164 research outputs found
ParticularitÄČile de evoluČie a meningitei tuberculoase la adulČi
Background. Development of meningitis in patients with tuberculosis (TB) conditions a serious
evolution of the disease, caused by irreversible changes that occur by cerebral edema. Objective of the
study. Studying of evolution and assess treatment outcomes in adult patients with TB
meningitis. Material and Methods. A cohort retrospective study was performed that included 46 adults
with TB meningitis, undergoing treatment at the Municipal Clinical Hospital of Phthisiopneumology in
Chisinau for the period 2000-2018 years. Results. Rate male/female - 4.75/1. Aged <40 years - 21
(46%). TB contact - 32 (70%) cases. The social risk factors was in 100%. Passive detection
predominated - 44 (96%). Meningitis has been established in patients with pulmonary TB in 38 (83%)
cases. The clinical forms of pulmonary TB were: infiltrative - 22 (68%), fibrocavitary - 6 (17%),
disseminated - 4 (15%), 14 (30%) - extrapulmonary TB. Diagnosis was confirmed by distinctiv changes
in the cerebrospinal fluid (CSF): serous CSF character, increased pleocytosis due to lymphocytes,
positive Pandy reaction, hypoglycorahia. Treatment for sensitive TB - 31 (68%), for resistant TB - 15
(22%). The death of the patients - 41 (89%) cases. Conclusion. TB meningitis develops in young adults
with contact TB. The TB meningitis diagnosis was confirmed by distinctiv typical changes in CSF. TB
meningitis evolution is unfavorable.
Introducere. Dezvoltarea meningitei la pacienČii cu tuberculozÄ (TB) condiČioneazÄ o evoluČie gravÄ
prin modificÄrile ireversibile cauzate de edemul cerebral. Scopul lucrÄrii. Studierea evoluČiei Či
rezultatelor tratamentului la adulČii cu meningita TB. Material Či Metode. S-a efectuat o cercetare
retrospectivÄ de tip cohort, care a inclus 46 de adulČi cu meningitÄ tuberculoasÄ, aflaČi pentru tratament
Ć®n Spitalul Clinic Municipal de Ftiziopneumologie din ChiČinÄu, Ć®n perioada 2000-2018. Rezultate.
Rata bÄrbaČi/femei - 4.75/1. VĆ¢rsta pacienČilor <40 ani - 21 (46%). Contact TB a fost Ć®n 32 (70%) cazuri.
Factori de risc sociali au fost Ć®n 100%. A predominat depistarea pasivÄ - 44 (96%). TB pulmonarÄ a fost
Ć®n 38 (83%) cazuri. Formele clinice de TB pulmonarÄ au fost: infiltrativÄ - 22 (68%), fibrocavitarÄ - 6
(17%), diseminatÄ - 4 (15%), 14 (30%) cazuri ā TB extrapulmonarÄ. Etiologia TB s-a stabilit prin
modificÄri distinctive Ć®n lichidul cefalo-rahidian (LCR): caracter seros al LCR, pleocitozÄ crescutÄ din
contul limfocitelor, reacČia Pandy pozitivÄ, hypoglycorahia. Tratament pentru TB sensibilÄ - 31 (68%),
pentru TB rezistentÄ - 15 (22%). Decesul bolnavilor - 41 (89%) cazuri. Concluzii. Meningita TB se
dezvoltÄ la pacienČii tineri din contact TB. Etiologia TB a meningitei se confirmÄ prin modificarile Ć®n
LCR. EvoluČia meningitei TB este gravÄ, necesitĆ¢nd un diagnostic Či tratament prompt
DeterminanČii sociali la pacienČii cu tuberculozÄ pulmonarÄ
Introduction. People with social vulnerability, such as
those without a place for living, migrants, unemployed,
and marginalized by addictive behaviors have a high risk
for tuberculosis. Objective of the study. The aim of the
study was to assess the distribution of the social determinants in patients with pulmonary tuberculosis. Material
and methods. A retrospective, selective, longitudinal study was performed that included 419 patients diagnosed
with tuberculosis and registered with a socially vulnerable
state in Chisinau during 2017-2019. Results. According to
the sex distribution, it was identified that the ratio men/
women consisted 3.5/1; the age group of 35-54 years was
prevailed with 226 (54%) cases, followed by the age group
of 18-35 years with 125 (30%) cases and the group of 55+
years ā with 56 (16%) cases. Unemployed were 328 (78%),
low level of education had 342 (82%) cases and poor living
conditions had 281 (67%) cases. There were in detention
41 (9%) cases and recently migrated were 53 (13%) cases.
