched for triple-negative breast cancer (TNBC) and displays consistent large chromosomal deletions. Here, we characterize evolution and maintenance of chromosome 4p (chr4p) loss in basal breast cancer. Analysis of The Cancer Genome Atlas data shows recurrent deletion of chr4p in basal breast cancer. Phylogenetic analysis of a panel of 23 primary tumor/patient-derived xenograft basal breast cancers reveals early evolution of chr4p deletion. Mechanistically we show that chr4p loss is associated with enhanced proliferation. Gene function studies identify an unknown gene, C4orf19, within chr4p, which suppresses proliferation when overexpressed-a member of the PDCD10-GCKIII kinase module we name PGCKA1. Genome-wide pooled overexpression screens using a barcoded library of human open reading frames identify chromosomal regions, including chr4p, that suppress proliferation when overexpressed in a context-dependent manner, implicating network interactions. Together, these results shed light on the early emergence of complex aneuploid karyotypes involving chr4p and adaptive landscapes shaping breast cancer genomes

Open-source games for health, multiplayer and gamepads. Co-creating fun care with children with asthma, young adults with cystic fibrosis, elders with COPD

Without air pollution, our life expectancy would increase by 34 months. With a commons-based economy, each and every human could afford medical care (vs one in two today). How not to produce risks? How to foster mutual care? We, people across regions and disciplines, get engaged to value pluralism and collective wisdom. We embrace play as a natural way to experiment, socialize, learn. We document and share our work so that everyone can freely use, study, improve, adapt it. In traditional medtech, corporate experts build a technical tool to manage a disease. Sealed in a black box, its price make it unaffordable to some. At Breathing Games, volunteer, diverse contributors co-create an evolving, rewarding, immersive story to promote holistic health. Free to use, study, improve, its gratuity helps develop solidarity. We present here our games (Asthma Heroes, Asthmonautes, Rise); controllers (Spirotroller enhanced, Spirotroller gaming, Breathing gamepad); creation as research (game testing, controller testing, games co-creation, translations); our next steps (international study, game accessibility via Raspberry Pi, link to air pollution sensor); and our advocacy activities for health as commons

Academic careers in Computer Science: Continuance and transience of lifetime co-authorships

International audienceScholarly publications reify fruitful collaborations between co-authors. A branch of research in the Science Studies focuses on analyzing the co-authorship networks of established scientists. Such studies tell us about how their collaborations developed through their careers. This paper updates previous work by reporting a transversal and a longitudinal studies spanning the lifelong careers of a cohort of researchers from the DBLP bibliographic database. We mined 3,860 researchers' publication records to study the evolution patterns of their co-authorships. Two features of co-authors were considered: 1) their expertise, and 2) the history of their partnerships with the sampled researchers. Our findings reveal the ephemeral nature of most collaborations: 70% of the new co-authors were only one-shot partners since they did not appear to collaborate on any further publications. Overall, researchers consistently extended their co-authorships 1) by steadily enrolling beginning researchers (i.e., people who had never published before), and 2) by increasingly working with confirmed researchers with whom they already collaborated

Impact of HPV vaccination and cervical screening on cervical cancer elimination: a comparative modelling analysis in 78 low-income and lower-middle-income countries.

BACKGROUND: The WHO Director-General has issued a call for action to eliminate cervical cancer as a public health problem. To help inform global efforts, we modelled potential human papillomavirus (HPV) vaccination and cervical screening scenarios in low-income and lower-middle-income countries (LMICs) to examine the feasibility and timing of elimination at different thresholds, and to estimate the number of cervical cancer cases averted on the path to elimination. METHODS: The WHO Cervical Cancer Elimination Modelling Consortium (CCEMC), which consists of three independent transmission-dynamic models identified by WHO according to predefined criteria, projected reductions in cervical cancer incidence over time in 78 LMICs for three standardised base-case scenarios: girls-only vaccination; girls-only vaccination and once-lifetime screening; and girls-only vaccination and twice-lifetime screening. Girls were vaccinated at age 9 years (with a catch-up to age 14 years), assuming 90% coverage and 100% lifetime protection against HPV types 16, 18, 31, 33, 45, 52, and 58. Cervical screening involved HPV testing once or twice per lifetime at ages 35 years and 45 years, with uptake increasing from 45% (2023) to 90% (2045 onwards). The elimination thresholds examined were an average age-standardised cervical cancer incidence of four or fewer cases per 100 000 women-years and ten or fewer cases per 100 000 women-years, and an 85% or greater reduction in incidence. Sensitivity analyses were done, varying vaccination and screening strategies and assumptions. We summarised results using the median (range) of model predictions. FINDINGS: Girls-only HPV vaccination was predicted to reduce the median age-standardised cervical cancer incidence in LMICs from 19·8 (range 19·4-19·8) to 2·1 (2·0-2·6) cases per 100 000 women-years over the next century (89·4% [86·2-90·1] reduction), and to avert 61·0 million (60·5-63·0) cases during this period. Adding twice-lifetime screening reduced the incidence to 0·7 (0·6-1·6) cases per 100 000 women-years (96·7% [91·3-96·7] reduction) and averted an extra 12·1 million (9·5-13·7) cases. Girls-only vaccination was predicted to result in elimination in 60% (58-65) of LMICs based on the threshold of four or fewer cases per 100 000 women-years, in 99% (89-100) of LMICs based on the threshold of ten or fewer cases per 100 000 women-years, and in 87% (37-99) of LMICs based on the 85% or greater reduction threshold. When adding twice-lifetime screening, 100% (71-100) of LMICs reached elimination for all three thresholds. In regions in which all countries can achieve cervical cancer elimination with girls-only vaccination, elimination could occur between 2059 and 2102, depending on the threshold and region. Introducing twice-lifetime screening accelerated elimination by 11-31 years. Long-term vaccine protection was required for elimination. INTERPRETATION: Predictions were consistent across our three models and suggest that high HPV vaccination coverage of girls can lead to cervical cancer elimination in most LMICs by the end of the century. Screening with high uptake will expedite reductions and will be necessary to eliminate cervical cancer in countries with the highest burden. FUNDING: WHO, UNDP, UN Population Fund, UNICEF-WHO-World Bank Special Program of Research, Development and Research Training in Human Reproduction, Canadian Institute of Health Research, Fonds de recherche du Québec-Santé, Compute Canada, National Health and Medical Research Council Australia Centre for Research Excellence in Cervical Cancer Control

