1,802 research outputs found

    A preliminary annotated checklist and evaluation of the diversity of the Chrysomelidae (Coleoptera) of the Baja California peninsula, Mexico

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    A preliminary annotated checklist of the Chrysomelidae of the Baja California peninsula, Mexico is presented based on literature records and the examination of approximately 16,000 chrysomelid specimens. Seven subfamilies and 218 described species have been identified. Ninty-one species are recognized from the Baja California peninsula for the first time. Twenty-nine species are listed as endemic. An additional 128 morphospecies have been identified as undescribed or not yet associated with described species of mainland Mexico or the United States. Adult host plant associations have been identified for approximately 120 species or 35% of the leaf beetle fauna of the region. Each of the 218 described species is associated with the eight plant communities as outlined by Wiggins (1980). Two dominant subfamilies comprise 76% of the leaf beetle fauna: Galerucinae, 87 species (40%) and Cryptocephalinae, 78 species (36%). The following new combinations are proposed: Neolema californica (Heinze, 1927), transferred from Lema Fabricius, 1798; Pseudoluperus histrio (Horn, 1895), transferred from Keitheatus Wilcox, 1965, and Diachus peninsularis (Schaeffer, 1906), transferred from Triachus J. L. LeConte, 1880. Lema peninsulae Crotch, 1873, is removed from synonymy with L. balteata J. L. LeConte, 1884 and reinstated as a valid species. A replacement name is proposed: Longitarsus bajaensis Andrews and Gilbert for Longitarsus bicolor Horn, 1894

    Cost-effectiveness analysis of the first-line therapies for nicotine dependence

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    Background: Nicotine dependence is the major obstacle for smokers who want to quit. Guidelines have identified five effective first-line therapies, four nicotine replacement therapies (NRTs)—gum, patch, nasal spray and inhaler—and bupropion. Studying the extent to which these various treatments are cost-effective requires additional research. Objectives: To determine cost-effectiveness (CE) ratios of pharmacotherapies for nicotine dependence provided by general practitioners (GPs) during routine visits as an adjunct to cessation counselling. Methods: We used a Markov model to generate two cohorts of one-pack-a-day smokers: (1) the reference cohort received only cessation counselling from a GP during routine office visits; (2) the second cohort received the same counselling plus an offer to use a pharmacological treatment to help them quit smoking. The effectiveness of adjunctive therapy was expressed in terms of the resultant differential in mortality rate between the two cohorts. Data on the effectiveness of therapies came from meta-analyses, and we used odds ratio for quitting as the measure of effectiveness. The costs of pharmacotherapies were based on the cost of the additional time spent by GPs offering, prescribing and following-up treatment, and on the retail prices of the therapies. We used the third-party-payer perspective. Results are expressed as the incremental cost per life-year saved. Results: The cost per life-year saved for only counselling ranged from €385 to €622 for men and from €468 to €796 for women. The CE ratios for the five pharmacological treatments varied from €1768 to €6879 for men, and from €2146 to €8799 for women. Significant variations in CE ratios among the five treatments were primarily due to differences in retail prices. The most cost-effective treatments were bupropion and the patch, and, then, in descending order, the spray, the inhaler and, lastly, gum. Differences in CE between men and women across treatments were due to the shape of their respective mortality curve. The lowest CE ratio in men was for the 45- to 49-year-old group and for women in the 50- to 54-year-old group. Sensitivity analysis showed that changes in treatment efficacy produced effects only for less-well proven treatments (spray, inhaler, and bupropion) and revealed a strong influence of the discount rate and natural quit rate on the CE of pharmacological treatments. Conclusion: The CE of first-line treatments for nicotine dependence varied widely with age and sex and was sensitive to the assumption for the natural quit rate. Bupropion and the nicotine patch were the two most cost-effective treatment

    A decade of One Health and Ecohealth in Southeast Asia: Inventory and perspectives

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    South East Asia (SEA) is a hot spot for diseases emergence as demonstrated for HPAI and SARS. To address challenges on disease emergence in livestock and human such as urbanisation, agriculture intensification, land use changes and others new integrated approaches have been increasingly introduced to the region to facilitated collaboration across disciplines, groups and stakeholders. Those approaches include the ‘ecohealth’ (EH) and ‘onehealth’ (OH) concept, both focusing on integrated research but having a different history and characteristics. The EH approach was pioneered over the last decades by the International Development Research Centre, Canada (IDRC). The OH concept builds up on Schwabe’s One Medicine and is currently institutionalised by the World Organisation for Animal Health (OIE) and FAO. To promote EH in the region, ILRI implemented an EH capacity building project (EcoZD) funded by IDRC between 2008 and 2013. The project targeted six Southeast Asian countries. In each country an across-disciplines research team was formed and implemented an EH case study aligned with capacity building on transdisciplinary research. In a subsequent step, ‘onehealth-ecohealth’ resource centres were established in three universities/institutions in Thailand, Vietnam and Indonesia. For this paper we also screened selected other OH/EH initiatives implemented since 2004 in SEA for their focus and impact. Most initiatives emphasised on capacity building others mainly on research or both. Challenges are various and complex, such as ‘loose’ or overlapping defi- nitions of OH/EH, cultural barriers, silo thinking, lack of qualitative research skills. While the use of integrated research has been successfully demonstrated in case studies (e.g. for Brucellosis in Yunnan) donor dependency, limited impact assessments of the added value of used integrated approaches and coordination gaps among the various initiatives remain a challenges and need more attention in the future

