Magnetar-like Emission from the Young Pulsar in Kes 75

We report detection of magnetar-like X-ray bursts from the young pulsar PSR J1846-0258, at the center of the supernova remnant Kes 75. This pulsar, long thought to be rotation-powered, has an inferred surface dipolar magnetic field of 4.9x10^13 G, higher than those of the vast majority of rotation-powered pulsars, but lower than those of the ~12 previously identified magnetars. The bursts were accompanied by a sudden flux increase and an unprecedented change in timing behavior. These phenomena lower the magnetic and rotational thresholds associated with magnetar-like behavior, and suggest that in neutron stars there exists a continuum of magnetic activity that increases with inferred magnetic field strength.Comment: 17 pages, 2 figures, accepted for publication in Science. Note: The content of this paper is embargoed until February 21, 200

Long-term X-ray changes in the emission from the anomalous X-ray pulsar 4U 0142+61

We present results obtained from X-ray observations of the anomalous X-ray pulsar (AXP) 4U 0142+61 taken between 2000-2007 using XMM-Newton, Chandra and Swift. In observations taken before 2006, the pulse profile is observed to become more sinusoidal and the pulsed fraction increased with time. These results confirm those derived using the Rossi X-ray Timing Explorer and expand the observed evolution to energies below 2 keV. The XMM-Newton total flux in the 0.5-10 keV band is observed to be nearly constant in observations taken before 2006, while an increase of ~10% is seen afterwards and coincides with the burst activity detected from the source in 2006-2007. After these bursts, the evolution towards more sinusoidal pulse profiles ceased while the pulsed fraction showed a further increase. No evidence for large-scale, long-term changes in the emission as a result of the bursts is seen. The data also suggest a correlation between the flux and hardness of the spectrum, with brighter observations on average having a harder spectrum. As pointed out by other authors, we find that the standard blackbody plus power-law model does not provide the best spectral fit to the emission from 4U 0142+61. We also report on observations taken with the Gemini telescope after two bursts. These observations show source magnitudes consistent with previous measurements. Our results demonstrate the wide range of X-ray variability characteristics seen in AXPs and we discuss them in light of current emission models for these sources.Comment: 10 pages, 9 figures, in emulateapj style. Submitted to Ap

Many-body Quantum Chaos and Entanglement in a Quantum Ratchet

We uncover signatures of quantum chaos in the many-body dynamics of a Bose-Einstein condensate-based quantum ratchet in a toroidal trap. We propose measures including entanglement, condensate depletion, and spreading over a fixed basis in many-body Hilbert space which quantitatively identify the region in which quantum chaotic many-body dynamics occurs, where random matrix theory is limited or inaccessible. With these tools we show that many-body quantum chaos is neither highly entangled nor delocalized in the Hilbert space, contrary to conventionally expected signatures of quantum chaos.Comment: 6 pages, 3 figures. 1 tabl

Engineering Solutions for Mitigation of Chimeric Antigen Receptor T-Cell Dysfunction

The clinical successes of chimeric antigen receptor (CAR)-T-cell therapy targeting cell surface antigens in B cell leukaemias and lymphomas has demonstrated the proof of concept that appropriately engineered T-cells have the capacity to destroy advanced cancer with long term remissions ensuing. Nevertheless, it has been significantly more problematic to effect long term clinical benefit in a solid tumour context. A major contributing factor to the clinical failure of CAR-T-cells in solid tumours has been named, almost interchangeably, as T-cell "dysfunction" or "exhaustion". While unhelpful ambiguity surrounds the term "dysfunction", "exhaustion" is canonically regarded as a pejorative term for T-cells. Recent understanding of T-cell developmental biology now identifies exhausted cells as vital for effective immune responses in the context of ongoing antigenic challenge. The purpose of this review is to explore the critical stages in the CAR-T-cell life-cycle and their various contributions to T-cell exhaustion. Through an appreciation of the predominant mechanisms of CAR-T-cell exhaustion and resultant dysfunction, we describe a range of engineering approaches to improve CAR-T-cell function

An Fe XXVI Absorption Line in the Persistent Spectrum of the Dipping Low Mass X-ray Binary 1A 1744-361

