Envelope tomography of long-period variable stars: I. The Schwarzschild mechanism and the Balmer emission lines

This paper is the first one in a series devoted to the study of the dynamics of the atmospheres of long-period variable stars. Results from a two-month-long monitoring of the Mira variables RT Cyg and X Oph around maximum light with the ELODIE spectrograph at the Haute-Provence Observatory are presented. The monitoring covers phases 0.80 to 1.16 for RT Cyg and phases 0.83 to 1.04 for X Oph. The cross-correlation profile of the spectrum of RT Cyg with a K0 III mask confirms that the absorption lines of RT Cyg in the optical domain appear double around maximum light. No line doubling was found in the optical spectrum of X Oph around maximum light, indicating that this feature is not common to all long-period variables. This paper also presents the application to RT Cyg of a new tomographic technique deriving the velocity field across the atmosphere by cross-correlating the optical spectrum with numerical masks constructed from synthetic spectra and probing layers of increasing depths. This technique reveals that both the temporal evolution of the line doubling, and its variation with depth in the atmosphere of RT Cyg, are consistent with the ``Schwarzschild scenario''. This scenario relates the temporal evolution of the red and blue peaks of the double absorption lines to the progression of a shock wave in the atmosphere. The temporal evolution of the Balmer Halpha, H beta, Hgamma and Hdelta emission lines around maximum light is also presented for RT Cyg and X Oph. The velocity variations of Halpha and of the absorption lines are discussed in the framework of two competing models for the formation of Balmer emission lines in long-period variable stars.Comment: 11 pages, 8 figures, Latex, accepted for publication in Astronomy and Astrophysics main journal. Also available at http://www-astro.ulb.ac.be/Html/ps.htm

The deformation complex is a homotopy invariant of a homotopy algebra

To a homotopy algebra one may associate its deformation complex, which is naturally a differential graded Lie algebra. We show that infinity quasi-isomorphic homotopy algebras have L-infinity quasi-isomorphic deformation complexes by an explicit construction.Comment: A revised version. The final version will appear in the volume "Current Developments and Retrospectives in Lie Theory

The Diderot meteorite: The second chassignite

The Diderot meteorite is a dunite discovered in Sahara. The martian origin is unambiguous and Diderot shares strong petrographical similarities with Chassigny

There is no degree map for 0-cycles on Artin stacks

We show that there is no way to define degrees of 0-cycles on Artin stacks with proper good moduli spaces so that (i) the degree of an ordinary point is non-zero, and (ii) degrees are compatible with closed immersions.Comment: 3 page

Envelope tomography of long-period variable stars III. Line-doubling frequency among Mira stars

This paper presents statistics of the line-doubling phenomenon in a sample of 81 long-period variable (LPV) stars of various periods, spectral types and brightness ranges. When correlated with a mask mimicking a K0III spectrum, 54% of the sample stars clearly showed a double-peaked cross-correlation profile around maximum light, reflecting double absorption lines. Several pieces of evidence are presented that point towards the double absorption lines as being caused by the propagation of a shock wave through the photosphere. The observation of the Balmer lines appearing in emission around maximum light in these stars corroborates the presence of a shock wave. The observed velocity discontinuities, ranging between 10 and 25 km/s, are not correlated with the brightness ranges. A comparison with the center-of-mass (COM) velocity obtained from submm CO lines originating in the circumstellar envelope reveals that the median velocity between the red and blue peaks is blueshifted with respect to the COM velocity, as expected if the shock moves upwards.Comment: Accepted by Astronomy & Astrophysics (21 pages, 15 figures

Herpesvirus Glycoproteins Undergo Multiple Antigenic Changes before Membrane Fusion

Herpesvirus entry is a complicated process involving multiple virion glycoproteins and culminating in membrane fusion. Glycoprotein conformation changes are likely to play key roles. Studies of recombinant glycoproteins have revealed some structural features of the virion fusion machinery. However, how the virion glycoproteins change during infection remains unclear. Here using conformation-specific monoclonal antibodies we show in situ that each component of the Murid Herpesvirus-4 (MuHV-4) entry machinery—gB, gH/gL and gp150—changes in antigenicity before tegument protein release begins. Further changes then occurred upon actual membrane fusion. Thus virions revealed their final fusogenic form only in late endosomes. The substantial antigenic differences between this form and that of extracellular virions suggested that antibodies have only a limited opportunity to block virion membrane fusion

