51 research outputs found
Recommended from our members
A high-resolution map of human evolutionary constraint using 29 mammals.
- Author
- Alföldi Jessica
- Baldwin Jen
- Baylor College of Medicine Human Genome Sequencing Center Sequencing Team
- Beal Kathryn
- Birney Ewan
- Bloom Toby
- Broad Institute Sequencing Platform and Whole Genome Assembly Team
- Chang Jean
- Chin Chee Whye
- Clamp Michele
- Clawson Hiram
- Cree Andrew
- Cuff James
- Delehaunty Kim
- Di Palma Federica
- Dihn Huyen H
- Dooling David
- Ernst Jason
- Fitzgerald Stephen
- Flicek Paul
- Fowler Gerald
- Fronik Catrina
- Fulton Bob
- Fulton Lucinda
- Garber Manuel
- Genome Institute at Washington University
- Gibbs Richard A
- Gnerre Sante
- Goldman Nick
- Graves Tina
- Green Eric D
- Guttman Mitchell
- Haussler David
- Heiman Dave
- Herrero Javier
- Holloway Alisha K
- Hubisz Melissa J
- Jaffe David B
- Jhangiani Shalili
- Jordan Gregory
- Joshi Vandita
- Jungreis Irwin
- Kellis Manolis
- Kent W James
- Kheradpour Pouya
- Kostka Dennis
- Kovar Christie L
- Lander Eric S
- Lara Marcia
- Lee Sandra
- Lewis Lora R
- Lin Michael F
- Lindblad-Toh Kerstin
- Lowe Craig B
- Mardis Elaine R
- Margulies Elliott H
- Martins Andre L
- Massingham Tim
- Mauceli Evan
- Minx Patrick
- Moltke Ida
- Muzny Donna M
- Nazareth Lynne V
- Nicol Robert
- Nusbaum Chad
- Okwuonu Geoffrey
- Parker Brian J
- Pedersen Jakob S
- Pollard Katherine S
- Raney Brian J
- Rasmussen Matthew D
- Robinson Jim
- Santibanez Jireh
- Siepel Adam
- Sodergren Erica
- Stark Alexander
- Vilella Albert J
- Ward Lucas D
- Warren Wesley C
- Washietl Stefan
- Weinstock George M
- Wen Jiayu
- Wilkinson Jane
- Wilson Richard K
- Worley Kim C
- Xie Xiaohui
- Young Sarah
- Zody Michael C
- Zuk Or
- Publication venue
- eScholarship, University of California
- Publication date
- 01/10/2011
- Field of study
The comparison of related genomes has emerged as a powerful lens for genome interpretation. Here we report the sequencing and comparative analysis of 29 eutherian genomes. We confirm that at least 5.5% of the human genome has undergone purifying selection, and locate constrained elements covering ∼4.2% of the genome. We use evolutionary signatures and comparisons with experimental data sets to suggest candidate functions for ∼60% of constrained bases. These elements reveal a small number of new coding exons, candidate stop codon readthrough events and over 10,000 regions of overlapping synonymous constraint within protein-coding exons. We find 220 candidate RNA structural families, and nearly a million elements overlapping potential promoter, enhancer and insulator regions. We report specific amino acid residues that have undergone positive selection, 280,000 non-coding elements exapted from mobile elements and more than 1,000 primate- and human-accelerated elements. Overlap with disease-associated variants indicates that our findings will be relevant for studies of human biology, health and disease
Recommended from our members
Integrated genomic and molecular characterization of cervical cancer.
- Author
- Albert Einstein College of Medicine
- Analytical Biological Services
- Barretos Cancer Hospital
- Baylor College of Medicine
- Beckman Research Institute of City of Hope
- Buck Institute for Research on Aging
- Canada's Michael Smith Genome Sciences Centre
- Cancer Genome Atlas Research Network
- Eli &Edythe L. Broad Institute of Massachusetts Institute of Technology &Harvard University
- Harvard Medical School
- Helen F. Graham Cancer Center &Research Institute at Christiana Care Health Services
- HudsonAlpha Institute for Biotechnology
- ILSbio LLC
- Indiana University School of Medicine
- Institute for Systems Biology
- Institute of Human Virology
- International Genomics Consortium
- Leidos Biomedical
- Massachusetts General Hospital
- McDonnell Genome Institute at Washington University
- Medical College of Wisconsin
- Medical University of South Carolina
- Memorial Sloan Kettering Cancer Center
- Montefiore Medical Center
- NantOmics
- National Cancer Institute
- National Hospital Abuja, Nigeria
- National Human Genome Research Institute
- National Institute of Environmental Health Sciences
- National Institute on Deafness &Other Communication Disorders
- Ontario Tumour Bank London Health Sciences Centre
- Ontario Tumour Bank Ontario Institute for Cancer Research
- Ontario Tumour Bank The Ottawa Hospital
- Oregon Health &Science University
- Research Institute at Nationwide Children's Hospital
- Samuel Oschin Comprehensive Cancer Institute Cedars-Sinai Medical Center
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University
- SRA International
- St Joseph's Candler Health System
- University of Abuja Teaching Hospital
- University of Alabama at Birmingham
- University of Bergen
- University of California Santa Cruz
- University of California Irvine
- University of Kansas Medical Center
- University of Lausanne
- University of New Mexico Health Sciences Center
- University of North Carolina at Chapel Hill
- University of Oklahoma Health Sciences Center
- University of Pittsburgh
- University of Southern California
- University of São Paulo Ribeir ão Preto Medical School
- University of Texas MD Anderson Cancer Center
- University of Washington
- University of Wisconsin School of Medicine &Public Health
- Van Andel Research Institute
- Washington University in St Louis
- Publication venue
- eScholarship, University of California
- Publication date
- 01/03/2017
- Field of study
Cervical cancer remains one of the leading causes of cancer-related deaths worldwide. Here we report the extensive molecular characterization of 228 primary cervical cancers, one of the largest comprehensive genomic studies of cervical cancer to date. We observed notable APOBEC mutagenesis patterns and identified SHKBP1, ERBB3, CASP8, HLA-A and TGFBR2 as novel significantly mutated genes in cervical cancer. We also discovered amplifications in immune targets CD274 (also known as PD-L1) and PDCD1LG2 (also known as PD-L2), and the BCAR4 long non-coding RNA, which has been associated with response to lapatinib. Integration of human papilloma virus (HPV) was observed in all HPV18-related samples and 76% of HPV16-related samples, and was associated with structural aberrations and increased target-gene expression. We identified a unique set of endometrial-like cervical cancers, comprised predominantly of HPV-negative tumours with relatively high frequencies of KRAS, ARID1A and PTEN mutations. Integrative clustering of 178 samples identified keratin-low squamous, keratin-high squamous and adenocarcinoma-rich subgroups. These molecular analyses reveal new potential therapeutic targets for cervical cancers
Recommended from our members
Integrated genomic and molecular characterization of cervical cancer.
