6 research outputs found
Peak nasal inspiratory flow as outcome for provocation studies in allergen exposure chambers: a GA²LEN study
Background: The GA²LEN chamber has been developed as a novel mobile allergen
exposure chamber (AEC) allowing standardized multicenter trials in allergy.
Hitherto, subjective nasal symptom scores have been the most often used
outcome parameter, but in standardized modern trials objective parameters are
preferred. Despite its practicability, the objective parameter peak nasal
inspiratory flow (PNIF) has been rarely used for allergy trials in the setting
of allergen exposure chambers. This study aims to evaluate PNIF as an outcome
parameter for provocation studies in AECs. Methods: In a randomized controlled
blinded setting subjects suffering from allergic rhinitis were exposed to
grass pollen, birch pollen, house dust mite and/or placebo in the GA²LEN
chamber. Different allergen concentrations were used to evaluate symptom
severities. Patients had to perform PNIF before and every 30 min during a
challenge using a portable PNIF meter. Results: 86 subjects participated in
203 challenges, altogether. House dust mite provocations caused the greatest
reduction in PNIF values, followed by grass pollen and birch pollen.
Provocations with every allergen or pollen concentration led to a significant
decrease (p < 0.05) in PNIF compared to baseline. Furthermore, positive
correlations were obtained between PNIF and peak expiratory flow, height and
weight, and inverse correlations between PNIF and total nasal symptom score,
nasal congestion score and visual analog scale of overall subjective symptoms.
Conclusion: PNIF is a helpful and feasible tool for conducting provocation
trials with allergens, especially grass pollen and house dust mite, in an AEC
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MOESM7 of Peak nasal inspiratory flow as outcome for provocation studies in allergen exposure chambers: a GA2LEN study
Additional file 7: Figure S3. Comparison of different allergens and their PNIF outcome. PNIF development compared between the different allergens and placebo. Both grass pollen and house dust mite (HDM) elicited significantly greater PNIF% reductions at each associated time of measurement than placebo (p < 0.001) and birch pollen (p < 0.01). PNIF% is displayed as medians and boxplots. Outliers are presented as degree sign, extreme outliers as asterisk