Hybrid Architecture for Engineering Magnonic Quantum Networks

We show theoretically that a network of superconducting loops and magnetic particles can be used to implement magnonic crystals with tunable magnonic band structures. In our approach, the loops mediate interactions between the particles and allow magnetic excitations to tunnel over long distances. As a result, different arrangements of loops and particles allow one to engineer the band structure for the magnonic excitations. Furthermore, we show how magnons in such crystals can serve as a quantum bus for long-distance magnetic coupling of spin qubits. The qubits are coupled to the magnets in the network by their local magnetic-dipole interaction and provide an integrated way to measure the state of the magnonic quantum network.Comment: Manuscript: 4 pages, 3 figures. Supplemental Material: 9 pages, 4 figures. V2: Published version in PRA: 14 pages + 8 figures. Substantial rearrangement of the content of the previous versio

Uncoupling of EGFR–RAS signaling and nuclear localization of YBX1 in colorectal cancer

The transcription factor YBX1 can act as a mediator of signals transmitted via the EGFR–RAS–MAPK axis. YBX1 expression has been associated with tumor progression and prognosis in multiple types of cancer. Immunohistochemical studies have revealed dependency between YBX1 expression and individual EGFR family members. We analyzed YBX1 and EGFR family proteins in a colorectal cancer (CRC) cohort and provide functional analyses of YBX1 in the context of EGFR–RAS–MAPK signaling. Immunohistochemistry for YBX1 and EGFR family receptors with two antibodies for YBX1 and EGFR were performed and related to clinicopathological data. We employed Caco2 cells expressing an inducible KRASV12 gene to determine effects on localization and levels of YBX1. Mouse xenografts of Caco2-KRASV12 cells were used to determine YBX1 dynamics in a tissue context. The two different antibodies against YBX1 showed discordant immunohistochemical stainings in cell culture and clinical specimens. Expression of YBX1 and EGFR family members were not correlated in CRC. Analysis of Caco2 xenografts displayed again heterogeneity of YBX1 staining with both antibodies. Our results suggest that YBX1 is controlled via complex regulatory mechanisms involving tumor stroma interaction and signal transduction processes. Our study highlights that YBX1 antibodies have different specificities, advocating their use in a combined manner

Efficiency of Nonlinear Particle Acceleration at Cosmic Structure Shocks

We have calculated the evolution of cosmic ray (CR) modified astrophysical shocks for a wide range of shock Mach numbers and shock speeds through numerical simulations of diffusive shock acceleration (DSA) in 1D quasi- parallel plane shocks. The simulations include thermal leakage injection of seed CRs, as well as pre-existing, upstream CR populations. Bohm-like diffusion is assumed. We model shocks similar to those expected around cosmic structure pancakes as well as other accretion shocks driven by flows with upstream gas temperatures in the range $T_0=10^4-10^{7.6}$K and shock Mach numbers spanning $M_s=2.4-133$. We show that CR modified shocks evolve to time-asymptotic states by the time injected particles are accelerated to moderately relativistic energies (p/mc \gsim 1), and that two shocks with the same Mach number, but with different shock speeds, evolve qualitatively similarly when the results are presented in terms of a characteristic diffusion length and diffusion time. For these models the time asymptotic value for the CR acceleration efficiency is controlled mainly by shock Mach number. The modeled high Mach number shocks all evolve towards efficiencies $\sim 50$%, regardless of the upstream CR pressure. On the other hand, the upstream CR pressure increases the overall CR energy in moderate strength shocks ($M_s \sim {\rm a few}$). (abridged)Comment: 23 pages, 12 ps figures, accepted for Astrophysical Journal (Feb. 10, 2005

Nanoscale temperature measurements using non-equilibrium Brownian dynamics of a levitated nanosphere

Einstein realised that the fluctuations of a Brownian particle can be used to ascertain properties of its environment. A large number of experiments have since exploited the Brownian motion of colloidal particles for studies of dissipative processes, providing insight into soft matter physics, and leading to applications from energy harvesting to medical imaging. Here we use optically levitated nanospheres that are heated to investigate the non-equilibrium properties of the gas surrounding them. Analysing the sphere's Brownian motion allows us to determine the temperature of the centre-of-mass motion of the sphere, its surface temperature and the heated gas temperature in two spatial dimensions. We observe asymmetric heating of the sphere and gas, with temperatures reaching the melting point of the material. This method offers new opportunities for accurate temperature measurements with spatial resolution on the nanoscale, and a new means for testing non-equilibrium thermodynamicsComment: 5 pages, 4 figures, supplementary material available upon reques

T Cell Activation Results in Conformational Changes in the Src Family Kinase Lck to Induce Its Activation

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Canonical Particle Acceleration in FRI Radio Galaxies

Matched resolution multi-frequency VLA observations of four radio galaxies are used to derive the asymptotic low energy slope of the relativistic electron distribution. Where available, low energy slopes are also determined for other sources in the literature. They provide information on the acceleration physics independent of radiative and other losses, which confuse measurements of the synchrotron spectra in most radio, optical and X-ray studies. We find a narrow range of inferred low energy electron energy slopes, n(E)=const*E^-2.1 for the currently small sample of lower luminosity sources classified as FRI (not classical doubles). This distribution is close to, but apparently inconsistent with, the test particle limit of n(E)=const*E^-2.0 expected from strong diffusive shock acceleration in the non-relativistic limit. Relativistic shocks or those modified by the back-pressure of efficiently accelerated cosmic rays are two alternatives to produce somewhat steeper spectra. We note for further study the possiblity of acceleration through shocks, turbulence or shear in the flaring/brightening regions in FRI jets as they move away from the nucleus. Jets on pc scales and the collimated jets and hot spots of FRII (classical double) sources would be governed by different acceleration sites and mechanisms; they appear to show a much wider range of spectra than for FRI sources.Comment: 16 figures, including 5 color. Accepted to Astrophysical Journa

Relativistic electron beams accelerated by an interplanetary shock

Collisionless shock waves have long been considered amongst the most prolific particle accelerators in the universe. Shocks alter the plasma they propagate through and often exhibit complex evolution across multiple scales. Interplanetary (IP) traveling shocks have been recorded in-situ for over half a century and act as a natural laboratory for experimentally verifying various aspects of large-scale collisionless shocks. A fundamentally interesting problem in both helio and astrophysics is the acceleration of electrons to relativistic energies (more than 300 keV) by traveling shocks. This letter presents first observations of field-aligned beams of relativistic electrons upstream of an IP shock observed thanks to the instrumental capabilities of Solar Orbiter. This study aims to present the characteristics of the electron beams close to the source and contribute towards understanding their acceleration mechanism. On 25 July 2022, Solar Orbiter encountered an IP shock at 0.98 AU. The shock was associated with an energetic storm particle event which also featured upstream field-aligned relativistic electron beams observed 14 minutes prior to the actual shock crossing. The distance of the beam's origin was investigated using a velocity dispersion analysis (VDA). Peak-intensity energy spectra were anaylzed and compared with those obtained from a semi-analytical fast-Fermi acceleration model. By leveraging Solar Orbiter's high-time resolution Energetic Particle Detector (EPD), we have successfully showcased an IP shock's ability to accelerate relativistic electron beams. Our proposed acceleration mechanism offers an explanation for the observed electron beam and its characteristics, while we also explore the potential contributions of more complex mechanisms.Comment: Main text: 6 pages, 2 figures. Supplementary material: 6 pages, 7 figure