Reinterpretation of LHC Results for New Physics: Status and recommendations after Run 2

We report on the status of efforts to improve the reinterpretation of searches and measurements at the LHC in terms of models for new physics, in the context of the LHC Reinterpretation Forum. We detail current experimental offerings in direct searches for new particles, measurements, technical implementations and Open Data, and provide a set of recommendations for further improving the presentation of LHC results in order to better enable reinterpretation in the future. We also provide a brief description of existing software reinterpretation frameworks and recent global analyses of new physics that make use of the current data

Light Induced Metastable State of Silver Nitroprusside Probed by Raman Spectroscopy

Low temperature Raman spectroscopic measurements on silver nitroprusside (AgNP), Ag-2Fe(CN)(5)NO] powders display reversible features of a partially converted metastable state. The results are compared with similarly observed metastable state in case of sodium nitroprusside (NaNP) and the differences have been discussed in terms of possible resistance to metastable state formation offered by silver atoms on the basis of hard soft acid base (HSAB) theory

Evaluation of growth rates and resistance to nematodes of Deccani and Bannur lambs and their crosses with Garole

Sheep rearing is a traditional occupation of about 85 000 shepherd families on the Deccan plateau in theMaharashtra State of India. They rear Deccani (D) sheep which usually bear only single lambs. Prolificacy is animportant trait for the efficiency of meat producing sheep. It was decided to evaluate and utilize Indian sheepgenetic resources with a view to improving the efficiency of sheep production on the Deccan plateau. Acrossbreeding experiment was conducted over 4 years, using rams of the D, Bannur (B) and Garole (G) breeds andD and B ewes with the aim of developing recommendations for the appropriate breed combination of a likelycomposite. It was found that crossing with G reduces live weight and growth rates significantly compared with Dbut lambs sired by G rams were more resistant to naturally acquired gastro-intestinal nematode infections and toartificial challenge withHaemonchus contortusthan those sired by D or B rams. The G breed, being from ahumid environment is, however, not adapted to the semi-arid Deccan plateau. The higher productivity (in terms ofweight of lamb weaned) of twin-bearing ewes compared with those bearing singles was evident even in extensiverearing conditions. The finding of increased resistance to gastro-intestinal nematodes in the G breed, which alsocarries a major gene for prolificacy, highlights the potential for inclusion of G in a composite breed. Negative effectson growth and survival from inclusion of the Garole need to be carefully managed

Phonon anomalies and structural transition in spin ice Dy2Ti2O7: a simultaneous pressure-dependent and temperature-dependent Raman study

We revisit the assignment of Raman phonons of rare-earth titanates by performing Raman measurements on single crystals of O18 isotope-rich spin ice Dy2Ti2O718 and nonmagnetic Lu2Ti2O718 pyrochlores and compare the results with their O16 counterparts. We show that the low-wavenumber Raman modes below 250 cm-1 are not due to oxygen vibrations. A mode near 200 cm-1, commonly assigned as F2g phonon, which shows highly anomalous temperature dependence, is now assigned to a disorder-induced Raman active mode involving Ti4+ vibrations. Moreover, we address here the origin of the new Raman mode, observed below TC similar to 110 K in Dy2Ti2O7, through a simultaneous pressure-dependent and temperature-dependent Raman study. Our study confirms the new mode to be a phonon mode. We find that dTC/dP = + 5.9 K/GPa. Temperature dependence of other phonons has also been studied at various pressures up to similar to 8 GPa. We find that pressure suppresses the anomalous temperature dependence. The role of the inherent vacant sites present in the pyrochlore structure in the anomalous temperature dependence is also discussed. Copyright (c) 2012 John Wiley & Sons, Ltd

Phonon anomalies and structural transition in spin-ice Dy<SUB>2</SUB>Ti<SUB>2</SUB>O<SUB>7</SUB>: a simultaneous pressure - and temperature-dependent Raman study

We revisit the assignment of Raman phonons of rare-earth titanates by performing Raman measurements on single crystals of O18-isotope rich spin-ice Dy2Ti2O718 and non-magnetic Lu2Ti2O718 pyrochlores and compare the results with their O16 counterparts. We show that the low wavenumber Raman modes below 250 cm#8722;1 are not due to oxygen vibrations. A mode near 200 cm#8722;1, commonly assigned as F2g phonon which shows highly anomalous temperature dependence, is now assigned to a disorder induced Raman active mode involving Ti4+ vibrations. Moreover, we address here the origin of the "new" Raman mode, observed earlier below Tc ~ 110 K in Dy2Ti2O7, through a simultaneous pressure- and temperature-dependent Raman study. Our study confirms the "new" mode to be a phonon mode. We find that dTc/dP = + 5.9 K/GPa. Temperature dependence of other phonons has also been studied at various pressures up to ~8 GPa. We find that pressure suppresses the anomalous temperature dependence. The role of the inherent vacant sites present in the pyrochlore structure in the anomalous temperature dependence is also discussed

TRC210258, a novel TGR5 agonist, reduces glycemic and dyslipidemic cardiovascular risk in animal models of diabesity

Shitalkumar P Zambad, Davinder Tuli, Anoop Mathur, Sameer A Ghalsasi, Anita R&nbsp;Chaudhary, Shailesh Deshpande, Ramesh C Gupta, Vijay Chauthaiwale, Chaitanya DuttTorrent Research Centre, Torrent Pharmaceuticals Ltd, Gujarat, IndiaBackground: Patients with diabesity have a significantly increased risk of developing cardiovascular disease. Therefore, therapy addressing the multiple metabolic abnormalities linked with diabesity and leading to further reduction of cardiovascular risk is highly desirable. Activation of the TGR5 receptor holds therapeutic potential for diabesity. In the present study, we evaluated the efficacy of TRC210258, a novel TGR5 agonist, in clinically relevant animal models of diabesity.Methods: A novel small molecule, TRC210258 (N-(4-chlorophenyl)-2-(4-fluoro phenoxy)-N-methylimidazo (1, 2-a) pyrimidine-3-carboxamide), was synthesized. The in vitro TGR5 receptor activation potential of TRC210258 was assessed by cyclic adinosine monophosphate (cAMP) assay and cAMP-responsive element reporter assay using cells overexpressing the human TGR5 receptor. The effect of TRC210258 on glucagon-like peptide-1 release was evaluated in vitro using a human enteroendocrine cell line. The effect of TRC210258 on energy expenditure and glycemic control was evaluated in high-fat diet-induced obese mice. Additionally, the effect of TRC210258 on dyslipidemic parameters was determined in high fat-fed hamsters.Results: TRC210258 demonstrated potent TGR5 agonist activity, with enhanced glucagon-like peptide-1 release and energy expenditure. Treatment with TRC210258 resulted in better glycemic control and improved parameters of dyslipidemia such as plasma triglyceride, low-density lipoprotein cholesterol, and non-high-density lipoprotein cholesterol levels. Treatment with TRC210258 also improved emerging dyslipidemic cardiovascular risk parameters, including remnant cholesterol and triglyceride clearance.Conclusion: This study highlights the potential of TRC210258, a novel TGR5 agonist, to improve dyslipidemic cardiovascular risk beyond glycemic control in patients with type 2 diabetes.Keywords: TGR5, diabesity, atherogenic dyslipidemia, triglyceride clearance, remnant cholesterol, cardiovascular risk