346 research outputs found
Humans expect generosity
Mechanisms supporting human ultra-cooperativeness are very much subject to debate. One psychological feature likely to be relevant is the formation of expectations, particularly about receiving cooperative or generous behavior from others. Without such expectations, social life will be seriously impeded and, in turn, expectations leading to satisfactory interactions can become norms and institutionalize cooperation. In this paper, we assess peopleâs expectations of generosity in a series of controlled experiments using the dictator game. Despite differences in respective roles, involvement in the game, degree of social distance or variation of stakes, the results are conclusive: subjects seldom predict that dictators will behave selfishly (by choosing the Nash equilibrium action, namely giving nothing). The majority of subjects expect that dictators will choose the equal split. This implies that generous behavior is not only observed in the lab, but also expected by subjects. In addition, expectations are accurate, matching closely the donations observed and showing that as a society we have a good grasp of how we interact. Finally, correlation between expectations and actual behavior suggests that expectations can be an important ingredient of generous or cooperative behavior
The emergence of altruism as a social norm
Expectations, exerting influence through social norms, are a very strong candidate to explain how complex societies function. In the Dictator game (DG), people expect generous behavior from others even when they cannot enforce any sharing of the pie. Here we assume that people donate following their expectations, and that they update their expectation after playing a DG by reinforcement learning to construct a model that explains the main experimental results in the DG. Full agreement with the experimental results is reached when some degree of mismatch between expectations and donations is added into the model. These results are robust against the presence of envious agents, but affected if we introduce selfish agents that do not update their expectations. Our results point to social norms being on the basis of the generous behavior observed in the DG and also to the wide applicability of reinforcement learning to explain many strategic interactions
TREX-DM: a low background Micromegas-based TPC for low mass WIMP detection
Dark Matter experiments are recently focusing their detection techniques in
low-mass WIMPs, which requires the use of light elements and low energy
threshold. In this context, we present the TREX-DM experiment, a low background
Micromegas-based TPC for low-mass WIMP detection. Its main goal is the
operation of an active detection mass 0.300 kg, with an energy threshold
below 0.4 keVee and fully built with previously selected radiopure materials.
This article describes the actual setup, the first results of the comissioning
in Ar+2\%iCH at 1.2 bar and the future updates for a possible
physics run at the Canfranc Underground Laboratory in 2016. A first background
model is also presented, based on Geant4 simulations and a muon/electron
discrimination method. In a conservative scenario, TREX-DM could be sensitive
to DAMA/LIBRA and other hints of positive WIMPs signals, with some space for
improvement with a neutron/electron discrimination method or the use of other
light gases.Comment: Proceedings of the 7th Symposium on Large TPCs for Low-Energy Rare
Event Detectio
Analyses of chondrogenic induction of adipose mesenchymal stem cells by combined co-stimulation mediated by adenoviral gene transfer
INTRODUCTION: Adipose-derived stem cells (ASCs) have the potential to differentiate into cartilage under stimulation with some reported growth and transcriptional factors, which may constitute an alternative for cartilage replacement approaches. In this study, we analyzed the in vitro chondrogenesis of ASCs transduced with adenoviral vectors encoding insulin-like growth factor-1 (IGF-1), transforming growth factor beta-1 (TGF-ÎČ1), fibroblast growth factor-2 (FGF-2), and sex-determining region Y-box 9 (SOX9) either alone or in combinations. METHODS: Aggregate cultures of characterized ovine ASCs were transduced with 100 multiplicity of infections of Ad.IGF-1, Ad.TGF-ÎČ1, Ad.FGF-2, and Ad.SOX9 alone or in combination. These were harvested at various time points for detection of cartilage-specific genes expression by quantitative real-time PCR or after 14 and 28 days for histologic and biochemical analyses detecting proteoglycans, collagens (II, I and X), and total sulfated glycosaminoglycan and collagen content, respectively. RESULTS: Expression analyses showed that co-expression of IGF-1 and FGF-2 resulted in higher significant expression levels of aggrecan, biglycan, cartilage matrix, proteoglycan, and collagen II (all P â€0.001 at 28 days). Aggregates co-transduced with Ad.IGF-1/Ad.FGF-2 showed a selective expression of proteoglycans and collagen II, with limited expression of collagens I and Ă demonstrated by histological analyses, and had significantly greater glycosaminoglycan and collagen production than the positive control (P â€0.001). Western blot analyses for this combination also demonstrated increased expression of collagen II, while expression of collagens I and Ă was undetectable and limited, respectively. CONCLUSION: Combined overexpression of IGF-1/FGF-2 within ASCs enhances their chondrogenic differentiation inducing the expression of chondrogenic markers, suggesting that this combination is more beneficial than the other factors tested for the development of cell-based therapies for cartilage repair
