484 research outputs found

    Lessico della cultura dialettale delle Madonie. 2. Voci di saggio

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    Nella prospettiva di una sistematica ricognizione del patrimonio lessicale di un'area di grande interesse etnodialettale come quella madonita e dopo il volume sulla cultura alimentare tradizionale, il volume presenta oltre 3000 voci di saggio e numerose unit\ue0 fraseologiche relative alla terminolgia connessa ai settori della cultura tradizionale. Le voci si riferiscono, in particolare, ai pi\uf9 significativi concetti dell'agricoltura e della pastorizia, ma presentano anche molti ambiti del mondo "naturale" (zoonimi, fitonimi, miconimi, meteoronimi). Il volume \ue8 corredato di carte linguistiche a colori sui principali tratti della cultura dialettale delle Madonie; il libro \ue8 arricchito da numerose illustrazioni sull'ergologia agricola e pastorale e sulla fauna locale (mammiferi, uccelli, rettili, anfibi). Il corpo del Lessico \ue8 infine integrato da numerosi etnotesti (con traduzione integrale), organizzati nella sezione "Racconti di antiche consuetudini"

    PROGETTAZIONE E VERIFICA SPERIMENTALE DI UNA MICROTURBINA IDRAULICA PER L\u2019INDUSTRIA ALIMENTARE

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    In questo articolo sono descritte le attivit\ue0 di ricerca e sviluppo di una micro-turbina idraulica inserita all\u2019interno di un macchinario che opera un nuovo processo di abbattimento della carica batterica applicabile nell\u2019industria dell\u2019imbottigliamento delle bevande. Peculiarit\ue0 della turbina progettata \ue8 la geometria della palettatura della girante, dritta ed a sviluppo puramente assiale, che ne rende estremamente economica la realizzazione. Lo scambio di energia avviene grazie al moto vorticoso impresso al fluido (swirl) mediante opportuno posizionamento dei condotti di adduzione. Lo studio della turbina \ue8 stato condotto mediante classico approccio unidimensionale, mentre il dimensionamento \ue8 stato effettuato con l\u2019ausilio di simulazioni CFD. Ultimata la progettazione, la turbina \ue8 stata realizzata e si \ue8 avviata una campagna di prove sperimentali su un banco di flussaggio appositamente allestito che ha consentito di verificare il soddisfacimento delle specifiche progettuali

    Ultrasound Triggered ZnO-Based Devices for Tunable and Multifaceted Biomedical Applications

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    Smart materials able to respond to an external stimulus or an environmental condition represent milestone developments in modern medicine. Among them, zinc oxide (ZnO) is a highly intriguing inorganic material with versatile morphologies/shapes and multifunctional properties like piezoelectricity, enhanced reactive oxygen species (ROS) generation, and antimicrobial ones. Here, the fabrication of smart ZnO-based films is shown that can remotely be activated by ultrasound (US). US exposure induces electrical potentials on the fabricated devices that can be exploited to stimulate electrically responsive cells or promote ROS generation for cancer treatment. ZnO microparticles with surface nanostructuring are thus synthesized and processed in the form of a paste to deposit thin films on flexible polymeric supports. ZnO paste formulation and the fabrication procedure of the final device are optimized in terms of uniformity, hydrophilicity, and purity. Graphene oxide and poly(2-hydroxyethyl methacrylate) are also layered onto the ZnO films in order to provide the devices with additional functionalities. ROS generation and electro-mechanical performances upon US stimulation are evaluated for all of the developed devices. Finally, biocompatibility studies are conducted with osteoblast-like cell cultures for possible applications in the contexts of bone tissue engineering/therapy

