ETSU GearUp: The Design and Development of an Alternative Energy Greenhouse.

East Tennessee State has partnered with David Crockett High School through the Federal Gaining Early Awareness and Readiness for Undergraduate Programs. This year\u27s project is an alternative energy greenhouse, which incorporates solar panels and a wind turbine. The focus is on familiarizing students with control systems including programmable logic controllers and power management. There is also an emphasis on the importance of green engineering. The high school\u27s students have been involved in the design and development of every aspect of the system. The development of the system is ongoing and will be further integrated into classes in the fall semester. This unique project requires the students to use classroom skills in real world circumstances. The hope is that allowing the students to be involved with projects such as this will encourage them to take higher math and science courses and pursue a college degree in the science and engineering fields

ETSU GearUp: The Design and Development of an Alternative Energy Greenhouse.

East Tennessee State has partnered with David Crockett High School through the Federal Gaining Early Awareness and Readiness for Undergraduate Programs. This year\u27s project is an alternative energy greenhouse, which incorporates solar panels and a wind turbine. The focus is on familiarizing students with control systems including programmable logic controllers and power management. There is also an emphasis on the importance of green engineering. The high school\u27s students have been involved in the design and development of every aspect of the system. The development of the system is ongoing and will be further integrated into classes in the fall semester. This unique project requires the students to use classroom skills in real world circumstances. The hope is that allowing the students to be involved with projects such as this will encourage them to take higher math and science courses and pursue a college degree in the science and engineering fields

Safety and efficacy of dexpramipexole in eosinophilic asthma (EXHALE): a randomized controlled trial

BACKGROUND: There is a need for new and effective oral asthma therapies. Dexpramipexole, an oral eosinophil-lowering drug, has not previously been studied in asthma. OBJECTIVE: We sought to evaluate the safety and efficacy of dexpramipexole in lowering blood and airway eosinophilia in subjects with eosinophilic asthma. METHODS: We performed a randomized, double-blind, placebo-controlled proof-of-concept trial in adults with inadequately controlled moderate to severe asthma and blood absolute eosinophil count (AEC) greater than or equal to 300/μL. Subjects were randomly assigned (1:1:1:1) to dexpramipexole 37.5, 75, or 150 mg BID (twice-daily) or placebo. The primary end point was the relative change in AEC from baseline to week 12. Prebronchodilator FEV1 week-12 change from baseline was a key secondary end point. Nasal eosinophil peroxidase was an exploratory end point. RESULTS: A total of 103 subjects were randomly assigned to dexpramipexole 37.5 mg BID (N = 22), 75 mg BID (N = 26), 150 mg BID (N = 28), or placebo (N = 27). Dexpramipexole significantly reduced placebo-corrected AEC week-12 ratio to baseline, in both the 150-mg BID (ratio, 0.23; 95% CI, 0.12-0.43; P < .0001) and the 75-mg BID (ratio, 0.34; 95% CI, 0.18-0.65; P = .0014) dose groups, corresponding to 77% and 66% reductions, respectively. Dexpramipexole reduced the exploratory end point of nasal eosinophil peroxidase week-12 ratio to baseline in the 150-mg BID (median, 0.11; P = .020) and the 75-mg BID (median, 0.17; P = .021) groups. Placebo-corrected FEV1 increases were observed starting at week 4 (nonsignificant). Dexpramipexole displayed a favorable safety profile. CONCLUSIONS: Dexpramipexole demonstrated effective eosinophil lowering and was well tolerated. Additional larger clinical trials are needed to understand the clinical efficacy of dexpramipexole in asthma