Harmful habits such as chronic alcoholism had 61 (15%) cases and patients who are addicted to drugs ā 7 (2%) cases.
HIV/AIDS was diagnosed in 52 (12%) cases, mental disorders ā in 14 (5%) cases, malnourished were 32 (7.6%) patients, undernourished ā 28% cases. 48 (11%) cases were in
tuberculosis contact. Conclusions. The social determinants
of the patients with pulmonary tuberculosis were dominated by unemployment, low level of education and poor living conditions, which often were associated with harmful
habits, TB contact, undernourished and HIV-infection.Introducere. Persoanele cu vulnerabilitate socialÄ, precum
cele fÄrÄ loc de trai, marginalizate prin comportamente adictive Či migranČi constituie un risc sporit de Ć®mbolnÄvire de
tuberculozÄ. Scopul. Scopul a fost de a evalua distribuČia determinanČilor sociali la pacienČii cu tuberculozÄ pulmonarÄ.
Material Či metode. A fost efectuat un studiu retrospectiv,
selectiv, descriptiv care a inclus 419 pacienČi diagnosticaČi
cu tuberculozÄ pulmonarÄ Či care au fost Ć®nregistraČi cu un
statut social vulnerabil Ć®n ChiČinÄu Ć®n perioada 2017-2019.
Rezultate. Distribuind pacienČii Ć®n dependenČÄ de sex, am
identificat cÄ raportul bÄrbaČi/femei a constituit 3,5/1, a
predominat grupul de vĆ¢rstÄ 35-54 ani cu 226 (54%) cazuri,
urmat de grupul de vĆ¢rstÄ 18-35 ani cu 125 (30%) cazuri Či
grupul de vĆ¢rstÄ 55+ ani ā cu 56 (16%) cazuri. Čomeri au
constituit 328 (78%) cazuri, nivelul scÄzut de studii au avut
342 (82%) cazuri, condiČii de viaČÄ sÄrace ā 281 (67%) cazuri. Au fost Ć®n detenČie 41 (9%) cazuri Či au migrat recent
53 (13%) cazuri. Deprinderi nocive ca alcoolism cronic au
avut 61 (15%) cazuri Či au utilizat droguri 7 (2%) pacienČi.
HIV/SIDA s-a diagnosticat la 52 (12%) pacienČi, tulburÄri
psihice ā la 14 (5%) cazuri, malnutriČi au fost 32 (7,6%) pacienČi Či subnutriČi ā 28% cazuri. Ćn contact tuberculos au
fost 48 (11%) cazuri. Concluzii. DeterminanČii sociali la pacienČii cu tuberculozÄ pulmonarÄ au fost dominaČi de Čomaj,
nivel redus de Čcolarizare, condiČii nesatisfÄcÄtoare de trai,
care frecvent s-au asociat cu deprinderi nocive, contactul
tuberculos, subnutriČia Či infecČia HIV
SOCIAL DETERMINANTS IN PATIENTS WITH PULMONARY TUBERCULOSIS
Universitatea de Stat de MedicinÄ Åi Farmacie āNicolae TestemiÅ£anuā, ChiÅinÄu, Republica MoldovaIntroducere. Persoanele cu vulnerabilitate socialÄ, precum cele fÄrÄ loc de trai, marginalizate prin comportamente adictive Či migranČi constituie un risc sporit de Ć®mbolnÄvire de tuberculozÄ. Scopul. Scopul a fost de a evalua distribuČia determinanČilor sociali la pacienČii cu tuberculozÄ pulmonarÄ. Material Či metode. A fost efectuat un studiu retrospectiv, selectiv, descriptiv care a inclus 419 pacienČi diagnosticaČi cu tuberculozÄ pulmonarÄ Či care au fost Ć®nregistraČi cu un statut social vulnerabil Ć®n ChiČinÄu Ć®n perioada 2017-2019. Rezultate. Distribuind pacienČii Ć®n dependenČÄ de sex, am identificat cÄ raportul bÄrbaČi/femei a constituit 3,5/1, a predominat grupul de vĆ¢rstÄ 35-54 ani cu 226 (54%) cazuri, urmat de grupul de vĆ¢rstÄ 18-35 ani cu 125 (30%) cazuri Či grupul de vĆ¢rstÄ 55+ ani ā cu 56 (16%) cazuri. Čomeri au constituit 328 (78%) cazuri, nivelul scÄzut de studii au avut 342 (82%) cazuri, condiČii de viaČÄ sÄrace ā 281 (67%) cazuri. Au fost Ć®n detenČie 41 (9%) cazuri Či au migrat recent 53 (13%) cazuri. Deprinderi nocive ca alcoolism cronic au avut 61 (15%) cazuri Či au utilizat droguri 7 (2%) pacienČi. HIV/SIDA s-a diagnosticat la 52 (12%) pacienČi, tulburÄri psihice ā la 14 (5%) cazuri, malnutriČi au fost 32 (7,6%) pacienČi Či subnutriČi ā 28% cazuri. Ćn contact tuberculos au fost 48 (11%) cazuri. Concluzii. DeterminanČii sociali la pacienČii cu tuberculozÄ pulmonarÄ au fost dominaČi de Čomaj, nivel redus de Čcolarizare, condiČii nesatisfÄcÄtoare de trai, care frecvent s-au asociat cu deprinderi nocive, contactul tuberculos, subnutriČia Či infecČia HIV.Introduction. People with social vulnerability, such as those without a place for living, migrants, unemployed, and marginalized by addictive behaviors have a high risk for tuberculosis. Objective of the study. The aim of the study was to assess the distribution of the social determinants in patients with pulmonary tuberculosis. Material and methods. A retrospective, selective, longitudinal study was performed that included 419 patients diagnosed with tuberculosis and registered with a socially vulnerable state in Chisinau during 2017-2019. Results. According to the sex distribution, it was identified that the ratio men/ women consisted 3.5/1; the age group of 35-54 years was prevailed with 226 (54%) cases, followed by the age group of 18-35 years with 125 (30%) cases and the group of 55+ years ā with 56 (16%) cases. Unemployed were 328 (78%), low level of education had 342 (82%) cases and poor living conditions had 281 (67%) cases. There were in detention 41 (9%) cases and recently migrated were 53 (13%) cases. Harmful habits such as chronic alcoholism had 61 (15%) cases and patients who are addicted to drugs ā 7 (2%) cases. HIV/AIDS was diagnosed in 52 (12%) cases, mental disorders ā in 14 (5%) cases, malnourished were 32 (7.6%) patients, undernourished ā 28% cases. 48 (11%) cases were in tuberculosis contact. Conclusions. The social determinants of the patients with pulmonary tuberculosis were dominated by unemployment, low level of education and poor living conditions, which often were associated with harmful habits, TB contact, undernourished and HIV-infection
Features of the pediatric patients with tuberculosis
Introduction
Tuberculosis among pediatric population is an
important health problem in many countries, especially
in low income countries.
The receptivity for TB is higher during the childhood
period due to social, epidemiological and biological risk
factors.
Purpose
To establish the peculiarities of pediatric patients
diagnosed with TB in the actual epidemiological context
of Chisinau city
Material and methods
A retrospective study, which included 43 children
diagnosed in Chisinau during the period 2017-2019
was performed
Results
Distribution by sex: 22 (51%) were boys and 21 (49%) girls.
From urban residence were 21 (49%) cases and from rural
residence - 22 (51%) cases. Tuberculous contact had 21
(51.16%) children. By the examination of the high-risk groups
36 (84%) cases were detected with tuberculosis contact,
including 21 (52%) cases of family contact. General
practitioners detected 27 (63%) cases and
phthisiopulmonologists - 16 (37%) cases. The new cases were
38 (88%) children and previously treated cases were 5 (12%)
cases. Tuberculosis of intrathoracic lymph nodes was
diagnosed in 40 (93%) children, primary tuberculosis complex
- in 2 (4.6%) cases and 1 (2.3%) case was diagnosed with acute
disseminated tuberculosis. Positive tuberculin test result was
identified in 29 (67%) children, hyperergic reaction - in 5
(12%) children and negative result - in 8 (19%) cases. Nonvaccinated BCG were only 2 (4.6%) cases.