    The double face of metals: The intriguing case of chromium

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    Chromium (Cr) is a common element in the Earth’s crust. It may exist in different oxidation states, Cr(0), Cr(III) and Cr(VI), with Cr(III) and Cr(VI) being relatively stable and largely predominant. Chromium’s peculiarity is that its behavior relies on its valence state. Cr(III) is a trace element in humans and plays a major role in glucose and fat metabolism. The beneficial effects of Cr(III) in obesity and types 2 diabetes are known. It has been long considered an essential element, but now it has been reclassified as a nutritional supplement. On the other hand, Cr(VI) is a human carcinogen and exposure to it occurs both in occupational and environmental contexts. It induces also epigenetic effects on DNA, histone tails and microRNA; its toxicity seems to be related to its higher mobility in soil and swifter penetration through cell membranes than Cr(III). The microorganisms Acinetobacter sp. Cr1 and Pseudomonas sp. Cr13 have been suggested as a promising agent for bioremediation of Cr(VI). This review intends to underline the important role of Cr(III) for human health and the dangerousness of Cr(VI) as a toxic element. The dual and opposing roles of this metal make it particularly interesting. An overview of the recent literature is reported in support

    Thallium use, toxicity, and detoxification therapy: An overview

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    Thallium (Tl) is released into the environment, where is present at very low levels, from both natural and anthropogenic sources. Tl is considered as one of the most toxic heavy metals; it is a non‐essential metal, present in low concentrations in humans. Tl toxicity causes dermatological and gastrointestinal diseases and disorders of the nervous system, and may even result in death. Many isotopes of Tl exist, with different uses. One of the isotopes of this metal (201Tl) is used in cardiovascular scintigraphy and for the diagnosis of malignant tumors such as breast or lung cancer and osteosarcoma bone cancer. Many Tl compounds are tasteless, colorless, and odorless. Due to these characteristics and their high toxicity, they have been used as poisons in suicides and murders for criminal purposes, as well as instances of accidental poisoning. Impaired glutathione metabolism, oxidative stress, and disruption of potassium‐regulated homeostasis may play a role in the mechanism of Tl toxicity. Solanum nigrum L. and Callitriche cophocarpa have been suggested as promising agents for the phytoremediation of Tl. In addition, macrocyclic compounds such as crown ethers (18‐crown‐6) are good candidates to absorb Tl from wastewater. Through this review, we present an update to general information about the uses and toxicity of Tl. Furthermore, the attention is focused on detoxification therapies

    First autochthonous Dirofilaria immitis (Leidy, 1856) infection in a dog in Hungary

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    AbstractA 4 year-old, male Hungarian Vizsla dog which had never been abroad was referred with poor general condition, decrease in body weight, haematemesis and jaundice to the Central Clinic of Veterinary Science University, Budapest. After symptomatic treatment abdominal ultrasonography and diagnostic laparatomy were carried out. The dog was humanely euthanized two days later following owner's consent because of sudden worsening of clinical conditions. Two adult heartworms (Dirofilaria immitis) were found in the right ventricle partially coiling around the tricuspid valve. PCR on blood was positive for both D. immitis and Dirofilaria repens while only D. repens microfilariae were found by modified Knott's test and the serological test was negative for D. immitis antigens. This is the first, confirmed report of autochthonous canine heartworm infection in Hungary

    Wolbachia, doxycycline and macrocyclic lactones: New prospects in the treatment of canine heartworm disease

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    Abstract Melarsomine dihydrochloride (Immiticide®, Merial) is the only approved adulticidal drug for the treatment of canine heartworm disease (HWD). However, in cases where arsenical therapy is not possible or is contraindicated, a monthly heartworm preventive along with doxycycline for a 4-week period, which targets the bacterial endosymbiont Wolbachia, might be considered. There are published reports on the efficacy of ivermectin and doxycycline in both experimentally and naturally infected dogs, but no data on the use of other macrocyclic lactones (MLs) with a similar treatment regime. Preliminary results of studies in dogs show that a topical formulation of moxidectin, the only ML currently registered as a microfilaricide, is also adulticidal when combined with doxycycline. It is not yet known if the efficacy of these combination therapies is due to pharmacokinetic synergism. A recent study showed that serum levels of doxycycline in dogs treated with the combination protocol were not statistically different compared to dogs treated with doxycycline alone. However, lungs from dogs treated with the combination therapy showed a marked reduction in T regulatory cells, indicating that treatment efficacy may be due to a heightened immune response against the parasite. Further studies are necessary to evaluate the long-term clinical outcome of combination protocols and to establish the most efficient treatment for HWD in dogs

