Experimental validation of an ANN model for random loading fatigue analysis

The use of artificial intelligence especially based on artificial neural networks (ANN) is now prevalent in many fields of data analysis and interpretation. There have been a number of papers published in the literature on the use of ANN for fatigue characterisation. Most of these have however been developed for rather focussed application with limited capability for fatigue life prediction for a broad scope of material and loading conditions. The authors recently presented a uniquely generalised ANN model that is capable of making fatigue life prediction for a broad range of material fatigue properties and loading spectral forms. The model was developed using simulated data albeit subject to conceivable constraints between possible materials properties and load forms. This paper presents a validation of the ANN model using a Society of Automotive Engineers (SAE) random fatigue loading experimental test data. The capabilities and potentials of the model are demonstrated by comparison with the SAE random load fatigue test results and with results obtained from other predictive methods. The performance of the ANN is highly encouraging as a general tool for random loading fatigue analysis

Artificial neural network for random fatigue loading analysis including the effect of mean stress

The effect of mean stress is a significant factor in design for fatigue, especially under high cycle service conditions. The incorporation of mean stress effect in random loading fatigue problems using the frequency domain method is still a challenge. The problem is due to the fact that all cycle by cycle mean stress effects are aggregated during the Fourier transform process into a single zero frequency content. Artificial neural network (ANN) has great scope for non-linear generalization. This paper presents artificial neural network methods for including the effect of mean stress in the frequency domain approach for predicting fatigue damage. The materials considered in this work are metallic alloys. The results obtained present the ANN method as a viable approach to make fatigue damage predictions including the effect of mean stress. Greater resolution was obtained with the ANN method than with other available methods

The Link between Genetic Factors in Children with Febrile Convulsions Appearance

The aim of this research paper is to reflect the link between genetic factors and presenting children with febrile convulsions.Keywords: febrile seizures, genetic factor, the pediatric clinic

Blind prediction of homo- and hetero- protein complexes : The CASP13-CAPRI experiment

We present the results for CAPRI Round 46, the 3rd joint CASP-CAPRI protein assembly prediction challenge. The Round comprised a total of 20 targets including 14 homo-oligomers and 6 hetero-complexes. Eight of the homo-oligomer targets and one hetero-dimer comprised proteins that could be readily modeled using templates from the Protein Data Bank, often available for the full assembly. The remaining 11 targets comprised 5 homo-dimers, 3 hetero-dimers and two higher-order assemblies. These were more difficult to model, as their prediction mainly involved 'ab-initio' docking of subunit models derived from distantly related templates. A total of ~30 CAPRI groups, including 9 automatic servers, submitted on average ~2000 models per target. About 17 groups participated in the CAPRI scoring rounds, offered for most targets, submitting ~170 models per target. The prediction performance, measured by the fraction of models of acceptable quality or higher submitted across all predictors groups, was very good to excellent for the 9 easy targets. Poorer performance was achieved by predictors for the 11 difficult targets, with medium and high quality models submitted for only 3 of these targets. A similar performance 'gap' was displayed by scorer groups, highlighting yet again the unmet challenge of modeling the conformational changes of the protein components that occur upon binding or that must be accounted for in template-based modeling. Our analysis also indicates that residues in binding interfaces were less well predicted in this set of targets than in previous Rounds, providing useful insights for directions of future improvements. This article is protected by copyright. All rights reserved

Blind prediction of homo- and hetero-protein complexes: The CASP13-CAPRI experiment

We present the results for CAPRI Round 46, the third joint CASP-CAPRI protein assembly prediction challenge. The Round comprised a total of 20 targets including 14 homo-oligomers and 6 heterocomplexes. Eight of the homo-oligomer targets and one heterodimer comprised proteins that could be readily modeled using templates from the Protein Data Bank, often available for the full assembly. The remaining 11 targets comprised 5 homodimers, 3 heterodimers, and two higher-order assemblies. These were more difficult to model, as their prediction mainly involved “ab-initio” docking of subunit models derived from distantly related templates. A total of ~30 CAPRI groups, including 9 automatic servers, submitted on average ~2000 models per target. About 17 groups participated in the CAPRI scoring rounds, offered for most targets, submitting ~170 models per target. The prediction performance, measured by the fraction of models of acceptable quality or higher submitted across all predictors groups, was very good to excellent for the nine easy targets. Poorer performance was achieved by predictors for the 11 difficult targets, with medium and high quality models submitted for only 3 of these targets. A similar performance “gap” was displayed by scorer groups, highlighting yet again the unmet challenge of modeling the conformational changes of the protein components that occur upon binding or that must be accounted for in template-based modeling. Our analysis also indicates that residues in binding interfaces were less well predicted in this set of targets than in previous Rounds, providing useful insights for directions of future improvements

Blind prediction of homo- and hetero-protein complexes: The CASP13-CAPRI experiment

International audienceWe present the results for CAPRI Round 46, the third joint CASP‐CAPRI protein assembly prediction challenge. The Round comprised a total of 20 targets including 14 homo‐oligomers and 6 heterocomplexes. Eight of the homo‐oligomer targets and one heterodimer comprised proteins that could be readily modeled using templates from the Protein Data Bank, often available for the full assembly. The remaining 11 targets comprised 5 homodimers, 3 heterodimers, and two higher‐order assemblies. These were more difficult to model, as their prediction mainly involved “ab‐initio” docking of subunit models derived from distantly related templates. A total of ~30 CAPRI groups, including 9 automatic servers, submitted on average ~2000 models per target. About 17 groups participated in the CAPRI scoring rounds, offered for most targets, submitting ~170 models per target. The prediction performance, measured by the fraction of models of acceptable quality or higher submitted across all predictors groups, was very good to excellent for the nine easy targets. Poorer performance was achieved by predictors for the 11 difficult targets, with medium and high quality models submitted for only 3 of these targets. A similar performance “gap” was displayed by scorer groups, highlighting yet again the unmet challenge of modeling the conformational changes of the protein components that occur upon binding or that must be accounted for in template‐based modeling. Our analysis also indicates that residues in binding interfaces were less well predicted in this set of targets than in previous Rounds, providing useful insights for directions of future improvements