271 research outputs found
A New Approach to Searching for Dark Matter Signals in Fermi-LAT Gamma Rays
Several cosmic ray experiments have measured excesses in electrons and
positrons, relative to standard backgrounds, for energies from ~ 10 GeV - 1
TeV. These excesses could be due to new astrophysical sources, but an
explanation in which the electrons and positrons are dark matter annihilation
or decay products is also consistent. Fortunately, the Fermi-LAT diffuse gamma
ray measurements can further test these models, since the electrons and
positrons produce gamma rays in their interactions in the interstellar medium.
Although the dark matter gamma ray signal consistent with the local electron
and positron measurements should be quite large, as we review, there are
substantial uncertainties in the modeling of diffuse backgrounds and,
additionally, experimental uncertainties that make it difficult to claim a dark
matter discovery. In this paper, we introduce an alternative method for
understanding the diffuse gamma ray spectrum in which we take the intensity
ratio in each energy bin of two different regions of the sky, thereby canceling
common systematic uncertainties. For many spectra, this ratio fits well to a
power law with a single break in energy. The two measured exponent indices are
a robust discriminant between candidate models, and we demonstrate that dark
matter annihilation scenarios can predict index values that require "extreme"
parameters for background-only explanations.Comment: v1: 11 pages, 7 figures, 1 table, revtex4; v2: 13 pages, 8 figures, 1
table, revtex4, Figure 4 added, minor additions made to text, references
added, conclusions unchanged, published versio
A luminosity constraint on the origin of unidentified high energy sources
The identification of point sources poses a great challenge for the high
energy community. We present a new approach to evaluate the likelihood of a set
of sources being a Galactic population based on the simple assumption that
galaxies similar to the Milky Way host comparable populations of gamma-ray
emitters. We propose a luminosity constraint on Galactic source populations
which complements existing approaches by constraining the abundance and spatial
distribution of any objects of Galactic origin, rather than focusing on the
properties of a specific candidate emitter. We use M31 as a proxy for the Milky
Way, and demonstrate this technique by applying it to the unidentified EGRET
sources. We find that it is highly improbable that the majority of the
unidentified EGRET sources are members of a Galactic halo population (e.g.,
dark matter subhalos), but that current observations do not provide any
constraints on all of these sources being Galactic objects if they reside
entirely in the disk and bulge. Applying this method to upcoming observations
by the Fermi Gamma-ray Space Telescope has the potential to exclude association
of an even larger number of unidentified sources with any Galactic source
class.Comment: 18 pages, 4 figures, to appear in JPhys
Churn, Baby, Churn: Strategic Dynamics Among Dominant and Fringe Firms in a Segmented Industry
This paper integrates and extends the literatures on industry evolution and dominant firms to develop a dynamic theory of dominant and fringe competitive interaction in a segmented industry. It argues that a dominant firm, seeing contraction of growth in its current segment(s), enters new segments in which it can exploit its technological strengths, but that are sufficiently distant to avoid cannibalization. The dominant firm acts as a low-cost Stackelberg leader, driving down prices and triggering a sales takeoff in the new segment. We identify a “churn” effect associated with dominant firm entry: fringe firms that precede the dominant firm into the segment tend to exit the segment, while new fringe firms enter, causing a net increase in the number of firms in the segment. As the segment matures and sales decline in the segment, the process repeats itself. We examine the predictions of the theory with a study of price, quantity, entry, and exit across 24 product classes in the desktop laser printer industry from 1984 to 1996. Using descriptive statistics, hazard rate models, and panel data methods, we find empirical support for the theoretical predictions
Heat-transport mechanisms in molecular building blocks of inorganic/organic hybrid superlattices
The role of clathrin in post-golgi trafficking in toxoplasma gondii
Apicomplexan parasites are single eukaryotic cells with a highly polarised secretory system that contains unique secretory organelles (micronemes and rhoptries) that are required for host cell invasion. In contrast, the role of the endosomal system is poorly understood in these parasites. With many typical endocytic factors missing, we speculated that endocytosis depends exclusively on a clathrin-mediated mechanism. Intriguingly, in Toxoplasma gondii we were only able to observe the endogenous clathrin heavy chain 1 (CHC1) at the Golgi, but not at the parasite surface. For the functional characterisation of Toxoplasma gondii CHC1 we generated parasite mutants conditionally expressing the dominant negative clathrin Hub fragment and demonstrate that CHC1 is essential for vesicle formation at the trans-Golgi network. Consequently, the functional ablation of CHC1 results in Golgi aberrations, a block in the biogenesis of the unique secretory microneme and rhoptry organelles, and of the pellicle. However, we found no morphological evidence for clathrin mediating endocytosis in these parasites and speculate that they remodelled their vesicular trafficking system to adapt to an intracellular lifestyle