    Field-based tests for the assessment of physical fitness in children and adolescents practicing sport: A systematic review within the ESA program

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    High levels of physical fitness (PF) can positively affect both health and cognitive function, thus monitoring its levels in youth can help increase health and quality of life in adult populations later on. This systematic review aims to identify PF field-based tests used in young European populations practicing sport to find tools that are adequate for the considered target involving a new battery within the Enriched Sport Activities (ESA) project. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement was followed. In the 83 identified articles, the main tests used were: vertical/horizontal jumps (for muscular strength/power); push-ups, running at maximum effort, sit-ups (for muscular strength/endurance); multistage non-intermittent and intermittent tests (for aerobic endurance); sit and reach (for flexibility); sprinting and agility T-tests (for speed and agility, respectively); 10 x 5 m shuttle run (SR) (for both speed and agility). Few studies assessed coordination, reaction time, power, and balance. Although the selected tests are widely used and validated, they do not determine all PF aspects and do not reflect sport-specific features. A final decision was made for the inclusion of the following tests: standing broad jump, seated medicine ball throw, 20 m SR test, 30 m sprint, Illinois test, and a new test, i.e., the crunning test, to assess different skill-related components at once. The use of this combination of tests allows for the assessment of all PF components and can help planning eective training programs and cultivate sporting talent

    Design, fabrication, and characterization of a multimodal reconfigurable bioreactor for bone tissue engineering

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    In the past decades, bone tissue engineering developed and exploited many typologies of bioreactors, which, besides providing proper culture conditions, aimed at integrating those bio-physical stimulations that cells experience in vivo, to promote osteogenic differentiation. Nevertheless, the highly challenging combination and deployment of many stimulation systems into a single bioreactor led to the generation of several unimodal bioreactors, investigating one or at mostly two of the required biophysical stimuli. These systems miss the physiological mimicry of bone cells environment, and often produced contrasting results, thus making the knowledge of bone mechanotransduction fragmented and often inconsistent. To overcome this issue, in this study we developed a perfusion and electroactive-vibrational reconfigurable stimulation bioreactor to investigate the differentiation of SaOS-2 bone-derived cells, hosting a piezoelectric nanocomposite membrane as cell culture substrate. This multimodal perfusion bioreactor is designed based on a numerical (finite element) model aimed at assessing the possibility to induce membrane nano-scaled vibrations (with ~12 nm amplitude at a frequency of 939 kHz) during perfusion (featuring 1.46 dyn cm−2 wall shear stress), large enough for inducing a physiologically-relevant electric output (in the order of 10 mV on average) on the membrane surface. This study explored the effects of different stimuli individually, enabling to switch on one stimulation at a time, and then to combine them to induce a faster bone matrix deposition rate. Biological results demonstrate that the multimodal configuration is the most effective in inducing SaOS-2 cell differentiation, leading to 20-fold higher collagen deposition compared to static cultures, and to 1.6- and 1.2-fold higher deposition than the perfused- or vibrated-only cultures. These promising results can provide tissue engineering scientists with a comprehensive and biomimetic stimulation platform for a better understanding of mechanotransduction phenomena beyond cells differentiation

    Cryo-STEM-EDX spectroscopy for the characterisation of nanoparticles in cell culture media

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    We present a study of barium titanate nanoparticles dispersed in cell culture media. Scanning transmission electron microscopy combined with energy dispersive X-ray spectroscopy was undertaken on samples prepared using both conventional drop casting and also plunge freezing and examination under cryogenic conditions. This showed that drying artefacts occurred during conventional sample preparation, whereby some salt components of the cell culture media accumulated around the barium titanate nanoparticles; these were removed using the cryogenic route. Importantly, the formation of a calcium and phosphorus rich coating around the barium titanate nanoparticles was retained under cryo-conditions, highlighting that significant interactions do occur between nanomaterials and biological media
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