MODELING CYLINDER-TO-CYLINDER COUPLING IN MULTI-CYLINDER HCCI ENGINES INCORPORATING REINDUCTION

ABSTRACT Residual-affected homogeneous charge compression ignition (HCCI) is a promising strategy for decreasing fuel consumption and NOx emissions in internal combustion engines. One practical approach for achieving residual-affected HCCI is by using variable valve actuation to reinduct previously exhausted combustion products. This process inherently couples neighboring engine cylinders as products exhausted by one cylinder may be reinducted by a neighboring one. In order to understand this coupling and its implication for controlling HCCI, this paper outlines a simple physics based model of a multi-cylinder HCCI engine using exhaust reinduction. It is based on a physics based model previously validated for a single cylinder, multi mode HCCI engine. The exhaust manifold model links exhaust gases from one cylinder to those of the other cylinders and also simulates the effect of exhaust reinduction from the previous cycle. Depending on the exhaust manifold geometry and orientation, the heat transfer in the manifold causes a difference in the temperature of the re-inducted product gas across the cylinders. The results show that a subtle difference in the re-inducted exhaust gas temperature results in a dramatic variation in combustion timing (approx. 3 degrees). This model provides a basis for understanding the steady state behavior and also for developing control strategies for multi-cylinder HCCI engines. The paper presents exhaust valve timing induced compression ratio modulation (via flexible valve actuation) as one of the approaches to mitigate the imbalance in combustion timing across cylinders

Identification of Novel Pathogenicity Loci in Clostridium perfringens Strains That Cause Avian Necrotic Enteritis

Type A Clostridium perfringens causes poultry necrotic enteritis (NE), an enteric disease of considerable economic importance, yet can also exist as a member of the normal intestinal microbiota. A recently discovered pore-forming toxin, NetB, is associated with pathogenesis in most, but not all, NE isolates. This finding suggested that NE-causing strains may possess other virulence gene(s) not present in commensal type A isolates. We used high-throughput sequencing (HTS) technologies to generate draft genome sequences of seven unrelated C. perfringens poultry NE isolates and one isolate from a healthy bird, and identified additional novel NE-associated genes by comparison with nine publicly available reference genomes. Thirty-one open reading frames (ORFs) were unique to all NE strains and formed the basis for three highly conserved NE-associated loci that we designated NELoc-1 (42 kb), NELoc-2 (11.2 kb) and NELoc-3 (5.6 kb). The largest locus, NELoc-1, consisted of netB and 36 additional genes, including those predicted to encode two leukocidins, an internalin-like protein and a ricin-domain protein. Pulsed-field gel electrophoresis (PFGE) and Southern blotting revealed that the NE strains each carried 2 to 5 large plasmids, and that NELoc-1 and -3 were localized on distinct plasmids of sizes ∼85 and ∼70 kb, respectively. Sequencing of the regions flanking these loci revealed similarity to previously characterized conjugative plasmids of C. perfringens. These results provide significant insight into the pathogenetic basis of poultry NE and are the first to demonstrate that netB resides in a large, plasmid-encoded locus. Our findings strongly suggest that poultry NE is caused by several novel virulence factors, whose genes are clustered on discrete pathogenicity loci, some of which are plasmid-borne

Clouds and convective self-aggregation in a multi-model ensemble of radiative-convective equilibrium simulations

The Radiative-Convective Equilibrium Model Intercomparison Project (RCEMIP) is an intercomparison of multiple types of numerical models configured in radiative-convective equilibrium (RCE). RCE is an idealization of the tropical atmosphere that has long been used to study basic questions in climate science. Here, we employ RCE to investigate the role that clouds and convective activity play in determining cloud feedbacks, climate sensitivity, the state of convective aggregation, and the equilibrium climate. RCEMIP is unique amongst intercomparisons in its inclusion of a wide range of model types, including atmospheric general circulation models (GCMs), single column models (SCMs), cloud-resolving models (CRMs), large eddy simulations (LES), and global cloud-resolving models (GCRMs). The first results are presented from the RCEMIP ensemble of more than 30 models. While there are large differences across the RCEMIP ensemble in the representation of mean profiles of temperature, humidity, and cloudiness, in a majority of models anvil clouds rise, warm, and decrease in area coverage in response to an increase in sea surface temperature (SST). Nearly all models exhibit self-aggregation in large domains and agree that self-aggregation acts to dry and warm the troposphere, reduce high cloudiness, and increase cooling to space. The degree of self-aggregation exhibits no clear tendency with warming. There is a wide range of climate sensitivities, but models with parameterized convection tend to have lower climate sensitivities than models with explicit convection. In models with parameterized convection, aggregated simulations have lower climate sensitivities than un-aggregated simulations

CASE REPORT: Phocomelia Syndrome - A Case Report

Phocomelia is an extremely rare malformation in which babies are born with limbs that look like flippers on a seal. Although various factors can cause phocomelia, the prominent roots came from the drug use of thalidomide and from genetic inheritance. Phocomelia is transmitted as an autosomal recessive trait with variable expressivity and malformation is linked to chromosome 8

Two days National Conference -VISHWATECH 2014 Real Time Data Acquisition and Control System Using ARM9 & GPRS Technology

Abstract-Day by day the scope of networked embedded system is rapidly increasing for monitoring & controlling either home appliances or industry devices. Users can monitor & control remote machines/systems by using embedded web server. Idea is utilized for DAC by using Advanced RISC machine (A RM 9) processor & in-build web server application with General Packet Rad io Serv ice (GPRS) technology. GPRS technology along with GSM makes it accessible fro m anywhere in the world. This paper proposes low cost system deve lopment. Various sensors installed at working place help in sensing real time environ mental conditioning like temperature, hu mid ity, carbon monoxide etc

Buccal drug delivery system: A review

The buccal area of the oral mucosa provides an adorable channel of systemic medication distribution within the mouth mucosa. Drugs are delivered via oral mucosal layer, that has a higher first-pass metabolism and degrades gastrointestinal. The medication is immediately transmitted via the systemic circulation via the buccal drug delivery mechanism, which allows for painless administration, quick enzymatic action, high bioavailability, and reduced liver metabolism. The disadvantages of the oral drug delivery route include substantial presystemic metabolism, which causes medicines to a break down in an acidic environment due to poor absorption. Buccal delivery is an attractive administrative route due to its ease of delivery through the buccal mucosal membrane lining of the oral cavity. This review paper provides a comprehensive overview of the oral mucosa, mucoadhesion, variables influencing the whole process, assessment methodologies, and how to eliminate obstacles when formulating buccal drug delivery formulations