Comparative study of nordihydroguaiaretic acid extraction methods from creosote bush (Larrea tridentata)
Kinetic study of nordihydroguaiaretic acid recovery from Larrea tridentata by microwave-assisted extraction
Nordihydroguaiaretic acid (NDGA) is a powerful antioxidant that can be found in plants like
Larrea tridentata (Zygophyllaceae), also known as creosote bush, which grows in semidesert
areas of Southwestern United States and Northern Mexico [1]. Several studies have
demonstrated that NDGA has important biological activities with great interest in the health area,
such as antiviral, cancer chemopreventive, and antitumorgenic activities [2]. Extraction of
bioactive compounds from plants is conventionally performed using a heatâreflux extraction
method. However, different techniques have been developed in order to decrease extraction
time and solvent consumption, as well as to increase the extraction yield and enhance the
extracts quality [3]. The objective of this study was to develop a microwaveâassisted extraction
(MAE) method for NDGA recovery from Larrea tridentata leaves, and compare the obtained
results with those found by using the conventional heatâreflux extraction (HRE)
Lowering the background level and the energy threshold of Micromegas x-ray detectors for axion searches
Axion helioscopes search for solar axions by their conversion in x-rays in
the presence of high magnetic fields. The use of low background x-ray detectors
is an essential component contributing to the sensitivity of these searches. In
this work, we review the recent advances on Micromegas detectors used in the
CERN Axion Solar Telescope (CAST) and proposed for the future International
Axion Observatory (IAXO). The actual setup in CAST has achieved background
levels below 10 keV cm s, a factor 100 lower than
the first generation of Micromegas detectors. This reduction is based on active
and passive shielding techniques, the selection of radiopure materials, offline
discrimination techniques and the high granularity of the readout. We describe
in detail the background model of the detector, based on its operation at CAST
site and at the Canfranc Underground Laboratory (LSC), as well as on Geant4
simulations. The best levels currently achieved at LSC are low than 10
keV cm s and show good prospects for the application of
this technology in IAXO. Finally, we present some ideas and results for
reducing the energy threshold of these detectors below 1 keV, using
high-transparent windows, autotrigger electronics and studying the cluster
shape at different energies. As a high flux of axion-like-particles is expected
in this energy range, a sub-keV threshold detector could enlarge the physics
case of axion helioscopes.Comment: Proceedings of 3rd International Conference on Technology and
Instrumentation in Particle Physics (TIPP 2014
SARS-CoV-2 Neutralizing Antibodies in Mexican Population: A Five Vaccine Comparison
Neutralizing antibodies (NAs) are key immunological markers and are part of the humoral response of the adaptive immune system. NA assays determine the presence of functional antibodies to prevent SARS-CoV-2 infection. We performed a real-world evidence study to detect NAs that confer protection against SARS-CoV-2 after the application of five vaccines (Pfizer/BioNTech, AstraZeneca, Sinovac, Moderna, and CanSino) in the Mexican population. Side effects of COVID-19 vaccines and clinical and demographic factors associated with low immunogenicity were also evaluated. A total of 242 SARS-CoV-2-vaccinated subjects were recruited. Pfizer/BioNTech and Moderna proved the highest percentage of inhibition in a mono-vaccine scheme. Muscular pain, headache, and fatigue were the most common adverse events. None of the patients reported severe adverse events. We found an estimated contagion-free time of 207 (IQR: 182â231) and 187 (IQR: 184â189) days for Pfizer/BioNTech and CanSino in 12 cases in each group. On the basis of our results, we consider that the emerging vaccination strategy in Mexico is effective and safe
The Effectiveness of Fiscal Policy in Mexico
Using a VAR model with quarterly information for the 1980 to 2008 period, this paper studies the dynamic effects of fiscal policy on Gross Domestic Product in the Mexican economy. We find evidence of nonâKeynesian effects of government expenditure on GDP in the short run. Also, we find evidence that government revenue has a significant impact on GDP only in the fourth quarter
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