- Author
- Albert Einstein College of Medicine
- Analytical Biological Services
- Barretos Cancer Hospital
- Baylor College of Medicine
- Beckman Research Institute of City of Hope
- Buck Institute for Research on Aging
- Canada's Michael Smith Genome Sciences Centre
- Cancer Genome Atlas Research Network
- Eli &Edythe L. Broad Institute of Massachusetts Institute of Technology &Harvard University
- Harvard Medical School
- Helen F. Graham Cancer Center &Research Institute at Christiana Care Health Services
- HudsonAlpha Institute for Biotechnology
- ILSbio LLC
- Indiana University School of Medicine
- Institute for Systems Biology
- Institute of Human Virology
- International Genomics Consortium
- Leidos Biomedical
- Massachusetts General Hospital
- McDonnell Genome Institute at Washington University
- Medical College of Wisconsin
- Medical University of South Carolina
- Memorial Sloan Kettering Cancer Center
- Montefiore Medical Center
- NantOmics
- National Cancer Institute
- National Hospital Abuja, Nigeria
- National Human Genome Research Institute
- National Institute of Environmental Health Sciences
- National Institute on Deafness &Other Communication Disorders
- Ontario Tumour Bank London Health Sciences Centre
- Ontario Tumour Bank Ontario Institute for Cancer Research
- Ontario Tumour Bank The Ottawa Hospital
- Oregon Health &Science University
- Research Institute at Nationwide Children's Hospital
- Samuel Oschin Comprehensive Cancer Institute Cedars-Sinai Medical Center
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University
- SRA International
- St Joseph's Candler Health System
- University of Abuja Teaching Hospital
- University of Alabama at Birmingham
- University of Bergen
- University of California Santa Cruz
- University of California Irvine
- University of Kansas Medical Center
- University of Lausanne
- University of New Mexico Health Sciences Center
- University of North Carolina at Chapel Hill
- University of Oklahoma Health Sciences Center
- University of Pittsburgh
- University of Southern California
- University of São Paulo Ribeir ão Preto Medical School
- University of Texas MD Anderson Cancer Center
- University of Washington
- University of Wisconsin School of Medicine &Public Health
- Van Andel Research Institute
- Washington University in St Louis
- Publication venue
- eScholarship, University of California
- Publication date
- 01/03/2017
- Field of study
Cervical cancer remains one of the leading causes of cancer-related deaths worldwide. Here we report the extensive molecular characterization of 228 primary cervical cancers, one of the largest comprehensive genomic studies of cervical cancer to date. We observed notable APOBEC mutagenesis patterns and identified SHKBP1, ERBB3, CASP8, HLA-A and TGFBR2 as novel significantly mutated genes in cervical cancer. We also discovered amplifications in immune targets CD274 (also known as PD-L1) and PDCD1LG2 (also known as PD-L2), and the BCAR4 long non-coding RNA, which has been associated with response to lapatinib. Integration of human papilloma virus (HPV) was observed in all HPV18-related samples and 76% of HPV16-related samples, and was associated with structural aberrations and increased target-gene expression. We identified a unique set of endometrial-like cervical cancers, comprised predominantly of HPV-negative tumours with relatively high frequencies of KRAS, ARID1A and PTEN mutations. Integrative clustering of 178 samples identified keratin-low squamous, keratin-high squamous and adenocarcinoma-rich subgroups. These molecular analyses reveal new potential therapeutic targets for cervical cancers
Integrated analysis of virus and host transcriptomes in cervical cancer in Asian and Western populations
- Author
- Adams
- Ajiro
- Akogbe
- Ashburner
- Burghardt
- C. The Gene Ontology
- Cancer Genome Atlas Research Network Albert Einstein College of Medicine, Analytical Biological Services, Barretos Cancer Hospital, Baylor College of Medicine, Beckman Research Institute of City of Hope, Buck Institute for Research on Aging, Canada's Michael Smith Genome Sciences Centre, Harvard Medical School, Helen F. Graham Cancer Center, Research Institute at Christiana Care Health Services, HudsonAlpha Institute for Biotechnology, Ilsbio L. L. C., Indiana University School of Medicine, Institute of Human Virology, Institute for Systems Biology, International Genomics Consortium, Leidos Biomedical, Massachusetts General Hospital, McDonnell Genome Institute at Washington University, Medical College of Wisconsin, Medical University of South Carolina, Memorial Sloan Kettering Cancer Center, C. Montefiore Medical, NantOmics, I. National Cancer, A.N. National Hospital, I. National Human Genome Research, S. National Institute of Environmental Health, D. National Institute on, D. Other Communication, L.H.S.C. Ontario Tumour Bank, O.I.f.C.R. Ontario Tumour Bank, T.O.H. Ontario Tumour Bank, H. Oregon, U. Science, C.-S.M.C. Samuel Oschin Comprehensive Cancer Institute, S.R.A. International, S. St Joseph's Candler Health, Eli, L.B.I.o.M.I.o.T. Edythe, U. Harvard, H. Research Institute at Nationwide Children's, U. Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, B. University of, M.D.A.C.C. University of Texas, H. University of Abuja Teaching, B. University of Alabama at, I. University of California, C. University of California Santa, C. University of Kansas Medical, L. University of, C. University of New Mexico Health Sciences, H. University of North Carolina at Chapel, C. University of Oklahoma Health Sciences, P. University of, R.a.P.M.S. University of Sao Paulo, C. University of Southern, W. University of, M. University of Wisconsin School of, H. Public, I. Van Andel Research, L. Washington University in St
- Chan
- Chanmee
- Choi
- Crosbie
- den Boon
- Gao
- Hu
- Hu
- Jeon
- Jia
- Kapranov
- Kelly
- Kim
- Li
- Lin
- Liu
- Maher
- Mandal
- Matsukura
- McPherson
- Menderes
- Newman
- Ojesina
- Patel
- Peitsaro
- Pertea
- Pyeon
- Richards
- S. National Center for Health Health, United States
- Sakaguchi
- Schwartz
- Scott
- Simpson
- Therneau
- Thorland
- Venuti
- Viens
- Wentzensen
- Xi
- Xia
- Yuan
- Zhao
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study
The AKR1B1 inhibitor epalrestat suppresses the progression of cervical cancer
- Author
- A Adey
- A Schwab
- B Yang
