Extending Properly n-REA Sets

In [5] Soare and Stob prove that if $A$ is an r.e. set which isn't computable then there is a set of the form $A \oplus W^A_e$ which isn't of r.e. Turing degree. If we define a properly $n+1$-REA set to be an $n+1$-REA set which isn't Turing equivalent to any $n$-REA set (and identify 0-REA sets with the computable sets) this result shows that every properly 1-REA set can be extended to a properly 2-REA set. This result was extended in [1] by Cholak and Hinman who proved that every 2-REA set can be extended to a properly 3-REA set. This leads naturally to the hypothesis that every properly $n$-REA set can be extended to a properly $n+1$-REA set. In this paper, we show this hypothesis is false and that there is a properly $3$-REA set which can't be extended to a properly $4$-REA set

Neogene fluvial landscape evolution in the hyperarid core of the Atacama Desert

Dating of extensive alluvial fan surfaces and fluvial features in the hyperarid core of the Atacama Desert, Chile, using cosmogenic nuclides provides unrivalled insights about the onset and variability of aridity. The predominantly hyperarid conditions help to preserve the traces of episodic climatic and/or slow tectonic change. Utilizing single clast exposure dating with cosmogenic 10Be and 21Ne, we determine the termination of episodes of enhanced fluvial erosion and deposition occurring at ~19, ~14, ~9.5 Ma; large scale fluvial modification of the landscape had ceased by ~2–3 Ma. The presence of clasts that record pre-Miocene exposure ages (~28 Ma and ~34 Ma) require stagnant landscape development during the Oligocene. Our data implies an early onset of (hyper-) aridity in the core region of the Atacama Desert, interrupted by wetter but probably still arid periods. The apparent conflict with interpretation that favour a later onset of (hyper-) aridity can be reconciled when the climatic gradients within the Atacama Desert are considered

Precambrian isotopic sources of the Anti-Atlas, Morocco

The isotopic data stored in detrital and magmatic zircons are crucial for assessing magma sources, terrane correlation, paleogeography and plate reconstructions. In many cases the comparison of the zircon age and isotope signature of a terrane of unknown provenance with the signature of possible sources, generally old cratonic areas, can resolve questions of origin and paleoposition. Obviously, a precise knowledge of the zircon characteristics of these old areas is essential for reliable comparisons. One of the major sources of sediments of the peri-Gondwanan terranes and of the European Variscan Belt is the West African craton. The northern boundary of this craton is the Pan- African Anti-Atlas belt, which is therefore an ideal place to better constrain the zircon isotopic features of sediments sourced from it. With that aim, we obtained LA-ICM-MS U-Pb and Hf isotopic data of more than 600 zircons separated from six samples of siliciclastic sedimentary rocks from the main Neoproterozoic stratigraphic units of the Anti-Atlas belt, from the Sirwa and Zenaga inliers. The data suggest that the north part of the West African craton formed during three cycles of juvenile crust formation, with variable amount of reworking of older crust. The youngest group of zircons, with a main population clustering around 610 Ma, has a predominantly juvenile character and evidence of moderate mixing with Paleoproterozoic crust, suggesting that the igneous and metamorphic rocks in which the zircons originally crystallized were formed in an ensialic magmatic arc environment. A group of zircons with ages in the range 1.79–2.3 Ga corresponds to the major crust forming event in the West African craton: the Eburnian- Birimian orogeny. The isotopic data indicate that the provenance area should represent a crustal domain that separated from a mantle reservoir at ∼2050–2300 Ma, and further evolved with a time-integrated 176Lu/177Hf of ∼0.013, characteristic of continental crust. The evolution of the Eburnian orogeny is apparently dominated by new crust formation in a magmatic arc environment. The Lower Paleoproterozoic and Neoarchean evolution (2.3–2.75 Ga) involves a group of detrital zircon ages that has not been identified up to now in the igneous or metamorphic rocks of the north West African craton basement. Their Hf isotopic signature points to reworking of juvenile crust mixed with moderate amounts of Archean crust. The significance of these ages is uncertain: they could represent a tectonothermal event not discovered yet in the Reguibat Shield or the zircons can be far-travelled from an unknown source.Peer Reviewe

