The effect of reionization on the CMB-density correlation

In this paper we show how the rescattering of CMB photons after cosmic reionization can give a significant linear contribution to the temperature-matter cross-correlation measurements. These anisotropies, which arise via a late time Doppler effect, are on scales much larger than the typical scale of non-linear effects at reionization; they can contribute to degree scale cross-correlations and could affect the interpretation of similar correlations resulting from the integrated Sachs-Wolfe effect. While expected to be small at low redshifts, these correlations can be large given a probe of the density at high redshift, and so could be a useful probe of the cosmic reionization history.Comment: 8 pages, 8 figure

Improved survival with initial MRSA therapy in high-risk community-onset pneumonia patients : application of a MRSA risk score

textCommunity-onset (CO) methicillin-resistant Staphylococcus aureus (MRSA) pneumonia is an evolving problem, and there is a great need for a reliable method to assess MRSA risk at hospital admission. A new MRSA prediction score classifies CO-pneumonia patients into low, medium, and high-risk groups based on objective criteria available at baseline. Our objective was to assess the effect of initial MRSA therapy on mortality in these three risk groups. We conducted a retrospective cohort study using data from the Veterans Health Administration. Patients were included if they were hospitalized with pneumonia and received antibiotics within the first 48 hours of admission. They were stratified into MRSA therapy and no MRSA therapy treatment arms based on antibiotics received in the first 48 hours. MRSA risk groups were analyzed separately. The primary outcome was 30-day patient mortality. Multivariable logistic regression was used to adjust for potential confounders. A total of 80,330 patients met inclusion criteria, of which 36% received MRSA therapy and 64% did not receive MRSA therapy. The majority of patients were classified as either low (51%) or medium (47%) risk, with only 2% classified as high-risk. In the high-risk group, unadjusted 30-day mortality was lower among patients who received initial MRSA therapy (40% versus 58%; p<0.0001). Likewise, multivariable logistic regression analysis also demonstrated that initial MRSA therapy was associated with a lower 30-day mortality in the high-risk group (adjusted odds ratio 0.57; 95% confidence interval 0.42-0.77). There was no benefit of initial MRSA therapy in the low or medium-risk groups. This study demonstrated improved survival with initial MRSA therapy in high-risk CO-pneumonia patients. The MRSA risk score should not replace clinical judgment, but it might be a useful tool to spare MRSA therapy for only those patients who are most likely to benefit.Pharmaceutical Science

Frontal brain asymmetries as effective parameters to assess the quality of audiovisual stimuli perception in adult and young cochlear implant users

How is music perceived by cochlear implant (CI) users? This question arises as "the next step" given the impressive performance obtained by these patients in language perception. Furthermore, how can music perception be evaluated beyond self-report rating, in order to obtain measurable data? To address this question, estimation of the frontal electroencephalographic (EEG) alpha activity imbalance, acquired through a 19-channel EEG cap, appears to be a suitable instrument to measure the approach/withdrawal (AW index) reaction to external stimuli. Specifically, a greater value of AW indicates an increased propensity to stimulus approach, and vice versa a lower one a tendency to withdraw from the stimulus. Additionally, due to prelingually and postlingually deafened pathology acquisition, children and adults, respectively, would probably differ in music perception. The aim of the present study was to investigate children and adult CI users, in unilateral (UCI) and bilateral (BCI) implantation conditions, during three experimental situations of music exposure (normal, distorted and mute). Additionally, a study of functional connectivity patterns within cerebral networks was performed to investigate functioning patterns in different experimental populations. As a general result, congruency among patterns between BCI patients and control (CTRL) subjects was seen, characterised by lowest values for the distorted condition (vs. normal and mute conditions) in the AW index and in the connectivity analysis. Additionally, the normal and distorted conditions were significantly different in CI and CTRL adults, and in CTRL children, but not in CI children. These results suggest a higher capacity of discrimination and approach motivation towards normal music in CTRL and BCI subjects, but not for UCI patients. Therefore, for perception of music CTRL and BCI participants appear more similar than UCI subjects, as estimated by measurable and not self-reported parameters

Focal Cerebral Infarction in Newborn: Description of Three Cases:

We observed 3 full-term newborns with focal ischemic injury of the middle cerebral artery (MCA), in which diagnosis of MCA stroke was suspected by US and confirmed by CT scan and MRI. A four-year follow-up was carried out to study the effect of neonatal stroke on neurodevelopmental outcome. All children had a history of pre-perinatal risk factors: neonatal cerebral infarction in term infants, in fact, has many possible causes, including bacterial meningitis, inherited or acquired coagulopathies, trauma and hypoxia-ischemia. The prognosis of neonatal MCA infarction depends on early diagnosis, on the CNS plasticity mechanism and, finally, on medical therapy and neuropsychological rehabilitation