- Cancer Genome Atlas Research N Albert Einstein College of M, Analytical Biological S, Barretos Cancer H, Baylor College of M, Beckman Research Institute of City of H, Buck Institute for Research on A, Canada's Michael Smith Genome Sciences C, Harvard Medical S, Helen FGCC, Research Institute at Christiana Care Health S, HudsonAlpha Institute for B, Ilsbio LLC, Indiana University School of M, Institute of Human V, Institute for Systems B, International Genomics C, Leidos B, Massachusetts General H, McDonnell Genome Institute at Washington U, Medical College of W, Medical University of South C, Memorial Sloan Kettering Cancer C, Montefiore Medical C, NantOmics, National Cancer I, National Hospital AN, National Human Genome Research I, National Institute of Environmental Health S, National Institute on D, Other Communication D, Ontario Tumour Bank LHSC, Ontario Tumour Bank OIfCR, Ontario Tumour Bank TOH, Oregon H, Science U, Samuel Oschin Comprehensive Cancer Institute C-SMC, International SRA, St Joseph's Candler Health S, Eli, Edythe LBIoMIoT, Harvard U, Research Institute at Nationwide Children's H, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins U, University of B, University of Texas MDACC, University of Abuja Teaching H, University of Alabama at B, University of California I, University of California Santa C, University of Kansas Medical C, University of L, University of New Mexico Health Sciences C, University of North Carolina at Chapel H, University of Oklahoma Health Sciences C, University of P, University of Sao Paulo RaPMS, University of Southern C, University of W, University of Wisconsin School of M, Public H, Van Andel Research I, Washington University in St L
- CT Charlesworth
- D Gupta
- F Bray
- F Janku
- F Zhao
- Feng Jiang
- G Hoxhaj
- GA Koning
- H Li
- I Crespo
- J He
- JE Torres-Mena
- Jie Ji
- Juan Zhou
- K Taniguchi
- K Yama
- KA Reddy
- KT Simms
- L Zhang
- M Drolet
- M Gomez-Herranz
- M Plebuch
- MB Xiao
- Min-Xue Xu
- Ming-Bing Xiao
- MJ Zhou
- PA Cohen
- R Gupta
- RBS Roden
- RE Sachs
- RL Siegel
- S Li
- S Suomela
- S Yao
- Sheng-Ze Zhu
- SQ Zhang
- SR Ferdosi
- T Malagon
- Tian-Yang Qian
- V Cheriyath
- V Cheriyath
- V Cheriyath
- V Keskar
- VK Pidugu
- VT Banala
- W Zhang
- W Zheng
- Wei-Song Xu
- X Chen
- X Wu
- XH Zhang
- Y Liu
- Z Pan
- Zhao-Xiu Liu
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
An effective and biocompatible polyethylenimine based vaginal suppository for gene delivery
- Author
- Benjaminsen
- Bogani
- Chun Gao
- Ci Ren
- Ciavattini
- Connell
- Crosbie
- Da Zhu
- Dai
- Deverman
- Ding
- Feng
- Fichorova
- Gardlik
- Geleoc
- Ghorab
- Ginsburg
- Gomaa
- Guo
- Harper
- Hazelbag
- Hildesheim
- Hu
- Hu
- Hui Shen
- Hui Wang
- Husain
- Jeong
- Jinfeng Xiong
- Joura
- Kaufmann
- Kawana
- Killock
- Kircheis
- Kyongo
- Li
- Liming Wang
- Lu Mao
- Matsumoto
- N. Cancer Genome Atlas Research M. Albert Einstein College of, S. Analytical Biological, H. Barretos Cancer, M. Baylor College of, H. Beckman Research Institute of City of, A. Buck Institute for Research on, C. Canada's Michael Smith Genome Sciences, S. Harvard Medical, F. G. C. C. Helen, S. Research Institute at Christiana Care Health, B. Hudson Alpha Institute for, L. L. C. Ilsbio, M. Indiana University School of, V. Institute of Human, B. Institute for Systems, C. International Genomics, B. Leidos, H. Massachusetts General, U. McDonnell Genome Institute at Washington, W. Medical College of, C. Medical University of South, C. Memorial Sloan Kettering Cancer, C. Montefiore Medical, NantOmics, I. National Cancer, A. N. National Hospital, I. National Human Genome Research, S. National Institute of Environmental Health, D. National Institute on, D. Other Communication, L. H. S. C. Ontario Tumour Bank, O. I. f. C. R. Ontario Tumour Bank, T. O. H. Ontario Tumour Bank, H. Oregon, U. Science, C.-S. M. C. Samuel Oschin Comprehensive Cancer Institute, S. R. A. International, S. St Joseph's Candler Health, Eli, L. B. I. o. M. I. o. T. Edythe, U. Harvard, H. Research Institute at Nationwide Children's, U. Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, B. University of, M. D. A. C. C. University of Texas, H. University of Abuja Teaching, B. University of Alabama at, I. University of California, C. University of California Santa, C. University of Kansas Medical, L. University of, C. University of New Mexico Health Sciences, H. University of North Carolina at Chapel, C. University of Oklahoma Health Sciences, P. University of, R. a. P. M. S. University of Sao Paulo, C. University of Southern, W. University of, M. University of Wisconsin School of, H. Public, I. Van Andel Research, and L. Washington University in St
- Neu
- Nixon
- Norman
- Oberlin
- Palliser
- Pan
- Pandey
- Paradkar
- Peng
- Perevyazko
- Prue
- Rodriguez-Gascon
- Ryu
- Steinbach
- Trimble
- Vernejoul
- Wencheng Ding
- Wilson
- Wilson
- Wirth
- Woodrow
- Xia
- Xiaomin Li
- Yin
- Yin
- Yue
- Yue
- Zhang
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study
Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia
- Author
- Aaron Black
- Adrian Ally
- Aly Karsan
- An He
- Andy Chu
- Angela Tam
- Anna L. Chu
- Ari Kahn
- B. A. S. C.
- B. A. S. C.
- B. S. c. M. S.
- B. S. C.
- B. S. C.
- B. S. C.
- B. S. C.
- B. S. C.
- B. S. C.
- B. S. C.
- B. S. C.
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- B. S. C.
- B. S. C.
- B. S. C.
- B. S. C.
- B. S. C.
- B. S. C.
- B. A.
- B. A.
- B. A.
- B. E.
- B. S.
- B. S.
- B. S.
- B. S.
- B. S.
- B. S.
- B. S.
- B. S.
- B. S.
- Baltimore
- Baty Jack D.
- Bethesda Md
- Bethesda Md
- Bethesda Md
- Bethesda Md
- Biotechnology Consultant Boston
- Bradley A. Ozenberger
- Bradley M. Broom
- Brenda Ayala
- British Columbia Cancer Agency's Genome Sciences Centre
- Broad Institute of Harvard
- Brown University
- Cambridge Ma
- Carrie Hirst
- Carrie Sougnez
- Center for Computational Molecular Biology
- Charles Lu
- Chicago
- Christopher Adams
- Columbus Oh
- Daniel C. Link M. D.
- Daniel J. Weisenberger
- Darlene Lee
- David A. Pot
- David E. Larson
- David H. Spencer
- David J. Van Den Berg
- Deepak Srinivasan
- Ding Li
- Division of Medical Oncology
- Dominik Stoll
- Dominique L. Berton
- Elaine R. Mardis
- Epigenome Center
- Eric E. Snyder
- Eric Chuah
- Erin Pleasance
- F. A. C. M. G.
- Fairfax Va
- Fred Hutchinson Cancer Research Center
- Frederick Applebaum
- Fulton Lucinda L.
- Fulton Robert
- Gad Getz
- Greg Eley
- Hagop Kantarjian M. D.
- Haiyan I. Li
- Heath Sharon E.
- Heather Schmidt
- Heidi J. Sofia
- Hoadley Katherine
- Houston
- Houston
- Hsin Ta Wu
- Hui Shen
- Hye Jung Chun
- Inanc Birol
- Jacqueline Payton
- Jacquie Schein
- James R. Downing
- Jay Bowen
- Jean Pierre J. Issa
- Jeremy Parker
- Jessica Walton
- John A. Demchok
- John F. Dipersio
- John N. Weinstein
- John W. Wallis
- John Welch
- Johns Hopkins University
- Joshua F. Mcmichael
- Jude Children's Research Hospital S. t.
