Citizens’ Motivated Reasoning About Public Performance: Experimental Findings from the US and Denmark

This is the author accepted manuscript. The final version is available from Taylor & Francis via the DOI in this recordRecent studies find motivated reasoning in citizens’ processing of information about public performance. Using experiments in the US and Denmark, we examine effects on an accuracy-based task of two forms of motivated reasoning: partisan identity-based reasoning and reasoning from ideology-based governance preferences (favoring either the public or the private sector). The experiments incorporate a political prime, a health care needs prime (to reduce politicization), and a neutral, no-prime, condition. We find that priming citizens to think politically accentuates the influence of partisan identities and governance preferences on reasoning. In contrast, priming about the need for a service reduces these biases. These findings extend knowledge of motivated reasoning in an accuracy-based task and priming with a no-prime benchmark, and confirm some findings of previous studies. Reducing the salience of partisan identities or governance preferences in the presentation of information may help stimulate more accuracy-based reasoning about public performance

ERRα promotes breast cancer cell dissemination to bone by increasing RANK expression in primary breast tumors

Bone is the most common metastatic site for breast cancer. Estrogen-related-receptor alpha (ERRα) has been implicated in cancer cell invasiveness. Here, we established that ERRα promotes spontaneous metastatic dissemination of breast cancer cells from primary mammary tumors to the skeleton. We carried out cohort studies, pharmacological inhibition, gain-of-function analyses in vivo and cellular and molecular studies in vitro to identify new biomarkers in breast cancer metastases. Meta-analysis of human primary breast tumors revealed that high ERRα expression levels were associated with bone but not lung metastases. ERRα expression was also detected in circulating tumor cells from metastatic breast cancer patients. ERRα overexpression in murine 4T1 breast cancer cells promoted spontaneous bone micro-metastases formation when tumor cells were inoculated orthotopically, whereas lung metastases occurred irrespective of ERRα expression level. In vivo, Rank was identified as a target for ERRα. That was confirmed in vitro in Rankl stimulated tumor cell invasion, in mTOR/pS6K phosphorylation, by transactivation assay, ChIP and bioinformatics analyses. Moreover, pharmacological inhibition of ERRα reduced primary tumor growth, bone micro-metastases formation and Rank expression in vitro and in vivo. Transcriptomic studies and meta-analysis confirmed a positive association between metastases and ERRα/RANK in breast cancer patients and also revealed a positive correlation between ERRα and BRCA1mut carriers. Taken together, our results reveal a novel ERRα/RANK axis by which ERRα in primary breast cancer promotes early dissemination of cancer cells to bone. These findings suggest that ERRα may be a useful therapeutic target to prevent bone metastases