Conclusions
The peculiarities of pediatric patients affected by tuberculosis are the similar involvement of
boys and girls, presence of tuberculosis contact, lack of antituberculosis treatment in most of
cases, predomination of extrapulmonary tuberculosis and positive or hyperergic results of
tuberculin skin test
Š„Š°ŃŠ°ŠŗŃŠµŃŠøŃŃŠøŠŗŠ° ŃŠ¼ŠµŃŃŠ½Š¾ŃŃŠø Š¾Ń ŃŃŠ±ŠµŃŠŗŃŠ»ŠµŠ·Š° Š»ŠµŠ³ŠŗŠøŃ Š² Š¼ŃŠ½ŠøŃŠøŠæŠ°Š»ŃŠ½Š¾Š¹ Š±Š¾Š»ŃŠ½ŠøŃŠµ Š¤ŃŠøŠ·ŠøŠ¾ŠæŃŠ»ŃŠ¼Š¾Š½Š¾Š»Š¾Š³ŠøŠø, ŠŠøŃŠøŠ½ŠµŠ².
The characteristics of pulmonary tuberculosis deaths in the Municipal Hospital of Phthisiopneumology, Chisinau.Scopul studiului a fost analiza particularitÄČilor clinice, paraclinice Či a factorilor de risc a bolnavilor decedaČi prin tuberculoza pulmonarÄ. A fost efectuat un studiu retrospectiv Či descriptiv, în baza datelor a 92 bolnavi decedaČi prin tuberculozÄ în Spitalul Municipal de Ftiziopneumologie din ChiČinÄu, în perioada anilor 2016-2018. Prin progresarea tuberculozei au decedat 40 (43,5%) bolnavi cazuri noi Či 23 (25,0%) din retratamente, iar 29 (31,8%) bolnavi de tuberculoza au decedat prin alte boli. Din spitalele somatice au fost transferaČi 45,6% bolnavii, de la domiciliu prin intermediul serviciului de urgenČa în stare gravÄ au fost internaČi 39,1% pacienČi Či numai 15,3% – îndreptaČi de medicul ftiziopneumolog. Au predominat formele grave de tuberculoza (pneumonia cazeoasÄ Či tuberculoza generalizatÄ). Co-infecČia TB/HIV a constituit 19,6%. FÄrÄ loc stabil de trai au fost 27,2% pacienČi decedaČi. La decedaČii prin alte boli cauzele principale de deces au fost cancerul de diferite localizÄri, pneumoniile comunitare, ciroza hepaticÄ.Š„Š°ŃŠ°ŠŗŃŠµŃŠøŃŃŠøŠŗŠ° ŃŠ¼ŠµŃŃŠ½Š¾ŃŃŠø Š¾Ń ŃŃŠ±ŠµŃŠŗŃŠ»ŠµŠ·Š° Š»ŠµŠ³ŠŗŠøŃ
Š² Š¼ŃŠ½ŠøŃŠøŠæŠ°Š»ŃŠ½Š¾Š¹ Š±Š¾Š»ŃŠ½ŠøŃŠµ Š¤ŃŠøŠ·ŠøŠ¾ŠæŃŠ»ŃŠ¼Š¾Š½Š¾Š»Š¾Š³ŠøŠø, ŠŠøŃŠøŠ½ŠµŠ²
CDPKs CPK6 and CPK3 Function in ABA Regulation of Guard Cell S-Type Anion- and Ca(2+)- Permeable Channels and Stomatal Closure
Abscisic acid (ABA) signal transduction has been proposed to utilize cytosolic Ca(2+) in guard cell ion channel regulation. However, genetic mutants in Ca(2+) sensors that impair guard cell or plant ion channel signaling responses have not been identified, and whether Ca(2+)-independent ABA signaling mechanisms suffice for a full response remains unclear. Calcium-dependent protein kinases (CDPKs) have been proposed to contribute to central signal transduction responses in plants. However, no Arabidopsis CDPK gene disruption mutant phenotype has been reported to date, likely due to overlapping redundancies in CDPKs. Two Arabidopsis guard cellāexpressed CDPK genes, CPK3 and CPK6, showed gene disruption phenotypes. ABA and Ca(2+) activation of slow-type anion channels and, interestingly, ABA activation of plasma membrane Ca(2+)-permeable channels were impaired in independent alleles of single and double cpk3cpk6 mutant guard cells. Furthermore, ABA- and Ca(2+)-induced stomatal closing were partially impaired in these cpk3cpk6 mutant alleles. However, rapid-type anion channel current activity was not affected, consistent with the partial stomatal closing response in double mutants via a proposed branched signaling network. Imposed Ca(2+) oscillation experiments revealed that Ca(2+)-reactive stomatal closure was reduced in CDPK double mutant plants. However, long-lasting Ca(2+)-programmed stomatal closure was not impaired, providing genetic evidence for a functional separation of these two modes of Ca(2+)-induced stomatal closing. Our findings show important functions of the CPK6 and CPK3 CDPKs in guard cell ion channel regulation and provide genetic evidence for calcium sensors that transduce stomatal ABA signaling