- Julie Gastier Foster
- Julien Baboud
- Kalicki Veizer Joelle
- Kanchi Krishna Latha
- Kandoth Cyriac
- Karen Mungall
- Ken Chen
- Kenna R. Mills Shaw
- Khanh Nguyen
- Klco Jeffery M.
- Koboldt Daniel C.
- Laird Peter W.
- Ley Timothy
- Lihua Zou
- Liming Yang
- Ling Lin
- Lisa Wise
- Los Angeles
- Louis S. t.
- Louis S. t.
- Louis S. t.
- Louis S. t.
- Louis S. t.
- Louis S. t.
- Louis S. t.
- Louis S. t.
- Louis S. t.
- Lucas Swanson
- Lukas D. Wartman
- M. D. P. h. D.
- M. D. P. h. D.
- M. D. P. h. D.
- M. D. P. h. D.
- M. D. P. h. D.
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- M. D. P. h. D.
- M. D. P. h. D.
- M. S. c. D. V. M.
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- M. S.
- M. S.
- M. S.
- M. S.
- M. S.
- M. S.
- M. S.
- M. S.
- M. S.
- Marco A. Marra
- Margi Sheth
- Mark A. Jensen
- Mark A. Watson
- Mark D. M. Leiserson B. A.
- Mark Backus
- Martin L. Ferguson
- Martin Carroll
- Martin Hirst
- Massachusetts Institute of Technology
- Matthew C. Nicholls
- Matthew J. Walter
- Memphis
- Michael C. Wendl
- Michael D. Mclellan
- Michael H. Tomasson
- Michael Mayo
- Michelle Le Beau
- Miller Christopher
- Miruna Balasundaram
- Mlf Consulting
- Moiz S. Bootwalla
- Mungall Andrew J.
- Natasja Wye
- National Cancer Institute
- National Cancer Institute
- National Human Genome Research Institute
- National Human Genome Research Institute
- Nianziang Zhang
- Nina Thiessen
- Noreen Dhalla
- P. h. D. M. P. H.
- P. h. D.
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- Patrick Plettner
- Peter Westervelt
- Philadelphia
- Philadelphia
- Phillip H. Lai
- Prachi Kothiyal
- Providence Ri
- Ranabir Guin
- Raphael Benjamin J.
- Rashmi N. Sanbhadti
- Readman Chiu
- Rehan Akbani
- Richard A. Moore
- Richard K. Wilson
- Richard Corbett
- Richard Varhol
- Robert A. Holt
- Robertson A. Gordon
- Rohini Raman
- Sciementis Llc
- Sean P. Barletta
- Seattle Cancer Care Alliance
- Seattle
- Shashikant Kulkarni
- Shelley Alonso
- Siteman Cancer Center S. t. Louis
- Siteman Cancer Center S. t. Louis
- Siteman Cancer Center S. t. Louis
- Sra International
- Stacey Gabriel
- Stanley Girshik
- Statham Ga
- Stephen B. Baylin
- Steven Jones
- Steven Kornblau
- Tamara L. Lamprecht
- Tanja Davidsen
- Tara Lichtenberg
- Temple University
- the Genome Institute at Washington University
- the Genome Institute at Washington University
- the Genome Institute at Washington University
- the Genome Institute at Washington University
- the Genome Institute at Washington University
- the Research Institute at Nationwide Children's Hospital
- Thomas C. Motter
- Thomas Grossman
- Timothy A. Graubert
- Todd D. Pihl
- Triche Timothy J.
- University of Southern California
- University of Texas M. D. Anderson Cancer Center
- University of Texas M. D. Anderson Cancer Center
- University of Chicago
- University of Pennsylvania
- Vancouver Canada
- Vandin Fabio
- Washington University
- Washington University
- Washington University
- Washington University
- Washington University
- Washington University
- Washington University
- Yaron Butterfield
- Yongjun Zhao
- Yunhu Wan
- Zhining Wang
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2013
- Field of study
BACKGROUND: Many mutations that contribute to the pathogenesis of acute myeloid leukemia (AML) are undefined. The relationships between patterns of mutations and epigenetic phenotypes are not yet clear. METHODS: We analyzed the genomes of 200 clinically annotated adult cases of de novo AML, using either whole-genome sequencing (50 cases) or whole-exome sequencing (150 cases), along with RNA and microRNA sequencing and DNA-methylation analysis. RESULTS: AML genomes have fewer mutations than most other adult cancers, with an average of only 13 mutations found in genes. Of these, an average of 5 are in genes that are recurrently mutated in AML. A total of 23 genes were significantly mutated, and another 237 were mutated in two or more samples. Nearly all samples had at least 1 nonsynonymous mutation in one of nine categories of genes that are almost certainly relevant for pathogenesis, including transcription-factor fusions (18% of cases), the gene encoding nucleophosmin (NPM1) (27%), tumor-suppressor genes (16%), DNA-methylation-related genes (44%), signaling genes (59%), chromatin-modifying genes (30%), myeloid transcription-factor genes (22%), cohesin-complex genes (13%), and spliceosome-complex genes (14%). Patterns of cooperation and mutual exclusivity suggested strong biologic relationships among several of the genes and categories. CONCLUSIONS: We identified at least one potential driver mutation in nearly all AML samples and found that a complex interplay of genetic events contributes to AML pathogenesis in individual patients. The databases from this study are widely available to serve as a foundation for further investigations of AML pathogenesis, classification, and risk stratification. (Funded by the National Institutes of Health.) Copyright © 2013 Massachusetts Medical Society
Additional file 8 of Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis
- Author
- Aadahl Mette
- Abbas Shahid
- Abecasis Goncalo
- Academy of Scientific and Innovative Research (AcSIR)
- Adair Linda S.
- Adams Hieab H. H.
- Adeyemo Adebowale A.
- Agency for Science Technology and Research (A*STAR)
- Aguilar-Salinas Carlos A.
- Akiyama Masato
- Al-Mulla Fahd
- Alexandria University
- Algebra University College
- Amsterdam Public Health Institute
- Arbeeva Liubov
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- van Duijn Cornelia M.
- van Heel David A.
- van Meurs Joyce B. J.
- van Setten Jessica
- Vanderbilt University Medical Center
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- Vestergaard Henrik
- Veturi Yogasudha
- Villalpando Clicerio Gonzalez
- Virgen de las Nieves University Hospital
- Vitart Veronique
- Vrije Universiteit Amsterdam de Boelelaan
- VU University Medical Center
- Völzke Henry
- Walker Mark
- Walters Robin G.
- Wang Carol A.
- Wang Chaolong
- Wang Jun-Sing
- Wang Ya Xing
- Wang Yuxuan
- Wang Zeyuan
- Wang Zhe
- Wareham Nicholas J.
- Warner Sophie C.
- Warren Helen R.
- Washington University in St. Louis
- Washington University School of Medicine in St. Louis
- Watkins Hugh
- Wei Wei-Qi
- Wei Wen B.
