Subjective satiety and plasma PYY concentration after wholemeal pasta

Dietary fiber and whole grain foods may contribute to the regulation of appetite; however, evidence has produced inconclusive findings. The objective was to evaluate the effects of an experimental wholemeal pasta on appetite ratings, plasma concentrations of gastrointestinal hormones involved in appetite control, and postprandial glucose/insulin responses in healthy adults. Fourteen healthy adults (7M/7F), mean age 30±2 yrs (mean±SEM), participated in a randomized, controlled, crossover trial. Participants consumed on two different days, at one week interval, 117g of wholemeal pasta or 100g of refined wheat pasta (control pasta), similar in energy and macronutrient composition except for fiber amount, which was higher in wholemeal pasta (11 vs 3 g). Appetite ratings, glucose/insulin/lipid and gastrointestinal hormone responses were measured at fasting and for 4-h after the ingestion of the pasta tests, after which self-reported energy intake for 8-h was evaluated. After the wholemeal pasta, the desire to eat and the sensation of hunger were lower (-16%, p=0.04 and -23%, p=0.004, respectively) and satiety was higher (+13%; p=0.08) compared with the control pasta; no effect on self-reported energy intake at subsequent meal was observed. After wholemeal pasta, glucose, triglyceride increased and GLP-1 responses were not different compared to control pasta but insulin response at 30 min (p<0.05) and ghrelin at 60 min (p=0.03) were lower and PYY levels higher (AUC=+44%, p=0.001). The appetite rating changes correlated with PYY plasma levels (p<0.03). In conclusion, consumption of whole grain instead of refined wheat pasta contributed to appetite control but did not seem to influence acute energy balance. Appetite ratings were associated with modifications in PYY hormone concentrations

Broncolitiasi del polmone in una giovane donna presentatosi come un carcinoide.

Caso clinico di una giovane donna con esame RX e TC del torace indicativi per una lesione polmonare ilare sinistra. L'esame FBS aveva evidenziato una vegetazione rossastra e facilmente sanguinante nel bronco lobare superiore sinistro e la scintigrafia con octeoscran un aumento di captazione a tale livello del radiocomposto con valori urinari aumentati di acido 5 idrossiindolacetico. Tali dati sono sospetti per un carcinoide bronchiale. La paziente è stata sottoposta a toracotomia con lobectomia superiore sinistra. L'esame istopatologico ha evidenziato una negatività per cromograniona, sinaptosifina, S-100, citocheratina 7 e 20, positività per vimentina e CD68, colorazione per amiloide negativa. Tali aspetti hanno deposto per una diagnosi definitiva di broncolitiasi del polmone sinistro

Analytical Management of Patients Undergoing Oral Anticoagulant Therapy Could Have a Strong Impact on Clinical Outcomes: A Follow-up Study

<p><b>Article full text</b></p> <p><br></p> <p>The full text of this article can be found here<b>. </b><a href="https://link.springer.com/article/10.1007/s40119-017-0090-x">https://link.springer.com/article/10.1007/s40119-017-0090-x</a></p><p></p> <p><br></p> <p><b>Provide enhanced content for this article</b></p> <p><br></p> <p>If you are an author of this publication and would like to provide additional enhanced content for your article then please contact <a href="http://www.medengine.com/Redeem/”mailto:[email protected]”"><b>[email protected]</b></a>.</p> <p><br></p> <p>The journal offers a range of additional features designed to increase visibility and readership. All features will be thoroughly peer reviewed to ensure the content is of the highest scientific standard and all features are marked as ‘peer reviewed’ to ensure readers are aware that the content has been reviewed to the same level as the articles they are being presented alongside. Moreover, all sponsorship and disclosure information is included to provide complete transparency and adherence to good publication practices. This ensures that however the content is reached the reader has a full understanding of its origin. No fees are charged for hosting additional open access content.</p> <p><br></p> <p>Other enhanced features include, but are not limited to:</p> <p><br></p> <p>• Slide decks</p> <p>• Videos and animations</p> <p>• Audio abstracts</p> <p>• Audio slides</p

