Mesospheric scatter and its microstructure

The difference in character between mesospheric returns from about 70 and about 80 km was noted. The 69-km echo is characterized by a single return with about .1 Hz width, while the 82.5 km return extends over more than 3 Hz bandwidth; this difference is also perceptible, but to a lesser degree, on the fading curves. The conclusion seems inescapable that internal random velocities of a few m/s are present within the scattering volume for the 82.5-km echo. The most likely source for these rather large velocities is convective instability arising from deformations of the temperature profile by breaking gravity waves. The distinction between the two types of scatter at these altitudes probably accounts for the behavior with frequency of the nightime fading period at low and very low frequencies. The fading period of D-region reflections at night was constant at about 7 min from 16 to 43 kHz, but that at frequencies of 70 kHz and above, the fading period decreased in such a way as to indicate the presence of irregularities smaller than about 1 km in size. This suggests that frequencies of 48 kHz and above, the fading period decreased in such a way as to indicate the presence of irregularities smaller than about 1 km in size. This suggests that frequencies of 48 kHz and below were reflected primarily from the region below 80 km where the narrow spectral irregularities dominate

Pion Charge Exchange on Deuterium

We investigate quantum corrections to a classical intranuclear cascade simulation of pion single charge exchange on the deuteron. In order to separate various effects the orders of scattering need to be distinguished and, to that end, we develop signals for each order of scattering corresponding to quasi-free conditions. Quantum corrections are evaluated for double scattering and are found to be large. Global agreement with the data is good.Comment: 30 pages, 12 figure

Being in the hidden third: Insights into transdisciplinary ontology

This paper reflects two transdisciplinary (TD) scholars’ attempts to glean deeper insights into Nicolescu’s transdisciplinary ontology (i.e., multiple Levels of Reality and the Hidden Third). Respecting that Nicolescu’s Hidden Third represents the convergence of quantum physics, philosophy, and inner experiences, one TD scholar explored ‘What is it like to be in the Hidden Third?’ by expanding on Nicolescu’s constructs of cyber-space-time and transhumanism, which are grounded in quantum physics. The other TD scholar tendered philosophical insights by offering the idea of ontological emergence and the act of becoming as informed by the transcendentals. The intent was to understand ‘the being of being’ or perhaps ‘the being of becoming.’ The richness of Nicolescu’s ontological thinking offers a range of interpretation and we are grateful for the opportunity to feed off his methodological genius to respectively flourish through questions, clarification and truth seeking

Conceptualizing a transdisciplinary nexus for addressing complex problems

We envision opening a way of perceiving the transdisciplinary Hidden Third as a transcendental nexus of both passive and active causal powers reflecting and engaged with the external structures that create the complex social realities in which we live. It is in these realities and their possible worlds that the revealing of our relational capacities and activating (actualising) potentialities occurs. We propose that innovative and co-created solutions to complex problems can emerge when something at work within each person helps very differently minded people with a stake in an issue to realise that they have capabilities and potential that can be actualised situationally. To facilitate this idea, we adopt a notion of transindividuality, which is constitutive through relationality. This is a futural process of imaginal thinking and imaginary thinking. We suggest that when temporarily functioning in an intermediate inner universe (mundus imaginalis), and by operating between the empirical (concrete facts) and the abstract (e.g., meditative thinking), active imaginal powers foster emergent solutions unbounded by the positivistic framing problems and their future consequences. We conceptualized a transdisciplinary nexus that draws from the mundus imaginalis and the Hidden Third to provide deeper insights into the role that people’s inner images of the world play when engaging in transdisciplinary problem solving

