AS-204/LM-1 L/V operational alternate mission trajectories

Operational alternate mission trajectories of AS-204 LM-1 launch vehicl

AS-204/LM-1 launch vehicle operational flight trajectory

Apollo Saturn-204/LM-1 launch vehicle operational flight trajector

Advanced 3D TH and THM Modeling to Shed Light on Thermal Convection in Fault Zones With Varying Thicknesses

Fault zones exhibit 3D variable thickness, a feature that remains inadequately explored, particularly with regard to the impact on fluid flow. Upon analyzing an analytic solution, we examine 3D thermal-hydraulic (TH) dynamical models through a benchmark experiment, which incorporates a fault zone with thickness variations corresponding to realistic orders of magnitude. The findings emphasize an area of interest where vigorous convection drives fluid flow, resulting in a temperature increase to 150°C at a shallow depth of 2.7 km in the thickest sections of the fault zone. Moreover, by considering various tectonic regimes (compressional, extensional, and strike-slip) within 3D thermal-hydraulic-mechanical (THM) models and comparing them to the benchmark experiment, we observe variations in fluid pressure induced by poroelastic forces acting on fluid flow within the area of interest. These tectonic-induced pressure changes influence the thermal distribution of the region and the intensity of temperature anomalies. Outcomes of this study emphasize the impact of poroelasticity-driven forces on transfer processes and highlight the importance of addressing fault geometry as a crucial parameter in future investigations of fluid flow in fractured systems. Such research has relevant applications in geothermal energy, CO2 storage, and mineral deposits

Fear Learning for Flexible Decision Making in RoboCup: A Discussion

In this paper, we address the stagnation of RoboCup com- petitions in the fields of contextual perception, real-time adaptation and flexible decision-making, mainly in regards to the Standard Platform League (SPL). We argue that our Situation-Aware FEar Learning (SAFEL) model has the necessary tools to leverage the SPL competition in these fields of research, by allowing robot players to learn the behaviour profile of the opponent team at runtime. Later, players can use this knowledge to predict when an undesirable outcome is imminent, thus having the chance to act towards preventing it. We discuss specific scenarios where SAFEL’s associative learning could help to increase the positive outcomes of a team during a soccer match by means of contextual adaptation

Telavancin versus Vancomycin for Hospital-Acquired Pneumonia due to Gram-positive Pathogens

The results from two methodologically identical double-blind studies indicate that telavancin is noninferior to vancomycin based on clinical response in the treatment of hospital-acquired pneumonia due to Gram-positive pathogens

Estimating food production in an urban landscape

There is increasing interest in urban food production for reasons of food security, environmental sustainability, social and health benefits. In developed nations urban food growing is largely informal and localised, in gardens, allotments and public spaces, but we know little about the magnitude of this production. Here we couple own-grown crop yield data with garden and allotment areal surveys and urban fruit tree occurrence to provide one of the first estimates for current and potential food production in a UK urban setting. Current production is estimated to be sufficient to supply the urban population with fruit and vegetables for about 30 days per year, while the most optimistic model results suggest that existing land cultivated for food could supply over half of the annual demand. Our findings provide a baseline for current production whilst highlighting the potential for change under the scaling up of cultivation on existing land

At Least Ten Genes Define the Imprinted Dlk1-Dio3 Cluster on Mouse Chromosome 12qF1

Background: Genomic imprinting is an exception to Mendelian genetics in that imprinted genes are expressed monoallelically, dependent on parental origin. In mammals, imprinted genes are critical in numerous developmental and physiological processes. Aberrant imprinted gene expression is implicated in several diseases including Prader-Willi/ Angelman syndromes and cancer. Methodology/Principal Findings: To identify novel imprinted genes, transcription profiling was performed on two uniparentally derived cell lines, androgenetic and parthenogenetic primary mouse embryonic fibroblasts. A maternally expressed transcript termed Imprinted RNA near Meg3/Gtl2 (Irm) was identified and its expression studied by Northern blotting and whole mounts in situ hybridization. The imprinted region that contains Irm has a parent of origin effect in three mammalian species, including the sheep callipyge locus. In mice and humans, both maternal and paternal uniparental disomies (UPD) cause embryonic growth and musculoskeletal abnormalities, indicating that both alleles likely express essential genes. To catalog all imprinted genes in this chromosomal region, twenty-five mouse mRNAs in a 1.96Mb span were investigated for allele specific expression. Conclusions/Significance: Ten imprinted genes were elucidated. The imprinting of three paternally expressed protein coding genes (Dlk1, Peg11, and Dio3) was confirmed. Seven noncoding RNAs (Meg3/Gtl2, Anti-Peg11, Meg8, Irm/‘‘Rian’’