The effect of Fe atoms on the adsorption of a W atom on W(100) surface

We report a first-principles calculation that models the effect of iron (Fe) atoms on the adsorption of a tungsten (W) atom on W(100) surfaces. The adsorption of a W atom on a clean W(100) surface is compared with that of a W atom on a W(100) surface covered with a monolayer of Fe atoms. The total energy of the system is computed as the function of the height of the W adatom. Our result shows that the W atom first adsorbs on top of the Fe monolayer. Then the W atom can replace one of the Fe atoms through a path with a moderate energy barrier and reduce its energy further. This intermediate site makes the adsorption (and desorption) of W atoms a two-step process in the presence of Fe atoms and lowers the overall adsorption energy by nearly 2.4 eV. The Fe atoms also provide a surface for W atoms to adsorb facilitating the diffusion of W atoms. The combination of these two effects result in a much more efficient desorption and diffusion of W atoms in the presence of Fe atoms. Our result provides a fundamental mechanism that can explain the activated sintering of tungsten by Fe atoms.Comment: 9 pages, 2 figure

Separation of suspended particles in microfluidic systems by directional-locking in periodic fields

We investigate the transport and separation of overdamped particles under the action of a uniform external force in a two-dimensional periodic energy landscape. Exact results are obtained for the deterministic transport in a square lattice of parabolic, repulsive centers that correspond to a piecewise-continuous linear-force model. The trajectories are periodic and commensurate with the obstacle lattice and exhibit phase-locking behavior in that the particle moves at the same average migration angle for a range of orientation of the external force. The migration angle as a function of the orientation of the external force has a Devil's staircase structure. The first transition in the migration angle was analyzed in terms of a Poincare map, showing that it corresponds to a tangent bifurcation. Numerical results show that the limiting behavior for impenetrable obstacles is equivalent to the high Peclet number limit in the case of transport of particles in a periodic pattern of solid obstacles. Finally, we show how separation occurs in these systems depending on the properties of the particles

Expression of neurogenin3 reveals an islet cell precursor population in the pancreas

Differentiation of early gut endoderm cells into the endocrine cells forming the pancreatic islets of Langerhans depends on a cascade of gene activation events controlled by transcription factors including the basic helix-loop-helix (bHLH) proteins. To delineate this cascade, we began by establishing the position of neurogenin3, a bHLH factor found in the pancreas during fetal development. We detect neurogenin3 immunoreactivity transiently in scattered ductal cells in the fetal mouse pancreas, peaking at embryonic day 15.5. Although not detected in cells expressing islet hormones or the islet transcription factors Isl1, Brn4, Pax6 or PDX1, neurogenin3 is detected along with early islet differentiation factors Nkx6.1 and Nkx2.2, establishing that it is expressed in immature cells in the islet lineage. Analysis of transcription factor-deficient mice demonstrates that neurogenin3 expression is not dependent on neuroD1/BETA2, Mash1, Nkx2.2, Nkx6.1, or Pax6. Furthermore, early expression of neurogenin3 under control of the Pdx1 promoter is alone sufficient to drive early and ectopic differentiation of islet cells, a capability shared by the pancreatic bHLH factor, neuroD1/BETA2, but not by the muscle bHLH factor, MyoD. However, the islet cells produced in these transgenic experiments are overwhelmingly α cells, suggesting that factors other than the bHLH factors are required to deviate from a default α cell fate. These data support a model in which neurogenin3 acts upstream of other islet differentiation factors, initiating the differentiation of endocrine cells, but switching off prior to final differentiation. The ability to uniquely identify islet cell precursors by neurogenin3 expression allows us to determine the position of other islet transcription factors in the differentiation cascade and to propose a map for the islet cell differentiation pathway

Vocabulary intervention for adolescents with language disorder: a systematic review

Background: Language disorder and associated vocabulary difficulties can persist into adolescence, and can impact on long-term life outcomes. Previous reviews have shown that a variety of intervention techniques can successfully enhance students’ vocabulary skills; however, none has investigated vocabulary intervention specifically for adolescents with language disorder. Aims: To carry out a systematic review of the literature on vocabulary interventions for adolescents with language disorder. Methods & Procedures: A systematic search of 14 databases and other sources yielded 1320 studies, of which 13 met inclusion criteria. Inclusion criteria were: intervention effectiveness studies with a focus on enhancing oral receptive and/or expressive vocabulary skills in the study's aims; participants in the age range 11;0–16;11 with receptive and/or expressive language difficulties of any aetiology. Main Contribution: There was a high degree of diversity between studies. Types of intervention included: semantic intervention (four studies); comparison of phonological versus semantic intervention (two); and combined phonological–semantic intervention (seven). The strongest evidence for effectiveness was found with a combined phonological–semantic approach. The evidence suggested a potential for all models of delivery to be helpful (individual, small group and whole class). Conclusions & Implications: Tentative evidence is emerging for the effectiveness of a phonological–semantic approach in enhancing the vocabulary skills of adolescents who have language disorder. Future research needs to refine and develop the methodologies used in this diverse group of studies in order to replicate their findings and to build consensus