Stable Kalman filters for processing clock measurement data

Kalman filters have been used for some time to process clock measurement data. Due to instabilities in the standard Kalman filter algorithms, the results have been unreliable and difficult to obtain. During the past several years, stable forms of the Kalman filter have been developed, implemented, and used in many diverse applications. These algorithms, while algebraically equivalent to the standard Kalman filter, exhibit excellent numerical properties. Two of these stable algorithms, the Upper triangular-Diagonal (UD) filter and the Square Root Information Filter (SRIF), have been implemented to replace the standard Kalman filter used to process data from the Deep Space Network (DSN) hydrogen maser clocks. The data are time offsets between the clocks in the DSN, the timescale at the National Institute of Standards and Technology (NIST), and two geographically intermediate clocks. The measurements are made by using the GPS navigation satellites in mutual view between clocks. The filter programs allow the user to easily modify the clock models, the GPS satellite dependent biases, and the random noise levels in order to compare different modeling assumptions. The results of this study show the usefulness of such software for processing clock data. The UD filter is indeed a stable, efficient, and flexible method for obtaining optimal estimates of clock offsets, offset rates, and drift rates. A brief overview of the UD filter is also given

Benchmark Calculations for Perchlorate from Three Human Cohorts

The presence of low concentrations of perchlorate in some drinking water sources has led to concern regarding potential effects on the thyroid. In a recently published report, the National Academy of Sciences indicated that the perchlorate dose required to cause hypothyroidism in adults would probably be > 0.40 mg/kg-day for months or longer. In this study, we calculated benchmark doses for perchlorate from thyroid-stimulating hormone (TSH) and free thyroxine (T(4)) serum indicators from two occupational cohorts with long-term exposure to perchlorate, and from a clinical study of volunteers exposed to perchlorate for 2 weeks. The benchmark dose for a particular serum indicator was defined as the dose predicted to cause an additional 5 or 10% of persons to have a serum measurement outside of the normal range. Using the data from the clinical study, we estimated the half-life of perchlorate in serum at 7.5 hr and the volume of distribution at 0.34 L/kg. Using these estimates and measurements of perchlorate in serum or urine, doses in the occupational cohorts were estimated and used in benchmark calculations. Because none of the three studies found a significant effect of perchlorate on TSH or free T(4), all of the benchmark dose estimates were indistinguishable from infinity. The lower 95% statistical confidence limits on benchmark doses estimated from a combined analysis of the two occupational studies ranged from 0.21 to 0.56 mg/kg-day for free T(4) index and from 0.36 to 0.92 mg/kg-day for TSH. Corresponding estimates from the short-term clinical study were within these ranges

A critical study of international higher education development: capital, capability, and a dialogical proposal for academic freedom as a responsibility

This thesis sets out to critically examine the field of higher education development, as one which is focused on socio-economic inequality and welfare, and determines educational purpose in poorer, or ‘developing’, countries accordingly. My question is whether mainstream development approaches to higher education are really contributing to the provision of more equal education services, or whether they risk reintroducing inequality by treating the priorities of poorer countries differently. To investigate whether there are educational values or purposes common to universities globally irrespective of socio-economic imperatives, I begin the study with a historiographical look at their growth in terms of both ideas of its purpose, and how purpose is realised in actuality. I then trace the emergence of the discourse of international development, and the role that higher education has come to play within it, showing how the field of international higher education development has simplified the notion of university purpose for its own devices. The thesis then looks at underlying assumptions about human nature, defined as the problem of humanism, common to both transcendent ideas of university purpose as well as the development discourse. To avoid the limitations of these assumptions, I argue that a theoretical approach is required that can engage with questions of hybridity and multiplicity in both the history and future of universities, without reducing those questions to abstract ideas. The approach I propose draws upon the dialogism of Mikhail Bakhtin, whose multi-layered understanding of language prevents any one understanding of another person, or of human nature more generally, being considered final. The educational implications for such an approach are finally explored in the concept of academic freedom, which is traditionally conceived of as a right, but is here reconceptualised also as a responsibility

Incorporation of a selective sigma-2 receptor ligand enhances uptake of liposomes by multiple cancer cells

