Pattern of maternal suicide attempt, offspring DSM-IV Major Depressive Disorder (MDD), housing tenure, marital status, smoking in pregnancy, maternal level of education, maternal psychiatric disorder before pregnancy, maternal family history of depression and maternal depression-related service use by classes of maternal depression symptoms.

<p>Imputed <i>N</i> = 10,559</p><p>^# p < .10</p><p>*p ≤ 0.05</p><p>** p ≤ 0.01</p><p>*** p ≤ 0.001 with minimal class as the reference group</p><p>Pattern of maternal suicide attempt, offspring DSM-IV Major Depressive Disorder (MDD), housing tenure, marital status, smoking in pregnancy, maternal level of education, maternal psychiatric disorder before pregnancy, maternal family history of depression and maternal depression-related service use by classes of maternal depression symptoms.</p

Logistic regression analyses showing association between each class of maternal depression symptoms in comparison to minimal class (reference group) and subsequent offspring past year suicidal ideation at age 16 years using alternative approaches to dealing with missing data (Odds Ratios (OR) and 95% Confidence Intervals (95% CI) displayed).

<p>^# p < .10</p><p>*p ≤ 0.05</p><p>** p ≤ 0.01</p><p>*** p ≤ 0.001</p><p>^a All models adjusted for confounders assessed in pregnancy, maternal suicide attempt and DSM-IV diagnosis of MDD in offspring</p><p>^b Model 1 shows the fully adjusted results using the full imputed dataset</p><p>^c Model 2 shows the fully adjusted results using imputed data for those offspring that were sent the questionnaire at age 16 years</p><p>^d Model 3 shows the fully adjusted results using only those with complete data on all variables in analysis</p><p>Logistic regression analyses showing association between each class of maternal depression symptoms in comparison to minimal class (reference group) and subsequent offspring past year suicidal ideation at age 16 years using alternative approaches to dealing with missing data (Odds Ratios (OR) and 95% Confidence Intervals (95% CI) displayed).</p

Flow chart of retention in the ‘Avon Longitudinal Study of Parents and Children’ (ALSPAC) sample.

<p>Flow chart of retention in the ‘Avon Longitudinal Study of Parents and Children’ (ALSPAC) sample.</p

Logistic regression analyses showing association between each class of maternal depression symptoms in comparison to minimal class (reference group) and subsequent offspring past year suicidal ideation at age 16 years (Odds Ratios (OR) and 95% Confidence Intervals (95% CI) displayed).

<p>Imputed <i>N</i> = 10,559</p><p>^# p < .10</p><p>*p ≤ 0.05</p><p>** p ≤ 0.01</p><p>*** p ≤ 0.001</p><p>^a Adjusting for confounders assessed in pregnancy (housing tenure, marital status, maternal level of education, smoking in pregnancy, maternal family history of depression and maternal psychiatric disorder before pregnancy)</p><p>^b Additionally adjusting for maternal suicide attempt (from pregnancy to child age 11 years)</p><p>^c Additionally adjusting for DSM-IV diagnosis of MDD in offspring (assessed using the DAWBA at ages 7, 10, 13 and 15 years)</p><p>Logistic regression analyses showing association between each class of maternal depression symptoms in comparison to minimal class (reference group) and subsequent offspring past year suicidal ideation at age 16 years (Odds Ratios (OR) and 95% Confidence Intervals (95% CI) displayed).</p

Five class model of maternal depression symptoms measured using the Edinburgh Postnatal Depression Scale (EPDS) from 18 weeks gestation to child age 11 years.

<p>Figure shows both model fitted estimated linear growth trajectories for each class (dotted line) and the observed pseudo-class trajectories for the identified classes (solid line); <i>N</i> = 10,559.</p

Correlations between parental alcohol measures (linear term) at age 4 and 12 years.

<p>Correlations between parental alcohol measures (linear term) at age 4 and 12 years.</p

Parental alcohol use (assessed at age 4 and 12 years using linear alcohol measures) and adolescent depressive symptoms.

<p>Parental alcohol use (assessed at age 4 and 12 years using linear alcohol measures) and adolescent depressive symptoms.</p

Descriptive information for maternal and partner alcohol use for both conduct problems and depressive symptoms.

<p>Descriptive information for maternal and partner alcohol use for both conduct problems and depressive symptoms.</p

Correlations between parental alcohol measures (linear term) at age 4 and 12 years.

<p>Correlations between parental alcohol measures (linear term) at age 4 and 12 years.</p

Parental alcohol consumption (assessed at age 4 years using linear and binary measures) and childhood conduct problem trajectories.

<p>Parental alcohol consumption (assessed at age 4 years using linear and binary measures) and childhood conduct problem trajectories.</p