Dogs and Death: A Changing Association

Dogs have always been associated with death. However, these associations have changed as our relationship with them has changed. In the beginning of our relationship dogs were often associated with evils and devils, then evolved to become our protectors, and now are viewed as family and loyal companions. Dogs have not changed, though - they have always been our companions and protectors. Rather, their associations with death tell us about ourselves and how we view the world.https://digitalcommons.usu.edu/fsrs2020/1020/thumbnail.jp

Preparing Elementary Educators to Teach Reading: An Exploratory Study of Preservice Teachers’ Evolving Sense of Reading Efficacy

Teacher educators must acknowledge and consider the nature of reading efficacy and its developmental progression if they are to design and deliver programs that produce individuals moving toward being competent and confident teachers of reading. Ninety-two candidates in varying stages of a K-6 teacher education program responded to the Reading Teachers’ Sense of Efficacy Scale. Data analysis using ANOVA and Fisher’s LSD post-hoc comparisons revealed student teachers (Tier 4) had higher overall perceived reading teacher efficacy (M = 131.96, SD = 12.45) than those in the first semester methodology courses (Tier 2) (M = 117.68, SD = 16.43), p = .001 and the second semester of methodology courses (Tier 3) (M = 121.52, SD = 13.61), p = .005. Additionally, Tier 4 preservice teachers had significantly higher perceived reading teacher efficacy than those in both Tier 2 and Tier 3 for 9 individual scale items (p\u3c .05). The perceived increased efficacy is largely credited to positive mastery experiences during the final internship semester

Mapping and quantifying hyperpolarized 3He magnetic resonance imaging apparent diffusion coefficient gradients

We measured hyperpolarized 3He magnetic resonance imaging (MRI) apparent diffusion coefficients (ADC) and quantified ADC gradients in each three-by-three voxel region of interest (ROI). Such local ADC gradients can be represented in vector maps showing the magnitude (|G3x3|) and direction of ADC gradients, providing a qualitative visualization tool and quantitative measurement of airway and air space heterogeneity. Twenty-four subjects (15 male, mean age=67+/-7 yr) with global initiative for chronic obstructive lung disease (GOLD) stage II (n=9, mean age 68+/-6 yr), GOLD stage III chronic obstructive pulmonary disease (COPD; n=7, mean age 67+/-8 yr), and age-matched healthy volunteers (n=8, mean age 67+/-6 yr) were enrolled based on their age and spirometry results. Hyperpolarized 3He MRI was performed on a whole body 3.0 Tesla system. Mean 3He ADC and ADC standard deviation were calculated for the center coronal slice, and the mean magnitude and direction of the ADC gradient vectors were calculated for each three-by-three voxel matrix (|G3x3|). While the 3He ADC standard deviation was not significantly different, mean |G3x3| was significantly different between subjects with stage II (0.14+/-0.03 cm/s) and stage III COPD (0.19+/-0.03 cm/s;

The Beliefs and Practices of Second Grade Teachers Who Implement Independent Reading and Its Effect on Students’ Reading Achievement and Reading Volume

The purpose of the present study was to explore the beliefs and practices of teachers who implement independent reading in their classrooms. Results showed that teachers who implemented independent reading believed in the importance of both the quantity and quality of student reading. The teachers’ practices of independent reading showed students selecting books that were “just-right” for them to read, social experiences around reading, guided practice through reading conferences with the teacher, and setting a purpose for reading through response activities. A nonexperimental comparative design was used to examine the effects of independent reading on reading volume and reading achievement. Results indicated that there were no statistically significant effects between the independent reading group and the no independent reading group for reading achievement or reading volume. Additionally, there was no statistically significant difference in growth of reading achievement between higher and lower readers in the independent reading group

Novel pyrrolobenzodiazepine benzofused hybrid molecules inhibit NF-κB activity and synergise with bortezomib and ibrutinib in hematological cancers

