GGS-groups over primary trees: Branch structures

We study branch structures in Grigorchuk-Gupta-Sidki groups (GGS-groups) over primary trees, that is, regular rooted trees of degree $p^n$ for a prime $p$. Apart from a small set of exceptions for $p=2$, we prove that all these groups are weakly regular branch over $G''$. Furthermore, in most cases they are actually regular branch over $\gamma_3(G)$. This is a significant extension of previously known results regarding periodic GGS-groups over primary trees and general GGS-groups in the case $n=1$. We also show that, as in the case $n=1$, a GGS-group generated by a constant vector is not branch.Comment: 14 page

Pro-p groups with few normal subgroups

Motivated by the study of pro-p groups With finite coclass, we consider the class of pro-p groups with few normal subgroups. This is not a well defined class and we offer several different definitions and study the connections between them. Furthermore, we propose a definition of periodicity for pro-p groups, thus, providing a general framework for some periodic patterns that have already been observed in the existing literature. We then focus oil examples and show that strikingly all the interesting examples not only have few normal Subgroups, but in addition have periodicity in the lattice of normal subgroups. (C) 2008 Elsevier Inc. All rights reserved

Lithium attenuates behavioral and biochemical effects of neuropeptide S in mice

Neuropeptide S (NPS) and its receptor NPSR comprise a recently deorphaned G-protein-coupled receptor system. There is a body of evidence suggesting the involvement of NPS in wakefulness, anxiety, locomotor activity and oxidative stress damage. Considering that mood stabilizers block the stimulatory effect of psychostimulants in rodents, the present study aimed to investigate the effects of the pretreatment with lithium and valproate on the hyperlocomotion evoked by NPS. Another relevant action induced by lithium and valproate is the neuroprotection against oxidative stress. Thus, aiming to get further information about the mechanisms of action of NPS, herein we evaluated the effects of NPS, lithium and valproate, and the combination of them on oxidative stress damage. Behavioral studies revealed that the pretreatment with lithium (100 mg/kg, i.p.) and valproate (200 mg/kg, i.p.) prevented hyperlocomotion evoked by NPS 0.1 nmol. Importantly, the dose of valproate used in this study reduced mouse locomotion, although it did not reach the statistical significance. Biochemical analyses showed that lithium attenuated thiobarbituric reactive species (TBARS) formation in the striatum, cerebellum and hippocampus. NPS per se reduced TBARS levels only in the hippocampus. Valproate did not significantly affect TBARS levels in the brain. However, the combination of mood stabilizers and NPS blocked, instead of potentiate, the neuroprotective effects of each one. No relevant alterations were observed in carbonylated proteins after all treatments. Altogether, the present findings suggested that mainly the mood stabilizer lithium evoked antagonistic effects on the mediation of hyperlocomotion and protection against lipid peroxidation induced by NPS

Age-related decline of de novo T cell responsiveness as a cause of COVID-19 severity

To the Editor, So far, little attention has been paid to the link between immunosenescence and the dramatic mortality rate of coronavirus disease 2019 (COVID-19) in older age groups. Indeed, the number of cases of COVID-19, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is very low among children and teenagers, in contrast to the increased frequency in adults and the elderly, who are also more at risk of developing very serious symptoms and death (Guan et al. 2020; Wu and McGoogan 2020). As shown in Fig. 1, a similar epidemiological profile was observed during previous coronavirus (severe acute respiratory syndrome coronavirus 1, SARS-CoV-1, and Middle east respiratory syndrome coronavirus, MERS-CoV) outbreaks (Jia et al. 2009; Salamatbakhsh et al. 2019). Notably, the same trend was also noted during West Nile virus and, with some exceptions in very young children, Ebolavirus outbreaks (Bower et al. 2016; Hayes et al. 2005). Likely this phenomenon is multifactorial. For instance, in elderly individuals with severe COVID-19, associated comorbidities are much more prevalent (Guan et al. 2020). In addition, the progressive accumulation of senescent cells during life may play a role in the vulnerability of old people to COVID-19, resulting in reduced functionality of the organs, such as the lungs, and facilitating conditions for the development of fibrosis. Moreover, senescent cells can generate a pro-inflammatory environment, referred to as SASP (for senescence-associated secretory phenotype), which includes many inflammatory cytokines (e.g., interleukin-6) and contributes to the basal hyperinflammatory status characteristic of the old person. This hyperinflammatory status might influence the expression of ACE2, CD147, cyclophilins, CD26, and other CoV-associated molecules in human tissues, thus favoring viral entry (Radzikowska et al. 2020). It likely also constitutes an already unbalanced pro-inflammatory background, on which the development of an exacerbated inflammatory response and acute respiratory distress syndrome may be facilitated upon SARS-CoV-2 infection

Time-sensitive autonomous architectures

Autonomous and software-defined vehicles (ASDVs) feature highly complex systems, coupling safety-critical and non-critical components such as infotainment. These systems require the highest connectivity, both inside the vehicle and with the outside world. An effective solution for network communication lies in Time-Sensitive Networking (TSN) which enables high-bandwidth and low-latency communications in a mixed-criticality environment. In this work, we present Time-Sensitive Autonomous Architectures (TSAA) to enable TSN in ASDVs. The software architecture is based on a hypervisor providing strong isolation and virtual access to TSN for virtual machines (VMs). TSAA latest iteration includes an autonomous car controlled by two Xilinx accelerators and a multiport TSN switch. We discuss the engineering challenges and the performance evaluation of the project demonstrator. In addition, we propose a Proof-of-Concept design of virtualized TSN to enable multiple VMs executing on a single board taking advantage of the inherent guarantees offered by TSN

Relação entre aplicabilidade da ciência e satisfação profissional na voz de doutorandos em química da UFSCAR

O presente trabalho tem como objetivo contribuir à ampliação das reflexões acerca da formação em Química durante a pós-graduação. Nesse sentido, seis pós-graduandos matriculados regularmente no programa de pós-graduação em Química de uma importante universidade pública brasileira foram convidados a refletir sobre as relações entre a produção de conhecimento e a satisfação profissional, através da discussão de diferentes afirmações concernentes ao assunto de interesse. As discussões foram gravadas em áudio e transcritas para análise e os resultados mostram a influência que certas concepções inadequadas da ciência podem exercer sobre o reconhecimento e satisfação profissional daqueles que fazem pós-graduação

Up to 10.7-Gb/s high-PDG RSOA-based colorless transmitter for WDM networks

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