Transcriptomic Signatures of Ash (Fraxinus spp.) Phloem
Ash (Fraxinus spp.) is a dominant tree species throughout urban and forested landscapes of North America (NA). The rapid invasion of NA by emerald ash borer (Agrilus planipennis), a wood-boring beetle endemic to Eastern Asia, has resulted in the death of millions of ash trees and threatens billions more. Larvae feed primarily on phloem tissue, which girdles and kills the tree. While NA ash species including black (F. nigra), green (F. pennsylvannica) and white (F. americana) are highly susceptible, the Asian species Manchurian ash (F. mandshurica) is resistant to A. planipennis perhaps due to their co-evolutionary history. Little is known about the molecular genetics of ash. Hence, we undertook a functional genomics approach to identify the repertoire of genes expressed in ash phloem.Using 454 pyrosequencing we obtained 58,673 high quality ash sequences from pooled phloem samples of green, white, black, blue and Manchurian ash. Intriguingly, 45% of the deduced proteins were not significantly similar to any sequences in the GenBank non-redundant database. KEGG analysis of the ash sequences revealed a high occurrence of defense related genes. Expression analysis of early regulators potentially involved in plant defense (i.e. transcription factors, calcium dependent protein kinases and a lipoxygenase 3) revealed higher mRNA levels in resistant ash compared to susceptible ash species. Lastly, we predicted a total of 1,272 single nucleotide polymorphisms and 980 microsatellite loci, among which seven microsatellite loci showed polymorphism between different ash species.The current transcriptomic data provide an invaluable resource for understanding the genetic make-up of ash phloem, the target tissue of A. planipennis. These data along with future functional studies could lead to the identification/characterization of defense genes involved in resistance of ash to A. planipennis, and in future ash breeding programs for marker development
Ćtude de l'Ć©quilibre entre les solutions hydrothermales et les feldspaths de la sĆ©rie KAlSi3O8-Rb Al Si3O8, Ć 600Ā° C sous une pression de 1 000 bars
Ghelis Marianne, Lagache Martine. Ćtude de l'Ć©quilibre entre les solutions hydrothermales et les feldspaths de la sĆ©rie KAlSi3O8-Rb Al Si3O8, Ć 600Ā° C sous une pression de 1 000 bars. In: Bulletin de la SociĆ©tĆ© franƧaise de MinĆ©ralogie et de Cristallographie, volume 95, 1, 1972. RĆ©union annuelle de l'Association FranƧaise de Cristallographie, Lille, 6-8 mai 1971
Etude d'une voie de transduction de l'acide abscissique dans les cellules en suspension d'Arabidopsis thaliana
PARIS-BIUSJ-ThĆØses (751052125) / SudocCentre Technique Livre Ens. Sup. (774682301) / SudocPARIS-BIUSJ-Physique recherche (751052113) / SudocSudocFranceF
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