ABINIT: Overview and focus on selected capabilities

Paper published as part of the special topic on Electronic Structure SoftwareABINIT is probably the first electronic-structure package to have been released under an open-source license about 20 years ago. It implements density functional theory, density-functional perturbation theory (DFPT), many-body perturbation theory (GW approximation and Bethe–Salpeter equation), and more specific or advanced formalisms, such as dynamical mean-field theory (DMFT) and the “temperaturedependent effective potential” approach for anharmonic effects. Relying on planewaves for the representation of wavefunctions, density, and other space-dependent quantities, with pseudopotentials or projector-augmented waves (PAWs), it is well suited for the study of periodic materials, although nanostructures and molecules can be treated with the supercell technique. The present article starts with a brief description of the project, a summary of the theories upon which ABINIT relies, and a list of the associated capabilities. It then focuses on selected capabilities that might not be present in the majority of electronic structure packages either among planewave codes or, in general, treatment of strongly correlated materials using DMFT; materials under finite electric fields; properties at nuclei (electric field gradient, Mössbauer shifts, and orbital magnetization); positron annihilation; Raman intensities and electro-optic effect; and DFPT calculations of response to strain perturbation (elastic constants and piezoelectricity), spatial dispersion (flexoelectricity), electronic mobility, temperature dependence of the gap, and spin-magnetic-field perturbation. The ABINIT DFPT implementation is very general, including systems with van der Waals interaction or with noncollinear magnetism. Community projects are also described: generation of pseudopotential and PAW datasets, high-throughput calculations (databases of phonon band structure, second-harmonic generation, and GW computations of bandgaps), and the library LIBPAW. ABINIT has strong links with many other software projects that are briefly mentioned.This work (A.H.R.) was supported by the DMREF-NSF Grant No. 1434897, National Science Foundation OAC-1740111, and U.S. Department of Energy DE-SC0016176 and DE-SC0019491 projects. N.A.P. and M.J.V. gratefully acknowledge funding from the Belgian Fonds National de la Recherche Scientifique (FNRS) under Grant No. PDR T.1077.15-1/7. M.J.V. also acknowledges a sabbatical “OUT” grant at ICN2 Barcelona as well as ULiège and the Communauté Française de Belgique (Grant No. ARC AIMED G.A. 15/19-09). X.G. and M.J.V. acknowledge funding from the FNRS under Grant No. T.0103.19-ALPS. X.G. and G.-M. R. acknowledge support from the Communauté française de Belgique through the SURFASCOPE Project (No. ARC 19/24-057). X.G. acknowledges the hospitality of the CEA DAM-DIF during the year 2017. G.H. acknowledges support from the U.S. Department of Energy, Office of Science, Office of Basic Energy Sciences, Materials Sciences and Engineering Division under Contract No. DE-AC02-05-CH11231 (Materials Project Program No. KC23MP). The Belgian authors acknowledge computational resources from supercomputing facilities of the University of Liège, the Consortium des Equipements de Calcul Intensif (Grant No. FRS-FNRS G.A. 2.5020.11), and Zenobe/CENAERO funded by the Walloon Region under Grant No. G.A. 1117545. M.C. and O.G. acknowledge support from the Fonds de Recherche du Québec Nature et Technologie (FRQ-NT), Canada, and the Natural Sciences and Engineering Research Council of Canada (NSERC) under Grant No. RGPIN-2016-06666. The implementation of the libpaw library (M.T., T.R., and D.C.) was supported by the ANR NEWCASTLE project (Grant No. ANR-2010-COSI-005-01) of the French National Research Agency. M.R. and M.S. acknowledge funding from Ministerio de Economia, Industria y Competitividad (MINECO-Spain) (Grants Nos. MAT2016-77100-C2-2-P and SEV-2015-0496) and Generalitat de Catalunya (Grant No. 2017 SGR1506). This work has received funding from the European Research Council (ERC) under the European Union’s Horizon 2020 Research and Innovation program (Grant Agreement No. 724529). P.G. acknowledges support from FNRS Belgium through PDR (Grant No. HiT4FiT), ULiège and the Communauté française de Belgique through the ARC project AIMED, the EU and FNRS through M.ERA.NET project SIOX, and the European Funds for Regional Developments (FEDER) and the Walloon Region in the framework of the operational program “Wallonie-2020.EU” through the project Multifunctional thin films/LoCoTED. The Flatiron Institute is a division of the Simons Foundation. A large part of the data presented in this paper is available directly from the Abinit Web page www.abinit.org. Any other data not appearing in this web page can be provided by the corresponding author upon reasonable request.Peer reviewe