We report on Chandra X-ray Observatory (CXO) High-Energy Transmission Grating (HETG) spectra of the dipping Low Mass X-ray Binary (LMXB) 1A 1744-361 during its July 2008 outburst. We find that its persistent emission is well modeled by a blackbody (kT ~ 1.0 keV) plus power-law ($\Gamma$ ~ 1.7) with an absorption edge at 7.6 keV. In the residuals of the combined spectrum we find a significant absorption line at 6.961+/-0.002 keV, consistent with the Fe XXVI (hydrogen-like Fe) 2 - 1 transition. We place an upper limit on the velocity of a redshifted flow of v < 221 km/s. We find an equivalent width for the line of 27^+2_-3 eV, from which we determine a column density of 7+/-1x10^17 cm^-2 via a curve-of-growth analysis. Using XSTAR simulations, we place a lower limit on the ionization parameter of > 10^3.6 erg cm/s. The properties of this line are consistent with those observed in other dipping LMXBs. Using Rossi X-ray Timing Explorer (RXTE) data accumulated during this latest outburst we present an updated color-color diagram which clearly shows that 1A 1744-361 is an "atoll" source. Finally, using additional dips found in the RXTE and CXO data we provide an updated orbital period estimate of 52+/-5 minutes.Comment: 8 pages, 7 figures, submitted to Ap

An Fe XXIV Absorption Line in the Persistent Spectrum of the Dipping Low-Mass X-Ray Binary 1A 1744-361

We report on Chandra X-ray Observatory (Chandra) High Energy Transmission Grating spectra of the dipping low-mass X-ray binary 1A 1744361 during its 2008 July outburst. We find that its persistent emission is well modeled by a blackbody (kT approx. 1.0 keV) plus power law (Gamma approx. 1.7) with an absorption edge. In the residuals of the combined spectrum, we find a significant absorption line at 6.961 +/- 0.002 keV, consistent with the Fe xxvi (hydrogen-like Fe) 2-1 transition.We place an upper limit on the velocity of a redshifted flow of nu 103.6 erg cm/s. We discuss what implications the feature has on the system and its geometry. We also present Rossi X-ray Timing Explorer data accumulated during this latest outburst and, via an updated color-color diagram, clearly show that 1A 1744361 is an "atoll" sourc

The Pulsed Spectra of Two Extraordinary Pulsars

We report on X-ray monitoring of two isolated pulsars within the same RXTE field of view. PSR J1811-1925 in the young supernova remnant G11.2-0.3 has a nearly sinusoidal pulse profile with a hard pulsed spectrum (photon index \~1.2). The pulsar is a highly efficient (~ 1% of spin-down energy) emitter of 2-50 keV pulsed X-rays despite having a fairly typical B ~ 2e12 G magnetic field. PSR J1809-1943/XTE J1810-197 is a newly discovered slow (P=5.54 s), apparently isolated X-ray pulsar which increased in flux by a factor of ~100 in 2003 January. Nine months of monitoring observations have shown a decrease in pulsed flux of ~ 30% without a significant change in its apparently thermal spectrum (kT ~0.7 keV) or pulse profile. During this time, the spin-down torque has fluctuated by a factor of ~ 2. Both the torque and the flux have remained steady for the last 3 months, at levels consistent with a magnetar interpretation.Comment: 3 pages, 4 figures, to appear in the Proceedings of X-ray Timing 2003: Rossi and Beyond, ed. P. Kaaret, F.K. Lamb, & J.H. Swank held in Cambridge, MA, Nov. 3-5, 200

Three-dimensional neurite tracing under globally varying contrast

We study the 3D neurite tracing problem in different imaging modalities. We consider that the examined images do not provide sufficient contrast between neurite and background, and the signal-to-noise ratio varies spatially. We first split the stack into box sub-volumes, and inside each box we evolve simultaneously a number of different open-curve snakes. The curves deform based on three criteria: local image statistics, local shape smoothness, and a term that enforces pairwise attraction between snakes, given their spatial proximity and shapes. We validate our method using larva Drosophila sensory neurons imaged with confocal laser scanning microscopy, as well as publicly available datasets