Intermediate Mass Black Hole Induced Quenching of Mass Segregation in Star Clusters

In many theoretical scenarios it is expected that intermediate-mass black holes (IMBHs, with masses M ~ 100-10000 solar masses) reside at the centers of some globular clusters. However, observational evidence for their existence is limited. Several previous numerical investigations have focused on the impact of an IMBH on the cluster dynamics or brightness profile. Here we instead present results from a large set of direct N-body simulations including single and binary stars. These show that there is a potentially more detectable IMBH signature, namely on the variation of the average stellar mass between the center and the half-light radius. We find that the existence of an IMBH quenches mass segregation and causes the average mass to exhibit only modest radial variation in collisionally relaxed star clusters. This differs from when there is no IMBH. To measure this observationally requires high resolution imaging at the level of that already available from the Hubble Space Telescope (HST) for the cores of a large sample of galactic globular clusters. With a modest additional investment of HST time to acquire fields around the half-light radius, it will be possible to identify the best candidate clusters to harbor an IMBH. This test can be applied only to globulars with a half-light relaxation time less than or equal to 1 Gyr, which is required to guarantee efficient energy equipartition due to two-body relaxation.Comment: 15 pages, 3 figures, ApJ, in pres

Fitting Event-History Models to Uneventful Data

Data with which to study disability dynamics usually take the form of successive current-status measures of disability rather than a record of events or spell durations. One recent paper presented a semi-Markov model of disability dynamics in which spell durations were inferred from sequences of current-status measures taken at 12-month intervals. In that analysis, it was assumed that no unobserved disablement transitions occurred between annual interviews. We use data from a longitudinal survey in which participants\u27 disability was measured at monthly intervals, and simulate the survival curves for remaining disabled that would be obtained with 1- and 12-month follow-up intervals. The median length of an episode of disability based on the 12-month interval data is over 22 months, while the true median, based on the 1-month interval data, is only one month

The Sirenic Links between Diabetes, Obesity, and Bladder Cancer

There is considerable evidence of a positive association between the incidence of type 2 diabetes mellitus (T2DM) and obesity with bladder cancer (BCa), with the link between T2DM and obesity having already been established. There also appear to be potential associations between Pleckstrin homology domain containing S1 (PLEKHS1) and the Insulin-like Growth Factor (IGF) axis. Seven literature searches were carried out to investigate the backgrounds of these potential links. PLEKHS1 is a candidate biomarker in BCa, with mutations that are easily detectable in urine and increased expression seemingly associated with worse disease states. PLEKHS1 has also been implicated as a potential mediator for the onset of T2DM in people with obesity. The substantial evidence of the involvement of IGF in BCa, the role of the IGF axis in obesity and T2DM, and the global prevalence of T2DM and obesity suggest there is scope for investigating the links between these components. Preliminary findings on the relationship between PLEKHS1 and the IGF axis signal possible associations with BCa progression. This indicates that PLEKHS1 plays a role in the pathogenesis of BCa that may be mediated by members of the IGF axis. Further detailed research is needed to establish the relationship between PLEKHS1 and the IGF axis in BCa and determine how these phenomena overlap with T2DM and obesity

Mass Segregation in NGC 2298: limits on the presence of an Intermediate Mass Black Hole

[abridged] Theoretical investigations have suggested the presence of Intermediate Mass Black Holes (IMBHs, with masses in the 100-10000 Msun range) in the cores of some Globular Clusters (GCs). In this paper we present the first application of a new technique to determine the presence or absence of a central IMBH in globular clusters that have reached energy equipartition via two-body relaxation. The method is based on the measurement of the radial profile for the average mass of stars in the system, using the fact that a quenching of mass segregation is expected when an IMBH is present. Here we measure the radial profile of mass segregation using main-sequence stars for the globular cluster NGC 2298 from resolved source photometry based on HST-ACS data. The observations are compared to expectations from direct N-body simulations of the dynamics of star clusters with and without an IMBH. The mass segregation profile for NGC 2298 is quantitatively matched to that inferred from simulations without a central massive object over all the radial range probed by the observations, that is from the center to about two half-mass radii. Profiles from simulations containing an IMBH more massive than ~ 300-500 Msun (depending on the assumed total mass of NGC 2298) are instead inconsistent with the data at about 3 sigma confidence, irrespective of the IMF and binary fraction chosen for these runs. While providing a null result in the quest of detecting a central black hole in globular clusters, the data-model comparison carried out here demonstrates the feasibility of the method which can also be applied to other globular clusters with resolved photometry in their cores.Comment: 21 pages, 3 figures, ApJ accepte