    Capacity building on 'ecohealth' in Southeast Asia - successes and challenges

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    One Health, Ecohealth and zoonoses research in Southeast Asia by ILRI and partners

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    Red Hot Mamma

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    Determinants of vaccination coverage and consequences for rabies control in Bali, Indonesia

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    Maintaining high vaccination coverage is key to successful rabies control, but mass dog vaccination can be challenging and population turnover erodes coverage. Declines in rabies incidence following successive island-wide vaccination campaigns in Bali suggest that prospects for controlling and ultimately eliminating rabies are good. Rabies, however, has continued to circulate at low levels. In the push to eliminate rabies from Bali, high coverage needs to be maintained across all areas of the island. We carried out door-to-door (DTD) questionnaire surveys (n = 10,352 dog-owning households) and photographic mark–recapture surveys (536 line transects, 2,597 observations of free-roaming dogs) in 2011–2012 to estimate dog population sizes and assess rabies vaccination coverage and dog demographic characteristics in Bali, Indonesia. The median number of dogs per subvillage unit (banjar) was 43 (range 0–307) for owned dogs estimated from the DTD survey and 17 (range 0–83) for unconfined dogs (including both owned and unowned) from transects. Vaccination coverage of owned dogs was significantly higher in adults (91.4%) compared to juveniles (<1 year, 43.9%), likely due to insufficient targeting of pups and from puppies born subsequent to vaccination campaigns. Juveniles had a 10–70 times greater risk of not being vaccinated in urban, suburban, and rural areas [combined odds ratios (ORs): 9.9–71.1, 95% CI: 8.6–96.0]. Free-roaming owned dogs were also 2–3 times more likely to be not vaccinated compared to those confined (combined Ors: 1.9–3.6, 95% CI: 1.4–5.4), with more dogs being confined in urban (71.2%) than in suburban (16.1%) and rural areas (8.0%). Vaccination coverage estimates from transects were also much lower (30.9%) than household surveys (83.6%), possibly due to loss of collars used to identify the vaccination status of free-roaming dogs, but these unconfined dogs may also include dogs that were unowned or more difficult to vaccinate. Overall, coverage levels were high in the owned dog population, but for future campaigns in Bali to have the highest chance of eliminating rabies, concerted effort should be made to vaccinate free-roaming dogs particularly in suburban and rural areas, with advertising to ensure that owners vaccinate pups. Long-lasting, cheap, and quick methods are needed to mark vaccinated animals and reassure communities of the reach of vaccination campaigns

    Knowledge changes and lessons learned, looking at outcome pathway of an Ecohealth project

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    Five Planets Transiting a Ninth Magnitude Star

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    The Kepler mission has revealed a great diversity of planetary systems and architectures, but most of the planets discovered by Kepler orbit faint stars. Using new data from the K2 mission, we present the discovery of a five planet system transiting a bright (V = 8.9, K = 7.7) star called HIP 41378. HIP 41378 is a slightly metal-poor late F-type star with moderate rotation (v sin(i) = 7 km/s) and lies at a distance of 116 +/- 18 from Earth. We find that HIP 41378 hosts two sub-Neptune sized planets orbiting 3.5% outside a 2:1 period commensurability in 15.6 and 31.7 day orbits. In addition, we detect three planets which each transit once during the 75 days spanned by K2 observations. One planet is Neptune sized in a likely ~160 day orbit, one is sub-Saturn sized likely in a ~130 day orbit, and one is a Jupiter sized planet in a likely ~1 year orbit. We show that these estimates for the orbital periods can be made more precise by taking into account dynamical stability considerations. We also calculate the distribution of stellar reflex velocities expected for this system, and show that it provides a good target for future radial velocity observations. If a precise orbital period can be determined for the outer Jovian planet through future observations, it will be an excellent candidate for follow-up transit observations to study its atmosphere and measure its oblateness.Comment: Accepted by ApJL. 12 pages, 6 figures, 2 table
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