Quale politica dopo il virus? Concetti politici alla luce della pandemia

Alle soglie del 2023 è ormai difficile sostenere che la crisi sanitaria dovuta all’epidemia da coro- navirus (e la conseguente crisi politico-economica) costituisca, come si affannavano a ripetere analisti e commentatori nel 2020, una svolta “epocale” della storia. È però innegabile che si tratti di un evento importante, i cui effetti più profondi sul modo di pensare la politica non possono ancora apparire in maniera chiara. Il volume intende chiedersi se una crisi di questa portata abbia avuto il potere o meno di mutare il retroterra culturale e il milieu all’interno dei quali trovano forma e sostanza idee e concetti della politica. Nel tentativo di uscire dal “qui e ora” a cui la pandemia ci ha costretto, l’obiettivo è di riflettere in una prospettiva diacronica su alcune delle principali categorie della politica al fine di verificare se abbiano subito una ridefinizione o quanto meno una revisione, di fronte agli eventi prodotti dalla diffusione del virus SARS-CoV-2 e dalle risposte che sul piano politico interno e internazionale sono state date dai diversi governi del mondo. Come in una sorta di “dizionario di politica”, il libro è strutturato a voci, ciascuna delle quali si compone di una parte iniziale di definizione del concetto e di ricostruzione della sua evoluzione storica attraverso il riferimento ai classici e alla più recente letteratura e da una seconda parte in cui il concetto in questione viene analizzato alla luce della crisi pandemica

ALICE: Physics Performance Report, Volume II

ALICE is a general-purpose heavy-ion experiment designed to study the physics of strongly interacting matter and the quark\u2013gluon plasma in nucleus\u2013nucleus collisions at the LHC. It currently involves more than 900 physicists and senior engineers, from both the nuclear and high-energy physics sectors, from over 90 institutions in about 30 countries. The ALICE detector is designed to cope with the highest particle multiplicities above those anticipated for Pb\u2013Pb collisions (dNch/dy up to 8000) and it will be operational at the start-up of the LHC. In addition to heavy systems, the ALICE Collaboration will study collisions of lower-mass ions, which are a means of varying the energy density, and protons (both pp and pA), which primarily provide reference data for the nucleus\u2013nucleus collisions. In addition, the pp data will allow for a number of genuine pp physics studies. The detailed design of the different detector systems has been laid down in a number of Technical Design Reports issued between mid-1998 and the end of 2004. The experiment is currently under construction and will be ready for data taking with both proton and heavy-ion beams at the start-up of the LHC. Since the comprehensive information on detector and physics performance was last published in the ALICE Technical Proposal in 1996, the detector, as well as simulation, reconstruction and analysis software have undergone significant development. The Physics Performance Report (PPR) provides an updated and comprehensive summary of the performance of the various ALICE subsystems, including updates to the Technical Design Reports, as appropriate. The PPR is divided into two volumes. Volume I, published in 2004 (CERN/LHCC 2003-049, ALICE Collaboration 2004 J. Phys. G: Nucl. Part. Phys. 30 1517\u20131763), contains in four chapters a short theoretical overview and an extensive reference list concerning the physics topics of interest to ALICE, the experimental conditions at the LHC, a short summary and update of the subsystem designs, and a description of the offline framework and Monte Carlo event generators. The present volume, Volume II, contains the majority of the information relevant to the physics performance in proton\u2013proton, proton\u2013nucleus, and nucleus\u2013nucleus collisions. Following an introductory overview, Chapter 5 describes the combined detector performance and the event reconstruction procedures, based on detailed simulations of the individual subsystems. Chapter 6 describes the analysis and physics reach for a representative sample of physics observables, from global event characteristics to hard processes