Women, know your limits: Cultural sexism in academia

Despite the considerable advances of the feminist movement across Western societies, in Universities women are less likely to be promoted, or paid as much as their male colleagues, or even get jobs in the first place. One way in which we can start to reflect on why this might be the case is through hearing the experiences of women academics themselves. Using feminist methodology, this article attempts to unpack and explore just some examples of ‘cultural sexism’ which characterise the working lives of many women in British academia.This article uses qualitative methods to describe and make sense of just some of those experiences. In so doing, the argument is also made that the activity of academia is profoundly gendered and this explicit acknowledgement may contribute to our understanding of the under-representation of women in senior positions

Mid-infrared silicon photonics

A mid-infrared silicon nanophotonic integrated circuit platform can have broad impact upon environmental monitoring, personalized healthcare, and public safety applications. Development of various mid-IR components, including optical parametric amplifiers, sources, modulators, and detectors, is reviewed

Mediated intimacy and postfeminism: A discourse analytic examination of sex and relationships advice in a women's magazine

This paper uses a discourse analytic perspective to analyse sex and relationship advice in a best-selling women's magazine. It identifies three different interpretative repertoires which together structure constructions of sexual relationships: the intimate entrepreneurship repertoire, organised around plans, goals and the scientific management of relationships; men-ology, in which women are instructed in how to learn to please men; and transforming the self, which calls on women to remodel their interior lives in order to construct a desirable subjectivity. The paper considers each repertoire in turn, and also looks at how they work together in order to privilege men and heterosexuality. Discussion focuses in particular on the postfeminist nature of the advice, in which pre-feminist, feminist and anti-feminist ideas are entangled in such a way as to make gender ideologies more pernicious and difficult to contest

Combining estimates of interest in prognostic modelling studies after multiple imputation: current practice and guidelines

Background: Multiple imputation (MI) provides an effective approach to handle missing covariate data within prognostic modelling studies, as it can properly account for the missing data uncertainty. The multiply imputed datasets are each analysed using standard prognostic modelling techniques to obtain the estimates of interest. The estimates from each imputed dataset are then combined into one overall estimate and variance, incorporating both the within and between imputation variability. Rubin's rules for combining these multiply imputed estimates are based on asymptotic theory. The resulting combined estimates may be more accurate if the posterior distribution of the population parameter of interest is better approximated by the normal distribution. However, the normality assumption may not be appropriate for all the parameters of interest when analysing prognostic modelling studies, such as predicted survival probabilities and model performance measures. Methods: Guidelines for combining the estimates of interest when analysing prognostic modelling studies are provided. A literature review is performed to identify current practice for combining such estimates in prognostic modelling studies. Results: Methods for combining all reported estimates after MI were not well reported in the current literature. Rubin's rules without applying any transformations were the standard approach used, when any method was stated. Conclusion: The proposed simple guidelines for combining estimates after MI may lead to a wider and more appropriate use of MI in future prognostic modelling studies

The Lore of Low Methane Livestock:Co-Producing Technology and Animals for Reduced Climate Change Impact

Methane emissions from sheep and cattle production have gained increasing profile in the context of climate change. Policy and scientific research communities have suggested a number of technological approaches to mitigate these emissions. This paper uses the concept of co-production as an analytical framework to understand farmers’ evaluation of a 'good animal’. It examines how technology and sheep and beef cattle are co-produced in the context of concerns about the climate change impact of methane. Drawing on 42 semi-structured interviews, this paper demonstrates that methane emissions are viewed as a natural and integral part of sheep and beef cattle by farmers, rather than as a pollutant. Sheep and beef cattle farmers in the UK are found to be an extremely heterogeneous group that need to be understood in their specific social, environmental and consumer contexts. Some are more amenable to appropriating methane reducing measures than others, but largely because animals are already co-constructed from the natural and the technical for reasons of increased production efficiency