- Weill Cornell Medicine-Qatar
- Weir David R.
- Weiss Stefan
- Wellcome Sanger Institute
- Wellcome Trust Centre for Human Genetics
- Wenzhou Medical University
- Westlake Laboratory of Life Sciences and Biomedicine
- Westlake University
- Whitfield John B.
- Wickremasinghe Ananda R.
- Widén Elisabeth
- Wielscher Matthias
- Wild Sarah H.
- Willemsen Allegonda H. M.
- Willer Cristen J.
- Wilson James F.
- Wilson James G.
- Wilson Peter W. F.
- Winkler Thomas W.
- Wojczynski Mary K.
- Wong Andrew
- Wong Tien-Yin
- Woo Jeong-Taek
- Wood Andrew R.
- Wu Jer-Yuarn
- Wu Kuan-Han H.
- Xia Rui
- Xue Chao
- Yamamoto Masayuki
- Yang Bin
- Yang Jian
- Yang Jingyun
- Yao Jie
- Yin Xianyong
- Yokota Mitsuhiro
- Yong Loo Lin School of Medicine
- Yonsei University
- Yoon Kyungheon
- Yousri Noha A.
- Yu Ketian
- Yuan Jian-Min
- Zajac Greg J. M.
- Zeggini Eleftheria
- Zeng Lingyao
- Zhang Jifeng
- Zhang Weihua
- Zhao Jing-Hua
- Zhao Wei
- Zheng Wei
- Zhou Wei
- Zhu Xiang
- Zhu Xiaofeng
- Zilhao Nuno R.
- Zimmermann Martina E.
- Zmuda Joseph M.
- Zonderman Alan B.
- Åsvold Bjørn Olav
- Publication venue
- figshare
- Publication date
- 01/01/2023
- Field of study
Additional file 8: Table S6. Association of lipid index variants with CAD, T2D and NAFLD
Additional file 19 of Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis
- Author
- Aadahl Mette
- Abbas Shahid
- Abecasis Goncalo
- Aberdeen Centre for Health Data Science
- Academy of Scientific and Innovative Research (AcSIR)
- Adair Linda S.
- Adams Hieab H. H.
- Adeyemo Adebowale A.
- Agency for Science Technology and Research (A*STAR)
- Aguilar-Salinas Carlos A.
- Akiyama Masato
- Al-Mulla Fahd
- Alexandria University
- Algebra University College
- Amsterdam Public Health Institute
- Arbeeva Liubov
- Arnett Donna K.
- Asselbergs Folkert W.
- Assimes Themistocles L.
- Atlanta VA Health Care System
- Attia John
- Attikon University Hospital
- Banas Bernhard
- Bandinelli Stefania
- Baras Aris
- Barts and The London School of Medicine and Dentistry
- Bayyana Swati
- Bechayda Sonny Augustin
- Beijing Institute for Brain Disorders
- Beijing Institute of Ophthalmology
- Beijing Tongren Hospital Capital Medical University
- Benjamins Jan W.
- Bennett David A.
- Bentley Amy R.
- Berlin Institute of Health
- Beulens Joline W. J.
- Bharadwaj Dwaipayan
- Bhatti Konain Fatima
- BHF Glasgow Cardiovascular Research Centre Faculty of Medicine
- Bielak Lawrence F.
- Biino Ginevra
- Bis Joshua C.
- Bispebjerg and Frederiksberg Hospital
- Bjerregaard Anne A.
- Black Corri
- Boehnke Michael
- Bollepalli Sailalitha
- Boomsma Dorret I.
- Bork-Jensen Jette
- Bornholms Hospital
- Boston University School of Public Health
- Bouchard Claude
- Bradfield Jonathan P.
- Bradford Yuki
- Brandslund Ivan
- Braund Peter S.
- Broad Institute
- Brody Jennifer A.
- Brown Christopher D.
- Brown Michael R.
- Brown Morris
- Brumpton Ben M.
- Buring Julie E.
- Burtt Noël P.
- Böger Carsten A.
- Cade Brian E.
- Cai Qiuyin
- Campbell Archie
- Campbell Harry
- Capital Medical University
- Carolina Population Center
- Case Western Reserve University
- Caulfield Mark J.
- Cañadas-Garre Marisa
- Center for Non-Communicable Diseases
- Chai Jin Fang
- Chambers John C.
- Chandak Giriraj R.
- Chang Kyong-Mi
- Chasman Daniel I.
- Chaturvedi Nish
- Chen Shufeng
- Chen YEugene
- Chen Yii-Der Ida
- Chen Zhengming
- Cheng Ching-Yu
- Children's Hospital Oakland Research Institute
- Children's Hospital Philadelphia and University of Pennsylvania School of Medicine
- Chinese Academy of Medical Sciences &
- Chinese National Human Genome Center at Shanghai
- Chitrala Kumaraswamy Naidu
- Cho Kelly
- Cho Yoon Shin
- Choi Hyeok Sun
- Choudhury Ananyo
- Christensen Henry
- Christensen Kaare
- Christian-Albrechts-Universitaet zu Kiel
- Christofidou Paraskevi
- Chuang Lee-Ming
- Churchill Hospital
- CIBIOR
- Cincinnati Children's Hospital Medical Center
- Ciullo Marina
- Clarendon Laboratory
- Clarke Shoa L.
- Clinical Trial Service Unit and Epidemiological Studies Unit
- College of Life Sciences
- College of Medicine
- Columbia University Mailman School of Public Health
- Concas Maria Pina
- Correa Adolfo
- Costanzo Maria C.
- Couture Christian
- Cruz Miguel
- CSIR-Centre for Cellular and Molecular Biology
- CSIR-Institute of Genomics and Integrative Biology
- Cuellar-Partida Gabriel
- Cupples LAdrienne
- Damrauer Scott M.
- Dantoft Thomas M.
- Dasman Diabetes Institute
- Data Tecnica International
- Data Tecnica International
- David Geffen School of Medicine at UCLA
- Daviglus Martha
- Daw EWarwick
- de Borst Gert J.
- de Graaf Jacqueline
- De Jager Philip L.
- de Kleijn Dominique
- de Silva H. Janaka
- de Vries Paul S.
- deCODE genetics/Amgen Inc.
- Dedoussis George
- Delgado Graciela E.
- Deloukas Panos
- Demirkan Ayşe
- Department of Clinical Neuroscience
- Department of Epidemiology and Data Science Amsterdam UMC
- Department of General Practice Amsterdam UMC
- Department of Nephrology Instituto de Investigaciones Biomédicas Sant Pau
- Dipartimento di Chimica e Farmacia Università di Sassari
- Dorajoo Rajkumar
- Doumatey Ayo P.
- Dromokaiteio Psychiatric Hospital
- Duke-NUS Medical School Singapore
- DZHK (German Centre for Cardiovascular Research) Partner site Greifswald
- Ealing Hospital
- Elders Petra J. M.
- Emory University
- Emory University School of Medicine
- Engmann Jorgen
- Erasmus University Medical Center
- Erdmann Jeanette
- Evans Michele K.
