6,273 research outputs found
Inelastic final-state interaction
The final-state interaction in multichannel decay processes is sytematically
studied with application to B decay in mind. Since the final-state inteaction
is intrinsically interwoven with the decay interaction in this case, no simple
phase theorem like "Watson's theorem" holds for experimentally observed final
states. We first examine in detail the two-channel problem as a toy-model to
clarify the issues and to remedy common mistakes made in earlier literature.
Realistic multichannel problems are too challenging for quantitative analysis.
To cope with mathematical complexity, we introduce a method of approximation
that is applicable to the case where one prominant inelastic channel dominates
over all others. We illustrate this approximation method in the amplitude of
the decay B to pi K fed by the intermediate states of a charmed meson pair.
Even with our approximation we need more accurate information of strong
interactions than we have now. Nonethless we are able to obtain some insight in
the issue and draw useful conclusions on general fearyres on the strong phases.Comment: The published version. One figure correcte
Enhancement of the stability of genetic switches by overlapping upstream regulatory domains
We study genetic switches formed from pairs of mutually repressing operons.
The switch stability is characterised by a well defined lifetime which grows
sub-exponentially with the number of copies of the most-expressed transcription
factor, in the regime accessible by our numerical simulations. The stability
can be markedly enhanced by a suitable choice of overlap between the upstream
regulatory domains. Our results suggest that robustness against biochemical
noise can provide a selection pressure that drives operons, that regulate each
other, together in the course of evolution.Comment: 4 pages, 5 figures, RevTeX
Robust Trapped-Ion Quantum Logic Gates by Continuous Dynamical Decoupling
We introduce a novel scheme that combines phonon-mediated quantum logic gates
in trapped ions with the benefits of continuous dynamical decoupling. We
demonstrate theoretically that a strong driving of the qubit decouples it from
external magnetic-field noise, enhancing the fidelity of two-qubit quantum
gates. Moreover, the scheme does not require ground-state cooling, and is
inherently robust to undesired ac-Stark shifts. The underlying mechanism can be
extended to a variety of other systems where a strong driving protects the
quantum coherence of the qubits without compromising the two-qubit couplings.Comment: Slightly longer than the published versio
Megawatt solar power systems for lunar surface operations
The work presented here shows that a solar power system can provide power on the order of one megawatt to a lunar base with a fairly high specific power. The main drawback to using solar power is still the high mass, and therefore, cost of supplying energy storage through the solar night. The use of cryogenic reactant storage in a fuel cell system, however, greatly reduces the total system mass over conventional energy storage schemes
Sampling rare switching events in biochemical networks
Bistable biochemical switches are ubiquitous in gene regulatory networks and
signal transduction pathways. Their switching dynamics, however, are difficult
to study directly in experiments or conventional computer simulations, because
switching events are rapid, yet infrequent. We present a simulation technique
that makes it possible to predict the rate and mechanism of flipping of
biochemical switches. The method uses a series of interfaces in phase space
between the two stable steady states of the switch to generate transition
trajectories in a ratchet-like manner. We demonstrate its use by calculating
the spontaneous flipping rate of a symmetric model of a genetic switch
consisting of two mutually repressing genes. The rate constant can be obtained
orders of magnitude more efficiently than using brute-force simulations. For
this model switch, we show that the switching mechanism, and consequently the
switching rate, depends crucially on whether the binding of one regulatory
protein to the DNA excludes the binding of the other one. Our technique could
also be used to study rare events and non-equilibrium processes in soft
condensed matter systems.Comment: 9 pages, 6 figures, last page contains supplementary informatio
Stronger computational modelling of signalling pathways using both continuous and discrete-state methods
Starting from a biochemical signalling pathway model expresses in a process algebra enriched with quantitative information, we automatically derive both continuous-space and discrete-space representations suitable for numerical evaluation. We compare results obtained using approximate stochastic simulation thereby exposing a flaw in the use of the differentiation procedure producing misleading results
Stability of adhesion clusters under constant force
We solve the stochastic equations for a cluster of parallel bonds with shared
constant loading, rebinding and the completely dissociated state as an
absorbing boundary. In the small force regime, cluster lifetime grows only
logarithmically with bond number for weak rebinding, but exponentially for
strong rebinding. Therefore rebinding is essential to ensure physiological
lifetimes. The number of bonds decays exponentially with time for most cases,
but in the intermediate force regime, a small increase in loading can lead to
much faster decay. This effect might be used by cell-matrix adhesions to induce
signaling events through cytoskeletal loading.Comment: Revtex, 4 pages, 4 Postscript files include
Calibrating AIS images using the surface as a reference
A method of evaluating the initial assumptions and uncertainties of the physical connection between Airborne Imaging Spectrometer (AIS) image data and laboratory/field spectrometer data was tested. The Tuscon AIS-2 image connects to lab reference spectra by an alignment to the image spectral endmembers through a system gain and offset for each band. Images were calibrated to reflectance so as to transform the image into a measure that is independent of the solar radiant flux. This transformation also makes the image spectra directly comparable to data from lab and field spectrometers. A method was tested for calibrating AIS images using the surface as a reference. The surface heterogeneity is defined by lab/field spectral measurements. It was found that the Tuscon AIS-2 image is consistent with each of the initial hypotheses: (1) that the AIS-2 instrument calibration is nearly linear; (2) the spectral variance is caused by sub-pixel mixtures of spectrally distinct materials and shade, and (3) that sub-pixel mixtures can be treated as linear mixtures of pure endmembers. It was also found that the image can be characterized by relatively few endmembers using the AIS-2 spectra
Investigation of potential diseases associated with Northern Territory mammal declines
There is compelling evidence of broad-scale declines in populations of small terrestrial native mammals in northern Australia, including the Top End of the Northern Territory (NT) over the past 20 years. Causes under consideration include changed fire regimes, introduced fauna (including predators) and disease. To date information on health and disease in northern Australian mammals has been limited.
Disease is increasingly recognised as a primary driver of some wildlife population declines and extinctions e.g., Tasmanian devil facial tumour disease, white nose syndrome in bats and chytrid fungus in amphibians.
Disease has been identified as a risk factor for extinction in declining and fragmented wildlife populations globally, particularly in situations of increased environmental stressors, changing ecosystems, arrival of new vertebrate threats or climate change. Unless wild populations are studied in detail over long periods of time, the effects of disease are easily overlooked and may be difficult to determine.
This study is the largest and most comprehensive study of health and disease in small mammals in northern Australia and is one of a small number of studies worldwide to have approached investigation of wildlife populations in this comprehensive manner
- …