Light and Shadow of Artificial Intelligence: Transformative Journalism Opportunities and ethical dilemmas brought about by ChatGPT -- A research review based on the literature of domestic core journals

Since the release of ChatGPT in 2022, the related research fields have shown an explosive growth trend. Given this, this study attempts to sort out the current research systematically results on ChatGPT in journalism and communication by the literature review to expand the horizon of future research. Journalism and communication scholars have carried out a series of research on ChatGPT from three aspects: journalism reform, media theory, and media ethics. These researchers made certain progress in theory and practice. However, the existing researches still have problems, such as unclear concept definition, single research method, and confusing research topic. Future research should base on the perspective of journalism and communication disciplines, expand research methods and enrich research perspectives, and constantly upgrade ChatGPT research from phenomenon discussion to theoretical innovation and academic exchange. Keywords: ChatGPT, News communication, Artificial intelligence, Media ethics DOI: 10.7176/NMMC/104-12 Publication date: July 31st 2023

Evaluation of the communication delay in a hybrid real-time simulator for weak grids

Real-time Simulation (RTS) is one of the effective means via which to study device level or system level dynamics, such as power converter online testing, evaluation, and control, and power system stability analysis. The RTS -enabled design-chain offers a time -effective, low-cost, and fail-safe development process. As the penetration of renewable energy is becoming higher, the demand in hybrid system real-time simulation becomes imperative, where fast-dynamic device level power converters and slow -dynamic large -scale power systems are simulated at the same time. This paper introduces a novel hybrid real-time simulation architecture based on the central processing unit (CPU) and the field-programmable gate array (FPGA). Compared with the off-the-shelf power system real-time simulation system, it offers both wide time scale simulation and high accuracy. The multi-time scale model can perform electromechanical electromagnetic transient hybrid simulation, which can be applied to the research of power systems penetrated with power converters. In the proposed simulation platform, the communication delay is introduced when different RTS platforms exchange real-time data. The communication delay should be considered in the stability analysis of the grid-connected inverters in a weak grid environment. Based on the virtual impedance characteristic formed by the control loop with and without communication delay, the impedance characteristics are analyzed and inter-simulator delay impacts are revealed in this paper. Theoretical analysis indicates that the communication delay, contrary to expectation, can improve the virtual impedance characteristics of the system. With the same hardware simulation parameters, the grid-converter system is verified on both the Typhoon system alone and the Typhoon-dSPACE-SpaceR hybrid simulation platform. The THD value of grid current in a weak grid environment that works in the Typhoon system is 4.98%, and 2.38% in the Typhoon-dSPACE-SpaceR hybrid simulation platform. This study eventually reveals the fact that the inter-simulation delay creates the illusion that the control system built in the novel hybrid real-time simulation is more stable under weak grid conditions

Mutant p53 drives clonal hematopoiesis through modulating epigenetic pathway

Clonal hematopoiesis of indeterminate potential (CHIP) increases with age and is associated with increased risks of hematological malignancies. While TP53 mutations have been identified in CHIP, the molecular mechanisms by which mutant p53 promotes hematopoietic stem and progenitor cell (HSPC) expansion are largely unknown. Here we discover that mutant p53 confers a competitive advantage to HSPCs following transplantation and promotes HSPC expansion after radiation-induced stress. Mechanistically, mutant p53 interacts with EZH2 and enhances its association with the chromatin, thereby increasing the levels of H3K27me3 in genes regulating HSPC self-renewal and differentiation. Furthermore, genetic and pharmacological inhibition of EZH2 decreases the repopulating potential of p53 mutant HSPCs. Thus, we uncover an epigenetic mechanism by which mutant p53 drives clonal hematopoiesis. Our work will likely establish epigenetic regulator EZH2 as a novel therapeutic target for preventing CHIP progression and treating hematological malignancies with TP53 mutations

Discrete element simulation of particle motion in ball mills based on similarity

Discrete element (DE) simulation of a ball mill with a large number of particles is challenging when each particle is considered. Similarity principle could be adopted to reduce the number of particles in a simulation whilst still maintaining the accurate flow behaviour of particles. This paper presents a scaling relationship between particle gravitational acceleration, mill diameter and mill rotational speed. A series of scaled simulations of particle motion with different mill diameters are carried out. Consistent motion of a single particle and multiple particles in ball mills with different diameters and rotational speeds verifies the proposed relationship, which could be an effective approach to reduce the size of simulations for ball mills

Author Correction: Mutant p53 drives clonal hematopoiesis through modulating epigenetic pathway

An amendment to this paper has been published and can be accessed via a link at the top of the paper

Metabolomics and Proteomics of Brassica napus Guard Cells in Response to Low CO2

Stomatal guard cell response to various stimuli is an important process that balances plant carbon dioxide (CO2) uptake and water transpiration. Elevated CO2 induces stomatal closure, while low CO2 promotes stomatal opening. The signaling process of elevated CO2 induced stomatal closure has been extensively studied in recent years. However, the mechanism of low CO2 induced stomatal opening is not fully understood. Here we report metabolomic and proteomic responses of Brassica napus guard cells to low CO2 using hyphenated mass spectrometry technologies. A total of 411 metabolites and 1397 proteins were quantified in a time-course study of low CO2 effects. Metabolites and proteins that exhibited significant changes are overrepresented in fatty acid metabolism, starch and sucrose metabolism, glycolysis and redox regulation. Concomitantly, multiple hormones that promote stomatal opening increased in response to low CO2. Interestingly, jasmonic acid precursors were diverted to a branch pathway of traumatic acid biosynthesis. These results indicate that the low CO2 response is mediated by a complex crosstalk between different phytohormones

Aurora kinase A regulates cancer-associated RNA aberrant splicing in breast cancer

The contribution of oncogenes to tumor-associated RNA splicing and the relevant molecular mechanisms therein require further elaboration. Here, we show that oncogenic Aurora kinase A (AURKA) promotes breast cancer-related RNA aberrant splicing in a context-dependent manner. AURKA regulated pan-breast cancer-associated RNA splicing events including GOLGA4, RBM4 and UBQLN1. Aberrant splicing of GOLGA4 and RBM4 was closely related to breast cancer development. Mechanistically, AURKA interacted with the splicing factor YBX1 and promoted AURKA-YBX1 complex-mediated GOLGA4 exon inclusion. AURKA binding to the splicing factor hnRNPK promoted AURKA-hnRNPK complex-mediated RBM4 exon skipping. Analysis of clinical data identified an association between the AURKA-YBX1/hnRNPK complex and poor prognosis in breast cancer. Blocking AURKA nuclear translocation with small molecule drugs partially reversed the oncogenic splicing of RBM4 and GOLGA4 in breast cancer cells. In summary, oncogenic AURKA executes its function on modulating breast cancer-related RNA splicing, and nuclear AURKA is distinguished as a hopeful target in the case of treating breast cancer