Relativistic theory of elastic deformable astronomical bodies: perturbation equations in rotating spherical coordinates and junction conditions

In this paper, the dynamical equations and junction conditions at the interface between adjacent layers of different elastic properties for an elastic deformable astronomical body in the first post-Newtonian approximation of Einstein theory of gravity are discussed in both rotating Cartesian coordinates and rotating spherical coordinates. The unperturbed rotating body (the ground state) is described as uniformly rotating, stationary and axisymmetric configuration in an asymptotically flat space-time manifold. Deviations from the equilibrium configuration are described by means of a displacement field. In terms of the formalism of relativistic celestial mechanics developed by Damour, Soffel and Xu, and the framework established by Carter and Quintana the post Newtonian equations of the displacement field and the symmetric trace-free shear tensor are obtained. Corresponding post-Newtonian junction conditions at interfaces also the outer surface boundary conditions are presented. The PN junction condition is an extension of Wahr's one which is a Newtonian junction conditions without rotating.Comment: Revtex4, 14 page

An integrated approach to the evaluation of patients with asymptomatic or minimally symptomatic hyperCKemia

Currently, there are no straightforward guidelines for the clinical and diagnostic management of hyperCKemia, a frequent and nonspecific presentation in muscle diseases. Therefore, we aimed to describe our diagnostic workflow for evaluating patients with this condition. Methods: We selected 83 asymptomatic or minimally symptomatic patients with persistent hyperCKemia for participation in this Italian multicenter study. Patients with facial involvement and distal or congenital myopathies were excluded, as were patients with suspected inflammatory myopathies or predominant respiratory or cardiac involvement. All patients underwent a neurological examination and nerve conduction and electromyography studies. The first step of the investigation included a screening for Pompe disease. We then evaluated the patients for myotonic dystrophy type II\u2013related CCTG expansion and excluded patients with copy number variations in the DMD gene. Subsequently, the undiagnosed patients were investigated using a target gene panel that included 20 genes associated with isolated hyperCKemia. Results: Using this approach, we established a definitive diagnosis in one third of the patients. The detection rate was higher in patients with severe hyperCKemia and abnormal electromyographic findings. Discussion: We have described our diagnostic workflow for isolated hyperCKemia, which is based on electrodiagnostic data, biochemical screening, and first-line genetic investigations, followed by successive targeted sequencing panels. Both clinical signs and electromyographic abnormalities are associated with increased diagnostic yields

A study on the relationship between mass concentrations, chemistry and number size distribution of urban fine aerosols in Milan, Barcelona and London

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ZFP36L1 Negatively Regulates Erythroid Differentiation of CD34+ Hematopoietic Stem Cells by Interfering with the Stat5b Pathway

ZFP36L1 negatively regulates erythroid differentiation of human hematopoietic progenitors by directly binding the 3′ UTR of Stat5b mRNA, thereby triggering its degradation. This study shows that posttranscriptional regulation is involved in the control of hematopoietic differentiation

Preparação e caracterização de um biocompósito obtido pela mistura de hidreto de titânio com nitrato de cálcio para implantes dentários

