Network social capital and labour market outcomes Evidence from Ireland

Using data from the International Social Survey Programme 2008 this paper tests empirically the effects of network social capital on Irish employment outcomes, while controlling for possible endogeneity. We allow the effects of social networks to vary for different groups and across different localities. We also test the hypothesis that network social capital works as a complement to human capital in the labour market, rather than as a substitute. We find that social participation and employment are not endogenous and that ‘weak ties’ matter for employment outcomes, whereas ‘strong ties’ are less important. The effects, however, vary across age and location. We also find that social and human capital may be substitutes rather than complements when it comes to the labour market. These findings are discussed with relevance and examples for policy

Transhumanism and the transformation of the experience and spectacle in the art of boxing

Going beyond the biological and physiological limitations imposed on us by the human body is something which the human race has strived to do throughout its history. There is something about our human nature that compels us to strive for improvement and enhancement in our physical and mental performance, and to stretch ever further the boundaries of human accomplishment. Nowhere can a stronger desire for enhanced performance be found than in the realm of competitive sport and, it is certainly arguable that, there are very few sports that can rival the competitiveness, endurance and physical exertion involved in the sport of boxing. Transhumanism is borne of this desire for continuous improvement and the refusal to resign ourselves to the restrictions placed on us by our natural biological constitution and environment, enhancing human capabilities and capacities by way of new and emergent technologies. With regard to sport, transhumanism could provide us with the ability to train longer, run, swim or cycle faster, jump higher, throw further and, in the case of boxing, punch harder. However, it is not restricted or confined to the enhancement of our physical powers, but could equally-well serve to improve our psychological capacities and alter the way in which we perceive and experience the world. In this way transhumanism could be employed to change the content of experience

The ethical problems associated with the creation of a synthetic consciousness

No abstract availabl

Organizing PMODE Dopplergrams of Jupiter with MATLAB

The interiors of the giant planets are poorly known. At the time of writing, such investigations have been limited to measuring gravitational effects from a handful of orbital probes. The most recent attempt to map the interior is via PMODE (the Planetary Multilevel Oscillations and Dynamics Experiment), designed to explore Jupiter’s core by collecting Dopplergrams. Small radial velocity shifts in Jupiter’s upper cloud decks enable us to map its atmospheric dynamics and consequently its interior via Dioseismology (techniques similar to Helioseismology, applied to Jupiter). This campaign produced a vast dataset with more than 50,000 exposures, every 30 seconds, over 24 nights. These unique data currently lack basic archival header information such as pointing locations, planetary latitude, instrumental statistics etc., which makes efficient analysis difficult. Our goal is to collect and insert required information automatically into each individual FITS file header and upload the entire database to NASA’s Planetary Data System for the general scientific community. The indexed catalog will open up a significant wealth of data for further study of Jupiter’s interior. We present the current state of the project, the ultimate end goals, and a plan for future analysis

Pancreas MRI segmentation into head, body, and tail enables regional quantitative analysis of heterogeneous disease

Background: Quantitative imaging studies of the pancreas have often targeted the three main anatomical segments, head, body, and tail, using manual region of interest strategies to assess geographic heterogeneity. Existing automated analyses have implemented whole-organ segmentation, providing overall quantification but failing to address spatial heterogeneity. Purpose: To develop and validate an automated method for pancreas segmentation into head, body, and tail subregions in abdominal MRI. Study Type: Retrospective. Subjects: One hundred and fifty nominally healthy subjects from UK Biobank (100 subjects for method development and 50 subjects for validation). A separate 390 UK Biobank triples of subjects including type 2 diabetes mellitus (T2DM) subjects and matched nondiabetics. Field strength/Sequence: A 1.5 T, three-dimensional two-point Dixon sequence (for segmentation and volume assessment) and a two-dimensional axial multiecho gradient-recalled echo sequence. Assessment: Pancreas segments were annotated by four raters on the validation cohort. Intrarater agreement and interrater agreement were reported using Dice overlap (Dice similarity coefficient [DSC]). A segmentation method based on template registration was developed and evaluated against annotations. Results on regional pancreatic fat assessment are also presented, by intersecting the three-dimensional parts segmentation with one available proton density fat fraction (PDFF) image. Statistical Test: Wilcoxon signed rank test and Mann–Whitney U-test for comparisons. DSC and volume differences for evaluation. A P value  Results: Good intrarater (DSC mean, head: 0.982, body: 0.940, tail: 0.961) agreement and interrater (DSC mean, head: 0.968, body: 0.905, tail: 0.943) agreement were observed. No differences (DSC, head: P = 0.4358, body: P = 0.0992, tail: P = 0.1080) were observed between the manual annotations and our method's segmentations (DSC mean, head: 0.965, body: 0.893, tail: 0.934). Pancreatic body PDFF was different between T2DM and nondiabetics matched by body mass index. Data Conclusion: The developed segmentation's performance was no different from manual annotations. Application on type 2 diabetes subjects showed potential for assessing pancreatic disease heterogeneity. Level of Evidence: 4 Technical Efficacy Stage: 3

Expression of the Id family helix-loop-helix regulators during growth and development in the hematopoietic system

To better understand the molecular mechanism(s) by which growth and differentiation of the primitive hematopoietic stem cell is initiated, as well as the means by which the maturing cell can commit to development along a specific cell lineage, we elected to study the Id family of helix-loop-helix (HLH) transcriptional regulators. Some members of the HLH family are expressed in a stage-specific manner during hematopoietic development and can regulate the ability of immature hematopoietic cells to terminally differentiate. None of the four Id family genes were detected in the most primitive progenitors. Id-1 was widely expressed in proliferating bi- and unipotential progenitors, but its expression was downregulated in cells of increasing maturity; conversely, Id-2 and, to a limited extent, Id-3 gene expression increased as cells matured and lost proliferative capacity. Id-2 expression ran counter to that of Id-1 not only during maturation, but during periods of cell growth and arrest as well. This is quite distinct from the nonhematopoietic tissues, in which these two factors are coordinately expressed and suggests that Id-1 and Id-2 might be regulating very different events during hematopoiesis than they regulate in other cell types

Quantitative magnetic resonance imaging predicts individual future liver performance after liver resection for cancer

The risk of poor post-operative outcome and the benefits of surgical resection as a curative therapy require careful assessment by the clinical care team for patients with primary and secondary liver cancer. Advances in surgical techniques have improved patient outcomes but identifying which individual patients are at greatest risk of poor post-operative liver performance remains a challenge. Here we report results from a multicentre observational clinical trial (ClinicalTrials.gov NCT03213314) which aimed to inform personalised pre-operative risk assessment in liver cancer surgery by evaluating liver health using quantitative multiparametric magnetic resonance imaging (MRI). We combined estimation of future liver remnant (FLR) volume with corrected T1 (cT1) of the liver parenchyma as a representation of liver health in 143 patients prior to treatment. Patients with an elevated preoperative liver cT1, indicative of fibroinflammation, had a longer post-operative hospital stay compared to those with a cT1 within the normal range (6.5 vs 5 days; p = 0.0053). A composite score combining FLR and cT1 predicted poor liver performance in the 5 days immediately following surgery (AUROC = 0.78). Furthermore, this composite score correlated with the regenerative performance of the liver in the 3 months following resection. This study highlights the utility of quantitative MRI for identifying patients at increased risk of poor post-operative liver performance and a longer stay in hospital. This approach has the potential to inform the assessment of individualised patient risk as part of the clinical decision-making process for liver cancer surgery