Features of the Higher Education for the Circular Economy: The Case of Italy

The higher education system plays a critical role in supporting the transition towards a circular economy (CE). It helps create business leaders and policymakers having appropriate skills, competences, and consciousness referring to the CE challenges. Nevertheless, few studies have specifically investigated how the higher education system is addressing the CE, how the current academic offering is integrating the CE principles, and which skills and competences are currently provided. This paper overcomes these limitations by investigating the current offering of the higher education for the CE in Italy. We analyze the academic programs, courses, and modules at different levels of 49 Italian universities and, by means of a detailed classification of the learning outcomes, provide a clear picture of the knowledge, skills, and competences offered by the CE education. We finally discuss implications of our findings concerning the development of CE education and CE jobs

Institutions and Economics of Water Scarcity and Droughts

Integrated water resources management seeks an efficient blend of all water resources (e.g., fresh surface water, groundwater, reused water, desalinated water) to meet the demands of the full range of water users (e.g., agriculture, municipalities, industry, and e-flows). Water scarcity and droughts already affect many regions of the world and are expected to increase due to climate change and economic growth. In this Special Issue, 10 peer-reviewed articles have been published that address the questions regarding the economic effects of water scarcity and droughts, management instruments, such as water pricing, water markets, technologies and user-based reallocation, and the strategies to enhance resiliency, adaptation to scarcity and droughts. There is a need to improve the operation of institutions in charge of the allocation and re-allocation of resources when temporal (drought) or structural over-allocation arises. Water scarcity, droughts and pollution have increased notably in recent decades. A drought is a temporary climatic effect or natural disaster that can occur anywhere and can be short or prolonged. Water scarcity involves a lack of supply relative to potential or current demand that generates conflict between alternative uses of water, especially regarding the requirements of societies, economic sectors, territories and ecosystems. Traditionally, users in water-scarce regions have adapted to dealing with water shortages; however, droughts can greatly increase problems since they are uncertain events and also affect water-abundant regions, with climate change increasing their frequency and severity [1]. Supply-side mechanisms have traditionally been employed to cope with drought by building infrastructure (wells, dams, channels, inter-basin transfers), and recently by including desalinised, brackish, and reclaimed wastewater into the resource mix. Berbel and Esteban [2] study the influence of drought as a catalyst for water policy reform in three developed economies with a Mediterranean climate (Spain, California and Australia), and find that solutions and institutions are trajectory-dependant and grounded in social institutions. Nevertheless, there is a convergence of the type of instruments employed to manage water scarcity and droughts. In this Special Issue, the reported case studies recount experiences from USA, China, and the European Union (southern Member States). A variety of proposals aimed at tackling droughts and scarcity have been discussed, ranging from economic tools (pricing and insurance) and the increased use of reclaimed wastewater, to reforming the institutional setting (water markets and priority rights). Most of these papers analyses economic instruments and agriculture, but other economic sectors as well as non-market values are also addressed

A System for Optimizing Fertilizer Dosing in Innovative Smart Fertigation Pipelines: Modeling, Construction, Testing and Control

Smart fertigation is a topic of great interest in the effort to optimize different activities involved in local and extensive agriculture for assisting crops, optimizing production by using wireless technologies, data-processing electronic boards and sensors network. With the advent of Agriculture 4.0, similar to Industry 4.0, Information Communication Technology (ICT), associated with mechatronics, is giving an added value to this technique allowing optimization of water, fertilizers, control of water flow in pipes and period of irrigation. This paper intends to illustrate findings related to an innovative low cost system for assisting crops and achieving an accurate farming by investigating on the design, construction, testing and control of dosing system for liquid and granular fertilizers. Four different dosage systems have been designed, realized and tested with different granular and liquid fertilizers; the analysis of an extensive experimental campaign allows to define the characteristic and the mathematical expressions for each analyzed fertilizer and for each dosage system. The accurate modeling allows to control with extreme precision the realized dosing systems after estimating the quantity of fertilizer which the crop needs by means of the smart fertigation system. The obtained results permit the optimization of the fertilizer dosage in terms of quantity, which at the same time translates into lower production costs, greater environmental sustainability and optimization of production in terms of quantity and quality

Neural Surface Antibodies and Neurodegeneration: Clinical Commonalities and Pathophysiological Relationships

Autoimmune encephalitis and neurodegenerative disorders share several clinical features, including behavioural and psychiatric manifestations, cognitive impairment, sleep and movement disorders. Therefore, it is not surprising that autoimmune encephalitis is one of the main differential diagnoses of rapidly progressive dementia. However, more chronic presentations of autoimmune disorders have been reported and can lead to the misdiagnosis of a neurodegenerative disease. On the other hand, antibodies against neuronal proteins, such as those directed against NMDAR, can occur during established neurogenerative disorders, and their role in this context is still unclear. They might be simple bystanders or modify the disease course and phenotype. Indeed, autoimmune encephalitis can leave long-term cognitive sequelae and specific antibodies to neuronal surface antigens are associated with clinical and pathological neurodegenerative features. Here we review the link between these antibodies and neurodegeneration. In particular we discuss: (a) the possibility that autoimmune encephalitis presents as a neurodegenerative disease, identifying the red flags that can help in the differential diagnosis between antibody-mediated and neurodegenerative disorders; (b) the occurrence of antibodies against neuronal surface antigens in patients with neurodegenerative disorders and their possible role in the disease course; and (c) the long-term cognitive and neuroradiological changes associated with autoimmune encephalitis, as well as the biomarkers that can help to predict the cognitive outcome. Finally, we review the clinical and pathological features of IgLON5 antibodies-related encephalitis, a unique model of the relationship between antibodies and neurodegeneration