- Ewha Womans University School of Medicine
- Faculteit Medische Wetenschappen/UMCG
- Faisalabad Institute of Cardiology
- Farmaki Aliki-Eleni
- Faul Jessica D.
- Feitosa Mary F.
- Feng QiPing
- Fernandez-Lopez Juan Carlos
- Fimlab Laboratories Department of Clinical Chemistry
- Finnish Institute for Health and Welfare
- Forer Lukas
- Fornage Myriam
- Francesco Cucca
- Frank Mirjam
- Franke Andre
- Franks Paul W.
- Frayling Timothy M.
- Fred Hutchinson Cancer Research Center
- Freie Universität Berlin
- Freitag-Wolf Sandra
- Fuchsberger Christian
- Fuwai Hospital Chinese Academy of Medical Sciences &
- Galesloot Tessel E.
- Gao Zishan
- Gaziano John M.
- Geisinger
- Genome Institute of Singapore
- George Institute for Global Health at Peking University Health Science Centre
- George Washington University
- German Center for Diabetes Research
- German Centre for Integrative Biodiversity Research (iDiv) Halle-Jena-Leipzig
- German Chronic Kidney Disease Study
- German Institute of Human Nutrition
- Ghanbari Mohsen
- Giannakopoulou Olga
- Giardoglou Tota
- Gieger Christian
- Girotto Giorgia
- Giulianini Franco
- Glenfield Hospital
- Goel Anuj
- Golightly Yvonne M.
- Gordon-Larsen Penny
- Graduate School of Medical Sciences
- Graff Mariaelisa
- Graham Sarah E.
- Grant Struan F. A.
- Grarup Niels
- Gu Dongfeng
- Gudbjartsson Daniel F.
- Gudnason Vilmundur
- Guo Xiuqing
- Gustafsson Stefan
- Haessler Jeffrey
- Hakonarson Hakon
- Hallym University
- Han Sohee
- Hansen Torben
- Harbor-UCLA Medical Center
- Harokopio University
- Hart Leen M.‘t
- Harvard Medical School
- Harvard School of Public Health
- Hattersley Andrew T.
- Havulinna Aki S.
- Haworth Simon
- Hayes M. Geoffrey
- Hayward Caroline
- Hazelhurst Scott
- Hebbar Prashantha
- Heid Iris M.
- Helgadottir Anna
- Heng Chew-Kiat
- Hewitt Alex W.
- Hidalgo Bertha
- Hilliard Austin T.
- Hindy George
- Hirschhorn Joel N.
- Hishigaki Haretsugu
- Ho Yuk-Lam
- Hoefer Imo E.
- Hofer Edith
- Hollander Anneke Iden
- Holm Hilma
- Holmes Michael V.
- Homuth Georg
- Hospital of Southern Jutland
- Hottenga Jouke Jan
- Huang Hongyan
- Huang Jianfeng
- Huang Wei
- Huazhong University of Science and Technology
- Huck Institutes of the Life Sciences
- Huerta-Chagoya Alicia
- Hui Qin
- Hung Yi-Jen
- Hunt Karen A.
- Hunt Steven C.
- Huo Shaofeng
- Hutri-Kähönen Nina
- Hveem Kristian
- Hwang Mi Yeong
- Hwu Chii-Min
- Icahn School of Medicine at Mount Sinai
- Icelandic Heart Association
- Ichihara Sahoko
- Iha Hiroyuki
- Ikeda Daisuke D.
- Ikram M. Arfan
- Imperial College
- Imperial College and Imperial Healthcare NHS Trust
- Imperial College London
- Ingelsson Erik
- Institute for Biomedicine (affiliated with the University of Lübeck)
- Institute for Maternal and Child Health - IRCCS Burlo Garofolo
- Institute of Astronomy and Astrophysics
- Institute of Epidemiology 2
- Institute of Genetics and Biophysics “Adriano Buzzati-Traverso” - CNR
- Institute of Molecular and Clinical Ophthalmology
- Institute of Nutrition and Functional Foods (INAF)
- Instituto de Investigaciones Biomédicas UNAM/ Instituto Nacional de Ciencias Médicas Y Nutrición Salvador Zubirán
- Instituto de Investigación Biosanitaria de Granada (ibs.GRANADA)
- Instituto Nacional de Medicina Genómica
- InstitutoNacional de Salud Publica Y Centro de Estudios en Diabetes
- Interuniversity Cardiology Institute of The Netherlands
- IRCCS Neuromed
- Irvin Marguerite R.
- Istituto di Ricerca Genetica e Biomedica
- Jackson Rebecca D.
- Jang Dongkeun
- Jang Hye-Mi
- Jarvelin Marjo-Riitta
- Jarvik Gail P.
- Jawaharlal Nehru University
- Ji Yingji
- Jichi Medical University
- Jin Zi-Bing
- John Radcliffe Hospital
- Jonas Jost B.
- Joshi Peter K.
- Jousilahti Pekka
- JSS Academy of Higher Education and Research
- Jukema J. Wouter
- Jung Bettina
- Justice Anne E.
- Jäger Susanne
- Jöckel Karl-Heinz
- Kamatani Yoichiro
- Kanai Masahiro
- Kanoni Stavroula
- Kaprio Jaakko
- Kardia Sharon L. R.
- Karolinska University Hospital
- Karpe Fredrik
- Kathiresan Sekar
- Kato Norihiro
- Katsuya Tomohiro
- Kawaguchi Takahisa
- Kee Frank
- Kentistou Katherine A.
- KfH Kidney Center Traunstein
- Khera Amit V.
- Khor Chiea Chuen
- Kiemeney Lambertus A. L. M.
- Kim Bong-Jo
- Kim Eung Kweon
- Kim Han-Na
- Kim Hyung-Lae
- Kim Young Jin
- King Abdulaziz University
- King's College London
- Kivimaki Mika
- Klarin Derek
- Kleber Marcus E.
- Koh Woon-Puay
- Koistinen Heikki A.
- Kolcic Ivana
- Kooner Jaspal S.
- Kooperberg Charles
- Kovacs Peter
- Kraaijeveld Adriaan O.
- Kraft Peter
- Krauss Ronald M.
- Kronenberg Florian
- Kubo Michiaki
- Kullo Iftikhar J.
- Kumari Meena
- Kurbasic Azra
- Kurume University School of Medicine
- Kutalik Zoltan
- Kuusisto Johanna
- Kyoto University Graduate School of Medicine
- Kyung Hee University School of Medicine
- Kähönen Mika
- Kårhus Line L.
- Laakso Markku
- Laboratory for Financial Engineering of Laval University
- Lamina Claudia
- Landspitali University Hospital
- Lange Leslie A.
- Langenberg Claudia
- Launer Lenore J.
- Le Phuong
- Lee Kong Chian School of Medicine
- Lee Hyejin
- Lee Jong Young
- Lehtimäki Terho
- Leiden University Medical Center
- Leipzig University Hospital
- Leonard Hampton L.