Chronic lymphocytic leukemia (CLL) and multiple myeloma (MM) are incurable hematological malignancies that are pathologically linked with aberrant NF-κB activation. In this study, we identified a group of novel C8-linked benzofused Pyrrolo[2,1-c][1,4]benzodiazepines (PBD) monomeric hybrids capable of sequence-selective inhibition of NF-κB with low nanomolar LD50 values in CLL (n=46) and MM cell lines (n=5). The lead compound, DC-1-192, significantly inhibited NF-κB DNA binding after just 4h exposure and demonstrating inhibitory effects on both canonical and non-canonical NF-κB subunits. In primary CLL cells, sensitivity to DC-1-192 was inversely correlated with RelA subunit expression (r2=0.2) and samples with BIRC3 or NOTCH1 mutations showed increased sensitivity (P=0.001). RNA-sequencing and gene set enrichment analysis confirmed the over-representation of NF-κB regulated genes in the down-regulated gene list. Furthermore, In vivo efficacy studies in NOD/SCID mice, using a systemic RPMI 8226 human multiple myeloma xenograft model, showed that DC-1-192 significantly prolonged survival (P=0.017). In addition, DC1-192 showed synergy with bortezomib and ibrutinib; synergy with ibrutinib was enhanced when CLL cells were co-cultured on CD40L-expressing fibroblasts in order to mimic the cytoprotective lymph node microenvironment (P = 0.01). Given that NF-κB plays a role in both bortezomib and ibrutinib resistance mechanisms, these data provide a strong rationale for the use of DC-1-192 in the treatment of NF-κB-driven cancers, particularly in the context of relapsed/refractory disease

Sec-Lib: Protecting Scholarly Digital Libraries From Infected Papers Using Active Machine Learning Framework

Researchers from academia and the corporate-sector rely on scholarly digital libraries to access articles. Attackers take advantage of innocent users who consider the articles\u27 files safe and thus open PDF-files with little concern. In addition, researchers consider scholarly libraries a reliable, trusted, and untainted corpus of papers. For these reasons, scholarly digital libraries are an attractive-target and inadvertently support the proliferation of cyber-attacks launched via malicious PDF-files. In this study, we present related vulnerabilities and malware distribution approaches that exploit the vulnerabilities of scholarly digital libraries. We evaluated over two-million scholarly papers in the CiteSeerX library and found the library to be contaminated with a surprisingly large number (0.3-2%) of malicious PDF documents (over 55% were crawled from the IPs of US-universities). We developed a two layered detection framework aimed at enhancing the detection of malicious PDF documents, Sec-Lib, which offers a security solution for large digital libraries. Sec-Lib includes a deterministic layer for detecting known malware, and a machine learning based layer for detecting unknown malware. Our evaluation showed that scholarly digital libraries can detect 96.9% of malware with Sec-Lib, while minimizing the number of PDF-files requiring labeling, and thus reducing the manual inspection efforts of security-experts by 98%

Does selective migration alter socioeconomic inequalities in mortality in Wales? : a record-linked total population e-cohort study

Funding for this work was received from Public Health Wales NHS Trust as part of a report on migration and health. Support for the report was also received from the National Centre for Population Health and Wellbeing Research (NCPHWR). Andrea Gartner is funded through the NCPHWR and David Fone, Shantini Paranjothy and Daniel Farewell are members of the NCPHWR team in Cardiff University, School of Medicine. Neither funder bears any responsibility for the analysis or interpretation of the data presented here. We used data from the CHALICE project, which was originally funded by the National Institute for Health Research Public Health Research (NIHR PHR) Programme (project number 09/3007/02). The views and opinions expressed therein are those of the authors and do not necessarily reflect those of the NIHR PHR Programme or the Department of Health. We would like to thank Jenny Morgan for her work on data cleaning and validation of the original dataset.Peer reviewedPublisher PD

Screening prevalence of fetal alcohol spectrum disorders in a region of the United Kingdom: a population-based birth-cohort study

We are extremely grateful to all the families who took part in this study, the midwives for their help in recruiting them, and the whole ALSPAC team, which includes interviewers, computer and laboratory technicians, clerical workers, research scientists, volunteers, managers, receptionists and nurses. This study was funded by a doctoral studentship from Cardiff University (awarded to CM). The UK Medical Research Council and Wellcome Trust (Grant ref.: 102215/2/13/2) and the University of Bristol provide core support for the Avon Longitudinal Study of Parents and Children (ALSPAC). Funding for the facial scan data was provided by Cardiff University.Peer reviewedPublisher PD