A Double-Mode RR Lyrae Star with a Strong Fundamental Mode Component

NSVS 5222076, a thirteenth magnitude star in the Northern Sky Variability Survey, was identified by Oaster as a possible new double-mode RR Lyrae star. We confirm the double-mode nature of NSVS 5222076, supplementing the survey data with new V band photometry. NSVS 5222076 has a fundamental mode period of 0.4940 day and a first overtone period of 0.3668 day. Its fundamental mode light curve has an amplitude twice as large as that of the first overtone mode, a ratio very rarely seen. Data from the literature are used to discuss the location in the Petersen diagram of double-mode RR Lyrae stars having strong fundamental mode pulsation. Such stars tend to occur toward the short period end of the Petersen diagram, and NSVS 5222976 is no exception to this rule.Comment: 14 pages, 4 figures, To be published in the March, 2006, issue of PAS

Do the relationships between hindlimb anatomy and sprint speed variation differ between sexes in Anolis lizards?

The ability of an animal to run fast has important consequences on its survival capacity and overall fitness. Previous studies have documented how variation in the morphology of the limbs is related to variation in locomotor performance. Although these studies have suggested direct relations between sprint speed and hindlimb morphology, few quantitative data exist. Consequently, it remains unclear whether selection acts in limb segment lengths, overall muscle mass or muscle architecture (e.g. muscle fiber length and cross-sectional area). Here, we investigate whether muscle architecture (mass, fiber length and physiological cross-sectional area), hindlimb segment dimensions, or both, explain variation in sprint speed across 14 species of Anolis lizards. Moreover, we test whether similar relationships exist between morphology and performance for both sexes, which may not be the case given the known differences in locomotor behavior and habitat use. Our results show that the main driver of sprint speed is the variation in femur length for both males and females. Our results further show sexual dimorphism in the traits studied and, moreover, show differences in the traits that predict maximal sprint speed in males and females. For example, snout vent length and overall muscle mass are also good predictors of sprint speed in males, whereas no relationships between muscle mass and sprint speed was observed in females. Only a few significant relationships were found between muscle architecture (fiber length, cross-sectional area) and sprint speed in male anoles, suggesting that overall muscles size, rather than muscle architecture, appears to be under selection

Resistance to paclitaxel in a cisplatin-resistant ovarian cancer cell line is mediated by P-glycoprotein

The IGROVCDDP cisplatin-resistant ovarian cancer cell line is also resistant to paclitaxel and models the resistance phenotype of relapsed ovarian cancer patients after first-line platinum/taxane chemotherapy. A TaqMan low-density array (TLDA) was used to characterise the expression of 380 genes associated with chemotherapy resistance in IGROVCDDP cells. Paclitaxel resistance in IGROVCDDP is mediated by gene and protein overexpression of P-glycoprotein and the protein is functionally active. Cisplatin resistance was not reversed by elacridar, confirming that cisplatin is not a P-glycoprotein substrate. Cisplatin resistance in IGROVCDDP is multifactorial and is mediated in part by the glutathione pathway and decreased accumulation of drug. Total cellular glutathione was not increased. However, the enzyme activity of GSR and GGT1 were up-regulated. The cellular localisation of copper transporter CTR1 changed from membrane associated in IGROV-1 to cytoplasmic in IGROVCDDP. This may mediate the previously reported accumulation defect. There was decreased expression of the sodium potassium pump (ATP1A), MRP1 and FBP which all have been previously associated with platinum accumulation defects in platinum-resistant cell lines. Cellular localisation of MRP1 was also altered in IGROVCDDP shifting basolaterally, compared to IGROV-1. BRCA1 was also up-regulated at the gene and protein level. The overexpression of P-glycoprotein in a resistant model developed with cisplatin is unusual. This demonstrates that P-glycoprotein can be up-regulated as a generalised stress response rather than as a specific response to a substrate. Mechanisms characterised in IGROVCDDP cells may be applicable to relapsed ovarian cancer patients treated with frontline platinum/taxane chemotherapy