Intersecting Brane Worlds -- A Path to the Standard Model ?

In this review we describe the general geometrical framework of brane world constructions in orientifolds of type IIA string theory with D6-branes wrapping 3-cycles in a Calabi-Yau 3-fold. These branes generically intersect in points on the internal space, and the patterns of intersections govern the chiral fermion spectra. We discuss how the open string spectra in intersecting brane models are constructed, how the Standard Model can be embedded, and also how supersymmetry can be realized in this class of string vacua. After the general considerations we specialize the discussion to the case of orbifold backgrounds with intersecting D6-branes and to the quintic Calabi-Yau manifold. Then, we discuss parts of the effective action of intersecting brane world models. Specifically we compute from the Born-Infeld action of the wrapped D-branes the tree-level, D-term scalar potential, which is important for the stability of the considered backgrounds as well as for questions related to supersymmetry breaking. Second, we review the recent computation concerning of gauge coupling unification and also of one-loop gauge threshold corrections in intersecting brane world models. Finally we also discuss some aspects of proton decay in intersecting brane world models.Comment: 31 pages, To appear in the proceedings of the RTN-workshop ``The quantum structure of spacetime and the geometric nature of fundamental interactions'', September 2003 in Copenhagen, revised version contains new refs and one corrected equatio

Personalized medicine in psychiatry: problems and promises

The central theme of personalized medicine is the premise that an individual’s unique physiologic characteristics play a significant role in both disease vulnerability and in response to specific therapies. The major goals of personalized medicine are therefore to predict an individual’s susceptibility to developing an illness, achieve accurate diagnosis, and optimize the most efficient and favorable response to treatment. The goal of achieving personalized medicine in psychiatry is a laudable one, because its attainment should be associated with a marked reduction in morbidity and mortality. In this review, we summarize an illustrative selection of studies that are laying the foundation towards personalizing medicine in major depressive disorder, bipolar disorder, and schizophrenia. In addition, we present emerging applications that are likely to advance personalized medicine in psychiatry, with an emphasis on novel biomarkers and neuroimaging