Observational constraints on the spectral index of the cosmological curvature perturbation

We evaluate the observational constraints on the spectral index $n$, in the context of the $\Lambda$CDM hypothesis which represents the simplest viable cosmology. We first take $n$ to be practically scale-independent. Ignoring reionization, we find at a nominal 2-$\sigma$ level $n\simeq 1.0 \pm 0.1$. If we make the more realisitic assumption that reionization occurs when a fraction $f\sim 10^{-5}$ to 1 of the matter has collapsed, the 2-$\sigma$ lower bound is unchanged while the 1-$\sigma$ bound rises slightly. These constraints are compared with the prediction of various inflation models. Then we investigate the two-parameter scale-dependent spectral index, predicted by running-mass inflation models, and find that present data allow significant scale-dependence of $n$, which occurs in a physically reasonable regime of parameter space.Comment: ReVTeX, 15 pages, 5 figures and 3 tables, uses epsf.sty Improved treatment of reionization and small bug fixed in the constant n case; more convenient parameterization and better treatment of the n dependence in the CMB anisotropy for the running mass case; conclusions basically unchanged; references adde

Towards the interoperability of computerised guidelines and electronic health records: an experiment with openEHR archetypes and a chronic heart failure guideline

Clinical guidelines contain recommendations based on the best empirical evidence available at the moment. There is a wide consensus about the benefits of guidelines and about the fact that they should be deployed through clinical information systems, making them available during clinical consultations. However, one of the main obstacles to this integration is the interaction with the electronic healthrecord system. With the aim of solving the interoperability problems of guideline systems, we have investigated the utilisation of the openEHR standardisation proposal in the context of one of the existing guideline representation languages. Concretely, we have designed a collection of archetypes to be used within a chronic heart failure guideline. The main contribution of our work is the utilisation of openEHR archetypes in the framework of guideline representation languages. Other contributions include both the concrete set of archetypes that we have selected and the methodological approach that we have followed to obtain itThis work has been supported by Fundaci´o Caixa Castell´o-Bancaixa, through the research project P11B2009-3

Quark mass correction to the string potential

A consistent method for calculating the interquark potential generated by the relativistic string with massive ends is proposed. In this approach the interquark potential in the model of the Nambu--Goto string with point--like masses at its ends is calculated. At first the calculation is done in the one--loop approximation and then the variational estimation is performed. The quark mass correction results in decreasing the critical distance (deconfinement radius). When quark mass decreases the critical distance also decreases. For obtaining a finite result under summation over eigenfrequencies of the Nambu--Goto string with massive ends a suitable mode--by--mode subtraction is proposed. This renormalization procedure proves to be completely unique. In the framework of the developed approach the one--loop interquark potential in the model of the relativistic string with rigidity is also calculated.Comment: 34 pages, LATE

String Nature of Confinement in (Non-)Abelian Gauge Theories

Recent progress achieved in the solution of the problem of confinement in various (non-)Abelian gauge theories by virtue of a derivation of their string representation is reviewed. The theories under study include QCD within the so-called Method of Field Correlators, QCD-inspired Abelian-projected theories, and compact QED in three and four space-time dimensions. Various nonperturbative properties of the vacua of the above mentioned theories are discussed. The relevance of the Method of Field Correlators to the study of confinement in Abelian models, allowing for an analytical description of this phenomenon, is illustrated by an evaluation of field correlators in these models.Comment: 100 pages, LaTeX2e, no figures, 1 table, based on the Ph.D. thesises at the Humboldt University of Berlin (1999) (available under http://dochost.rz.hu-berlin.de) and the Institute of Theoretical and Experimental Physics, Moscow (2000), new results are included, extended with respect to the journal versio

Permeability of self-affine rough fractures

The permeability of two-dimensional fractures with self-affine fractal roughness is studied via analytic arguments and numerical simulations. The limit where the roughness amplitude is small compared with average fracture aperture is analyzed by a perturbation method, while in the opposite case of narrow aperture, we use heuristic arguments based on lubrication theory. Numerical simulations, using the lattice Boltzmann method, are used to examine the complete range of aperture sizes, and confirm the analytic arguments.Comment: 11 pages, 9 figure