The use of an aircraft test stand for VTOL handling qualities studies

The VTOL flight tests stand for testing control concepts on the X-14B VSS aircraft in hover, is described. This stand permits realistic and safe piloted evaluation and checkout of various control systems and of parameter variations within each system to determine acceptability to the pilot. Pilots can use it as a practical training tool to practice procedures and flying techniques and become familiar with the aircraft characteristics. Some examples of test experience are given. The test stand allows the X14B to maneuver in hover from centered position + or - 9.7 deg in roll and + or - 9.3 deg in pitch, about + or - 6 deg in yaw, and + or - 15 cm in vertical translation. The unique vertical free flight freedom enables study of liftoffs and landings with power conditions duplicated. The response on the stand agrees well with that measured in free hovering flight, and pilot comments confirm this

The time-dependent localization of Ki 67 antigen-positive cells in human skin wounds

A total of 77 human skin wounds with a post-infliction interval between 3 h and 7 months were investigated and the proliferation marker antigen Ki 67 was visualized in paraffin sections using a specific monoclonal antibody (MIB). The re-built epidermal layer covering the former lesional area showed only a few basal cells positively staining for Ki 67 antigen. No enhanced reactivity was found when compared to uninjured skin. In basal cells of the epidermis adjacent to the wound area, however, varying numbers of positive cells occurred, but no information useful for a reliable time estimation of skin wounds could be obtained due to the considerable variability in the number of Ki 67 positive epidermal basal cells found in non-damaged skin. Fibroblastic cells in the wound area revealed an increased number of Ki 67-positive sites which could first be detected in a 1.5-day-old skin lesion. Positive results could be obtained in every specimen investigated after a post-infliction interval of 6 days up to 1.5 months. Only the scar tissue of the oldest wound examined (wound age 7 months) revealed no increase in the number of positively staining fibroblasts. Therefore, positive results indicate a wound age of at least approximately 1.5 days and the lack of an increased number of positive fibroblastic cells in a sufficient number of specimens indicates at a wound age of less than 6 days, but cannot totally exclude longer post-infliction intervals

Environmental Scanning and Knowledge Representation for the Detection of Organised Crime Threats

ePOOLICE aims at developing an efficient and effective strategic early warning system that utilises environmental scanning for the early warning and detection of current, emergent and future organised crime threats. Central to this concept is the use of environmental scanning to detect ‘weak signals’ in the external environment to monitor and identify emergent and future threats prior to their materialization into tangible criminal activity. This paper gives a brief overview of the application of textual concept extraction and categorization, and the Semantic Web technologies Formal Concept Analysis and Conceptual Graphs as part of the systems technological architecture, describing their benefits in aiding effective early warning

MuRF1 mono-ubiquitinates TRα to inhibit T3-induced cardiac hypertrophy in vivo

Thyroid hormone (TH) is recognized for its role in cellular metabolism and growth and participates in homeostasis of the heart. T3 activates pro-survival pathways including Akt and mTOR. Treatment with T3 after myocardial infarction is cardioprotective and promotes elements of physiological hypertrophic response after cardiac injury. Although T3 is known to benefit the heart, very little about its regulation at the molecular level has been described to date. The ubiquitin proteasome system (UPS) regulates nuclear hormone receptors such as estrogen, progesterone, androgen, and glucocorticoid receptors by both degradatory and non-degradatory mechanisms. However, how the UPS regulates T3-mediated activity is not well understood. In this study, we aim to determine the role of the muscle-specific ubiquitin ligase muscle ring finger-1 (MuRF1) in regulating T3-induced cardiomyocyte growth. An increase in MuRF1 expression inhibits T3-induced physiological cardiac hypertrophy, whereas a decrease in MuRF1 expression enhances T3’s activity both in vitro and in cardiomyocytes in vivo. MuRF1 interacts directly with TRα to inhibit its activity by posttranslational ubiquitination in a non-canonical manner. We then demonstrated that a nuclear localization apparatus that regulates/inhibits nuclear receptors by sequestering them within a subcompartment of the nucleus was necessary for MuRF1 to inhibit T3 activity. This work implicates a novel mechanism that enhances the beneficial T3 activity specifically within the heart, thereby offering a potential target to enhance cardiac T3 activity in an organ-specific manner