Development of a Multivariate Prediction Model for Early-Onset Bronchiolitis Obliterans Syndrome and Restrictive Allograft Syndrome in Lung Transplantation.

Chronic lung allograft dysfunction and its main phenotypes, bronchiolitis obliterans syndrome (BOS) and restrictive allograft syndrome (RAS), are major causes of mortality after lung transplantation (LT). RAS and early-onset BOS, developing within 3 years after LT, are associated with particularly inferior clinical outcomes. Prediction models for early-onset BOS and RAS have not been previously described. LT recipients of the French and Swiss transplant cohorts were eligible for inclusion in the SysCLAD cohort if they were alive with at least 2 years of follow-up but less than 3 years, or if they died or were retransplanted at any time less than 3 years. These patients were assessed for early-onset BOS, RAS, or stable allograft function by an adjudication committee. Baseline characteristics, data on surgery, immunosuppression, and year-1 follow-up were collected. Prediction models for BOS and RAS were developed using multivariate logistic regression and multivariate multinomial analysis. Among patients fulfilling the eligibility criteria, we identified 149 stable, 51 BOS, and 30 RAS subjects. The best prediction model for early-onset BOS and RAS included the underlying diagnosis, induction treatment, immunosuppression, and year-1 class II donor-specific antibodies (DSAs). Within this model, class II DSAs were associated with BOS and RAS, whereas pre-LT diagnoses of interstitial lung disease and chronic obstructive pulmonary disease were associated with RAS. Although these findings need further validation, results indicate that specific baseline and year-1 parameters may serve as predictors of BOS or RAS by 3 years post-LT. Their identification may allow intervention or guide risk stratification, aiming for an individualized patient management approach

Characterization test plan for a PCB to DIE transition in a fcCBGA application

International audienc

CMOS inverters based positive type second generation current conveyor

International audienc

Transconductance CMOS inverter based AC coupling amplifier

International audienc

RF Low-Pass Design Guiding Rules to Improve PCB to Die Transition Applied to Different Types of Low-Cost Packages

International audienc

OOK/NCP-FSK modulator based on coupled open-closed-loop VCOs

International audienc

Two-stage unbuffered CFOA based non-inverting resistive-feedback amplifier: a study based on the description of the operational transconductance conveyor (OTC)

International audienceA study of the non-inverting amplifier based on a two stages CMOS unbuffered current-feedback-operational-amplifier (UCF0A) is proposed in this paper. Using a small-signal equivalent circuit (macro-model) of the non-inverting amplifier, a theoretical explanation of the closed loop gain is given. The opamp phase margin and its bandwidth have been estimated from the quality factor Q of resonance and using a novel description of the UCF0A input stage called Operational Transconductance Conveyor (OTC). The OTC description can be viewed as an extension of type II second generation current conveyors. Based on the fundamental parameters of the proposed OTC, a theoretical approach given in this paper explains how to evaluate precisely the value of the UCFOA compensation capacitance. PSPICE was used to simulate both the theoretical macro-model and the CMOS configuration from a 0.35m typical BSIM3V3 transistor models

6–10 GHz ultra-wideband CMOS LNA

International audienc

OTA based on CMOS inverters and application in the design of tunable bandpass filter

International audienc

Transimpedance instrumentation amplifier based on current inversion

International audiencethis paper presents a novel instrumentation amplifier operating a differential current measurement from a resistive bridge. The proposed transimpedance instrumentation amplifier is constructed with two voltage opamps. One opamp is used to realize the current inversion and the second as a single input transimpedance amplifier. The resistive bridge is biased by a DC current and that it differs from the traditional voltage Wheatstone bridge. Simulation results by PSpice from a full custom 0.35m CMOS opamp (BSIM transistor models) and the commercially LT1097 from linear technology (macro-model) show well performances of the proposed topology and confirm the validity of the circuit. Under ±2V opamps supply voltages, the CMOS full custom configuration consume 273W per MHz and provides a linear sensitivity of 5mV