- Lettre Guillaume
- Li Hengtong
- Li Huaixing
- Li Liming
- Li Xiaohui
- Li Xiaoyin
- Liang Jingjing
- Lieb Wolfgang
- Life Course Epidemiology (LCE)
- Lin Kuang
- Lin Maoxuan
- Lin Shih-Yi
- Lin Xu
- Lind Lars
- Lingren Todd
- Linneberg Allan
- Liu Fangchao
- Liu Jianjun
- Liu Jun
- Lo Ken Sin
- Local Health Unit Toscana Centro
- Locke Adam E.
- Loeffler Markus
- London North West University Healthcare NHS Trust
- Long Jirong
- Loos Ruth J. F.
- Lorés-Motta Laura
- Loukola Anu
- Ltd
- Lu Xiangfeng
- Luan Jian’an
- Lund University
- Lund University Diabetes Centre
- Lynch Julie A.
- Lyssenko Valeriya
- Lyytikäinen Leo-Pekka
- Magnusson Patrik K. E.
- Mahajan Anubha
- Mamakou Vasiliki
- Mangino Massimo
- Manichaikul Ani
- Marouli Eirini
- Marques-Vidal Pedro
- Marten Jonathan
- Martin Hilary C.
- Martin Lisa Warsinger
- Martin Nicholas G.
- Mashhad University of Medical Sciences
- MASPEC Institut
- Massachusetts General Hospital
- Massachusetts General Hospital Cancer Center
- Massachusetts Institute of Technology
- Matsuda Fumihiko
- Matteo Floris
- Mauro Pala
- Mayo Clinic
- McCarthy Mark I.
- McDaid Aaron F.
- McKnight Amy Jayne
- Medical Faculty Mannheim/Heidelberg University
- Medical University of Graz
- Medina-Gomez Carolina
- Medizinische Universitat Innsbruck
- Meidtner Karina
- Mellström Dan
- Mercader Josep M.
- Milken Institute School of Public Health
- Miller Jason E.
- Millwood Iona Y.
- Minerva Foundation Institute for Medical Research Helsinki
- Mitchell Jonathan S.
- Mitchell Paul
- Mitchell Ruth E.
- Mohlke Karen L.
- Mook-Kanamori Dennis O.
- Mori Trevor A.
- Morris Andrew P.
- Morrison Alanna C.
- MRC Human Genetics Unit
- MRC Integrative Epidemiology Unit at the University of Bristol
- Munroe Patricia B.
- Munz Matthias
- Murakami Yoshinori
- Männikkö Minna
- März Winfried
- Møllehave Line T.
- Nabika Toru
- Nagoya University Graduate School of Medicine
- Nakatochi Masahiro
- Nalls Mike A.
- Namjou Bahram
- Nanjing University of Chinese Medicine
- Nardone Giuseppe Giovanni
- Narita Akira
- Natarajan Pradeep
- National and Capodistrian University of Athens
- National Center for Global Health and Medicine
- National Defense Medical Center Taiwan
- National Heart Lung, and Blood Institute (NHLBI)
- National Human Genome Research Institute
- National Institute of Health
- National Institute of Medical Sciences and Nutrition Salvador Zubirán
- National Institute on Aging
- National Institutes of Health Bethesda
- National Taiwan University Hospital
- National University Heart Centre
- National University Heart Centre Singapore
- National Yang Ming Chiao Tung University
- National Yang Ming University
- Nelson Amanda E.
- Nelson Christopher P.
- Nethander Maria
- Neville Matt J.
- Newcastle University
- Nielsen Aneta A.
- NIHR Biomedical Research Centre at Guy's and St Thomas' Foundation Trust
- Niinikoski Harri
- Nikus Kjell
- Nongmaithem Suraj S.
- Noordam Raymond
- North Kari E.
- Northwestern University
- Northwestern University Feinberg School of Medicine
- Norwegian University of Science and Technology
- Novo Nordisk Foundation Center for Basic Metabolic Research
- Ntalla Ioanna
- Nuffield Department of Medicine
- Nutile Teresa
- Obura Morgan O.
- Ohio State University
- Ohlsson Claes
- Okada Yukinori
- Oklahoma City Veterans Affairs Medical Center
- Olafsson Isleifur
- Oldehinkel Albertine J.
- Oldmeadow Christopher
- Orozco Lorena
- Osaka University Graduate School of Medicine
- Ospedali Riuniti and University of Trieste
- Oxford University Hospitals Foundation Trust
- O’Donnell Christopher J.
- Pacheco Jennifer Allen
- Pahkala Katja
- Pajukanta Päivi
- Palmer Colin N. A.
- Pandit Anita
- Parra Esteban J.
- Pasterkamp Gerard
- Pauper Marc
- Pedersen Nancy L.
- Pedersen Oluf
- Peloso Gina M.
- Pennell Craig E.
- Pennington Biomedical Research Center
- Penninx Brenda
- Pennsylvania State University
- Peters Annette
- Petersen Eva R. B.
- Peyser Patricia A.
- Pitkänen Niina
- Pitsillides Achilleas
- Polasek Ozren
- Poulter Neil
- Poveda Alaitz
- Pramstaller Peter P.
- Prasad Gauri
- Preuss Michael H.
- Privatpraxis Prof Jonas und Dr Panda-Jonas
- Province Michael A.
- Psaty Bruce M.
- Pérusse Louis
- QIMR Berghofer Medical Research Instititute
- Qu Jia
- Quantinuum Research LLC
- Queen Mary University of London
- Queen's University
- Radboud University Nijmegen
- Rader Daniel J.
- Raitakari Olli T.
- Rallidis Loukianos S.
- Ramdas Shweta
- Ramirez Julia
- Ramsay Michèle
- Rao D.C.
- Rasheed Asif
- Rasheed Humaira
- Rayner Nigel W.
- Redline Susan
- Regeneron Genetics Center
- Reilly Dermot F.
- Reiner Alexander P.
- Rhee Sang Youl
- Ridker Paul M.
- RIKEN Center for Integrative Medical Sciences
- Ripatti Samuli
- Ritchie Marylyn D.
- Rosenthal Elisabeth A.
- Rotimi Charles N.
- Rotter Jerome I.
- Ruggiero Daniela
- Ruotsalainen Sanni E.
- Rush Alzheimer’s Disease Center
- Rush University Medical Center
- Ryu Seungho
- Sabanayagam Charumathi
- Sabater-Lleal Maria
- Sahlgrenska University Hospital
- Sakaue Saori
- Saleheen Danish
- Salomaa Veikko
- Samani Nilesh J.
- Sattar Naveed
- Schering-Plough
- Schmidt Börge
- Schmidt Ellen M.
- Schmidt Helena
- Schmidt Reinhold
- Scholz Markus
- School of Clinical Medicine
- School of Medicine and Public Health
- Schulze Matthias B.
- Schunkert Heribert
- Scott Rodney J.
- Sengupta Dhriti
- Sever Peter
- Shanghai Institute of Nutrition and Health
- Shimane University School of Medicine
- Shin Jae Hun
- Shu Xiao-Ou
- Sim Xueling
- Simonsick Eleanor
- Singapore Eye Research Institute
- Singapore Immunology Network (SIgN) Agency for Science Technology and Research Singapore, Biopolis
- Slieker Roderick C.
- Smith Blair H.
- Smith Jennifer A.
- Smyth Laura J.
