Die Bildung von Fluorisocyanat (F—NCO) in Argonmatrix

Matrix samples of F-CO-N3, and X-CO-NF2 (X = H, NF2, CF3) were photolyzed by mercury arc light and the new infrared bands at 2172, 861, 695, 646, 529 cm-1 assigned to the F-NCO molecule. 15N isotopic substitution confirmed the assignment of the IR bands of the new compound

Synthesis & Spectral Characterization of Some New Carbacylamidophosphate Derivatives. Crystal Structures of CCl3C(O)NHP(O)[NH(C5H9)]2 and CH3C6H4C(O)NHP(O)[NH(C5H9)]2

Full Title: Synthesis and Spectral Characterization of Some New Carbacylamidophosphate Derivatives. Crystal Structures of CCl3C(O)NHP(O)[NH(C5H9)]2 and CH3C6H4C(O)NHP(O)[NH(C5H9)]2Some new carbacylamidophosphate derivatives with the general formula RC(O)NHP(O)[NH(C5H9)]2: (R=CCl3), 1a; (R=CHCl2), 2a; (R=CH2Cl), 3a; (R=CF3), 4a; (R=C6H5), 1b; (R=p-Cl-C6H4), 2b; (R=p-Br-C6H4), 3b; (R=p-Me-C6H4), 4b; were synthesized and characterized by 1H, 13C, 31PNMRand IR spectroscopy and elemental analysis. The crystalline solids of 1a and 4b were studied bysingle crystal X-ray diffraction analysis. The dimeric aggregate and the centrosymmetric dimer formed via intermolecular N-H....O=P and N-H....O=C hydrogen bonds in 1a and 4b, respectively. In all the synthesized molecules, similar spectral patterns were obtained in the 13C NMR spectra for carbon atoms of cyclic amines with 2J PNC = 0 and 3JPNC ranging from 4 to 6 Hz.KEYWORDS: Carbacylamidophosphates, hydrogen bonds, IR spectroscopy, NMR spectroscopy

The inverse-trans-influence in tetravalent lanthanide and actinide bis(carbene) complexes

Across the periodic table the trans-influence operates, whereby tightly bonded ligands selectively lengthen mutually trans metal–ligand bonds. Conversely, in high oxidation state actinide complexes the inverse-trans-influence operates, where normally cis strongly donating ligands instead reside trans and actually reinforce each other. However, because the inversetrans-influence is restricted to high-valent actinyls and a few uranium(V/VI) complexes, it has had limited scope in an area with few unifying rules. Here we report tetravalent cerium, uranium and thorium bis(carbene) complexes with trans C¼M¼C cores where experimental and theoretical data suggest the presence of an inverse-trans-influence. Studies of hypothetical praseodymium(IV) and terbium(IV) analogues suggest the inverse-trans-influence may extend to these ions but it also diminishes significantly as the 4f orbitals are populated. This work suggests that the inverse-trans-influence may occur beyond high oxidation state 5f metals and hence could encompass mid-range oxidation state actinides and lanthanides. Thus, the inverse-trans-influence might be a more general f-block principle

Antiarrhythmic and antioxidant activity of novel pyrrolidin-2-one derivatives with adrenolytic properties

A series of novel pyrrolidin-2-one derivatives (17 compounds) with adrenolytic properties was evaluated for antiarrhythmic, electrocardiographic and antioxidant activity. Some of them displayed antiarrhythmic activity in barium chloride-induced arrhythmia and in the rat coronary artery ligation-reperfusion model, and slightly decreased the heart rate, prolonged P–Q, Q–T intervals and QRS complex. Among them, compound EP-40 (1-[2-hydroxy-3-[4-[(2-hydroxyphenyl)piperazin-1-yl]propyl]pyrrolidin-2-one showed excellent antiarrhythmic activity. This compound had significantly antioxidant effect, too. The present results suggest that the antiarrhythmic effect of compound EP-40 is related to their adrenolytic and antioxidant properties. A biological activity prediction using the PASS software shows that compound EP-35 and EP-40 can be characterized by antiischemic activity; whereas, compound EP-68, EP-70, EP-71 could be good tachycardia agents