Biophysical Characteristics Reveal Neural Stem Cell Differentiation Potential

Distinguishing human neural stem/progenitor cell (huNSPC) populations that will predominantly generate neurons from those that produce glia is currently hampered by a lack of sufficient cell type-specific surface markers predictive of fate potential. This limits investigation of lineage-biased progenitors and their potential use as therapeutic agents. A live-cell biophysical and label-free measure of fate potential would solve this problem by obviating the need for specific cell surface markers

Catalysing sustainable fuel and chemical synthesis

Concerns over the economics of proven fossil fuel reserves, in concert with government and public acceptance of the anthropogenic origin of rising CO2 emissions and associated climate change from such combustible carbon, are driving academic and commercial research into new sustainable routes to fuel and chemicals. The quest for such sustainable resources to meet the demands of a rapidly rising global population represents one of this century’s grand challenges. Here, we discuss catalytic solutions to the clean synthesis of biodiesel, the most readily implemented and low cost, alternative source of transportation fuels, and oxygenated organic molecules for the manufacture of fine and speciality chemicals to meet future societal demands

Be-10 erosion rates controlled by transient response to normal faulting through incision and landsliding

Quantifying erosion rates, and how they compare to rock uplift rates, is fundamental for understanding landscape response to tectonics and associated sediment fluxes from upland areas. The erosional response to uplift is well-represented by river incision and the associated landslide activity. However, characterising the relationship between these processes remains a major challenge in tectonically active areas, in some cases because landslides can preclude obtaining reliable erosion rates from cosmogenic radionuclide (CRN) concentrations. Here, we quantify the control of tectonics and its coupled geomorphic response on the erosion rates of catchments in southern Italy that are experiencing a transient response to normal faulting. We analyse in-situ 10Be concentrations for detrital sediment samples, collected along the strike of faults with excellent tectonic constraints and landslide inventories. We demonstrate that 10Be-derived erosion rates are controlled by fault throw rates and the extent of transient incision and associated landsliding in the catchments. We show that the low-relief sub-catchments above knickpoints erode at uniform background rates of ∼0.10 mm/yr, while downstream of knickpoints, erosion removes ∼50% of the rock uplifted by the faults, at rates of 0.10–0.64 mm/yr. Despite widespread landsliding, CRN samples provide relatively consistent and accurate erosion rates, most likely because landslides are frequent, small, and shallow, and represent the integrated record of landsliding over several seismic cycles. Consequently, we combine these validated 10Be erosion rates and data from a geomorphological landslide inventory in a published numerical model, to gain further insight into the long-term landslide rates and sediment mixing, highlighting the potential of CRN data to study landslide dynamics

The evolution of the Patagonian Ice Sheet from 35 ka to the present day (PATICE)

\ua9 2020 The AuthorsWe present PATICE, a GIS database of Patagonian glacial geomorphology and recalibrated chronological data. PATICE includes 58,823 landforms and 1,669 geochronological ages, and extends from 38\ub0S to 55\ub0S in southern South America. We use these data to generate new empirical reconstructions of the Patagonian Ice Sheet (PIS) and subsequent ice masses and ice-dammed palaeolakes at 35 ka, 30 ka, 25 ka, 20 ka, 15 ka, 13 ka (synchronous with the Antarctic Cold Reversal), 10 ka, 5 ka, 0.2 ka and 2011 AD. At 35 ka, the PIS covered of 492.6 x103 km2, had a sea level equivalent of ~1,496 mm, was 350 km wide and 2090 km long, and was grounded on the Pacific continental shelf edge. Outlet glacier lobes remained topographically confined and the largest generated the suites of subglacial streamlined bedforms characteristic of ice streams. The PIS reached its maximum extent by 33 – 28 ka from 38\ub0S to 48\ub0S, and earlier, around 47 ka from 48\ub0S southwards. Net retreat from maximum positions began by 25 ka, with ice-marginal stabilisation then at 21 – 18 ka, which was then followed by rapid, irreversible deglaciation. By 15 ka, the PIS had separated into disparate ice masses, draining into large ice-dammed lakes along the eastern margin, which strongly influenced rates of recession. Glacial readvances or stabilisations occurred at least at 14 – 13 ka, 11 ka, 6 – 5 ka, 2 – 1 ka, and 0.5 – 0.2 ka. We suggest that 20th century glacial recession (% a-1) is occurring faster than at any time documented during the Holocene

High mountain region of the Northern Romanian Carpathians responded sensitively to Holocene climate and land use changes : A multi-proxy analysis

A high-altitude lake sediment sequence (Buhăiescu Mare, 1918 m a.s.l.) in the subalpine zone of the Rodna Mountains was analysed through a multi-proxy approach to determine the sensitivity of high mountain habitats to climate, fire and land use changes. The early Holocene regional forests were dominated by Pinus (sylvestris and mugo) and replaced by Picea abies from 9800 cal. yr BP. After an extended hiatus in the profile (c. 9800–4200 cal. yr BP), probably because of the physical removal of sediments through avalanche or high-flow events, P. abies, Abies alba and Fagus sylvatica forests developed after 4200 cal. yr BP. The timberline and treeline reacted sensitively to past changes in climate and human impact. The site was probably situated above the treeline throughout most of the investigated period. However, a treeline ecotone or krummholz zone may have sporadically reached the lake’s elevation in the early Holocene. A decline in timberline and treeline elevation was noted during the last 1200 years, and more evidently over the past 200 years, with replacement by subalpine shrubs (Alnus viridis) and alpine herbaceous communities. Because these vegetation changes were associated with an increased prevalence of pollen-based anthropogenic indicators, charcoal particles and abiotic indicators, human-induced fires and clearance and resultant erosion inputs to the lake are implied. Effects of current warming on the altitude range of trees are not yet visible, probably because land use has more strongly contributed to changes in land cover than the climate fluctuations of the last millennium in the Rodna Mountains