Annihilation vs. Decay: Constraining dark matter properties from a gamma-ray detection
Most proposed dark matter candidates are stable and are produced thermally in
the early Universe. However, there is also the possibility of unstable (but
long-lived) dark matter, produced thermally or otherwise. We propose a strategy
to distinguish between dark matter annihilation and/or decay in the case that a
clear signal is detected in gamma-ray observations of Milky Way dwarf
spheroidal galaxies with gamma-ray experiments. The sole measurement of the
energy spectrum of an indirect signal would render the discrimination between
these cases impossible. We show that by examining the dependence of the
intensity and energy spectrum on the angular distribution of the emission, the
origin could be identified as decay, annihilation, or both. In addition, once
the type of signal is established, we show how these measurements could help to
extract information about the dark matter properties, including mass,
annihilation cross section, lifetime, dominant annihilation and decay channels,
and the presence of substructure. Although an application of the approach
presented here would likely be feasible with current experiments only for very
optimistic dark matter scenarios, the improved sensitivity of upcoming
experiments could enable this technique to be used to study a wider range of
dark matter models.Comment: 29 pp, 8 figs; replaced to match published version (minor changes and
some new references
Constraints on dark matter models from a Fermi LAT search for high-energy cosmic-ray electrons from the Sun
During its first year of data taking, the Large Area Telescope (LAT) onboard
the Fermi Gamma-Ray Space Telescope has collected a large sample of high-energy
cosmic-ray electrons and positrons (CREs). We present the results of a
directional analysis of the CRE events, in which we searched for a flux excess
correlated with the direction of the Sun. Two different and complementary
analysis approaches were implemented, and neither yielded evidence of a
significant CRE flux excess from the Sun. We derive upper limits on the CRE
flux from the Sun's direction, and use these bounds to constrain two classes of
dark matter models which predict a solar CRE flux: (1) models in which dark
matter annihilates to CREs via a light intermediate state, and (2) inelastic
dark matter models in which dark matter annihilates to CREs.Comment: 18 pages, 8 figures, accepted for publication in Physical Review D -
contact authors: Francesco Loparco ([email protected]), M. Nicola Mazziotta
([email protected]) and Jennifer Siegal-Gaskins ([email protected]
Searches for Cosmic-Ray Electron Anisotropies with the Fermi Large Area Telescope
The Large Area Telescope on board the \textit{Fermi} satellite
(\textit{Fermi}-LAT) detected more than 1.6 million cosmic-ray
electrons/positrons with energies above 60 GeV during its first year of
operation. The arrival directions of these events were searched for
anisotropies of angular scale extending from 10 up to
90, and of minimum energy extending from 60 GeV up to 480 GeV. Two
independent techniques were used to search for anisotropies, both resulting in
null results. Upper limits on the degree of the anisotropy were set that
depended on the analyzed energy range and on the anisotropy's angular scale.
The upper limits for a dipole anisotropy ranged from to .Comment: 16 pages, 10 figures, accepted for publication in Physical Review D -
contact authors: M.N. Mazziotta and V. Vasileio
Model-Based Deconvolution of Cell Cycle Time-Series Data Reveals Gene Expression Details at High Resolution
In both prokaryotic and eukaryotic cells, gene expression is regulated across the cell cycle to ensure “just-in-time” assembly of select cellular structures and molecular machines. However, present in all time-series gene expression measurements is variability that arises from both systematic error in the cell synchrony process and variance in the timing of cell division at the level of the single cell. Thus, gene or protein expression data collected from a population of synchronized cells is an inaccurate measure of what occurs in the average single-cell across a cell cycle. Here, we present a general computational method to extract “single-cell”-like information from population-level time-series expression data. This method removes the effects of 1) variance in growth rate and 2) variance in the physiological and developmental state of the cell. Moreover, this method represents an advance in the deconvolution of molecular expression data in its flexibility, minimal assumptions, and the use of a cross-validation analysis to determine the appropriate level of regularization. Applying our deconvolution algorithm to cell cycle gene expression data from the dimorphic bacterium Caulobacter crescentus, we recovered critical features of cell cycle regulation in essential genes, including ctrA and ftsZ, that were obscured in population-based measurements. In doing so, we highlight the problem with using population data alone to decipher cellular regulatory mechanisms and demonstrate how our deconvolution algorithm can be applied to produce a more realistic picture of temporal regulation in a cell
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