Big data to optimise product strategy in electronic industry

This research identifies the success factors for new product development and competitive advantage as well as argues how big data can expedite the process of launching a new product initiative. By combining the research findings and the patterns of background theories, an inquisitive framework for the new product development and competitive advantage is proposed. This model and framework is a prototype, which with the aid of scenario recommends the parsimonious and an unified way to elucidate the requisite of the market analysis, organizational potential and customer insights for product strategy and competitive advantage

Tackling Fuel Poverty in London

The challenge of economic and health inequalities caused by fuel poverty are rooted in the rise in fuel costs which have strong implications affecting the cost of living. Fuel costs and rising inflation due to economic and political reasons threaten individuals and families who are already struggling financially, putting them in/at risk of fuel poverty. The UK is one of the first countries to define the challenge of households living in fuel poverty prompting necessary actions, policies and interventions. This study presents the results of an empirical investigation following direct enquires to the Greater London Authority (GLA) and all of London boroughs via Freedom of Information (FOI) requests on retrofit interventions, including an overview of financial incentives and planning assessments with an aim to increase the number of home energy upgrades since April 2021. London adopted its own action plan in 2018 to renew its focus and alleviate more than 350,000 households in fuel poverty (GLA, 2018). The assessment and indicator for fuel poverty has changed over time, from the Low Income High Cost (LIHC) to Low Income Low Energy Efficiency (LILEE) indicator in 2021. However, identifying households in fuel poverty remains challenging and some indicators are somewhat disconnected from what is happening on the ground. The findings suggest that there is a need to establish tools and methodologies that are connected to the national and local context. Fuel poverty is affecting people’s health and well-being, particularly those already facing socio-economic and health inequalities. After the COVID pandemic, a political awareness of fuel poverty is found in the Mayoral manifesto, however the Fuel Poverty Action Plan does not have binding targets and is not regularly updated. Current Fuel Poverty Partnership Tasks are focusing on awareness and communication or the urgent support to households already affected, but not in tackling the root causes of fuel poverty in upgrading fuel poor homes. The uptake on retrofits from 2021 is still low and far from reaching 100k homes and the net zero target in 2030 is approaching fast. The study concludes that while LILEE is decreasing other indicators are increasing with rising energy prices. The London Building Stock Model is not widely used by boroughs, and it only maps the Energy Performance Certificate (EPC) rating which is not sufficient to identify households in fuel poverty. Most schemes such as Energy Companies Obligation (ECO) do not specifically target fuel poverty but have a wider scope of retrofit towards net zero. The Mayor of London should explore a new indicator tool by crossing data from LBSM with socio-economic data to identify fuel poor households more accurately. The indicator could potentially include geographical location, building typology (age, etc), socio-economic / demographics, leading to action plan and retrofit strategies

Colossal Tunneling Electroresistance in Co-Planar Polymer Ferroelectric Tunnel Junctions

Ferroelectric tunnel junctions (FTJs) are ideal resistance-switching devices due to their deterministic behavior and operation at low voltages. However, FTJs have remained mostly as a scientific curiosity due to three critical issues: lack of rectification in their current-voltage characteristic, small tunneling electroresistance (TER) effect, and absence of a straightforward lithography-based device fabrication method that would allow for their mass production. Co-planar FTJs that are fabricated using wafer-scale adhesion lithography technique are demonstrated, and a bi-stable rectifying behavior with colossal TER approaching 106% at room temperature is exhibited. The FTJs are based on poly(vinylidenefluoride-co-trifluoroethylene) [P(VDF-TrFE)], and employ asymmetric co-planar metallic electrodes separated by &lt;20 nm. The tunneling nature of the charge transport is corroborated using Simmons direct tunneling model. The present work is the first demonstration of functional FTJs manufactured via a scalable lithography-based nano-patterning technique and could pave the way to new and exciting memory device concepts.</p

Comparing Health-Related Quality of Life of Cancer Patients under Chemotherapy and of Their Caregivers

Introduction. Cancer is a major disorder physically and psychologically affecting both patients and their caregivers. In this study, health-related quality of life (HRQoL) of patient-caregiver dyads during the period of chemotherapy was assessed. Material and Methods. Two hundred twenty-two cancer patient-caregiver dyads were enrolled in the study, which was conducted from October 2008 to March 2009. HRQoL was evaluated with EQ-5D. Results. The mean age of the sample was 57.4 and 48.9 for patients and caregivers, respectively. The EQ-5D descriptive system indicates that female patients more frequently experience anxiety and depression than male patients. Male and higher-education caregivers had higher VAS scores, while demographic factors did not seem to influence patients' HRQoL. Anxiety and depression of caregivers were correlated with patients' problems in self-care and usual activities. Conclusions. Quality of life is highly influenced during the period of chemotherapy for both patients and caregivers and is often under reported. Interventions that can improve HRQoL, especially in the domain of mental health for both cancer patients and their caregivers, need to be implemented

XUV digital in-line holography using high-order harmonics

A step towards a successful implementation of timeresolved digital in-line holography with extreme ultraviolet radiation is presented. Ultrashort XUV pulses are produced as high-order harmonics of a femtosecond laser and a Schwarzschild objective is used to focus harmonic radiation at 38 nm and to produce a strongly divergent reference beam for holographic recording. Experimental holograms of thin wires are recorded and the objects reconstructed. Descriptions of the simulation and reconstruction theory and algorithms are also given. Spatial resolution of few hundreds of nm is potentially achievable, and micrometer resolution range is demonstrated.Comment: 8 pages, 8 figure

The dark side of meaningful work‐from‐home: A nonlinear approach

Changes in the technological environment of work already in motion over the last few years, but accelerated by the COVID-19 pandemic, place individuals' search for meaningfulness in their work under a new light. In this context, we draw on enrichment theory and the ego-depletion perspective and challenge the prevailing notion that meaningfulness is always positive and hypothesize that, under certain conditions, there can be such a thing as “too much meaningfulness.” A two-wave study of 243 full-time employees working from home during the COVID-19 pandemic in the United States offers support for a nonlinear effect of meaningfulness of work for workaholics, such that it has a positive effect on individuals up to a certain point, but a negative effect if there are excessive amounts of meaningfulness. We discuss these findings in light of the debate around the moral duty of managers and firms to offer meaningful jobs to employees and offer practical suggestions for firms

Modelling pathogen load dynamics to elucidate mechanistic determinants of host-Plasmodium falciparum interactions

During infection, increasing pathogen load stimulates both protective and harmful aspects of the host response. The dynamics of this interaction are hard to quantify in humans, but doing so could improve understanding of mechanisms of disease and protection. We sought to model the contributions of parasite multiplication rate and host response to observed parasite load in individual subjects with Plasmodium falciparum malaria, using only data obtained at the time of clinical presentation, and then to identify their mechanistic correlates. We predicted higher parasite multiplication rates and lower host responsiveness in severe malaria cases, with severe anemia being more insidious than cerebral malaria. We predicted that parasite growth-inhibition was associated with platelet consumption, lower expression of CXCL10 and type-1 interferon-associated genes, but increased cathepsin G and matrix metallopeptidase 9 expression. We found that cathepsin G and matrix metallopeptidase 9 directly inhibit parasite invasion into erythrocytes. Parasite multiplication rate was associated with host iron availability and higher complement factor H levels, lower expression of gametocyte-associated genes but higher expression of translation-associated genes in the parasite. Our findings demonstrate the potential of using explicit modelling of pathogen load dynamics to deepen understanding of host-pathogen interactions and identify mechanistic correlates of protection