No camines sola

La situación actual de exclusión social del colectivo de mujeres responsables de familias monoparentales del barrio de Añaza, sumada a una brecha digital existente en nuestra sociedad entre hombres y mujeres, hace necesaria la creación de programas formativos que reduzcan dicha brecha y mejoren la empleabilidad de las mujeres, mejorando su situación laboral, y con ella, la personal y familiar. Por ello, pretendemos ofrecer un proyecto con la colaboración de la Asociación Familias Monoparentales de Canarias (AFAMOCAN), por medio del cual dotaremos a las usuarias de esta asociación de diversos conocimientos y habilidades para el dominio de herramientas digitales y conocimientos de búsqueda activa de empleo, ofreciéndoles diversos protocolos que deben seguir para integrarse de forma adecuada al mundo laboral. El hecho de formarse en cuestiones digitales y laborales también permitirá a dicho colectivo sentirse con mayor seguridad a la hora de enfrentarse a una entrevista de trabajo, lo que a su vez hará que mejore su autoestima.The current situation of social exclusion of the group of single parent women of the neighborhood of Añaza, added to a digital divide existing in our society between men and women, makes it necessary to create training programs that reduce this gap and increase the employability of women, improving their work and boosting their personal and family situation. For this reason, we intend to offer a project in collaboration with Canary Single Parent Families Association (Asociación de Familias Monoparentales de Canarias -AFAMOCAN), by which we will provide users of this association with digital knowledge and abilities, and knowledge of active job search, offering various protocols they must follow in order to get a proper integration into the world of work. Participate in training activities in digital and labor issues also will allow the group to feel more confident when facing a job interview, which in turn will improve their self-esteem

The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies

International audienceSignificance There is growing evidence that preexisting autoantibodies neutralizing type I interferons (IFNs) are strong determinants of life-threatening COVID-19 pneumonia. It is important to estimate their quantitative impact on COVID-19 mortality upon SARS-CoV-2 infection, by age and sex, as both the prevalence of these autoantibodies and the risk of COVID-19 death increase with age and are higher in men. Using an unvaccinated sample of 1,261 deceased patients and 34,159 individuals from the general population, we found that autoantibodies against type I IFNs strongly increased the SARS-CoV-2 infection fatality rate at all ages, in both men and women. Autoantibodies against type I IFNs are strong and common predictors of life-threatening COVID-19. Testing for these autoantibodies should be considered in the general population

The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies

International audienceSignificance There is growing evidence that preexisting autoantibodies neutralizing type I interferons (IFNs) are strong determinants of life-threatening COVID-19 pneumonia. It is important to estimate their quantitative impact on COVID-19 mortality upon SARS-CoV-2 infection, by age and sex, as both the prevalence of these autoantibodies and the risk of COVID-19 death increase with age and are higher in men. Using an unvaccinated sample of 1,261 deceased patients and 34,159 individuals from the general population, we found that autoantibodies against type I IFNs strongly increased the SARS-CoV-2 infection fatality rate at all ages, in both men and women. Autoantibodies against type I IFNs are strong and common predictors of life-threatening COVID-19. Testing for these autoantibodies should be considered in the general population

Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19

BackgroundWe previously reported that impaired type I IFN activity, due to inborn errors of TLR3- and TLR7-dependent type I interferon (IFN) immunity or to autoantibodies against type I IFN, account for 15-20% of cases of life-threatening COVID-19 in unvaccinated patients. Therefore, the determinants of life-threatening COVID-19 remain to be identified in similar to 80% of cases.MethodsWe report here a genome-wide rare variant burden association analysis in 3269 unvaccinated patients with life-threatening COVID-19, and 1373 unvaccinated SARS-CoV-2-infected individuals without pneumonia. Among the 928 patients tested for autoantibodies against type I IFN, a quarter (234) were positive and were excluded.ResultsNo gene reached genome-wide significance. Under a recessive model, the most significant gene with at-risk variants was TLR7, with an OR of 27.68 (95%CI 1.5-528.7, P=1.1x10(-4)) for biochemically loss-of-function (bLOF) variants. We replicated the enrichment in rare predicted LOF (pLOF) variants at 13 influenza susceptibility loci involved in TLR3-dependent type I IFN immunity (OR=3.70[95%CI 1.3-8.2], P=2.1x10(-4)). This enrichment was further strengthened by (1) adding the recently reported TYK2 and TLR7 COVID-19 loci, particularly under a recessive model (OR=19.65[95%CI 2.1-2635.4], P=3.4x10(-3)), and (2) considering as pLOF branchpoint variants with potentially strong impacts on splicing among the 15 loci (OR=4.40[9%CI 2.3-8.4], P=7.7x10(-8)). Finally, the patients with pLOF/bLOF variants at these 15 loci were significantly younger (mean age [SD]=43.3 [20.3] years) than the other patients (56.0 [17.3] years; P=1.68x10(-5)).ConclusionsRare variants of TLR3- and TLR7-dependent type I IFN immunity genes can underlie life-threatening COVID-19, particularly with recessive inheritance, in patients under 60 years old