315 research outputs found

    Influence of plastic deformation on the defective structure of TI-6AL-4V

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    The influence of plastic deformation on the defect structure of Ti-6Al-4V titanium alloy was investigated. X-ray analysis was performed with interpretation of the diffractogram reflections and determination of the parameters of the crystal structure. The data obtained were used to calculate the dislocation density of a titanium alloy after cold-rolled plastic deformation

    Nano-chemistry and scanning probe nanolithographies

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    The development of nanometer-scale lithographies is the focus of an intense research activity because progress on nanotechnology depends on the capability to fabricate, position and interconnect nanometer-scale structures. The unique imaging and manipulation properties of atomic force microscopes have prompted the emergence of several scanning probe-based nanolithographies. In this tutorial review we present the most promising probe-based nanolithographies that are based on the spatial confinement of a chemical reaction within a nanometer-size region of the sample surface. The potential of local chemical nanolithography in nanometer-scale science and technology is illustrated by describing a range of applications such as the fabrication of conjugated molecular wires, optical microlenses, complex quantum devices or tailored chemical surfaces for controlling biorecognition processes.The authors would like to thank Fabio Biscarini for providing the much needed input to write the manuscript and Marta Tello for her valuable suggestions. This work was financially supported by the MCyT (Spain) (MAT2003-02655) and the European Commission (NAIMO, IP NMP4-CT-2004-500355).Peer reviewe

    Endophthalmitis Due to Microbacterium Species: Case Report and Review of Microbacterium Infections

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    Microbacterium species (formerly CDC [Centers for Disease Control and Prevention] coryneform group A-4 and A-5 bacteria) are widely distributed in the environment and rarely cause infections in humans. We present a case of endophthalmitis due to Microbacterium species that occurred after accidental trauma and review the literature on microbacterium infections. If the infected tissue or medical device is removed and antimicrobial therapy (preferably with β-lactams or glycopeptides) is instituted, the prognosis is usually favorable for patients with microbacterium infection

    Антипомпажное регулирование центробежного компрессора

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    Анализ существующих методов и средств регулирования работы центробежных нагнетателей для поиска оптимального варианта антипомпажного регулирования, а также выбор подходящей конструкции регулирующего органа, как устройства для обеспечения газодинамической устойчивости центробежного нагнетателя газоперекачивающего агрегата, устранения колебаний расхода и давления газа в системе "нагнетатель–сеть"Analysis of existing methods and means of regulating the operation of centrifugal blowers to find the optimal version of antisurge control, as well as the choice of a suitable design of the regulating organ as a device for ensuring gas-dynamic stability of a centrifugal blower of a gas compressor unit, eliminating fluctuations in gas flow and pressure in the "supercharger-network

    Anti-Vascular endothelial growth factor therapy impairs endothelial function of retinal microcirculation in colon cancer patients – an observational study

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    Background: To assess acute effects of bevacizumab (anti-VEGF therapy) on cerebral microvessels and systemic cardiovascular regulation. Design and subjects: 20 consecutive patients with colorectal cancer (median age: 60.4 years, range 45.5-73.9 years) received bevacizumab intravenously (5 mg/kg) uncoupled of chemotherapy. Prior to and within the first 24 hours after bevacizumab infusion, patients were investigated for retinal endothelial function. A series of a triple 24-hour ambulatory blood pressure measurement was conducted. Retinal endothelial function was determined as flicker light-induced vasodilation. The integrity of baroreflex arc and autonomic cardiovascular control was examined by stimulatory manoeuvres. Results: Bevacizumab therapy significantly reduced the vasodilatory capacity of retinal arterioles in response to flicker light. A slight decrease in diastolic pressure and heart rate was observed after bevacizumab infusion but this was unrelated to changes in retinal function. The pressure response upon nitroglycerin was largely preserved after bevacizumab infusion. The proportion of patients with abnormal nocturnal blood pressure regulation increased under anti-angiogenic therapy. Autonomic blood pressure control was not affected by bevacizumab treatment. Conclusions: Bevacizumab acutely impairs microvascular function independent of blood pressure changes. Imaging of the retinal microcirculation seems a valuable tool for monitoring pharmacodynamic effects of bevacizumab
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