Background: The sigma-2 receptor is an attractive target for tumor imaging and targeted therapy because it is overexpressed in multiple types of solid tumors, including prostate cancer, breast cancer, and lung cancer. SV119 is a synthetic small molecule that binds to sigma-2 receptors with high affinity and specificity. This study investigates the utility of SV119 in mediating the selective targeting of liposomal vectors in various types of cancer cells. Methods: SV119 was covalently linked with polyethylene glycol-dioleyl amido aspartic acid conjugate (PEG-DOA) to generate a novel functional lipid, SV119-PEG-DOA. This lipid was utilized for the preparation of targeted liposomes to enhance their uptake by cancer cells. Liposomes with various SV119 densities (0, 1, 3, and 5 mole%) were prepared and their cellular uptake was investigated in several tumor cell lines. In addition, doxorubicin (DOX) was loaded into the targeted and unmodified liposomes, and the cytotoxic effect on the DU-145 cells was evaluated by MTT assay. Results: Liposomes with or without SV119-PEG-DOA both have a mean diameter of approximately 90 nm and a neutral charge. The incorporation of SV119-PEG-DOA significantly increased the cellular uptake of liposomes by the DU-145, PC-3, A549, 201T, and MCF-7 tumor cells, which was shown by fluorescence microscopy and the quantitative measurement of fluorescence intensity. In contrast, the incorporation of SV119 did not increase the uptake of liposomes by the normal BEAS-2B cells. In a time course study, the uptake of SV119 liposomes by DU-145 cells was also significantly higher at each time point compared to the unmodified liposomes. Furthermore, the DOX-loaded SV119 liposomes showed significantly higher cytotoxicity to DU-145 cells compared to the DOX-loaded unmodified liposomes. Conclusion: SV119 liposomes were developed for targeted drug delivery to cancer cells. The targeting efficiency and specificity of SV119 liposomes to cancer cells was demonstrated in vitro. The results of this study suggest that SV119-modified liposomes might be a promising drug carrier for tumor-targeted delivery. © 2012 Zhang et al, publisher and licensee Dove Medical Press Ltd

Covariance analysis of the airborne laser ranging system

The requirements and limitations of employing an airborne laser ranging system for detecting crustal shifts of the Earth within centimeters over a region of approximately 200 by 400 km are presented. The system consists of an aircraft which flies over a grid of ground deployed retroreflectors, making six passes over the grid at two different altitudes. The retroreflector baseline errors are assumed to result from measurement noise, a priori errors on the aircraft and retroreflector positions, tropospheric refraction, and sensor biases

Symbiont 'bleaching' in planktic foraminifera during the Middle Eocene Climatic Optimum

Many genera of modern planktic foraminifera are adapted to nutrient-poor (oligotrophic) surface waters by hosting photosynthetic symbionts, but it is unknown how they will respond to future changes in ocean temperature and acidity. Here we show that ca. 40 Ma, some fossil photosymbiont-bearing planktic foraminifera were temporarily 'bleached' of their symbionts coincident with transient global warming during the Middle Eocene Climatic Optimum (MECO). At Ocean Drilling Program (ODP) Sites 748 and 1051 (Southern Ocean and mid-latitude North Atlantic, respectively), the typically positive relationship between the size of photosymbiont-bearing planktic foraminifer tests and their carbon isotope ratios (δ13C) was temporarily reduced for ∼100 k.y. during the peak of the MECO. At the same time, the typically photosymbiont-bearing planktic foraminifera Acarinina suffered transient reductions in test size and relative abundance, indicating ecological stress. The coincidence of minimum δ18O values and reduction in test size–δ13C gradients suggests a link between increased sea-surface temperatures and bleaching during the MECO, although changes in pH and nutrient availability may also have played a role. Our findings show that host-photosymbiont interactions are not constant through geological time, with implications for both the evolution of trophic strategies in marine plankton and the reliability of geochemical proxy records generated from symbiont-bearing planktic foraminifera