Halo statistics in non-Gaussian cosmologies: the collapsed fraction, conditional mass function, and halo bias from the path-integral excursion set method

Characterizing the level of primordial non-Gaussianity (PNG) in the initial conditions for structure formation is one of the most promising ways to test inflation and differentiate among different scenarios. The scale-dependent imprint of PNG on the large-scale clustering of galaxies and quasars has already been used to place significant constraints on the level of PNG in our observed Universe. Such measurements depend upon an accurate and robust theory of how PNG affects the bias of galactic halos relative to the underlying matter density field. We improve upon previous work by employing a more general analytical method - the path-integral extension of the excursion set formalism - which is able to account for the non-Markovianity caused by PNG in the random-walk model used to identify halos in the initial density field. This non-Markovianity encodes information about environmental effects on halo formation which have so far not been taken into account in analytical bias calculations. We compute both scale-dependent and -independent corrections to the halo bias, along the way presenting an expression for the conditional collapsed fraction for the first time, and a new expression for the conditional halo mass function. To leading order in our perturbative calculation, we recover the halo bias results of Desjacques et. al. (2011), including the new scale-dependent correction reported there. However, we show that the non-Markovian dynamics from PNG can lead to marked differences in halo bias when next-to-leading order terms are included. We quantify these differences here. [abridged]Comment: Accepted for publication in MNRAS. Includes minor revisions recommended by referee, slightly revised notation for clarity, and corrected typo

Constraints on scalar-tensor theories of gravity from observations

In spite of their original discrepancy, both dark energy and modified theory of gravity can be parameterized by the effective equation of state (EOS) $\omega$ for the expansion history of the Universe. A useful model independent approach to the EOS of them can be given by so-called Chevallier-Polarski-Linder (CPL) parametrization where two parameters of it ($\omega_{0}$ and $\omega_{a}$) can be constrained by the geometrical observations which suffer from degeneracies between models. The linear growth of large scale structure is usually used to remove these degeneracies. This growth can be described by the growth index parameter $\gamma$ and it can be parameterized by $\gamma_{0} + \gamma_{a} (1 - a)$ in general. We use the scalar-tensor theories of gravity (STG) and show that the discernment between models is possible only when $\gamma_a$ is not negligible. We show that the linear density perturbation of the matter component as a function of redshift severely constrains the viable subclasses of STG in terms of $\omega$ and $\gamma$. From this method, we can rule out or prove the viable STG in future observations. When we use $Z(\phi) =1$, $F$ shows the convex shape of evolution in a viable STG model. The viable STG models with $Z(\phi) = 1$ are not distinguishable from dark energy models when we strongly limit the solar system constraint.Comment: 19 pages, 20 figures, 2 tables, submitted to JCA

Cross-correlation of WISE Galaxies with the Cosmic Microwave Background

We estimated the cross-power spectra of a galaxy sample from the Wide-field Infrared Survey Explorer (WISE) survey with the 7-year Wilkinson Microwave Anisotropy Probe (WMAP) temperature anisotropy maps. A conservatively-selected galaxy sample covers ~13000sq.deg, with a median redshift of z=0.15. Cross-power spectra show correlations between the two data sets with no discernible dependence on the WMAP Q, V and W frequency bands. We interpret these results in terms of the the Integrated Sachs-Wolfe (ISW) effect: for the |b|>20 deg sample at l=6-87, we measure the amplitude (normalized to be 1 for vanilla LambdaCDM expectation) of the signal to be 3.4+-1.1, i.e., 3.1 sigma detection. We discuss other possibilities, but at face value, the detection of the linear ISW effect in a flat universe is caused by large scale decaying potentials, a sign of accelerated expansion driven by Dark Energy.Comment: 5 pages, 5 figures. Accepted for publication in MNRA

Non-adiabatic primordial fluctuations

We consider general mixtures of isocurvature and adiabatic cosmological perturbations. With a minimal assumption set consisting of the linearized Einstein equations and a primordial perfect fluid we derive the second-order action and its curvature variables. We also allow for varying equation of state and speed of sound profiles. The derivation is therefore carried out at the same level of generality that has been achieved for adiabatic modes before. As a result we find a new conserved super-horizon quantity and relate it to the adiabatically conserved curvature perturbation. Finally we demonstrate how the formalism can be applied by considering a Chaplygin gas-like primordial matter model, finding two scale-invariant solutions for structure formation.Comment: 11 page