- Snieder Harold
- Southam Lorraine
- Southern University of Science and Technology
- Spector Tim D.
- Spracklen Cassandra N.
- St George's University of London
- St. Olavs University Hospital
- Stanford University
- Stanford University School of Medicine
- Stark Klaus J.
- Stefansson Kari
- Strachan David P.
- Stringham Heather M.
- Sun Yan V.
- Sung Yun Ju
- Sungkyunkwan University
- Sungkyunkwan University School of Medicine
- Surakka Ida
- Swiss Institute of Bioinformatics
- Sygehus Lillebælt
- SYNLAB Medizinisches Versorgungszentrum Weiden GmbH
- Tabara Yasuharu
- Tai EShyong
- Taichung Veterans General Hospital
- Taipei Veterans General Hospital
- Takayama Jun
- Takeuchi Fumihiko
- Tamiya Gen
- Tampere University Hospital
- Tampereen Yliopisto
- Tang Hua
- Tardif Jean-Claude
- Technical University of Munich
- Technische Universität München
- Terao Chikashi
- Terzikhan Natalie
- Thanaraj Thangavel Alphonse
- The Institute for Translational Genomics and Population Sciences
- The University of Newcastle
- the University of Texas Health Science
- The University of Texas Health Science Center at Houston
- The University of Tokyo
- Theusch Elizabeth
- Thiery Joachim
- Thorleifsson Gudmar
- Thorsteinsdottir Unnur
- Timmers Paul R. H. J.
- Timpson Nicholas J.
- Tohoku University
- Traunstein Hospital
- Trembath Richard C.
- Trivedi Bhavi
- Trompet Stella
- Tsao Noah L.
- Tsao Philip S.
- Turku University Hospital and University of Turku
- Turman Constance
- Tusié-Luna Teresa
- Tönjes Anke
- Universidad Adolfo Ibáñez
- Universidad de Granada
- Universidad Nacional Autónoma de México
- University Greifswald
- University Hospital of Southern Denmark
- University Medical Center Groningen
- University Medical Center Utrecht
- University Medicine Greifswald
- University of Alabama at Birmingham School of Public Health
- University of Alabama Birmingham
- University of Bergen
- University of Bristol
- University of California San Francisco
- University of Cambridge
- University of College London
- University of Colorado Denver
- University of Copenhagen
- University of Copenhagen Faculty of Health Sciences
- University of Dundee
- University of Eastern Finland
- University of Edinburgh
- University of Essen
- University of Essex
- University of Exeter Medical School
- University of Glasgow
- University of Gothenburg
- University of Gothenburg Sahlgrenska Academy
- University of Groningen
- University of Heidelberg
- University of Helsinki
- University of Houston
- University of Iceland
- University of Illinois College of Medicine
- University of Kelaniya
- University of Lausanne
- University of Leicester
- University of Manchester
- University of Massachusetts
- University of Massachusetts Boston
- University of Melbourne
- University of Michigan
- University of Michigan Medical School
- University of Michigan School of Public Health
- University of Mississippi Medical Center
- University of Montreal
- University of Newcastle Faculty of Medicine and Health Sciences
- University of Newcastle Australia
- University of North Carolina
- University of Oslo
- University of Oulu
- University of Oxford Medical Sciences Division
- University of Pennsylvania
- University of Pennsylvania Perelman School of Medicine
- University of Pittsburgh
- University of Pittsburgh Graduate School of Public Health
- University of Queensland
- University of Regensburg
- University of San Carlos
- University of Science and Technology of China
- University of South Carolina
- University of Southern Denmark
- University of Split School of Medicine
- University of Surrey
- University of Sydney
- University of Tasmania
- University of Texas Health Science Center at Houston
- University of the Witwatersrand
- University of Toronto
- University of Turku
- University of Utah
- University of Virginia
- University of Washington School of Medicine
- University of Washington Seattle
- University of Western Australia
- University of Zaragoza
- Universität Potsdam
- Universitätsklinikum Regensburg
- Université de Montréal
- Uppsala University
- Uppsala University
- VA Boston Healthcare System
- VA Palo Alto Health Care System
- Vaccargiu Simona
- van Dam Rob M.
- van der Harst Pim
- van der Laan Sander W.
- van der Most Peter J.
- van Dijk Ko Willems
- van Duijn Cornelia M.
- van Heel David A.
- van Meurs Joyce B. J.
- van Setten Jessica
- Vanderbilt University Medical Center
- Vazquez-Moreno Miguel
- Vedantam Sailaja
- Verma Anurag
- Verve Therapeutics
- Verweij Niek
- Vestergaard Henrik
- Veturi Yogasudha
- Villalpando Clicerio Gonzalez
- Virgen de las Nieves University Hospital
- Vitart Veronique
- Vrije Universiteit Amsterdam de Boelelaan
- VU University Medical Center
- Völzke Henry
- Walker Mark
- Walters Robin G.
- Wang Carol A.
- Wang Chaolong
- Wang Jun-Sing
- Wang Ya Xing
- Wang Yuxuan
- Wang Zeyuan
- Wang Zhe
- Wareham Nicholas J.
- Warner Sophie C.
- Warren Helen R.
- Washington University in St. Louis
- Washington University School of Medicine in St. Louis
- Watkins Hugh
- Wei Wei-Qi
- Wei Wen B.
- Weill Cornell Medicine-Qatar
- Weir David R.
- Weiss Stefan
- Wellcome Sanger Institute
- Wellcome Trust Centre for Human Genetics
- Wenzhou Medical University
- Westlake Laboratory of Life Sciences and Biomedicine
- Westlake University
- Whitfield John B.
- Wickremasinghe Ananda R.
- Widén Elisabeth
- Wielscher Matthias
- Wild Sarah H.
- Willemsen Allegonda H. M.
- Willer Cristen J.
- Wilson James F.
- Wilson James G.
- Wilson Peter W. F.
- Winkler Thomas W.
- Wojczynski Mary K.
- Wong Andrew
- Wong Tien-Yin
- Woo Jeong-Taek
- Wood Andrew R.
- Wu Jer-Yuarn
- Wu Kuan-Han H.
- Xia Rui
- Xue Chao
- Yamamoto Masayuki
- Yang Bin
- Yang Jian
- Yang Jingyun
- Yao Jie
- Yin Xianyong
- Yokota Mitsuhiro
- Yong Loo Lin School of Medicine
- Yonsei University
- Yoon Kyungheon
- Yousri Noha A.
- Yu Ketian
- Yuan Jian-Min
- Zajac Greg J. M.
- Zeggini Eleftheria
- Zeng Lingyao
- Zhang Jifeng
- Zhang Weihua
- Zhao Jing-Hua
- Zhao Wei
- Zheng Wei
- Zhou Wei
- Zhu Xiang
- Zhu Xiaofeng
- Zilhao Nuno R.
- Zimmermann Martina E.
- Zmuda Joseph M.
- Zonderman Alan B.
- Åsvold Bjørn Olav
- Publication venue
- figshare
- Publication date
- 01/01/2023
- Field of study
Additional file 19: Table S11. Significant female-specific multi-ancestry meta-analysis results
- …