Connecting in Real-time Power System Labs: An Italian Test-case

Sharing of hardware and software facilities together with knowledge and expertise among laboratories is a key point in research. In the power systems field this is possible even remotely by coupling real-time simulators located in different laboratories. In this paper an experimental test-bed is described. It consists of the remote interconnection of the realtime simulators, located at Politecnico di Torino and Politecnico di Bari respectively, in order to perform Remote Power Hardware-in-the-Loop experiments. The possibilities and limitations of this type of co-simulation are described and a case study is presented

A Comparison of the Conditioning Regimens BEAM and FEAM for Autologous Hematopoietic Stem Cell Transplantation in Lymphoma: An Observational Study on 1038 Patients From Fondazione Italiana Linfomi

Abstract Background Carmustine (BCNU)-Etoposide-Citarabine-Melphalan (BEAM) chemotherapy is the standard conditioning regimen for autologous stem cell transplantation (ASCT) in lymphomas. Owing to BCNU shortages, many centers switched to Fotemustine-substituted BEAM (FEAM), lacking proof of equivalence. Methods We conducted a retrospective cohort study in 18 Italian centers to compare safety and efficacy of BEAM and FEAM regimens for ASCT in lymphomas performed from 2008 to 2015. Results We enrolled 1038 patients (BEAM n=607, FEAM n=431), of which 27% had Hodgkin's lymphoma (HL), 14% indolent Non-Hodgkin's lymphoma (iNHL) and 59% aggressive NHL (aNHL). Baseline characteristics including age, sex, stage, B-symptoms, extranodal involvement, previous treatments, response before ASCT, overall conditioning intensity, were well balanced between BEAM and FEAM; notable exceptions were: ASCT year (median: BEAM=2011 vs FEAM=2013, p Conclusions BEAM and FEAM do not appear different in terms of survival and disease control. However, due to concerns of higher toxicity, Fotemustine substitution in BEAM does not seem justified, if not for easier supply

Prevalence of anatomical variants and coronary anomalies in 543 consecutive patients studied with 64-slice CT coronary angiography

The aim of our study was to assess the prevalence of variants and anomalies of the coronary artery tree in patients who underwent 64-slice computed tomography coronary angiography (CT-CA) for suspected or known coronary artery disease. A total of 543 patients (389 male, mean age 60.5 ± 10.9) were reviewed for coronary artery variants and anomalies including post-processing tools. The majority of segments were identified according to the American Heart Association scheme. The coronary dominance pattern results were: right, 86.6%; left, 9.2%; balanced, 4.2%. The left main coronary artery had a mean length of 112 ± 55 mm. The intermediate branch was present in the 21.9%. A variable number of diagonals (one, 25%; two, 49.7%; more than two, 24%; none, 1.3%) and marginals (one, 35.2%; two, 46.2%; more than two, 18%; none, 0.6%) was visualized. Furthermore, CT-CA may visualize smaller branches such as the conus branch artery (98%), the sinus node artery (91.6%), and the septal branches (93%). Single or associated coronary anomalies occurred in 18.4% of the patients, with the following distribution: 43 anomalies of origin and course, 68 intrinsic anomalies (59 myocardial bridging, nine aneurisms), three fistulas. In conclusion, 64-slice CT-CA provides optimal visualization of the variable and complex anatomy of coronary arteries because of the improved isotropic spatial resolution and flexible post-processing tool

Adherence issues related to sublingual immunotherapy as perceived by allergists

Objectives: Sublingual immunotherapy (SLIT) is a viable alternative to subcutaneous immunotherapy to treat allergic rhinitis and asthma, and is widely used in clinical practice in many European countries. The clinical efficacy of SLIT has been established in a number of clinical trials and meta-analyses. However, because SLIT is self-administered by patients without medical supervision, the degree of patient adherence with treatment is still a concern. The objective of this study was to evaluate the perception by allergists of issues related to SLIT adherence. Methods: We performed a questionnaire-based survey of 296 Italian allergists, based on the adherence issues known from previous studies. The perception of importance of each item was assessed by a VAS scale ranging from 0 to 10. Results: Patient perception of clinical efficacy was considered the most important factor (ranked 1 by 54% of allergists), followed by the possibility of reimbursement (ranked 1 by 34%), and by the absence of side effects (ranked 1 by 21%). Patient education, regular follow-up, and ease of use of SLIT were ranked first by less than 20% of allergists. Conclusion: These findings indicate that clinical efficacy, cost, and side effects are perceived as the major issues influencing patient adherence to SLIT, and that further improvement of adherence is likely to be achieved by improving the patient information provided by prescribers. © 2010 Scurati et al, publisher and licensee Dove Medical Press Ltd