RESUMO Neste trabalho foram realizados estudos sobre a fabricação de um biocompósito à base de titânio para implantes dentários a partir da mistura de pó de hidreto de titânio (92%) com nitrato de cálcio (8% em volume). O pó de hidreto de titânio foi adicionado na solução aquosa de nitrato de cálcio, dissolvido por agitação mecânica, e em seguida os precursores foram misturados e dispersados/homogeneizados por ultrassom. Posteriormente, a mistura foi secada em evaporador rotativo, compactada com 600 MPa à temperatura ambiente, desmoldada e sinterizada em alto vácuo a 1200 oC durante 2 horas. Foi analisada a microestrutrura e fases formadas, as propriedades mecânicas, a rugosidade da superfície, a porosidade aberta, a molhabilidade da superfície e a citotoxicidade do biocompósito. As fases identificadas após a sinterização foram α-Ti e CaTiO3. O limite de resistência em compressão, o módulo de Young (E) e o ângulo de contato do biocompósito diminuíram significativamente com relação ao hidreto de titânio puro sinterizado nas mesmas condições. O limite médio de resistência em compressão do hidreto de titânio foi de 1794,67 MPa e do biocompósito foi de 481,36 MPa. O módulo de Young e o ângulo de contato do hidreto de titânio e do biocompósito foram de aproximadamente 112 GPa e 94 graus, e de 75 GPa e 83 graus, respectivamente. A rugosidade de superfície foi da mesma ordem de grandeza entre os materiais e ficou aproximadamente entre 1,4 e 1,5 µm (Ra) e 1,4 e 1,9 µm (Ra e Sa), medidas com rugosímetro de contato e com microscópio confocal a laser, respectivamente. A porosidade aberta do biocompósito sinterizado foi de aproximadamente três vezes maior do que aquela do hidreto de titânio sinterizado. Nos ensaios de citotoxicidade a porcentagem de células viáveis do biocompósito foi superior àquela do controle negativo e àquela do hidreto de titânio sinterizado

Machine learning risk prediction of mortality for patients undergoing surgery with perioperative SARS-CoV-2: the COVIDSurg mortality score

To support the global restart of elective surgery, data from an international prospective cohort study of 8492 patients (69 countries) was analysed using artificial intelligence (machine learning techniques) to develop a predictive score for mortality in surgical patients with SARS-CoV-2. We found that patient rather than operation factors were the best predictors and used these to create the COVIDsurg Mortality Score (https://covidsurgrisk.app). Our data demonstrates that it is safe to restart a wide range of surgical services for selected patients.Laura Bravo ... COVIDSurg Collaborative : (Royal Adelaide Hospital, N. N. Dudi-Venkata, H. M. Kroon, T. Sammour) ... et al.

Avaliação dos mecanismos de aderência entre argamassa colante e substrato não poroso

A resistência de aderência de um sistema de revestimento cerâmico é uma das mais importantes propriedades deste tipo de acabamento. O conhecimento das propriedades dos substratos e argamassas, e a capacidade de bem avaliar a interação entre os elementos são preceitos básicos para construírem-se revestimentos duráveis. Nesse sentido, o aperfeiçoamento dos modelos que descrevem os mecanismos de aderência, objetos de estudo deste trabalho, são essenciais, principalmente devido a diferenças nas características dos materiais relativas à porosidade, verificadas tanto em substratos como nas placas. O planejamento experimental consistiu no assentamento de um revestimento cerâmico externo utilizando-se a técnica de piso sobre piso, ensaios de resistência de aderência, aquisição de imagens em MEV dos pisos retirados do campo de testes e caracterização das argamassas colantes de estudo. Os resultados mostraram uma relação entre a resistência de aderência e a extensão de contato entre a argamassa e o substrato, indicando que o mecanismo de aderência para o assentamento de placas sobre substratos não porosos está diretamente relacionado com a extensão do contato entre os materiais, resultando em um modelo de aderência para o caso de revestimento cerâmico em substrato pouco poroso

Role of MeCP2, DNA methylation, and HDACs in regulating synapse function

Over the past several years there has been intense effort to delineate the role of epigenetic factors, including methyl-CpG-binding protein 2, histone deacetylases, and DNA methyltransferases, in synaptic function. Studies from our group as well as others have shown that these key epigenetic mechanisms are critical regulators of synapse formation, maturation, as well as function. Although most studies have identified selective deficits in excitatory neurotransmission, the latest work has also uncovered deficits in inhibitory neurotransmission as well. Despite the rapid pace of advances, the exact synaptic mechanisms and gene targets that mediate these effects on neurotransmission remain unclear. Nevertheless, these findings not only open new avenues for understanding neuronal circuit abnormalities associated with neurodevelopmental disorders but also elucidate potential targets for addressing the pathophysiology of several intractable neuropsychiatric disorders